Structures of azaspiracid analogs, azaspiracid-4 and azaspiracid-5, causative toxins of azaspiracid poisoning in Europe

Bioscience, Biotechnology and Biochemistry

Volumn 65, Issue 3, 2001, Pages 740-742

  Ofuji, Katsuya ^a   Satake, Masayuki ^a   McMahon, Terry ^b   James, Kevin J ^c   Naoki, Hideo ^d   Oshima, Yasukatsu ^a   Yasumoto, Takeshi ^a  

^a TOHOKU UNIVERSITY   (Japan)

^b MARINE INSTITUTE   (Ireland)

^c Munster Technological University   (Ireland)

^d SUNTORY INSTITUTE FOR BIOORGANIC RESEARCH   (Japan)

Author keywords

Azaspiracid; Azaspiracid analogs; Shellfish poisoning

Indexed keywords

MYTILUS EDULIS;

23 HYDROXY 22 DEMETHYLAZASPIRACID; 23-HYDROXY-22-DEMETHYLAZASPIRACID; 3 HYDROXY 22 DEMETHYLAZASPIRACID; 3-HYDROXY-22-DEMETHYLAZASPIRACID; AZASPIRACID; FUSED HETEROCYCLIC RINGS; MARINE TOXIN; SPIRO COMPOUND;

ANIMAL; ARTICLE; BIVALVE; CHEMICAL STRUCTURE; CHEMISTRY; EUROPE; FOOD POISONING; HUMAN; ISOLATION AND PURIFICATION;

ANIMALS; BIVALVIA; EUROPE; FOOD POISONING; HETEROCYCLIC COMPOUNDS, 3-RING; HUMANS; MARINE TOXINS; MOLECULAR STRUCTURE; SPIRO COMPOUNDS;

EID: 0035289355     PISSN: 09168451     EISSN: None     Source Type: Journal    
DOI: 10.1271/bbb.65.740     Document Type: Article

References (6)

1. a) McMahon, T. and Silke, J., Winter toxicity of unknown aetiology in mussels. Harmful Algae News, 14, 2 (1996);
2. b) McMahon, T. and Silke, J., Re-occurrence of winter toxicity. Harmful Algae News, 17, 12 (1998).
3. Satake, M., Ofuji, K., Naoki, H., James, K. J., Furey, A., McMahon, T., Silke, J., and Yasumoto, T., Azaspiracid, a new marine toxin having unique spiro ring assemblies, isolated from Irish mussels, Mytilus edulis. J. Am. Chem. Soc., 120, 9967-9968 (1998).
4. Ofuji, K., Satake, M., McMahon, T., Silke, J., James, K. J., Naoki, H., Oshima, Y., and Yasumoto, T., Two analogs of azaspiracid isolated from mussels, Mytilus edulis, involved in human intoxication in Ireland. Nat. Toxins, 7, 99-102 (1999).
5. Ito, E., Satake, M., Ofuji, K., Kurita, N., McMahon, T., James, K., and Yasumoto, T., Multiple organ damage caused by a new toxin azaspiracid, isolated from mussels produced in Ireland. Toxicon, 38, 917-930 (2000).
6. 3) for R-8: 1.67 (3H), 2.88 (1H), 2.97 (1H), 3.61 (3H), 5.56 (1H), 5.85 (1H), 7.47 (4H), 7.53 (1H), 7.55 (1H), 7.63 (1H), 7.79 (1H), 7.88 (1H), 8.02 (2H), 8.06 (1H).