Ivermectin disposition kinetics after subcutaneous and intramuscular administration of an oil-based formulation to cattle

Veterinary Parasitology

Volumn 86, Issue 3, 1999, Pages 203-215

  Lifschitz, A ^a   Virkel, G ^a   Pis, A ^a   Imperiale, F ^a   Sanchez, S ^a   Alvarez, L ^a   Kujanek, R ^b   Lanusse, C ^a  

^a UNIVERSIDAD NACIONAL DEL CENTRO DE LA PROVINCIA DE BUENOS AIRES   (Argentina)

^b Bayer Argentina SA ^*  (Argentina)

Author keywords

Cattle; Ivermectin; Oil based formulation; Pharmacokinetics

Indexed keywords

BAYMEC PROLONG; IVERMECTIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CATTLE; CONTROLLED STUDY; DERIVATIZATION; DRUG ABSORPTION; DRUG FORMULATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INTRAMUSCULAR DRUG ADMINISTRATION; MALE; NONHUMAN; PHARMACOKINETICS; SUBCUTANEOUS DRUG ADMINISTRATION;

ANIMALS; ANTHELMINTICS; AREA UNDER CURVE; CATTLE; CATTLE DISEASES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG CARRIERS; HALF-LIFE; INJECTIONS, INTRAMUSCULAR; INJECTIONS, SUBCUTANEOUS; IVERMECTIN; MALE; SPECTROMETRY, FLUORESCENCE;

EID: 0032862202     PISSN: 03044017     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-4017(99)00142-9     Document Type: Article

References (25)

1. Alvinerie M., Sutra J.F., Galtier P. Ivermectin in goat milk after subcutaneous injection. Vet. Res. 24:1993;417-421.
2. Alvinerie M., Sutra J.F., Galtier P., Toutain P. Microdose d' ivermectine chez la vache latiere: concentrations plasmatique et residus dans le lait. Revue Med. Vet. 145:1994;761-764.
3. Alvinerie M., Sutra J.F., Badri M., Galtier P. Determination of moxidectin in plasma by high-performance liquid chromatography with automated solid-phase extraction and fluorescence detection. J. Chromatogr. B. 674:1995;119-124.
4. Baggot J., McKellar Q. The absorption, distribution, and elimination of anthelmintic drugs: the role of pharmacokinetics. J. Vet. Pharmacol. Ther. 17:1994;409-419.
5. Bogan J., McKellar Q. The pharmacodynamics of ivermectin in sheep and cattle. J. Vet. Pharmacol. Ther. 11:1988;260-268.
6. Campbell W.C., Fisher M.H., Stapley E.O., Albers-Schoenberg G., Jacob T.A. Ivermectin: a potent new antiparasitic agent. Science. 221:1983;823-828.
7. Chen M. An alternative approach for assessment of absorption rate in bioequivalence studies. Pharm. Res. 9:1992;1380-1385.
8. Chiu S., Green M., Baylis F., Eline D., Rosegay A., Meriwether H., Jacob T. Absorption, tissue distribution, and excretion of tritium-labelled ivermectin in cattle, sheep, and rat. J. Agric. Food Chem. 38:1990;2072-2078.
9. De Montigny P., Shim J.S.K., Pivinichny J.V. Liquid chromatographic determination of ivermectin with trifluoro-acetic anhydride and N-methylimidazole as the derivatization reagent. J.Pharm. Biomed. Anal. 8:1990;507-511.
10. Egerton J., Eary C., Suhayda D. The anthelmintic efficacy of ivermectin in experimentally infected cattle. Vet. Parasitol. 8:1981;59-70.
11. Fink, D., Porras, A., 1989. Pharmacokinetics of ivermectin in animals and humans. In: Campbell, W. (Ed.), Ivermectin and Abamectin, Springer-Verlag, New York, USA, pp. 90-113.
12. Fisher, M., Mrozik, H., 1989. Chemistry. In: Campbell. W. (Ed.), Ivermectin and Abamectin, Springer-Verlag, New York, USA, pp. 1-23.
13. Gibaldi, M., Perrier, D., 1982. Pharmacokinetics, second ed., revised and expanded. Marcel Dekker, Inc., New York.
14. Hennessy D. Modifying the formulation or delivery mechanism to increase the activity of anthelmintic compounds. Vet. Parasitol. 72:1997;367-390.
15. Jackson H. Ivermectin as a systemic insecticide. Parasitol. Today. 5:1989;146-155.
16. Lanusse C., Prichard R. Relationship between pharmacological properties and clinical efficacy of ruminant anthelmintics. Vet. Parasitol. 49:1993;123-158.
17. Lanusse C., Lifschitz A., Virkel G., Alvarez L., Sanchez S., Sutra J.F., Galtier P., Alvinerie M. Comparative plasma disposition kinetics of ivermectin, moxidectin , moxidectin and doramectin in cattle. J. Vet. Pharmacol. Ther. 20:1997;91-99.
18. Lifschitz, A., Virkel, G., Sutra, J.F., Galtier, P., Alvinerie, M., Lanusse, C., 1998. Distribution of endectocide compounds to target tissues in cattle. Proceedings of 43rd Annual Meeting of American Association of Veterinary Parasitologists, 59 p.
19. Lo P., Fink D., Williams J., Blodinger J. Pharmacokinetics studies of ivermectin: effect of formulation. Vet. Res. Commun. 9:1985;251-268.
20. McKellar Q. Chemotherapy and delivery systems-helminths. Vet. Parasitol. 54:1994;249-258.
21. McKellar Q., Benchaoui H. Avermectins and milbemycins. J. Vet. Pharmacol. Ther. 19:1996;331-351.
22. Nowakowski M., Lynch M., Smith D., Logan N., Mouzin D., Lukaszewicz J., Ryan N., Hunter R., Jones R. Pharmacokinetics and bioequivalence of parenterally administered doramectin in cattle. J. Vet. Pharmacol. Ther. 18:1995;290-298.
23. Prichard R., Steel J., Lacey E., Hennessy D. Pharmacokinetics of ivermectin in sheep following intravenous, intra-abomasal or intra-ruminal administration. J. Vet. Pharmacol. Ther. 8:1985;88-94.
24. Toutain P.L., Upson D.W., Terhune T.N., McKenzie M.E. Comparative pharmacokinetics of doramectin and ivermectin in cattle. Vet. Parasitol. 72:1997;3-8.
25. Wicks S., Kaye B., Weatherley A., Lewis D., Davison E., Gibson S., Smith D. Effect of formulation on the pharmacokinetics and efficacy of doramectin. Vet. Parasitol. 49:1993;17-26.