Moxidectin and ivermectin metabolic stability in sheep ruminal and abomasal contents

Journal of Veterinary Pharmacology and Therapeutics

Volumn 28, Issue 5, 2005, Pages 411-418

  Lifschitz, A ^a,b   Virkel, G ^a,b   Ballent, M ^a,b   Sallovitz, J ^a   Pis, A ^a   Lanusse, C ^a,b  

^a UNIVERSIDAD NACIONAL DEL CENTRO DE LA PROVINCIA DE BUENOS AIRES   (Argentina)

^b Facultad de Ciencias Naturales e Instituto M Lillo   (Argentina)

Author keywords

[No Author keywords available]

Indexed keywords

IVERMECTIN; MOXIDECTIN;

ALFALFA; ANIMAL EXPERIMENT; ANIMAL FOOD; ARTICLE; CONTROLLED STUDY; DIGESTION; DRUG METABOLISM; DRUG STABILITY; FLUORESCENCE ANALYSIS; HAY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VITRO STUDY; NONHUMAN; PRIORITY JOURNAL; RUMINANT STOMACH; SHEEP; SOLID PHASE EXTRACTION; STOMACH JUICE;

ABOMASUM; ADMINISTRATION, ORAL; ANIMALS; ANTHELMINTICS; INJECTIONS, SUBCUTANEOUS; IVERMECTIN; MACROLIDES; RUMEN; SHEEP;

ANIMALIA; MEDICAGO SATIVA; OVIS ARIES;

EID: 27444444790     PISSN: 01407783     EISSN: 13652885     Source Type: Journal    
DOI: 10.1111/j.1365-2885.2005.00674.x     Document Type: Article

References (46)

1. Afzal, J., Stout, S., daCunha, A. & Miller, P. (1994) Moxidectin: absorption, tissue distribution, excretion and biotransformation of Carbon-14-labeled moxidectin in sheep. Journal of Agricultural and Food Chemistry, 42, 1767-1773.
2. Ali, D. & Hennessy, D. (1995) The effect of level of feed intake on the pharmacokinetic disposition of oxfendazole in sheep. International Journal for Parasitology, 25, 63-70.
3. Ali, D. & Hennessy, D. (1996) The effect of level of feed intake on the pharmacokinetic disposition and efficacy of ivermectin in sheep. Journal of Veterinary Pharmacology and Therapeutics, 19, 89-94.
4. Alvinerie, M. & Galtier, P. (1984) Simultaneous determination of albendazole on enantiomerism of its principal metabolites in plasma by normal phase high-performance liquid Chromatographic. Journal of Pharmaceutical and Biomedical Analysis, 24, 417-421.
5. Alvinerie, M., Sutra, J.F. & Galtier, P. (1993) Ivermectin in goat milk after subcutaneous injection. Veterinary Research, 24, 417-421.
6. American Veterinary Medical Association (AVMA) (2001) Report of the AVMA Panel on Euthanasia. Journal of American Veterinary Medical Association, 218, 669-696.
7. Andrew, N. & Halley, B. (1996) Stability of ivermectin in rumen fluids. Journal of Veterinary Pharmacology and Therapeutics, 19, 295-296.
8. Armour, J., Bairden, K., Batty, A.F., Davison, C.C. & Ross, D.B. (1985) Persistent anthelmintic activity of ivermectin. in cattle. Veterinary Record, 116, 151-153.
9. Benz, G.W., Roncalli, R.A. & Gross, S.J. (1989) Use of ivermectin in cattle, sheep, goats and swine. In Ivermectin and Abamectin. Ed. Campbell, W. pp. 215-229. Springer-Verlag New York Inc., New York, USA.
10. Bogan, J. & McKellar, Q. (1988) The pharmacodynamics of ivermectin in sheep and cattle. Journal of Veterinary Pharmacology and Therapeutics, 11, 260-268.
11. Borgsteede, F. (1993) The efficacy and persistent anthelmintic effect of ivermectin in sheep. Veterinary Parasitology, 50, 117-124.
12. Chiu, S.H.L. & Lu, A.Y.H. (1989) Metabolism and tissue residues. In Ivermectin and Abamectin. Ed. Campbell, W. pp. 131-143. Springer-Verlag New York Inc., New York, USA.
13. Chiu, S., Taub, R., Sestokas, E., Lu, A. & Jacob, T. (1987) Comparative in vivo and in vitro metabolism of ivermectin in steers, sheep, swine, and rat. Drug Metabolism Reviews, 18, 289-302.
14. Cristofol, C., Virkel, G., Alvarez, L., Sanchez, S., Arboix, M. & Lanusse, C. (2001) Albendazole sulphoxide enantiomeric ratios in plasma and target tissues after intravenous administration of ricobendazole to cattle. Journal of Veterinary Pharmacology and Therapeutics, 24, 117-124.
15. De Montigny, P., Shim, J. & Pivinichny, J. (1990) Liquid Chromatographic determination of ivermectin with trifluoro-acetic anhydride and N-methylimidazole as the derivatization reagent. Journal of Pharmaceutical and Biomedical Analysis, 8, 507-511.
16. Fisher, M. & Mrozik, H. (1989) Chemistry. In Ivermectin and Abamectin. Ed. Campbell, W. pp. 1-23. Springer-Verlag New York Inc., New York, USA.
17. Hennessy, D. (2001) Quantitative Disposition of Moxidectin in the Gastrointestinal Tract of Sheep. 18th International Conference of the World Association for the Advancement of Veterinary Parasitology, Stresa, Italy, Abstract N6.
18. Hennessy, D., Ali, D. & Tremain, S. (1994) The partition and fate of soluble and digesta particulate associated oxfendazole and its metabolites in the gastrointestinal tract of sheep. International Journal for Parasitology, 24, 327-333.
19. Hennessy, D., Page, S. & Gottschall, D. (2000) The behaviour of doramectin in the gastrointestinal tract, its secretion in bile and pharmacokinetic disposition in the peripheral circulation after oral and intravenous administration to sheep. Journal of Veterinary Pharmacology and Therapeutics. 23, 203-213.
20. Imperiale, F., Lifschitz, A., Sallovitz, J., Virkel, G. & Lanusse, C. (2004) Comparative depletion of ivermectin and moxidectin milk residues in dairy sheep after oral and subcutaneous administration. Journal of Dairy Research. 71, 427-433.
21. Kwei, G., Alvaro, R., Chen, Q. et al. (1999) Disposition of ivermectin and cyclosporin A in CF-1 mice deficient in MDR1-A P-glycoprotein. Drug Metabolism and Disposition, 27, 581-587.
22. Lanusse, C. & Prichard, R. (1993) Clinical pharmacokinetics and metabolism of benzimidazole anthelmintics in ruminants. Drug Metabolism Review, 25, 235-279.
23. Lanusse, C., Nare, B., Gascon, L. & Prichard, R. (1992) Metabolism of albendazole and albendazole sulphoxide by ruminal and ileal fluids of sheep and cattle. Xenobiotica, 22, 419-426.
24. Lanusse, C., Lifschitz, A., Virkel, G., Alvarez, L., Sanchez, S., Sutra, J.F., Galtier, P. & Alvinerie, M. (1997) Comparative plasma disposition kinetics of ivermectin, moxidectin and doramectin in cattle. Journal of Veterinary Pharmacology and Therapeutics, 20, 91-99.
25. Lespine, A., Sutra, J.F., Dupuy, J., Alvinerie, M. & Aumont, G. (2004) The influence of parasitism on the pharmacokinetics of moxidectin in lambs. Parasitology Research, 93, 121-126.
26. Lifschitz, A., Virkel, G., Imperiale, F., Sutra, J.F., Galtier, P., Lanusse, C. & Alvinerie, M. (1999) Moxidectin in cattle: correlation between plasma and target tissues disposition kinetics. Journal of Veterinary Pharmacology and Therapeutics. 22, 266-273.
27. Lifschitz, A., Virkel, G., Sallovitz, J., Sutra, J.F., Galtier, P., Alvinerie, M. & Lanusse, C. (2000) Comparative distribution of ivermectin and doramectin to tissues of parasite location in cattle. Veterinary Parasitology, 87, 327-338.
28. Marriner, S.E., McKinnon, I. & Bogan, J.A. (1987) The pharmacokinetics of ivermectin after the oral and subcutaneous administration to sheep and horses. Journal of Veterinary Pharmacology and Therapeutics, 10, 175-179.
29. McKellar, Q. & Benchaoui, H. (1996) Avermectins and milbemycins. Journal of Veterinary Pharmacology and Therapeutics, 19, 331-351.
30. Molento, M., Lifschitz, A., Sallovitz, J., Lanusse, C. & Prichard, R. (2004) Influence of verapamil on the pharmacokinetics of the antiparasitic drugs ivermectin and moxidectin in sheep. Parasitology Research, 92, 121-127.
31. Pouliot, J.F., L'Heureux, F., Liu, Z., Prichard, R. & Georges, E. (1997) Reversal of P-glycoprotein-associated multidrug resistance by ivermectin. Biochemical Pharmacology, 53, 17-25.
32. Prichard, R., Steel, J., Lacey, E. & Hennessy, D. (1985) Pharmacokinetics of ivermectin in sheep following intravenous, intra-abomasal or intraruminal administration. Journal of Veterinary Pharmacology and Therapeutics, 8, 88-94.
33. Rowland, I. (1986) Reduction by the gut microflora of animals and man. Biochemical Pharmacology, 35, 27-32.
34. Sánchez, S., Alvarez, L. & Lanusse, C. (1997) Fasting-induced changes on the pharmacokinetic behaviour of albendazole and its metabolites in cattle. Journal of Veterinary Pharmacology and Therapeutics, 20, 38-47.
35. Schinkel, A., Wagenaar, E., Mol, C. & van Deemter, L. (1996) P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs. Journal of Clinical Investigation, 97, 2517-2524.
36. Shoop, W., Mrozik, H. & Fisher, M. (1995) Structure and activity of avermectins and milbemycins in animal health. Veterinary Parasitology, 59, 139-156.
37. Steel, J.W. (1993) Pharmacokinetics and metabolism of avermectins in livestock. Veterinary Parasitology, 48, 45-57.
38. Takiguchi, Y., Mishima, H., Okuda, M., Terao, M., Aoki, A. & Fukuda, R. (1980) Milbemycins, a new family of macrolide antibiotics: fermentation, isolation and physico-chemical properties. Journal of Antibiotics, 33, 1120-1127.
39. Taylor, S., Mallon, T., Blanchflower, J., Kennedy, D. & Green, W. (1992) Effects of diet on plasma concentrations of oral anthelmintics for cattle and sheep. The Veterinary Record, 130, 264-268.
40. Tway, T.C., Wood, J.S. Jr & Downing, G.V. (1981) Determination of ivermectin in cattle and sheep tissues using high-performance liquid chromatography with fluorescence detection. Journal of Agricultural and Food Chemistry, 29, 1059-1063.
41. Vercruysse, J., Claerebout, E., Dorny, P., Demeulenaere, D. & Deroover, E. (1997) Persistence of the efficacy of pour-on and injectable moxidectin against Ostertagia ostertagia and Dyctiocaulus viviparous in experimental infected cattle. Veterinary Record, 140, 64-66.
42. Virkel, G., Lifschitz, A., Pis, A. & Lanusse, C. (1999) Influence of diet on the pattern of gastrointestinal biotransformation of netobimin and albendazole sulphoxide in sheep. European Journal of Drug Metabolism and Pharmacokinetics, 24, 31-37.
43. Virkel, G., Lifschitz, A., Pis, A. & Lanusse, C. (2002) In vitro ruminal biotransformation of benzimidazole sulphoxide enthelmintics: enantioselective sulphoreduction in sheep and cattle. Journal of Veterinary Pharmacology and Therapeutics, 25, 15-23.
44. Virkel, G., Lifschitz, A., Sallovitz, J., Inza, G. & Lanusse, C. (2004) Effect of the ionophore antibiotic monensin on the ruminal biotransformation of benzimidazole anthelmintics. Veterinary Journal, 167, 265-271.
45. Vynckier, L. & Debackere, M. (1993) Plasma ronidazole concentrations in sheep after intravenous, oral intraruminal and intraabomasal administration. Journal of Veterinary Pharmacology and Therapeutics, 16, 70-78.
46. Zulalian, J., Stout, S., daCunha, A., Garces, T. & Miller, P. (1994) Absorption, tissue distribution, metabolism, and excretion of moxidectin in cattle. Journal of Agricultural and Food Chemistry, 42, 381-387.