The pharmacokinetics and metabolism of ivermectin in domestic animal species

Veterinary Journal

Volumn 179, Issue 1, 2009, Pages 25-37

  González Canga, Aránzazu ^a   Sahagún Prieto, Ana M ^a   Jose Diez Liebana M ^a   Martínez, Nélida Fernández ^a   Vega, Matilde Sierra ^a   Vieitez, Juan J García ^a  

^a UNIVERSITY OF LEÓN   (Spain)

Author keywords

Absorption; Animal species; Cattle; Distribution; Dog; Excretion; Goat; Ivermectin; Metabolism; Pharmacokinetics; Pig; Review; Sheep

Indexed keywords

IVERMECTIN; VERAPAMIL;

ANTIMICROBIAL ACTIVITY; CATTLE; DOG; DOMESTIC ANIMAL; DOSE RESPONSE; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG DISTRIBUTION; DRUG DOSAGE FORM COMPARISON; DRUG EFFICACY; DRUG EXCRETION; DRUG FORMULATION; DRUG INTERACTION; DRUG METABOLISM; DRUG PROTEIN BINDING; GOAT; HELMINTHIASIS; HORSE; NONHUMAN; PARASITE CONTROL; REVIEW; SHEEP; SINGLE DRUG DOSE; SPECIES DIFFERENCE; SWINE; VETERINARY MEDICINE;

ANIMALS; ANIMALS, DOMESTIC; ANTIPARASITIC AGENTS; AREA UNDER CURVE; CATS; CATTLE; DOGS; DOSE-RESPONSE RELATIONSHIP, DRUG; GOATS; INTESTINAL ABSORPTION; IVERMECTIN; METABOLIC CLEARANCE RATE; SHEEP; SPECIES SPECIFICITY; SWINE;

ANIMALIA; BOS; CANIS FAMILIARIS; CAPRA HIRCUS; OVIS ARIES; SUIDAE;

EID: 56849131523     PISSN: 10900233     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tvjl.2007.07.011     Document Type: Review

References (60)

1. Ali D.N., and Hennessy D.R. The effect of level of feed intake on the pharmacokinetic disposition and efficacy of ivermectin in sheep. Journal of Veterinary Pharmacology and Therapeutics 19 (1996) 89-94
2. Alvinerie M., Sutra J.F., and Galtier P. Ivermectin in goat plasma and milk after subcutaneous injection. Annales de Recherches Vétérinaires 24 (1993) 417-421
3. Alvinerie M., Sutra J.F., Galtier P., Lifschitz A., Virkel G., Sallovitz J., and Lanusse C. Persistence of ivermectin in plasma and faeces following administration of a sustained-release bolus to cattle. Research in Veterinary Science 66 (1998) 57-61
4. Alvinerie M., Sutra J.F., Galtier P., and Toutain P.L. Microdose d́ivermectine chez la vaca laitière: concentrations plasmatiques et rèsidus dans le lait. Recueil de Médecine Vétérinaire 145 (1994) 761-764
5. Alvinerie M., Tardieu D., Sutra J.F., Bojensen G., and Galtier P. Metabolic profile of ivermectin in goats: an in vivo and in vitro evaluation. In: Lees P. (Ed). European Association for Veterinary Pharmacology and Toxicology. Proceedings of the 6th International Congress (1994), Blackwell Scientific Publications, Edinburgh 262
6. Anderson R.R. The use of ivermectin in horses: research and clinical observations. Compendium on Continuing Education 6 (1984) S517-S520
7. Andrew N.W., and Halley B.A. Stability of ivermectin in rumen fluids. Journal of Veterinary Pharmacology and Therapeutics 19 (1996) 295-299
8. Armour J., Bairden K., Batty A.F., Davison C.C., and Ross D.B. Persistent anthelmintic activity of ivermectin in cattle. The Veterinary Record 116 (1985) 151-153
9. Atta A.H., and Abo-Shihada M.N. Comparative pharmacokinetics of doramectin and ivermectin in sheep. Journal of Veterinary Pharmacology and Therapeutics 23 (2000) 49-52
10. Barber S., Bowles V., Lespine A., and Alvinerie M. The comparative serum disposition kinetics of subcutaneous administration of doramectin, ivermectin and moxidectin in the Australian merino sheep. Journal of Veterinary Pharmacology and Therapeutics 26 (2003) 343-348
11. Barth D. Persistent anthelmintic effect of ivermectin in cattle. The Veterinary Record 113 (1983) 300
12. Bassissi M.F., Alvinerie M., and Lespine A. Macrocyclic lactones: distribution in plasma lipoproteins of several animal species including humans. Comparative Biochemistry and Physiology 138 (2004) 437-444
13. Benz G.W., Roncalli R.A., and Gross S.J. Use of ivermectin in cattle, sheep, goats, and swine. In: Campbell W.C. (Ed). Ivermectin and Abamectin (1989), Springer-Verlag, New York 215-229
14. Bogan J.A., and McKellar Q.A. The pharmacodynamics of ivermectin in sheep and cattle. Journal of Veterinary Pharmacology and Therapeutics 11 (1988) 260-268
15. Bousquet-Mélou A., Mercadier S., Alvinerie M., and Toutain P.L. Endectocide exchanges between grazing cattle after pour-on administration of doramectin, ivermectin and moxidectin. International Journal of Parasitology 34 (2004) 1299-1307
16. Bremner, K.C., Berrie, D.A., Hotson, I.K., 1983. Persistence of the anthelmintic activity of ivermectin in calves. The Veterinary Record 113, 569.
17. Campbell W.C. Ivermectin and Abamectin (1989), Springer-Verlag, New York
18. Campbell W.C., and Benz G.W. Ivermectin: a review of efficacy and safety. Journal of Veterinary Pharmacology and Therapeutics 7 (1984) 1-16
19. Cerkvenik V., Doganoc D.Z., Skubic V., Beek W.M.J., and Keukens H.J. Thermal and long-term freezing stability of ivermectin residues in sheep milk. European Food Research and Technology 213 (2001) 72-76
20. Cerkvenik V., Grabnar I., Skubic V., Doganoc D.Z., Beek W.M., Keukens H.J., Drobnic M., and Pogacnik M. Ivermectin pharmacokinetics in lactating sheep. Veterinary Parasitology 104 (2002) 175-185
21. Chiu S.H.L., Carlin R., Taub R., Sestokas E., Zweig J., Vandenheuvel W.J., and Jacob T.A. Comparative metabolic disposition of ivermectin in fat tissues of cattle, sheep, and rats. Drug Metabolism and Disposition 16 (1988) 728-736
22. Chiu S.H.L., Green M.L., Baylis F.P., Eline D., Rosegay A., Meriwether H., and Jacob T.A. Absorption, tissue distribution, and excretion of tritium-labeled ivermectin in cattle, sheep, and rat. Journal of Agricultural and Food Chemistry 38 (1990) 2072-2078
23. Chiu S.H.L., Sestokas E., Taub R., Buhs R.P., Green M., Sestokas R., Vandenheuvel W.J., Arison B.H., and Jacob T.A. Metabolic disposition of ivermectin in tissues of cattle, sheep, and rats. Drug Metabolism and Disposition 14 (1986) 590-600
24. Chiu S.H.L., Sestokas E., Taub R., Green M.L., Baylis F.P., Jacob T.A., and Lu A.Y.H. Metabolic disposition of ivermectin in swine. Journal of Agricultural and Food Chemistry 38 (1990) 2079-2085
25. Craven J., Bjørn H., Hennesy D., Friis C., and Nansen P. Pharmacokinetics of moxidectin and ivermectin following intravenous injection in pigs with different body compositions. Journal of Veterinary Pharmacology and Therapeutics 24 (2001) 99-104
26. Craven J., Bjørn H., Hennesy D.R., and Friis C. The effects of body composition on the pharmacokinetics of subcutaneously injected ivermectin and moxidectin in pigs. Journal of Veterinary Pharmacology and Therapeutics 25 (2002) 227-232
27. Craven J., Hennessy D.R., and Friis C. Does the rate of fat deposition influence the pharmacokinetic disposition of subcutaneously administered moxidectin and ivermectin in pigs?. Journal of Veterinary Pharmacology and Therapeutics 25 (2002) 351-357
28. Daurio C.P., Cheung E.N., Jeffcoat A.R., and Skelly B.J. Bioavailability of ivermectin administered orally to dogs. Veterinary Research Communications 16 (1992) 125-130
29. Echeverría J., Mestorino N., and Errecalde J. Comparative pharmacokinetics of ivermectin after its subcutaneous administration in healthy sheep and sheep infected with mange. Journal of Veterinary Pharmacology and Therapeutics 25 (2002) 159-160
30. Echeverría J., Mestorino N., Giorgieri S., Turic E., Alt M., and Errecalde J. Pharmacokinetics of ivermectin after its intravenous and subcutaneous administration to cattle. Journal of Veterinary Pharmacology and Therapeutics 20 (1997) 77-78
31. Escudero E., Carceles C.M., Galtier P., and Alvinerie M. Influence of fasting on the pharmacokinetics of ivermectin in goats. Journal of Veterinary Pharmacology and Therapeutics 20 (1997) 71-72
32. Gayrard V., Alvinerie M., and Toutain P.L. Comparison of pharmacokinetic profiles of doramectin and ivermectin pour-on formulations in cattle. Veterinary Parasitology 81 (1999) 47-55
33. ®, 1%) following oral administration in donkeys. Research in Veterinary Science 79 (2005) 233-238
34. Gokbulut C., Nolan A.M., and McKellar Q.A. Plasma pharmacokinetics and faecal excretion of ivermectin, doramectin and moxidectin following oral administration in horses. Equine Veterinary Journal 33 (2001) 494-498
35. Gonzalez A., Sahagun A., Diez M.J., Fernandez N., Sierra M., and Garcia J.J. Bioavailability of a commercial formulation of ivermectin after subcutaneous administration to sheep. American Journal of Veterinary Research 68 (2007) 101-106
36. Gonzalez A., Sahagun A.M., Diez M.J., Fernandez N., Sierra M., and Garcia J.J. Pharmacokinetics of a novel formulation of ivermectin after administration to goats. American Journal of Veterinary Research 67 (2006) 323-328
37. Laffont C.M., Alvinerie M., Bousquet-Mélou A., and Toutain P.L. Licking behaviour and environmental contamination arising from pour-on ivermectin for cattle. International Journal of Parasitology 3 (2001) 1687-1692
38. Laffont C.M., Toutain P.L., Alvinerie M., and Bousquet-Melou A. Intestinal secretion is a major route for parent ivermectin elimination in the rat. Drug Metabolism and Disposition 30 (2002) 626-630
39. Lanusse C., Lifschitz A., Virkel G., Alvarez L., Sanchez S., Sutra J.F., Galtier P., and Alvinerie M. Comparative plasma disposition kinetics of ivermectin, moxidectin and doramectin in cattle. Journal of Veterinary Pharmacology and Therapeutics 20 (1997) 91-99
40. Lifschitz A., Murno G., Pis A., Sallovitz J., Virkel G., and Lanusse C. Malnutrition modifies the disposition kinetics of ivermectin in calves. Journal of Veterinary Pharmacology and Therapeutics 20 (1997) 71-72
41. Lifschitz A., Pis A., Alvarez L., Virkel G., Sanchez S., Sallovitz J., Kujanek R., and Lanusse C. Bioequivalence of ivermectin formulations in pigs and cattle. Journal of Veterinary Pharmacology and Therapeutics 22 (1999) 27-34
42. Lifschitz A., Sallovitz J., Imperiale F., Pis A., Lorda J., and Lanusse C. Pharmacokinetic evaluation of four generic formulations in calves. Veterinary Parasitology 119 (2004) 247-257
43. Lifschitz A., Virkel G., Ballent M., Sallovitz J., Pis A., and Lanusse C. Moxidectin and ivermectin metabolic stability in sheep ruminal and abomasal contents. Journal of Veterinary Pharmacology and Therapeutics 28 (2005) 411-418
44. Lifschitz A., Virkel G., Pis A., Imperiale F., Sanchez S., Alvarez L., Kujanek R., and Lanusse C. Ivermectin disposition kinetics after subcutaneous and intramuscular administration of an oil-based formulation to cattle. Veterinary Parasitology 86 (1999) 203-215
45. Lifschitz A., Virkel G., Sallovitz J., Sutra J.F., Galtier P., Alvinerie M., and Lanusse C. Comparative distribution of ivermectin and doramectin to parasite location tissues in cattle. Veterinary Parasitology 87 (2000) 327-338
46. Lo P.K.A., Fink D.W., Williams J.B., and Blodinger J. Pharmacokinetic studies of ivermectin: effects of formulation. Veterinary Research Communications 9 (1985) 251-258
47. Marriner S.E., McKinnon I., and Bogan J.A. The pharmacokinetics of ivermectin after oral and subcutaneous administration to sheep and horses. Journal of Veterinary Pharmacology and Therapeutics 10 (1987) 175-179
48. McKellar Q.A., and Benchaoui H.A. Avermectins and milbemycins. Journal of Veterinary Pharmacology and Therapeutics 19 (1996) 331-351
49. McKellar Q.A., Jackson F., Coop R.L., Jackson E., and Scott E. Effect of parasitism with Nematodirus battus on the pharmacokinetics of levamisole, ivermectin, and netobimin. Veterinary Parasitology 39 (1991) 123-136
50. McKellar Q.A., and Marriner S.E. Comparison of the anthelmintic efficacy of oxfendazole or ivermectin administered orally and ivermectin administered subcutaneously to sheep during the periparturient period. The Veterinary Record 18 (1987) 383-386
51. Mestorino N., Turic E., Pesoa J., Echeverría J., and Errecalde J.O. Pharmacokinetics in plasma of ivermectin after its oral (solution and tablets) administration to sheep. Journal of Veterinary Pharmacology and Therapeutics 26 (2003) 307-309
52. Molento M.B., Lifschitz A., Sallovitz J., Lanusse C., and Prichard R. Influence of verapamil on the pharmacokinetics of the antiparasitic drugs ivermectin and moxidectin in sheep. Parasitology Research 92 (2004) 121-127
53. Pérez R., Cabezas I., Godoy C., Rubilar L., Muñoz L., Arboix M., Castells G., and Alvinerie M. Pharmacokinetics of doramectin and ivermectin after oral administration in horses. The Veterinary Journal 163 (2002) 161-167
54. Pérez R., Cabezas I., Sutra J.F., Galtier P., and Alvinerie M. Fecal excretion profile of moxidectin and ivermectin after oral administration in horses. The Veterinary Journal 161 (2001) 85-92
55. Prichard R.K., Steel J.W., Lacey E., and Hennessy D.R. Pharmacokinetics of ivermectin in sheep following intravenous, intra-abomasal or intraruminal administration. Journal of Veterinary Pharmacology and Therapeutics 8 (1985) 88-94
56. Rohrer S.P., and Evans D.V. Binding characteristics of ivermectin in plasma from Collie dogs. Veterinary Research Communications 14 (1990) 157-165
57. Scott E.W., Kinabo L.D., and McKellar Q.A. Pharmacokinetics of ivermectin after oral administration to adult milking goats. Journal of Veterinary Pharmacology and Therapeutics 13 (1990) 432-435
58. Scott E.W., and McKellar Q.A. The distribution and some pharmacokinetic parameters of ivermectin in pigs. Veterinary Research Communications 16 (1992) 139-146
59. Steel J.W. Pharmacokinetics and metabolism of avermectins in livestock. Veterinary Parasitology 48 (1993) 45-47
60. Toutain P.L., Campan M., Galtier P., and Alvinerie M. Kinetic and insecticidal properties of ivermectin residues in the milk of dairy cows. Journal of Veterinary Pharmacology and Therapeutics 11 (1988) 288-291