메뉴 건너뛰기




Volumn 93, Issue 1, 2009, Pages 42-51

Systems based mapping demonstrates that recovery from alkylation damage requires DNA repair, RNA processing, and translation associated networks

Author keywords

Alkylation; DNA damage; DNA repair; E. coli; Gene deletion; Genomic phenotyping; Interactome mapping; mRNA processing; Systems biology; Translation

Indexed keywords

ESCHERICHIA COLI PROTEIN; GENE PRODUCT; MESSENGER RNA; MESYLIC ACID METHYL ESTER; PROTEIN;

EID: 57049112622     PISSN: 08887543     EISSN: 10898646     Source Type: Journal    
DOI: 10.1016/j.ygeno.2008.09.001     Document Type: Article
Times cited : (14)

References (64)
  • 1
    • 0023001905 scopus 로고
    • Reduction of the toxicity and mutagenicity of alkylating agents in mammalian cells harboring the Escherichia coli alkyltransferase gene
    • Brennand J., and Margison G.P. Reduction of the toxicity and mutagenicity of alkylating agents in mammalian cells harboring the Escherichia coli alkyltransferase gene. Proc. Natl. Acad. Sci. U. S. A. 83 17 (1986) 6292-6296
    • (1986) Proc. Natl. Acad. Sci. U. S. A. , vol.83 , Issue.17 , pp. 6292-6296
    • Brennand, J.1    Margison, G.P.2
  • 2
    • 0022263688 scopus 로고
    • Methylating agents: their target amino acids in nuclear proteins
    • Boffa L.C., and Bolognesi C. Methylating agents: their target amino acids in nuclear proteins. Carcinogenesis 6 9 (1985) 1399-1401
    • (1985) Carcinogenesis , vol.6 , Issue.9 , pp. 1399-1401
    • Boffa, L.C.1    Bolognesi, C.2
  • 3
    • 0022399410 scopus 로고
    • Mechanisms of carcinogenesis induced by alkylating agents
    • Saffhill R., Margison G.P., and O'Connor P.J. Mechanisms of carcinogenesis induced by alkylating agents. Bioch. Biophys. Acta 823 (1985) 111-145
    • (1985) Bioch. Biophys. Acta , vol.823 , pp. 111-145
    • Saffhill, R.1    Margison, G.P.2    O'Connor, P.J.3
  • 4
    • 0036182039 scopus 로고    scopus 로고
    • Proteomic approaches to characterize protein modifications: new tools to study the effects of environmental exposures
    • Liebler D.C. Proteomic approaches to characterize protein modifications: new tools to study the effects of environmental exposures. Environ. Health Perspect. 110 Suppl 1 (2002) 3-9
    • (2002) Environ. Health Perspect. , vol.110 , Issue.SUPPL. 1 , pp. 3-9
    • Liebler, D.C.1
  • 5
    • 34447127578 scopus 로고    scopus 로고
    • Protein targets of reactive electrophiles in human liver microsomes
    • Shin N.Y., et al. Protein targets of reactive electrophiles in human liver microsomes. Chem. Res. Toxicol. 20 6 (2007) 859-867
    • (2007) Chem. Res. Toxicol. , vol.20 , Issue.6 , pp. 859-867
    • Shin, N.Y.1
  • 6
    • 33748256154 scopus 로고    scopus 로고
    • Covalent adduction of human serum albumin by 4-hydroxy-2-nonenal: kinetic analysis of competing alkylation reactions
    • Szapacs M.E., et al. Covalent adduction of human serum albumin by 4-hydroxy-2-nonenal: kinetic analysis of competing alkylation reactions. Biochemistry 45 35 (2006) 10521-10528
    • (2006) Biochemistry , vol.45 , Issue.35 , pp. 10521-10528
    • Szapacs, M.E.1
  • 7
    • 31844449784 scopus 로고    scopus 로고
    • Cytosolic and nuclear protein targets of thiol-reactive electrophiles
    • Dennehy M.K., et al. Cytosolic and nuclear protein targets of thiol-reactive electrophiles. Chem. Res. Toxicol. 19 1 (2006) 20-29
    • (2006) Chem. Res. Toxicol. , vol.19 , Issue.1 , pp. 20-29
    • Dennehy, M.K.1
  • 8
    • 38149130689 scopus 로고    scopus 로고
    • The protein degradation response of Saccharomyces cerevisiae to classical DNA-damaging agents
    • Burgis N.E., and Samson L.D. The protein degradation response of Saccharomyces cerevisiae to classical DNA-damaging agents. Chem. Res. Toxicol. 20 12 (2007) 1843-1853
    • (2007) Chem. Res. Toxicol. , vol.20 , Issue.12 , pp. 1843-1853
    • Burgis, N.E.1    Samson, L.D.2
  • 9
    • 0021078520 scopus 로고
    • Cytotoxicity of monofunctional alkylating agents. Methyl methanesulfonate and methyl-N′-nitro-N-nitrosoguanidine have different mechanisms of toxicity for 10T1/2 cells
    • Smith G.J., and Grisham J.W. Cytotoxicity of monofunctional alkylating agents. Methyl methanesulfonate and methyl-N′-nitro-N-nitrosoguanidine have different mechanisms of toxicity for 10T1/2 cells. Mutat. Res. 111 3 (1983) 405-417
    • (1983) Mutat. Res. , vol.111 , Issue.3 , pp. 405-417
    • Smith, G.J.1    Grisham, J.W.2
  • 10
    • 0036923370 scopus 로고    scopus 로고
    • Recovery pathways in S. cerevisiae revealed by genomic phenotyping and interactome mapping
    • Begley T.J., et al. Recovery pathways in S. cerevisiae revealed by genomic phenotyping and interactome mapping. Mol. Cancer Res. 1 (2002) 103-112
    • (2002) Mol. Cancer Res. , vol.1 , pp. 103-112
    • Begley, T.J.1
  • 11
    • 4944238229 scopus 로고    scopus 로고
    • Hot spots for modulating toxicity identified by genomic phenotyping and localization mapping
    • Begley T.J., et al. Hot spots for modulating toxicity identified by genomic phenotyping and localization mapping. Mol. Cell 16 1 (2004) 117-125
    • (2004) Mol. Cell , vol.16 , Issue.1 , pp. 117-125
    • Begley, T.J.1
  • 12
    • 0033573938 scopus 로고    scopus 로고
    • Global response of Saccharomyces cerevisiae to an alkylating agent
    • Jelinsky S.A., and Samson L.D. Global response of Saccharomyces cerevisiae to an alkylating agent. Proc. Natl. Acad. Sci. U. S. A. 96 4 (1999) 1486-1491
    • (1999) Proc. Natl. Acad. Sci. U. S. A. , vol.96 , Issue.4 , pp. 1486-1491
    • Jelinsky, S.A.1    Samson, L.D.2
  • 13
    • 0037168646 scopus 로고    scopus 로고
    • A genome-wide screen for methyl methanesulfonate-sensitive mutants reveals genes required for S phase progression in the presence of DNA damage
    • Chang M., et al. A genome-wide screen for methyl methanesulfonate-sensitive mutants reveals genes required for S phase progression in the presence of DNA damage. Proc. Natl. Acad. Sci. U. S. A. 99 26 (2002) 16934-16939
    • (2002) Proc. Natl. Acad. Sci. U. S. A. , vol.99 , Issue.26 , pp. 16934-16939
    • Chang, M.1
  • 14
    • 0032570769 scopus 로고    scopus 로고
    • A chemical and genetic approach together define the biological consequences of 3-methyladenine lesions in the mammalian genome
    • Engelward B.P., et al. A chemical and genetic approach together define the biological consequences of 3-methyladenine lesions in the mammalian genome. J. Biol. Chem. 273 9 (1998) 5412-5418
    • (1998) J. Biol. Chem. , vol.273 , Issue.9 , pp. 5412-5418
    • Engelward, B.P.1
  • 15
    • 0026409978 scopus 로고
    • Induction of S. cerevisiae MAG 3-methyladenine DNA glycosylase transcript levels in response to DNA damage
    • Chen J., and Samson L. Induction of S. cerevisiae MAG 3-methyladenine DNA glycosylase transcript levels in response to DNA damage. Nucleic Acids Res. 19 23 (1991) 6427-6432
    • (1991) Nucleic Acids Res. , vol.19 , Issue.23 , pp. 6427-6432
    • Chen, J.1    Samson, L.2
  • 16
    • 0017655895 scopus 로고
    • An adaptive response of E. coli to low levels of alkylating agent: comparison with previously characterised DNA repair pathways
    • Jeggo P., et al. An adaptive response of E. coli to low levels of alkylating agent: comparison with previously characterised DNA repair pathways. Mol. Gen. Genet. 157 1 (1977) 1-9
    • (1977) Mol. Gen. Genet. , vol.157 , Issue.1 , pp. 1-9
    • Jeggo, P.1
  • 17
    • 0037221988 scopus 로고    scopus 로고
    • AlkB mystery solved: oxidative demethylation of N1-methyladenine and N3-methylcytosine adducts by a direct reversal mechanism
    • Begley T.J., and Samson L.D. AlkB mystery solved: oxidative demethylation of N1-methyladenine and N3-methylcytosine adducts by a direct reversal mechanism. Trends Biochem. Sci. 28 1 (2003) 2-5
    • (2003) Trends Biochem. Sci. , vol.28 , Issue.1 , pp. 2-5
    • Begley, T.J.1    Samson, L.D.2
  • 18
    • 0032612507 scopus 로고    scopus 로고
    • Alkylation carcinogenesis in mice with altered levels of DNA repair methyltransferase
    • Sekiguchi M., and Sanada M. Alkylation carcinogenesis in mice with altered levels of DNA repair methyltransferase. Prog. Exp. Tumor Res. 35 (1999) 25-36
    • (1999) Prog. Exp. Tumor Res. , vol.35 , pp. 25-36
    • Sekiguchi, M.1    Sanada, M.2
  • 19
    • 0025890181 scopus 로고
    • 6-methylguanine-DNA methyltransferase in transgenic mice introduced with the E. coli ada gene
    • 6-methylguanine-DNA methyltransferase in transgenic mice introduced with the E. coli ada gene. Mutat. Res. 254 3 (1991) 225-230
    • (1991) Mutat. Res. , vol.254 , Issue.3 , pp. 225-230
    • Nakatsuru, Y.1
  • 20
    • 0023893566 scopus 로고
    • A second DNA methyltransferase repair enzyme in Escherichia coli
    • Rebeck G.W., et al. A second DNA methyltransferase repair enzyme in Escherichia coli. Proc. Natl. Acad. Sci. U. S. A. 85 9 (1988) 3039-3043
    • (1988) Proc. Natl. Acad. Sci. U. S. A. , vol.85 , Issue.9 , pp. 3039-3043
    • Rebeck, G.W.1
  • 21
    • 0023665248 scopus 로고
    • Characterisation and nucleotide sequence of ogt, the O6-alkylguanine-DNA-alkyltransferase gene of E. coli
    • Potter P.M., et al. Characterisation and nucleotide sequence of ogt, the O6-alkylguanine-DNA-alkyltransferase gene of E. coli. Nucleic Acids Res. 15 22 (1987) 9177-9193
    • (1987) Nucleic Acids Res. , vol.15 , Issue.22 , pp. 9177-9193
    • Potter, P.M.1
  • 22
    • 0022432065 scopus 로고
    • Methyl phosphotriesters in alkylated DNA are repaired by the Ada regulatory protein of E. coli
    • McCarthy T.V., and Lindahl T. Methyl phosphotriesters in alkylated DNA are repaired by the Ada regulatory protein of E. coli. Nucleic Acids Res. 13 8 (1985) 2683-2698
    • (1985) Nucleic Acids Res. , vol.13 , Issue.8 , pp. 2683-2698
    • McCarthy, T.V.1    Lindahl, T.2
  • 23
    • 0021717558 scopus 로고
    • Cloning and characterization of the alkA gene of Escherichia coli that encodes 3-methyladenine DNA glycosylase II
    • Nakabeppu Y., Kondo H., and Sekiguchi M. Cloning and characterization of the alkA gene of Escherichia coli that encodes 3-methyladenine DNA glycosylase II. J. Biol. Chem. 259 22 (1984) 13723-13729
    • (1984) J. Biol. Chem. , vol.259 , Issue.22 , pp. 13723-13729
    • Nakabeppu, Y.1    Kondo, H.2    Sekiguchi, M.3
  • 24
    • 0020536360 scopus 로고
    • A new gene (alkB) of Escherichia coli that controls sensitivity to methyl methane sulfonate
    • Kataoka H., Yamamoto Y., and Sekiguchi M. A new gene (alkB) of Escherichia coli that controls sensitivity to methyl methane sulfonate. J. Bacteriol. 153 3 (1983) 1301-1307
    • (1983) J. Bacteriol. , vol.153 , Issue.3 , pp. 1301-1307
    • Kataoka, H.1    Yamamoto, Y.2    Sekiguchi, M.3
  • 25
    • 0020056580 scopus 로고
    • Adaptation to alkylation resistance involves the induction of a DNA glycosylase
    • Evensen G., and Seeberg E. Adaptation to alkylation resistance involves the induction of a DNA glycosylase. Nature 296 5859 (1982) 773-775
    • (1982) Nature , vol.296 , Issue.5859 , pp. 773-775
    • Evensen, G.1    Seeberg, E.2
  • 26
    • 0141925645 scopus 로고    scopus 로고
    • Base excision repair intermediates induce p53-independent cytotoxic and genotoxic responses
    • Sobol R.W., et al. Base excision repair intermediates induce p53-independent cytotoxic and genotoxic responses. J. Biol. Chem. 278 41 (2003) 39951-39959
    • (2003) J. Biol. Chem. , vol.278 , Issue.41 , pp. 39951-39959
    • Sobol, R.W.1
  • 27
    • 0035225929 scopus 로고    scopus 로고
    • Mammalian DNA beta-polymerase in base excision repair of alkylation damage
    • Sobol R.W., and Wilson S.H. Mammalian DNA beta-polymerase in base excision repair of alkylation damage. Prog. Nucleic Acid Res. Mol. Biol. 68 (2001) 57-74
    • (2001) Prog. Nucleic Acid Res. Mol. Biol. , vol.68 , pp. 57-74
    • Sobol, R.W.1    Wilson, S.H.2
  • 28
    • 0017828018 scopus 로고
    • Properties of 3-methyladenine-DNA glycosylase from Escherichia coli
    • Riazuddin S., and Lindahl T. Properties of 3-methyladenine-DNA glycosylase from Escherichia coli. Biochemistry 17 (1978) 2110-2118
    • (1978) Biochemistry , vol.17 , pp. 2110-2118
    • Riazuddin, S.1    Lindahl, T.2
  • 29
    • 0030041960 scopus 로고    scopus 로고
    • Repair-deficient 3-methyladenine DNA glycosylase homozygous mutant mouse cells have increased sensitivity to alkylation-induced chromosome damage and cell killing
    • Engelward B.P., et al. Repair-deficient 3-methyladenine DNA glycosylase homozygous mutant mouse cells have increased sensitivity to alkylation-induced chromosome damage and cell killing. EMBO J. 15 4 (1996) 945-952
    • (1996) EMBO J. , vol.15 , Issue.4 , pp. 945-952
    • Engelward, B.P.1
  • 30
    • 0037168654 scopus 로고    scopus 로고
    • Reversal of DNA alkylation damage by two human dioxygenases
    • Duncan T., et al. Reversal of DNA alkylation damage by two human dioxygenases. Proc. Natl. Acad. Sci. U. S. A. 99 26 (2002) 16660-16665
    • (2002) Proc. Natl. Acad. Sci. U. S. A. , vol.99 , Issue.26 , pp. 16660-16665
    • Duncan, T.1
  • 31
    • 0037068446 scopus 로고    scopus 로고
    • Oxidative demethylation by Escherichia coli AlkB directly reverts DNA base damage
    • Trewick S.C., et al. Oxidative demethylation by Escherichia coli AlkB directly reverts DNA base damage. Nature 419 6903 (2002) 174-178
    • (2002) Nature , vol.419 , Issue.6903 , pp. 174-178
    • Trewick, S.C.1
  • 32
    • 0037068433 scopus 로고    scopus 로고
    • AlkB-mediated oxidative demethylation reverses DNA damage in Escherichia coli
    • Falnes P.O., Johansen R.F., and Seeberg E. AlkB-mediated oxidative demethylation reverses DNA damage in Escherichia coli. Nature 419 6903 (2002) 178-182
    • (2002) Nature , vol.419 , Issue.6903 , pp. 178-182
    • Falnes, P.O.1    Johansen, R.F.2    Seeberg, E.3
  • 33
    • 0035221419 scopus 로고    scopus 로고
    • The DNA-repair protein AlkB, EGL-9, and leprecan define new families of 2-oxoglutarate- and iron-dependent dioxygenases
    • Aravind L., and Koonin E.V. The DNA-repair protein AlkB, EGL-9, and leprecan define new families of 2-oxoglutarate- and iron-dependent dioxygenases. Genome Biol. 2 3 (2001)
    • (2001) Genome Biol. , vol.2 , Issue.3
    • Aravind, L.1    Koonin, E.V.2
  • 34
    • 4544339891 scopus 로고    scopus 로고
    • Alkylation damage in DNA and RNA-repair mechanisms and medical significance
    • Drablos F., et al. Alkylation damage in DNA and RNA-repair mechanisms and medical significance. DNA Repair (Amst) 3 11 (2004) 1389-1407
    • (2004) DNA Repair (Amst) , vol.3 , Issue.11 , pp. 1389-1407
    • Drablos, F.1
  • 35
    • 0017896185 scopus 로고
    • The adaptive response of E. coli to low levels of alkylating agent: the role of polA in killing adaptation
    • Jeggo P., et al. The adaptive response of E. coli to low levels of alkylating agent: the role of polA in killing adaptation. Mol. Gen. Genet. 162 3 (1978) 299-305
    • (1978) Mol. Gen. Genet. , vol.162 , Issue.3 , pp. 299-305
    • Jeggo, P.1
  • 36
    • 0017395439 scopus 로고
    • A new pathway for DNA repair in Escherichia coli
    • Samson L., and Cairns J. A new pathway for DNA repair in Escherichia coli. Nature 267 5608 (1977) 281-283
    • (1977) Nature , vol.267 , Issue.5608 , pp. 281-283
    • Samson, L.1    Cairns, J.2
  • 37
    • 0035023305 scopus 로고    scopus 로고
    • Comparative gene expression profiles following UV exposure in wild-type and SOS-deficient Escherichia coli
    • Courcelle J., et al. Comparative gene expression profiles following UV exposure in wild-type and SOS-deficient Escherichia coli. Genetics 158 1 (2001) 41-64
    • (2001) Genetics , vol.158 , Issue.1 , pp. 41-64
    • Courcelle, J.1
  • 38
    • 0035162698 scopus 로고    scopus 로고
    • Genomic expression responses to DNA-damaging agents and the regulatory role of the yeast ATR homolog Mec1p
    • Gasch A.P., et al. Genomic expression responses to DNA-damaging agents and the regulatory role of the yeast ATR homolog Mec1p. Mol. Biol. Cell 12 10 (2001) 2987-3003
    • (2001) Mol. Biol. Cell , vol.12 , Issue.10 , pp. 2987-3003
    • Gasch, A.P.1
  • 39
    • 0033772765 scopus 로고    scopus 로고
    • Regulatory networks revealed by transcriptional profiling of damaged Saccharomyces cerevisiae cells: rpn4 links base excision repair with proteasomes [In Process Citation]
    • Jelinsky S.A., et al. Regulatory networks revealed by transcriptional profiling of damaged Saccharomyces cerevisiae cells: rpn4 links base excision repair with proteasomes [In Process Citation]. Mol. Cell. Biol. 20 21 (2000) 8157-8167
    • (2000) Mol. Cell. Biol. , vol.20 , Issue.21 , pp. 8157-8167
    • Jelinsky, S.A.1
  • 40
    • 33646748283 scopus 로고    scopus 로고
    • A systems approach to mapping DNA damage response pathways
    • Workman C.T., et al. A systems approach to mapping DNA damage response pathways. Science 312 5776 (2006) 1054-1059
    • (2006) Science , vol.312 , Issue.5776 , pp. 1054-1059
    • Workman, C.T.1
  • 41
    • 31544450286 scopus 로고    scopus 로고
    • T. Baba, et al., Construction of Escherichia coli K-12 in-frame, single-gene knockout mutants: the Keio collection. Mol. Syst. Biol. 2 (2006) 2006 0008.
    • T. Baba, et al., Construction of Escherichia coli K-12 in-frame, single-gene knockout mutants: the Keio collection. Mol. Syst. Biol. 2 (2006) 2006 0008.
  • 42
    • 0033971754 scopus 로고    scopus 로고
    • EcoGene: a genome sequence database for Escherichia coli K-12
    • Rudd K.E. EcoGene: a genome sequence database for Escherichia coli K-12. Nucleic Acids Res. 28 1 (2000) 60-64
    • (2000) Nucleic Acids Res. , vol.28 , Issue.1 , pp. 60-64
    • Rudd, K.E.1
  • 43
    • 0021984180 scopus 로고
    • DNA sequence analysis of the dye gene of Escherichia coli reveals amino acid homology between the dye and OmpR proteins
    • Drury L.S., and Buxton R.S. DNA sequence analysis of the dye gene of Escherichia coli reveals amino acid homology between the dye and OmpR proteins. J. Biol. Chem. 260 7 (1985) 4236-4242
    • (1985) J. Biol. Chem. , vol.260 , Issue.7 , pp. 4236-4242
    • Drury, L.S.1    Buxton, R.S.2
  • 44
    • 0347125234 scopus 로고    scopus 로고
    • GenProtEC: an updated and improved analysis of functions of Escherichia coli K-12 proteins
    • Serres M.H., Goswami S., and Riley M. GenProtEC: an updated and improved analysis of functions of Escherichia coli K-12 proteins. Nucleic Acids Res. 32 Database issue (2004) D300-D302
    • (2004) Nucleic Acids Res. , vol.32 , Issue.Database issue
    • Serres, M.H.1    Goswami, S.2    Riley, M.3
  • 45
    • 0024340351 scopus 로고
    • Involvement of DnaK protein in mini-F plasmid replication: temperature-sensitive seg mutations are located in the dnaK gene
    • Ezaki B., et al. Involvement of DnaK protein in mini-F plasmid replication: temperature-sensitive seg mutations are located in the dnaK gene. Mol. Gen. Genet. 218 2 (1989) 183-189
    • (1989) Mol. Gen. Genet. , vol.218 , Issue.2 , pp. 183-189
    • Ezaki, B.1
  • 46
    • 0032916509 scopus 로고    scopus 로고
    • mRNA degradation. A tale of poly(A) and multiprotein machines
    • Carpousis A.J., Vanzo N.F., and Raynal L.C. mRNA degradation. A tale of poly(A) and multiprotein machines. Trends Genet. 15 1 (1999) 24-28
    • (1999) Trends Genet. , vol.15 , Issue.1 , pp. 24-28
    • Carpousis, A.J.1    Vanzo, N.F.2    Raynal, L.C.3
  • 47
    • 0037119408 scopus 로고    scopus 로고
    • The physiological role of RNase T can be explained by its unusual substrate specificity
    • Zuo Y., and Deutscher M.P. The physiological role of RNase T can be explained by its unusual substrate specificity. J. Biol. Chem. 277 33 (2002) 29654-29661
    • (2002) J. Biol. Chem. , vol.277 , Issue.33 , pp. 29654-29661
    • Zuo, Y.1    Deutscher, M.P.2
  • 48
    • 0037016444 scopus 로고    scopus 로고
    • Combined functional genomic maps of the C. elegans DNA damage response
    • Boulton S.J., et al. Combined functional genomic maps of the C. elegans DNA damage response. Science 295 5552 (2002) 127-131
    • (2002) Science , vol.295 , Issue.5552 , pp. 127-131
    • Boulton, S.J.1
  • 49
    • 27144530248 scopus 로고    scopus 로고
    • Towards a proteome-scale map of the human protein-protein interaction network
    • Rual J.F., et al. Towards a proteome-scale map of the human protein-protein interaction network. Nature 437 7062 (2005) 1173-1178
    • (2005) Nature , vol.437 , Issue.7062 , pp. 1173-1178
    • Rual, J.F.1
  • 50
    • 23844494458 scopus 로고    scopus 로고
    • Predictive models of molecular machines involved in Caenorhabditis elegans early embryogenesis
    • Gunsalus K.C., et al. Predictive models of molecular machines involved in Caenorhabditis elegans early embryogenesis. Nature 436 7052 (2005) 861-865
    • (2005) Nature , vol.436 , Issue.7052 , pp. 861-865
    • Gunsalus, K.C.1
  • 51
    • 0035805255 scopus 로고    scopus 로고
    • Integrated genomic and proteomic analyses of a systematically perturbed metabolic network
    • Ideker T., et al. Integrated genomic and proteomic analyses of a systematically perturbed metabolic network. Science 292 5518 (2001) 929-934
    • (2001) Science , vol.292 , Issue.5518 , pp. 929-934
    • Ideker, T.1
  • 52
    • 33646687963 scopus 로고    scopus 로고
    • A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration
    • Lim J., et al. A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. Cell 125 4 (2006) 801-814
    • (2006) Cell , vol.125 , Issue.4 , pp. 801-814
    • Lim, J.1
  • 53
    • 34547140875 scopus 로고    scopus 로고
    • The human disease network
    • Goh K.I., et al. The human disease network. Proc. Natl. Acad. Sci. U. S. A. 104 21 (2007) 8685-8690
    • (2007) Proc. Natl. Acad. Sci. U. S. A. , vol.104 , Issue.21 , pp. 8685-8690
    • Goh, K.I.1
  • 54
    • 35148838537 scopus 로고    scopus 로고
    • Drug-target network
    • Yildirim M.A., et al. Drug-target network. Nat. Biotechnol. 25 10 (2007) 1119-1126
    • (2007) Nat. Biotechnol. , vol.25 , Issue.10 , pp. 1119-1126
    • Yildirim, M.A.1
  • 55
    • 0242490780 scopus 로고    scopus 로고
    • Cytoscape: a software environment for integrated models of biomolecular interaction networks
    • Shannon P., et al. Cytoscape: a software environment for integrated models of biomolecular interaction networks. Genome Res. 13 11 (2003) 2498-2504
    • (2003) Genome Res. , vol.13 , Issue.11 , pp. 2498-2504
    • Shannon, P.1
  • 56
    • 33745160404 scopus 로고    scopus 로고
    • Large-scale identification of protein-protein interaction of Escherichia coli K-12
    • Arifuzzaman M., et al. Large-scale identification of protein-protein interaction of Escherichia coli K-12. Genome Res. 16 5 (2006) 686-691
    • (2006) Genome Res. , vol.16 , Issue.5 , pp. 686-691
    • Arifuzzaman, M.1
  • 57
    • 11144234660 scopus 로고    scopus 로고
    • Global network analysis of phenotypic effects: protein networks and toxicity modulation in Saccharomyces cerevisiae
    • Said M.R., et al. Global network analysis of phenotypic effects: protein networks and toxicity modulation in Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. U. S. A. 101 52 (2004) 18006-18011
    • (2004) Proc. Natl. Acad. Sci. U. S. A. , vol.101 , Issue.52 , pp. 18006-18011
    • Said, M.R.1
  • 58
    • 0037168641 scopus 로고    scopus 로고
    • Identification and cloning of human polynucleotide phosphorylase, hPNPase old-35, in the context of terminal differentiation and cellular senescence
    • Leszczyniecka M., et al. Identification and cloning of human polynucleotide phosphorylase, hPNPase old-35, in the context of terminal differentiation and cellular senescence. Proc. Natl. Acad. Sci. U. S. A. 99 26 (2002) 16636-16641
    • (2002) Proc. Natl. Acad. Sci. U. S. A. , vol.99 , Issue.26 , pp. 16636-16641
    • Leszczyniecka, M.1
  • 59
    • 0041589211 scopus 로고    scopus 로고
    • Down-regulation of Myc as a potential target for growth arrest induced by human polynucleotide phosphorylase (hPNPaseold-35) in human melanoma cells
    • Sarkar D., et al. Down-regulation of Myc as a potential target for growth arrest induced by human polynucleotide phosphorylase (hPNPaseold-35) in human melanoma cells. J. Biol. Chem. 278 27 (2003) 24542-24551
    • (2003) J. Biol. Chem. , vol.278 , Issue.27 , pp. 24542-24551
    • Sarkar, D.1
  • 60
    • 0034612342 scopus 로고    scopus 로고
    • One-step inactivation of chromosomal genes in Escherichia coli K-12 using PCR products
    • Datsenko K.A., and Wanner B.L. One-step inactivation of chromosomal genes in Escherichia coli K-12 using PCR products. Proc. Natl. Acad. Sci. U. S. A. 97 12 (2000) 6640-6645
    • (2000) Proc. Natl. Acad. Sci. U. S. A. , vol.97 , Issue.12 , pp. 6640-6645
    • Datsenko, K.A.1    Wanner, B.L.2
  • 61
    • 0036088133 scopus 로고    scopus 로고
    • DIP, the Database of Interacting Proteins: a research tool for studying cellular networks of protein interactions
    • Xenarios I., et al. DIP, the Database of Interacting Proteins: a research tool for studying cellular networks of protein interactions. Nucleic Acids Res. 30 1 (2002) 303-305
    • (2002) Nucleic Acids Res. , vol.30 , Issue.1 , pp. 303-305
    • Xenarios, I.1
  • 62
    • 0025183708 scopus 로고
    • Basic local alignment search tool
    • Altschul S.F., et al. Basic local alignment search tool. J. Mol. Biol. 215 3 (1990) 403-410
    • (1990) J. Mol. Biol. , vol.215 , Issue.3 , pp. 403-410
    • Altschul, S.F.1
  • 63
    • 0021528507 scopus 로고
    • 3-Methyladenine residues in DNA induce the SOS function sfiA in Escherichia coli
    • Boiteux S., Huisman O., and Laval J. 3-Methyladenine residues in DNA induce the SOS function sfiA in Escherichia coli. EMBO 3 (1984) 2569-2573
    • (1984) EMBO , vol.3 , pp. 2569-2573
    • Boiteux, S.1    Huisman, O.2    Laval, J.3
  • 64
    • 57049090181 scopus 로고    scopus 로고
    • J. Rooney, A. Patel, M.R. Zappala, D.S. Conklin, R.P. Cunningham, T.J. Begley, A molecular bar-coded DNA repair resource for pooled toxicogenomic screens. (in press at DNA repair).
    • J. Rooney, A. Patel, M.R. Zappala, D.S. Conklin, R.P. Cunningham, T.J. Begley, A molecular bar-coded DNA repair resource for pooled toxicogenomic screens. (in press at DNA repair).


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.