Short, strong hydrogen bonds at the active site of human acetylcholinesterase: Proton NMR studies

Biochemistry

Volumn 40, Issue 19, 2001, Pages 5682-5690

  Massiah, Michael A ^a   Viragh, Carol ^b   Reddy, Putta M ^b   Kovach, Ildiko M ^b   Johnson, Joseph ^c   Rosenberry, Terrone L ^c   Mildvan, Albert S ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b CATHOLIC UNIVERSITY OF AMERICA   (United States)

^c MAYO CLINIC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYSIS; CRYSTALLINE MATERIALS; ESTERS; FRACTIONATION; HYDROGEN BONDS; NEGATIVE IONS; NUCLEAR MAGNETIC RESONANCE; PH EFFECTS; PROTONS;

NUCLEOPHILICITY;

ENZYMES;

ARTICLE; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME CONFORMATION; HUMAN; HYDROGEN BOND; NONHUMAN; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; TORPEDO CALIFORNICA;

ACETOPHENONES; ACETYLCHOLINESTERASE; ANIMALS; BINDING SITES; CATALYTIC DOMAIN; CHOLINESTERASE INHIBITORS; DIMERIZATION; HUMANS; HYDROGEN BONDING; HYDROGEN-ION CONCENTRATION; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PARAOXON; PHOSPHONIC ACIDS; PROTONS; RECOMBINANT PROTEINS; TORPEDO;

EQUUS CABALLUS; TORPEDO CALIFORNICA;

EID: 0035873095     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi010243j     Document Type: Article

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