Bioavailabitlity of a commercial formulation of ivermectin after subcutaneous administration to sheep

American Journal of Veterinary Research

Volumn 68, Issue 1, 2007, Pages 101-106

  Gonzalez Canga, Aranzazu ^a   Sahagun, Ana ^a   Diez, M Jose ^a   Fernandez, Nelida ^a   Sierra, Matilde ^a   García Vieitez, Juan J ^a  

^a UNIVERSITY OF LEÓN   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

DORAMECTIN; IVERMECTIN; UNCLASSIFIED DRUG; ZOOMECTIN; ANTIPARASITIC AGENT;

ARTICLE; BLOOD SAMPLING; CONTROLLED STUDY; DRUG ABSORPTION; DRUG ACCUMULATION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG ELIMINATION; FEMALE; FLUORESCENCE ANALYSIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; NONHUMAN; QUANTITATIVE ANALYSIS; SHEEP; SINGLE DRUG DOSE; ANIMAL; ANIMAL DISEASE; BIOAVAILABILITY; BLOOD; INTRAVENOUS DRUG ADMINISTRATION; METABOLISM; SUBCUTANEOUS DRUG ADMINISTRATION;

ANIMALIA; OVIS ARIES;

ANIMALS; ANTIPARASITIC AGENTS; BIOLOGICAL AVAILABILITY; FEMALE; INJECTIONS, INTRAVENOUS; INJECTIONS, SUBCUTANEOUS; IVERMECTIN; SHEEP;

EID: 33846528519     PISSN: 00029645     EISSN: None     Source Type: Journal    
DOI: 10.2460/ajvr.68.1.101     Document Type: Article

References (31)

1. Campbell WC. Ivermectin: an update. Parasitol Today 1985;1:10-16.
2. Campbell WC, Benz GW. Ivermectin: a review of efficacy and safety. J Vet Pharmacol Ther 1984;7:1-16.
3. Steel JW. Pharmacokinetics and metabolism of avermectins in livestock. Vet Parasitol 1993;48:45-47.
4. Baggot JD, McKellar QA. The absorption, distribution and elimination of anthelmintic drugs: the role of pharmacokinetics. J Vet Pharmacol Ther 1994;17:409-419.
5. McKellar QA, Benchaoui HA. Avermectins and milbemycins. J Vet Pharmacol Ther 1996;19:331-351.
6. Lo PKA, Fink DW, Williams JB, et al. Pharmacokinetic studies of ivermectin: effects of formulation. Vet Res Commun 1985;9:251-258.
7. Prichard RK, Steel JW, Lacey E, et al. Pharmacokinetics of ivermectin in sheep following intravenous, intra-abomasal or intraruminal administration. J Vet Pharmacol Ther 1985;8:88-94.
8. Marriner SE, McKinnon I, Bogan JA. The pharmacokinetics of ivermectin after oral and subcutaneous administration to sheep and horses. J Vet Pharmacol Ther 1987;10:175-179.
9. McKellar QA, Marriner SE. Comparison of the anthelmintic efficacy of oxfendazole or ivermectin administered orally and ivermectin administered subcutaneously to sheep during the periparturient period. Vet Rec 1987;18:383-386.
10. Bogan JA, McKellar QA. The pharmacodynamics of ivermectin in sheep and cattle. J Vet Pharmacol Ther 1988;11:260-268.
11. McKellar QA, Jackson F, Coop RL, et al. Effect of parasitism with Nematodirus battus on the pharmacokinetics of levamisole, ivermectin, and netobimin. Vet Parasitol 1991;39:123-136.
12. Taylor SM, Mallon TR, Blanchflower WJ, et al. Effects of diet on plasma concentrations of oral anthelmintics for cattle and sheep. Vet Rec 1992;130:264-268.
13. Gogolewski RP, Allerton GR, Langholff WK, et al. An ivermectin tablet for sheep: efficacy against gastrointestinal nematodes and bioavailability comparison with a liquid ivermectin formulation. Vet Parasitol 1995;60:297-302.
14. Ali DN, Hennessy DR. The effect of level of feed intake on the pharmacokinetic disposition and efficacy of ivermectin in sheep. J Vet Pharmacol Ther 1996;19:89-94.
15. Atta AH, Abo-Shihada MN. Comparative pharmacokinetics of doramectin and ivermectin in sheep. J Vet Pharmacol Ther 2000;23:49-52.
16. Cerkvenik V, Grabnar I, Skubic V, et al. Ivermectin pharmacokinetics in lactating sheep. Vet Parasitol 2002;104:175-185.
17. Echevarría J, Mestorino N, Errecalde J. Comparative pharmacokinetics of ivermectin after its subcutaneous administration in healthy sheep and sheep infected with mange. J Vet Pharmacol Ther 2002; 25:159-160.
18. Mestorino N, Turic E, Pesoa J, et al. Pharmacokinetics in plasma of ivermectin after its oral (solution and tablets) administration to sheep. J Vet Pharmacol Ther 2003;26:307-309.
19. Pérez R, Palma C, Cabezas I, et al. Effect of parasitism on the pharmacokinetic disposition of ivermectin in lambs. J Vet Med 2006;53:43-48.
20. Fink DW, Porras AG. Pharmacokinetics of ivermectin in animals and humans. In: Campbell WC, ed. Ivermectin and abamectin. New York: Springer-Verlag Inc, 1989;113-130.
21. Lanusse CE, Lifschitz A, Virkel G, et al. Comparative plasma disposition kinetics of ivermectin, moxidectin and doramectin in cattle. J Vet Pharmacol Ther 1997;20:91-99.
22. Prieto JG, Merino G, Pulido MM, et al. Improved method to determine ivermectin in plasma. J Pharm Biomed Anal 2003;31:639-645.
23. Yamaoka K, Nakagawa T, Uno T. Application of Akaike's information criterion (AIC) in the evaluation of linear pharmacokinetic equations. J Pharmacokinet Biopharm 1978;6:165-175.
24. Gibaldi M, Perrier D. Multicompartment models. In: Gibaldi M, Perrier D, eds. Pharmacokinetics. 2nd ed. New York: Marcel Dekker Inc, 1982;45-111.
25. Wagner JG. Simple linear models and more complicated linear models. In: Wagner JG, ed. Pharmacokinetics for the pharmaceutical scientist. Lancaster, Pa: Technomic, 1993;1-41.
26. Barber S, Bowles V, Lespine A, et al. The comparative serum disposition kinetics of subcutaneous administration of doramectin, ivermectin and moxidectin in the Australian Merino sheep. J Vet Pharmacol Ther 2003;26:343-348.
27. Gayrard V, Alvinerie M, Toutain PL. Comparison of pharmacokinetic profiles of doramectin and ivermectin pour-on formulations in cattle. Vet Parasitol 1999;81:47-55.
28. Scott EW, Kinabo LD, McKellar QA. Pharmacokinetics of ivermectin after oral administration to adult milking goats. J Vet Pharmacol Ther 1990;13:432-435.
29. Scott EW, McKellar QA. The distribution and some pharmacokinetic parameters of ivermectin in pigs. Vet Res Commun 1992;16:139-146.
30. MacKintosh CG, Mason PC, Manley T, et al. Efficacy and pharmacokinetics of febantel and ivermectin in red deer (Cervus elaphus). N Z Vet J 1985;33:127-131.
31. Andrews SJ, Ferrari MM, Pow JDE, et al. Nematode egg output and plasma concentration of ivermectin after its administration to red deer. Vet Rec 1993;132:161-163.