Indanesulfonamides as carbonic anhydrase inhibitors and anticonvulsant agents: Structure-activity relationship and pharmacological evaluation

European Journal of Medicinal Chemistry

Volumn 43, Issue 12, 2008, Pages 2853-2860

  Thiry, Anne ^a   Rolin, Stéphanie ^a   Vullo, Daniela ^b   Frankart, Aurélie ^a   Scozzafava, Andrea ^b   Dogné, Jean Michel ^a   Wouters, Johan ^a   Supuran, Claudiu T ^b   Masereel, Bernard ^a  

^a UNIVERSITY OF NAMUR   (Belgium)

^b UNIVERSITY OF FLORENCE   (Italy)

Author keywords

Blood brain barrier permeation; Carbonic anhydrase; Epilepsy; Maximal electroshock seizure

Indexed keywords

CARBONATE DEHYDRATASE INHIBITOR; INDANESULFONAMIDE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANTICONVULSANT ACTIVITY; ARTICLE; BLOOD BRAIN BARRIER; CONTROLLED STUDY; DRUG DESIGN; DRUG MECHANISM; DRUG SCREENING; DRUG STRUCTURE; MALE; MOUSE; NONHUMAN; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTICONVULSANTS; BLOOD-BRAIN BARRIER; CARBONIC ANHYDRASE INHIBITORS; CARBONIC ANHYDRASES; CENTRAL NERVOUS SYSTEM; COMPUTER SIMULATION; ELECTROSHOCK; HUMANS; ISOENZYMES; MALE; MICE; MICE, INBRED STRAINS; MODELS, ANIMAL; MODELS, CHEMICAL; MOLECULAR STRUCTURE; RECOMBINANT PROTEINS; REPRODUCIBILITY OF RESULTS; SEIZURES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 56949093449     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2008.02.018     Document Type: Article

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