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Volumn 33, Issue 7, 2008, Pages 561-569

ASA404. Vascular-disrupting agent, oncolytic

Author keywords

[No Author keywords available]

Indexed keywords

5,6 DIMETHYLXANTHENONE 4 ACETIC ACID; CARBOPLATIN; CISPLATIN; CYCLOPHOSPHAMIDE; DOCETAXEL; DOXORUBICIN; ETOPOSIDE; FLAVONE DERIVATIVE; FLAVONOID; MELPHALAN; MITOFLAXONE; PACLITAXEL; TAXANE DERIVATIVE; THALIDOMIDE; VINCRISTINE;

EID: 56749151224     PISSN: 03778282     EISSN: None     Source Type: Journal    
DOI: 10.1358/dof.2008.033.07.1216922     Document Type: Article
Times cited : (5)

References (71)
  • 1
    • 0026100365 scopus 로고
    • Potential antitumour agents. 61. Structure-activity relationships for in vivo colon-38 activity among disubstituted 9-oxo-9H-xanthene-4-acetic acids
    • Rewcastle, G.W., Atwell, G.J., Li, Z.A., Baguley, B.C., Denny, W.A. Potential antitumour agents. 61. Structure-activity relationships for in vivo colon-38 activity among disubstituted 9-oxo-9H-xanthene-4-acetic acids. J Med Chem 1991, 34(1): 217-22.
    • (1991) J Med Chem , vol.34 , Issue.1 , pp. 217-222
    • Rewcastle, G.W.1    Atwell, G.J.2    Li, Z.A.3    Baguley, B.C.4    Denny, W.A.5
  • 2
    • 0036809057 scopus 로고    scopus 로고
    • An improved synthesis of 5,6-dimethylxanthenone-4-acetic acid (DMXAA)
    • Atwell, G.J., Yang, S., Denny, W.A. An improved synthesis of 5,6-dimethylxanthenone-4-acetic acid (DMXAA). Eur J Med Chem 2002, 37(10): 825-8.
    • (2002) Eur J Med Chem , vol.37 , Issue.10 , pp. 825-828
    • Atwell, G.J.1    Yang, S.2    Denny, W.A.3
  • 3
    • 56749104073 scopus 로고    scopus 로고
    • Denny, W.A, Baguley, B.C, Atwell, G.J, Rewcastle, G.W, Cancer Research UK; Pfizer, Inc, Compounds having antitumour and antibacterial properties. EP 0278176, US 5281620
    • Denny, W.A., Baguley, B.C., Atwell, G.J., Rewcastle, G.W. (Cancer Research UK; Pfizer, Inc.). Compounds having antitumour and antibacterial properties. EP 0278176, US 5281620.
  • 4
    • 0025250387 scopus 로고
    • Light-induced breakdown of flavone acetic acid and xanthenone analogues in solution
    • Rewcastle, G.W., Kestell, P., Baguley, B.C., Denny, W.A. Light-induced breakdown of flavone acetic acid and xanthenone analogues in solution. J Natl Cancer Inst 1990, 82(6): 528-9.
    • (1990) J Natl Cancer Inst , vol.82 , Issue.6 , pp. 528-529
    • Rewcastle, G.W.1    Kestell, P.2    Baguley, B.C.3    Denny, W.A.4
  • 5
    • 34548090017 scopus 로고    scopus 로고
    • Synthesis and biological activity of azido analogues of 5,6-dimethylxanthenone-4-acetic acid for use in photoaffinity labeling
    • Palmer, B.D., Henare, K., Woon, S.-T. et al. Synthesis and biological activity of azido analogues of 5,6-dimethylxanthenone-4-acetic acid for use in photoaffinity labeling. J Med Chem 2007, 50(16): 3757-64.
    • (2007) J Med Chem , vol.50 , Issue.16 , pp. 3757-3764
    • Palmer, B.D.1    Henare, K.2    Woon, S.-T.3
  • 6
    • 34247249906 scopus 로고    scopus 로고
    • Vascular disrupting agents in clinical development
    • Hinnen, P., Eskeens, F.A.L.M. Vascular disrupting agents in clinical development. Br J Cancer 2007, 96(8): 1159-65.
    • (2007) Br J Cancer , vol.96 , Issue.8 , pp. 1159-1165
    • Hinnen, P.1    Eskeens, F.A.L.M.2
  • 7
    • 0024330132 scopus 로고
    • Flavone acetic acid - Preclinical and clinical activity
    • Kerr, D.J., Kaye, S.B. Flavone acetic acid - Preclinical and clinical activity. Eur J Cancer 1989, 25(9): 1271-2.
    • (1989) Eur J Cancer , vol.25 , Issue.9 , pp. 1271-1272
    • Kerr, D.J.1    Kaye, S.B.2
  • 9
    • 0037125028 scopus 로고    scopus 로고
    • Induction of endothelial cell apoptosis by the anti-vascular agent 5,6-dimethylxanthenone-4-acetic acid
    • Ching, L.-M., Cao, Z., Kieda, C., Zwain, S., Jameson, M.B., Baguley, B.C. Induction of endothelial cell apoptosis by the anti-vascular agent 5,6-dimethylxanthenone-4-acetic acid. Br J Cancer 2002, 86(12): 1937-42.
    • (2002) Br J Cancer , vol.86 , Issue.12 , pp. 1937-1942
    • Ching, L.-M.1    Cao, Z.2    Kieda, C.3    Zwain, S.4    Jameson, M.B.5    Baguley, B.C.6
  • 10
    • 0037106501 scopus 로고    scopus 로고
    • Effects of 5,6-dimethylxanthenone-4-acetic acid (DMXAA) on human tumor microcirculation assessed by dynamic contrast-enhanced magnetic resonance imaging
    • Galbraith, S.M., Rustin, G.J.S., Lodge, M.A. et al. Effects of 5,6-dimethylxanthenone-4-acetic acid (DMXAA) on human tumor microcirculation assessed by dynamic contrast-enhanced magnetic resonance imaging. J Clin Oncol 2002, 20(18): 3826-40.
    • (2002) J Clin Oncol , vol.20 , Issue.18 , pp. 3826-3840
    • Galbraith, S.M.1    Rustin, G.J.S.2    Lodge, M.A.3
  • 11
    • 67650999152 scopus 로고    scopus 로고
    • Phase II study of DMXAA (ASA404) 1800 mg/ m2 combined with carboplatin and paclitaxel in non-small cell lung cancer
    • Sept 2-6, Seoul, Abst P3-116
    • McKeage, M., von Pawel, J. Phase II study of DMXAA (ASA404) 1800 mg/ m2 combined with carboplatin and paclitaxel in non-small cell lung cancer. J Thorac Oncol [12th World Conf Lung Cancer (Sept 2-6, Seoul) 2007] 2007, 2(8, Suppl. 4): Abst P3-116.
    • (2007) J Thorac Oncol [12th World Conf Lung Cancer , vol.2 , Issue.8 SUPPL. 4
    • McKeage, M.1    von Pawel, J.2
  • 13
    • 0028124643 scopus 로고
    • Correlation between immune and vascular activities of xanthenone acetic acid antitumor agents
    • Zwi, L.J., Baguley, B.C., Gavin, J.B., Wilson, W.R. Correlation between immune and vascular activities of xanthenone acetic acid antitumor agents. Oncol Res 1994, 6(2): 79-85.
    • (1994) Oncol Res , vol.6 , Issue.2 , pp. 79-85
    • Zwi, L.J.1    Baguley, B.C.2    Gavin, J.B.3    Wilson, W.R.4
  • 14
    • 1642352048 scopus 로고    scopus 로고
    • Relationship between tumour endothelial cell apoptosis and tumour blood flow shutdown following treatment with the antivascular agent DMXAA in mice
    • Ching, L.-M., Zwain, S., Baguley, B.C. Relationship between tumour endothelial cell apoptosis and tumour blood flow shutdown following treatment with the antivascular agent DMXAA in mice. Br J Cancer 2004, 90(4): 906-10.
    • (2004) Br J Cancer , vol.90 , Issue.4 , pp. 906-910
    • Ching, L.-M.1    Zwain, S.2    Baguley, B.C.3
  • 15
    • 33646417630 scopus 로고    scopus 로고
    • The effects of the vascular disrupting agents combretastatin A-4 disodium, phosphate, 5,6-dimethlyxanthenone-4-acetic acid and ZD6126 in a murine tumour: A comparative assessment using MRI and MRS
    • Breidahl, T., Neilson, F.U., Stodkilde-Jorgenson, H., Maxwell, R.J., Horsman, M.R. The effects of the vascular disrupting agents combretastatin A-4 disodium, phosphate, 5,6-dimethlyxanthenone-4-acetic acid and ZD6126 in a murine tumour: A comparative assessment using MRI and MRS. Acta Oncol 2006, 45(3): 306-16.
    • (2006) Acta Oncol , vol.45 , Issue.3 , pp. 306-316
    • Breidahl, T.1    Neilson, F.U.2    Stodkilde-Jorgenson, H.3    Maxwell, R.J.4    Horsman, M.R.5
  • 16
    • 33745960743 scopus 로고    scopus 로고
    • Activity of the vascular-disrupting agent 5,6-dimenthylxanthenone-4-acetic acid against human head and neck carcinoma xenografts
    • Seshadri, M., Mazurchuk, R., Spernyak, J.A., Bhattacharya, A., Rustum, Y.M., Bellnier, D.A. Activity of the vascular-disrupting agent 5,6-dimenthylxanthenone-4-acetic acid against human head and neck carcinoma xenografts. Neoplasia 2006, 8(7): 534-42.
    • (2006) Neoplasia , vol.8 , Issue.7 , pp. 534-542
    • Seshadri, M.1    Mazurchuk, R.2    Spernyak, J.A.3    Bhattacharya, A.4    Rustum, Y.M.5    Bellnier, D.A.6
  • 17
    • 33847247311 scopus 로고    scopus 로고
    • Visualizing the acute effects of vascular-targeted therapy in vivo using intravital microscopy and magnetic resonance imaging: Correlation with endothelial apoptosis, cytokine induction, and treatment
    • Seshadri, M., Spernyak, J.A., Maier, P.G., Cheney, R.T., Mazurchuk, R., Bellnier, D.A. Visualizing the acute effects of vascular-targeted therapy in vivo using intravital microscopy and magnetic resonance imaging: Correlation with endothelial apoptosis, cytokine induction, and treatment. Neoplasia 2007, 9(2): 128-35.
    • (2007) Neoplasia , vol.9 , Issue.2 , pp. 128-135
    • Seshadri, M.1    Spernyak, J.A.2    Maier, P.G.3    Cheney, R.T.4    Mazurchuk, R.5    Bellnier, D.A.6
  • 18
    • 18844385964 scopus 로고    scopus 로고
    • Tumor dose response to the vascular disrupting agent, 5,6-dimethylxanthenone-4-acetic acid, using in vivo magnetic resonance spectroscopy
    • McPhail, L.D., Chung, Y.L., Madhu, B., Clark, S., Griffiths, J.R., Kelland, L.R., Robinson, S.P. Tumor dose response to the vascular disrupting agent, 5,6-dimethylxanthenone-4-acetic acid, using in vivo magnetic resonance spectroscopy. Clin Cancer Res 2005, 11(10): 3705-13.
    • (2005) Clin Cancer Res , vol.11 , Issue.10 , pp. 3705-3713
    • McPhail, L.D.1    Chung, Y.L.2    Madhu, B.3    Clark, S.4    Griffiths, J.R.5    Kelland, L.R.6    Robinson, S.P.7
  • 19
    • 33646342514 scopus 로고    scopus 로고
    • Rat tumor response to the vascular disrupting agent, 5,6-dimethylxanthenone-4-acetic acid as measured by dynamic contrast-enhanced magnetic resonance imaging, plasma 5-hydroxyindoleacetic acid levels, and tumor necrosis
    • McPhail, L.D., McIntyre, D.J.O., Ludwig, C., Kestell, P., Griffiths, J.R., Kelland, L.R., Robinson, S.P. Rat tumor response to the vascular disrupting agent, 5,6-dimethylxanthenone-4-acetic acid as measured by dynamic contrast-enhanced magnetic resonance imaging, plasma 5-hydroxyindoleacetic acid levels, and tumor necrosis. Neoplasia 2006, 8(3): 199-206.
    • (2006) Neoplasia , vol.8 , Issue.3 , pp. 199-206
    • McPhail, L.D.1    McIntyre, D.J.O.2    Ludwig, C.3    Kestell, P.4    Griffiths, J.R.5    Kelland, L.R.6    Robinson, S.P.7
  • 20
    • 35448952260 scopus 로고    scopus 로고
    • Assessment of tumor response to the vascular disrupting agent, 5,6-dimethylxanthenone-4-acetic acid or combretastatin-A4-phosphate by intrinsic susceptibility magnetic resonance imaging
    • McPhail, L.D., Griffiths, J.R., Kelland, L.R., Robinson, S.P. Assessment of tumor response to the vascular disrupting agent, 5,6-dimethylxanthenone-4-acetic acid or combretastatin-A4-phosphate by intrinsic susceptibility magnetic resonance imaging. Int J Radiat Oncol Biol Phys 2007, 69(4): 1238-45.
    • (2007) Int J Radiat Oncol Biol Phys , vol.69 , Issue.4 , pp. 1238-1245
    • McPhail, L.D.1    Griffiths, J.R.2    Kelland, L.R.3    Robinson, S.P.4
  • 22
    • 0024335180 scopus 로고
    • Blood flow failure as a major determinant in the antitumor action of flavone acetic acid
    • Zwi, L.J., Baguley, B.C., Gavin, J.B., Wilson, W. R. Blood flow failure as a major determinant in the antitumor action of flavone acetic acid. J Natl Cancer Inst 1989, 81(13): 1005-13.
    • (1989) J Natl Cancer Inst , vol.81 , Issue.13 , pp. 1005-1013
    • Zwi, L.J.1    Baguley, B.C.2    Gavin, J.B.3    Wilson, W.R.4
  • 23
    • 84965831662 scopus 로고
    • Important role of serotonin in the antitumour effects of tumor necrosis factor-alpha in mice
    • Manda, T., Hishigawa, F., Mori, J., Shimomura, K. Important role of serotonin in the antitumour effects of tumor necrosis factor-alpha in mice. Cancer Res 1988, 48(15): 4250-5.
    • (1988) Cancer Res , vol.48 , Issue.15 , pp. 4250-4255
    • Manda, T.1    Hishigawa, F.2    Mori, J.3    Shimomura, K.4
  • 24
    • 0030625644 scopus 로고    scopus 로고
    • Increased plasma serotonin following treatment with flavone-8-acetic acid, 5,6-dimethylxanthenone-4-acetic acid, vinblastine, and colchicines: Relation to vascular effects
    • Baguley, B.C., Zhuang, L., Kestell, P. Increased plasma serotonin following treatment with flavone-8-acetic acid, 5,6-dimethylxanthenone-4-acetic acid, vinblastine, and colchicines: Relation to vascular effects. Oncol Res 1997, 9(2): 55-60.
    • (1997) Oncol Res , vol.9 , Issue.2 , pp. 55-60
    • Baguley, B.C.1    Zhuang, L.2    Kestell, P.3
  • 25
    • 0035164766 scopus 로고    scopus 로고
    • Measurement of plasma 5-hydroxy-indoleacetic acid as a possible clinical surrogate marker for the action of antivascular agents
    • Kestell, P., Zhao, L.L., Jameson, M.B., Stratford, M.R.L., Folkes, L.K., Baguley, B.C. Measurement of plasma 5-hydroxy-indoleacetic acid as a possible clinical surrogate marker for the action of antivascular agents. Clin Chim Acta 2001, 314(1-2): 159-66.
    • (2001) Clin Chim Acta , vol.314 , Issue.1-2 , pp. 159-166
    • Kestell, P.1    Zhao, L.L.2    Jameson, M.B.3    Stratford, M.R.L.4    Folkes, L.K.5    Baguley, B.C.6
  • 26
    • 0026089375 scopus 로고
    • Tumor-dependent increased plasma nitrate concentrations as an indication of the antitumor effect of flavone-8-acetic acid and analogs in mice
    • Thomsen, L.L., Ching, L.M., Zhuang, L., Gavin, J.B., Baguley, B.C. Tumor-dependent increased plasma nitrate concentrations as an indication of the antitumor effect of flavone-8-acetic acid and analogs in mice. Cancer Res 1991, 51(1): 77-81.
    • (1991) Cancer Res , vol.51 , Issue.1 , pp. 77-81
    • Thomsen, L.L.1    Ching, L.M.2    Zhuang, L.3    Gavin, J.B.4    Baguley, B.C.5
  • 27
    • 0031925590 scopus 로고    scopus 로고
    • Role of nitric oxide in angiogenesis and microcirculation in tumors
    • Fukumura, D., Jain, R.K. Role of nitric oxide in angiogenesis and microcirculation in tumors. Cancer Metastasis Rev 1998, 17(1): 77-89.
    • (1998) Cancer Metastasis Rev , vol.17 , Issue.1 , pp. 77-89
    • Fukumura, D.1    Jain, R.K.2
  • 28
    • 0025094128 scopus 로고
    • Evidence for the production of nitric oxide by activated macrophages treated with the antitumor agents flavone-8-acetic acid and xanthenone-4-acetic acid
    • Thomsen, L.L., Ching, L.-M., Baguley, B.C. Evidence for the production of nitric oxide by activated macrophages treated with the antitumor agents flavone-8-acetic acid and xanthenone-4-acetic acid. Cancer Res 1990, 50(21): 6966-70.
    • (1990) Cancer Res , vol.50 , Issue.21 , pp. 6966-6970
    • Thomsen, L.L.1    Ching, L.-M.2    Baguley, B.C.3
  • 29
    • 0033083206 scopus 로고    scopus 로고
    • Stimulation of tumors to synthesize tumor necrosis factor-alpha in situ using 5,6-dimethylxanthenone-4-acetic acid: A novel approach to cancer therapy
    • Joseph, W.R., Cao, Z., Mountjoy, K.G., Marshall, E.S., Baguley, B.C., Ching, L.-M. Stimulation of tumors to synthesize tumor necrosis factor-alpha in situ using 5,6-dimethylxanthenone-4-acetic acid: A novel approach to cancer therapy. Cancer Res 1999, 59(3): 633-8.
    • (1999) Cancer Res , vol.59 , Issue.3 , pp. 633-638
    • Joseph, W.R.1    Cao, Z.2    Mountjoy, K.G.3    Marshall, E.S.4    Baguley, B.C.5    Ching, L.-M.6
  • 30
    • 0033565644 scopus 로고    scopus 로고
    • Induction of intratumoral tumor necrosis factor (TNF) synthesis and hemorrhagic necrosis by 5,6-dimethylxanthenone-4-acetic acid (DMXAA) in TNF knock-out mice
    • Ching, L.M., Goldsmith, D., Joseph, W.R., Korner, H., Sedgwick, J.D., Baguley, B.C. Induction of intratumoral tumor necrosis factor (TNF) synthesis and hemorrhagic necrosis by 5,6-dimethylxanthenone-4-acetic acid (DMXAA) in TNF knock-out mice. Cancer Res 1999, 59(14): 3304-7.
    • (1999) Cancer Res , vol.59 , Issue.14 , pp. 3304-3307
    • Ching, L.M.1    Goldsmith, D.2    Joseph, W.R.3    Korner, H.4    Sedgwick, J.D.5    Baguley, B.C.6
  • 31
    • 0037068317 scopus 로고    scopus 로고
    • The antitumour activity of 5,6-dimethylxanthenone-4-acetic acid (DMXAA) in TNF receptor knock-out mice
    • Zhao, L., Ching, L.-M., Kestell, P., Baguley, B.C. The antitumour activity of 5,6-dimethylxanthenone-4-acetic acid (DMXAA) in TNF receptor knock-out mice. Br J Cancer 2002, 87(4): 465-70.
    • (2002) Br J Cancer , vol.87 , Issue.4 , pp. 465-470
    • Zhao, L.1    Ching, L.-M.2    Kestell, P.3    Baguley, B.C.4
  • 32
    • 0028063124 scopus 로고
    • Activation of LPS-inducible genes by the antitumor agent 5,6-dimethylxanthenone-4-acetic acid in primary murine macrophages - Dissection of signaling pathways leading to gene induction and tyrosine phosphorylation
    • Perera, P.Y., Barber, S.A., Ching, L.-M., Vogel, S.N. Activation of LPS-inducible genes by the antitumor agent 5,6-dimethylxanthenone-4-acetic acid in primary murine macrophages - Dissection of signaling pathways leading to gene induction and tyrosine phosphorylation. J Immunol 1994, 153(10): 4684-93.
    • (1994) J Immunol , vol.153 , Issue.10 , pp. 4684-4693
    • Perera, P.Y.1    Barber, S.A.2    Ching, L.-M.3    Vogel, S.N.4
  • 33
    • 0035866391 scopus 로고    scopus 로고
    • IP-10 induction and inhibition of angiogrenesis by the antitumor agent 5,6-dimethylxanthenone-4-acetic acid
    • Cao, Z., Baguley, B.C., Ching, L.-M. IP-10 induction and inhibition of angiogrenesis by the antitumor agent 5,6-dimethylxanthenone-4-acetic acid. Cancer Res 2001, 61(4): 1517-21.
    • (2001) Cancer Res , vol.61 , Issue.4 , pp. 1517-1521
    • Cao, Z.1    Baguley, B.C.2    Ching, L.-M.3
  • 34
    • 29244466134 scopus 로고    scopus 로고
    • Activation of tumor-associated macrophages by the vascular disrupting agent 5,6 dimethylxanthenone-4-acetic acid (DMXAA) induces an effective CD8+ T-cell-mediated anti-tumor immune response in immunogenic and non-immunogenic murine models of lung cancer and mesothelioma
    • Jassar, A.S., Suzuki, E., Kapoor, V. et al. Activation of tumor-associated macrophages by the vascular disrupting agent 5,6 dimethylxanthenone-4-acetic acid (DMXAA) induces an effective CD8+ T-cell-mediated anti-tumor immune response in immunogenic and non-immunogenic murine models of lung cancer and mesothelioma. Cancer Res 2005, 65(24): 11752-61.
    • (2005) Cancer Res , vol.65 , Issue.24 , pp. 11752-11761
    • Jassar, A.S.1    Suzuki, E.2    Kapoor, V.3
  • 35
    • 33746905529 scopus 로고    scopus 로고
    • Inhibition of DMXAA-induced tumor necrosis factor production in murine splenocyte cultures by NF-κB inhibitors
    • Wang, L.-C.S., Woon, S.-T., Baguley, B.C., Ching, L.-M. Inhibition of DMXAA-induced tumor necrosis factor production in murine splenocyte cultures by NF-κB inhibitors. Oncol Res 2006, 16(1): 1-14.
    • (2006) Oncol Res , vol.16 , Issue.1 , pp. 1-14
    • Wang, L.-C.S.1    Woon, S.-T.2    Baguley, B.C.3    Ching, L.-M.4
  • 36
    • 34547125116 scopus 로고    scopus 로고
    • The vascular disrupting agent 5,6-dimethylxanthenone-4-acetic acid (DMXAA), directly activates dendritic cells through a MyD88-independent mechanism and generates anti-tumor cytotoxic T-lymphocytes
    • Wallace, A., LaRosa, D.F., Kapoor, V. et al. The vascular disrupting agent 5,6-dimethylxanthenone-4-acetic acid (DMXAA), directly activates dendritic cells through a MyD88-independent mechanism and generates anti-tumor cytotoxic T-lymphocytes. Cancer Res 2007, 67(14): 7011-9.
    • (2007) Cancer Res , vol.67 , Issue.14 , pp. 7011-7019
    • Wallace, A.1    LaRosa, D.F.2    Kapoor, V.3
  • 37
    • 34447330454 scopus 로고    scopus 로고
    • The chemotherapeutic agent 5,6-dimethylxanthenone-4-acetic acid, potently and specifically activates the TBK1-IRF-3 signalling axis
    • Roberts, Z.J., Goutagny, N., Perera, P.-Y. et al. The chemotherapeutic agent 5,6-dimethylxanthenone-4-acetic acid, potently and specifically activates the TBK1-IRF-3 signalling axis. J Exp Med 2007, 204(7): 1559-69.
    • (2007) J Exp Med , vol.204 , Issue.7 , pp. 1559-1569
    • Roberts, Z.J.1    Goutagny, N.2    Perera, P.-Y.3
  • 38
    • 32044441053 scopus 로고    scopus 로고
    • A comparison of the ability of DMXAA and xanthenone analogues to activate NF-kappaB in murine and human cell lines
    • Woon, S.-T., Reddy, C.B., Drummond, C.J., Schooltink, M.A., Baguley, B.C., Kieda, C., Ching, L.-M. A comparison of the ability of DMXAA and xanthenone analogues to activate NF-kappaB in murine and human cell lines. Oncol Res 2005, 15(7-8): 351-64.
    • (2005) Oncol Res , vol.15 , Issue.7-8 , pp. 351-364
    • Woon, S.-T.1    Reddy, C.B.2    Drummond, C.J.3    Schooltink, M.A.4    Baguley, B.C.5    Kieda, C.6    Ching, L.-M.7
  • 39
    • 0037726779 scopus 로고    scopus 로고
    • NF-kappaB activation in vivo in both host and tumour cells by the antivascular agent, 5,6-dimethylxanthenone-4-acetic acid (DMXAA)
    • Woon, S.-T., Zwain, S., Schooltink, M.A., Newth, A.L., Baguley, B.C., Ching, L.-M. NF-kappaB activation in vivo in both host and tumour cells by the antivascular agent, 5,6-dimethylxanthenone-4-acetic acid (DMXAA). Eur J Cancer 2003, 39(8): 1176-83.
    • (2003) Eur J Cancer , vol.39 , Issue.8 , pp. 1176-1183
    • Woon, S.-T.1    Zwain, S.2    Schooltink, M.A.3    Newth, A.L.4    Baguley, B.C.5    Ching, L.-M.6
  • 40
    • 0036369652 scopus 로고    scopus 로고
    • Uptake of the antivascular agent 5,6-dimethylxanthenone-4-acetic acid (DMXAA) and activation of NF-kappaB in human tumour cell lines
    • Woon, S.-T., Baguley, B.C., Palmer, B.D., Fraser, J., Ching, L.-M. Uptake of the antivascular agent 5,6-dimethylxanthenone-4-acetic acid (DMXAA) and activation of NF-kappaB in human tumour cell lines. Oncol Res 2002, 13(2): 95-101.
    • (2002) Oncol Res , vol.13 , Issue.2 , pp. 95-101
    • Woon, S.-T.1    Baguley, B.C.2    Palmer, B.D.3    Fraser, J.4    Ching, L.-M.5
  • 41
    • 0033201439 scopus 로고    scopus 로고
    • Induction of STA T and NF kappa B activation by the antitumour agents 5,6-dimethylxanthenone-4-acetic acid and flavone acetic acid in a murine macrophage cell line
    • Ching, L.M., Young, H.A., Eberly, K., Yu, C.-R. Induction of STA T and NF kappa B activation by the antitumour agents 5,6-dimethylxanthenone-4-acetic acid and flavone acetic acid in a murine macrophage cell line. Biochem Pharmacol 1999, 58(7): 1173-81.
    • (1999) Biochem Pharmacol , vol.58 , Issue.7 , pp. 1173-1181
    • Ching, L.M.1    Young, H.A.2    Eberly, K.3    Yu, C.-R.4
  • 42
    • 0035266136 scopus 로고    scopus 로고
    • Vascular attack by 5,6-dimethylxanthenone-4-acetic acid combined with B7.1(CD80)-mediated immunotherapy overcomes immume resistance and leads to the eradication of large tumors and multiple foci
    • Kanwar, J.R., Kanwar, R., Pandey, S., Ching, L.-M., Krissansen, G.W. Vascular attack by 5,6-dimethylxanthenone-4-acetic acid combined with B7.1(CD80)-mediated immunotherapy overcomes immume resistance and leads to the eradication of large tumors and multiple foci. Cancer Res 2001, 61(5): 1948-56.
    • (2001) Cancer Res , vol.61 , Issue.5 , pp. 1948-1956
    • Kanwar, J.R.1    Kanwar, R.2    Pandey, S.3    Ching, L.-M.4    Krissansen, G.W.5
  • 43
    • 0036891440 scopus 로고    scopus 로고
    • Combination of vascular targeting agents with thermal or radiation therapy
    • Horsman, M.R., Murata, R. Combination of vascular targeting agents with thermal or radiation therapy. Int J Rad Oncol Biol Phys 2002, 54(5): 1518-23.
    • (2002) Int J Rad Oncol Biol Phys , vol.54 , Issue.5 , pp. 1518-1523
    • Horsman, M.R.1    Murata, R.2
  • 44
    • 20344389791 scopus 로고    scopus 로고
    • Tumor vascular response to photodynamic therapy and the antivascular agent 5,6-dimethylxanthenone-4-acetic acid: Implications for combination therapy
    • Seshadri, M., Spernyak, J.A., Mazurchak, R., Camacho, S.H., Oseroff, A.R., Cheney, R.T., Bellnier, D.A. Tumor vascular response to photodynamic therapy and the antivascular agent 5,6-dimethylxanthenone-4-acetic acid: Implications for combination therapy. Clin Cancer Res 2005, 11(11): 4241-50.
    • (2005) Clin Cancer Res , vol.11 , Issue.11 , pp. 4241-4250
    • Seshadri, M.1    Spernyak, J.A.2    Mazurchak, R.3    Camacho, S.H.4    Oseroff, A.R.5    Cheney, R.T.6    Bellnier, D.A.7
  • 45
    • 0034759198 scopus 로고    scopus 로고
    • Improved tumor response by combining radiation and the vascular-damaging drug 5,6-dimethylxanthenone-4-acetic acid
    • Murata, R., Sieman, D.W., Overgaard, J., Horsman, M.R. Improved tumor response by combining radiation and the vascular-damaging drug 5,6-dimethylxanthenone-4-acetic acid. Radiat Res 2001, 156(5): 503-9.
    • (2001) Radiat Res , vol.156 , Issue.5 , pp. 503-509
    • Murata, R.1    Sieman, D.W.2    Overgaard, J.3    Horsman, M.R.4
  • 46
    • 0031016945 scopus 로고    scopus 로고
    • Mechanisms of enhancement of the antitumour activity of melphlan by the tumour-blood-flow inhibitor 5,6-dimethylxanthenone-4-acetic acid
    • Pruijn, F.B., van Daalen, M., Holford, N.H.G., Wilson, W.R. Mechanisms of enhancement of the antitumour activity of melphlan by the tumour-blood-flow inhibitor 5,6-dimethylxanthenone-4-acetic acid. Cancer Chemother Pharmacol 1997, 39(6): 541-6.
    • (1997) Cancer Chemother Pharmacol , vol.39 , Issue.6 , pp. 541-546
    • Pruijn, F.B.1    van Daalen, M.2    Holford, N.H.G.3    Wilson, W.R.4
  • 47
    • 0031858141 scopus 로고    scopus 로고
    • Enhancement of the anti-tumour effects of the anti-vascular agent 5,6-dimethylxanthenone-4-acetic acid (DMXAA) by combination with 5-hydroxytryptamine and bioreductive drugs
    • Lash, C.J., Li, A.E., Rutland, M., Baguley, B.C., Zwi, L.J., Wilson, W.R. Enhancement of the anti-tumour effects of the anti-vascular agent 5,6-dimethylxanthenone-4-acetic acid (DMXAA) by combination with 5-hydroxytryptamine and bioreductive drugs. Br J Cancer 1998, 78(4): 439-45.
    • (1998) Br J Cancer , vol.78 , Issue.4 , pp. 439-445
    • Lash, C.J.1    Li, A.E.2    Rutland, M.3    Baguley, B.C.4    Zwi, L.J.5    Wilson, W.R.6
  • 48
    • 0037222218 scopus 로고    scopus 로고
    • Marked potentiation of the antitumour activity of chemotherapeutic drugs by the antivascular agent 5,6-dimethylxanthenone-4-acetic acid (DMXAA)
    • Siim, B.G., Lee, A.E., Shalal-Zwain, S. et al. Marked potentiation of the antitumour activity of chemotherapeutic drugs by the antivascular agent 5,6-dimethylxanthenone-4-acetic acid (DMXAA). Cancer Chemother Pharmacol 2003, 51(1): 43-52.
    • (2003) Cancer Chemother Pharmacol , vol.51 , Issue.1 , pp. 43-52
    • Siim, B.G.1    Lee, A.E.2    Shalal-Zwain, S.3
  • 49
    • 0036568457 scopus 로고    scopus 로고
    • Vascular targeting agents enhance chemotherapeutic agent activaties in solid tumor therapy
    • Siemann, D.W., Mercer, E., Lepler, S., Rogiani, A.M. Vascular targeting agents enhance chemotherapeutic agent activaties in solid tumor therapy. Int J Cancer 2002, 99(1): 1-6.
    • (2002) Int J Cancer , vol.99 , Issue.1 , pp. 1-6
    • Siemann, D.W.1    Mercer, E.2    Lepler, S.3    Rogiani, A.M.4
  • 50
    • 0033895294 scopus 로고    scopus 로고
    • Modulation of the pharmacokinetics of the antitumour agent 5,6-dimethylxanthenone-4-actic acid (DMXAA) by thalidomide
    • Kestell, P., Zhao, L., Baguley, B.C., Palmer, B.D., Muller, G., Paxton, J.W., Ching, L.M. Modulation of the pharmacokinetics of the antitumour agent 5,6-dimethylxanthenone-4-actic acid (DMXAA) by thalidomide. Cancer Chemother Pharmacol 2000, 46(2): 135-41.
    • (2000) Cancer Chemother Pharmacol , vol.46 , Issue.2 , pp. 135-141
    • Kestell, P.1    Zhao, L.2    Baguley, B.C.3    Palmer, B.D.4    Muller, G.5    Paxton, J.W.6    Ching, L.M.7
  • 51
    • 0031846669 scopus 로고    scopus 로고
    • Interaction of thalidomide, phthalimide analogues of thalidomide and pentoxifylline with the antitumour agent 5,6-dimethylxanthenone-4-acetic acid: Concomitant reduction of serum tumour necrosis factor-alpha and enhancement of antitumour activity
    • Ching, L.-M., Browne, W.L., Tchernegovski, R., Gregory, T., Baguley, B.C., Palmer, B.D. Interaction of thalidomide, phthalimide analogues of thalidomide and pentoxifylline with the antitumour agent 5,6-dimethylxanthenone-4-acetic acid: Concomitant reduction of serum tumour necrosis factor-alpha and enhancement of antitumour activity. Br J Cancer 1998, 78(3): 336-43.
    • (1998) Br J Cancer , vol.78 , Issue.3 , pp. 336-343
    • Ching, L.-M.1    Browne, W.L.2    Tchernegovski, R.3    Gregory, T.4    Baguley, B.C.5    Palmer, B.D.6
  • 52
    • 0029087486 scopus 로고
    • Effect of thalidomide on tumour necrosis factor production and anti-tumour activity induced by 5,6-dimethylxanthenone-4-acetic acid
    • Ching, L.-M., Xu, Z.-F., Gummer, B.H., Palmer, B.D., Joseph, W.R., Baguley, B.C. Effect of thalidomide on tumour necrosis factor production and anti-tumour activity induced by 5,6-dimethylxanthenone-4-acetic acid. Br J Cancer 1995, 72(2): 339-43.
    • (1995) Br J Cancer , vol.72 , Issue.2 , pp. 339-343
    • Ching, L.-M.1    Xu, Z.-F.2    Gummer, B.H.3    Palmer, B.D.4    Joseph, W.R.5    Baguley, B.C.6
  • 53
    • 37249045539 scopus 로고    scopus 로고
    • Consequences of increased vascular permeability induced by treatment of mice with 5,6-dimethylxanthenone-4-acetic acid (DMXAA) and thalidomide
    • Chung, F., Lui, J., Ching, L.-M., Baguley, B.C. Consequences of increased vascular permeability induced by treatment of mice with 5,6-dimethylxanthenone-4-acetic acid (DMXAA) and thalidomide. Cancer Chemother Pharmacol 2008, 61(3): 497-502.
    • (2008) Cancer Chemother Pharmacol , vol.61 , Issue.3 , pp. 497-502
    • Chung, F.1    Lui, J.2    Ching, L.-M.3    Baguley, B.C.4
  • 54
    • 0032895102 scopus 로고    scopus 로고
    • Thalidomide increases both intra-tumoural tumour necrosis factor-alpha production and anti-tumour activity in response to 5,6-dimethylxanthenone-4-acetic acid
    • Cao, Z., Joseph, W.R., Browne, W.L., Mountjoy, K.G., Palmer, B.D., Baguley, B.C., Ching, L.M. Thalidomide increases both intra-tumoural tumour necrosis factor-alpha production and anti-tumour activity in response to 5,6-dimethylxanthenone-4-acetic acid. Br J Cancer 1999, 80(5-6): 716-23.
    • (1999) Br J Cancer , vol.80 , Issue.5-6 , pp. 716-723
    • Cao, Z.1    Joseph, W.R.2    Browne, W.L.3    Mountjoy, K.G.4    Palmer, B.D.5    Baguley, B.C.6    Ching, L.M.7
  • 55
    • 2142714499 scopus 로고    scopus 로고
    • Modulation of thalidomide pharmacokinetics by cyclophosphamide or 5,6-dimethylxanthenone-4-acetic acid (DMXAA) in mice: The role of tumour necrosis factor
    • Chung, F., Wang, L.-C. S., Kestell, P., Baguley, B.C., Ching, L.-M. Modulation of thalidomide pharmacokinetics by cyclophosphamide or 5,6-dimethylxanthenone-4-acetic acid (DMXAA) in mice: The role of tumour necrosis factor. Cancer Chemother Pharmacol 2004, 53(5): 377-83.
    • (2004) Cancer Chemother Pharmacol , vol.53 , Issue.5 , pp. 377-383
    • Chung, F.1    Wang, L.-C.S.2    Kestell, P.3    Baguley, B.C.4    Ching, L.-M.5
  • 56
    • 0036137568 scopus 로고    scopus 로고
    • Oral activity and pharmacokinetics of 5,6-dimethylxanthenone-4-acetic acid (DMXAA) in mice
    • Zhao, L., Kestell, P., Ching, L.-M., Baguley, B.C. Oral activity and pharmacokinetics of 5,6-dimethylxanthenone-4-acetic acid (DMXAA) in mice. Cancer Chemother Pharmacol 2002, 49(1): 20-6.
    • (2002) Cancer Chemother Pharmacol , vol.49 , Issue.1 , pp. 20-26
    • Zhao, L.1    Kestell, P.2    Ching, L.-M.3    Baguley, B.C.4
  • 57
    • 0346963094 scopus 로고    scopus 로고
    • Improvement of the antitumour activity of intraperitoneally and orally administered 5,6-dimethylxanthenone-4-acetic acid by optimal scheduling
    • Zhao, L., Ching, L.-M., Kestell, P., Baguley, B.C. Improvement of the antitumour activity of intraperitoneally and orally administered 5,6-dimethylxanthenone-4-acetic acid by optimal scheduling. Clin Cancer Res 2003, 9(17): 6545-50.
    • (2003) Clin Cancer Res , vol.9 , Issue.17 , pp. 6545-6550
    • Zhao, L.1    Ching, L.-M.2    Kestell, P.3    Baguley, B.C.4
  • 58
    • 0033052183 scopus 로고    scopus 로고
    • Plasma disposition, metabolism and excretion of the experimental antitumour agent 5,6-dimethylxanthenone-4-acetic acid in the mouse, rat and rabbit
    • Kestell, P., Paxton, J.W., Rewcastle, G.W., Dunlop, I., Baguley, B.C. Plasma disposition, metabolism and excretion of the experimental antitumour agent 5,6-dimethylxanthenone-4-acetic acid in the mouse, rat and rabbit. Cancer Chemother Pharmacol 1999, 43(4): 323-30.
    • (1999) Cancer Chemother Pharmacol , vol.43 , Issue.4 , pp. 323-330
    • Kestell, P.1    Paxton, J.W.2    Rewcastle, G.W.3    Dunlop, I.4    Baguley, B.C.5
  • 59
    • 0036163823 scopus 로고    scopus 로고
    • Gender differences in the metabolism and pharmacokinetics of the experimental anticancer agent 5,6-dimethylxanthenone-4-acetic acid (DMXAA)
    • Zhou, S.F., Kestell, P., Tingle, M.D., Paxton, J.W. Gender differences in the metabolism and pharmacokinetics of the experimental anticancer agent 5,6-dimethylxanthenone-4-acetic acid (DMXAA). Cancer Chemother Pharmacol 2002, 49(2): 126-32.
    • (2002) Cancer Chemother Pharmacol , vol.49 , Issue.2 , pp. 126-132
    • Zhou, S.F.1    Kestell, P.2    Tingle, M.D.3    Paxton, J.W.4
  • 60
    • 0035038182 scopus 로고    scopus 로고
    • Reversible binding of the novel anti-tumour agent 5,6-dimethylxanthenone-4-acetic acid to plasma proteins and its distribution into blood cells in various species
    • Zhou, S.F., Paxton, J.W., Kestell, P., Tingle, M.D. Reversible binding of the novel anti-tumour agent 5,6-dimethylxanthenone-4-acetic acid to plasma proteins and its distribution into blood cells in various species. J Pharm Pharmacol 2001, 53(4): 463-71.
    • (2001) J Pharm Pharmacol , vol.53 , Issue.4 , pp. 463-471
    • Zhou, S.F.1    Paxton, J.W.2    Kestell, P.3    Tingle, M.D.4
  • 61
    • 0034947850 scopus 로고    scopus 로고
    • Identification and reactivity of the major metabolite (beta-1-glucuronide) of the anti-tumour agent, 5,6-dimethylxanthenone-4-acetic acid (DMXAA) in humans
    • Zhou, S.F., Paxton, J.W., Tingle, M.D. et al. Identification and reactivity of the major metabolite (beta-1-glucuronide) of the anti-tumour agent, 5,6-dimethylxanthenone-4-acetic acid (DMXAA) in humans. Xenobiotica 2001, 31(5): 277-93.
    • (2001) Xenobiotica , vol.31 , Issue.5 , pp. 277-293
    • Zhou, S.F.1    Paxton, J.W.2    Tingle, M.D.3
  • 62
    • 0037212081 scopus 로고    scopus 로고
    • Preclinical factors influencing the relative contributions of phase I and phase II enzymes to the metabolism of the experimental anti-cancer drug 5,6-dimethylxanthenone-4-acetic acid
    • Zhou, S.F., Kestell, P., Baguley, B.C., Paxton, J.W. Preclinical factors influencing the relative contributions of phase I and phase II enzymes to the metabolism of the experimental anti-cancer drug 5,6-dimethylxanthenone-4-acetic acid. Biochem Pharmacol 2003, 65(1): 109-20.
    • (2003) Biochem Pharmacol , vol.65 , Issue.1 , pp. 109-120
    • Zhou, S.F.1    Kestell, P.2    Baguley, B.C.3    Paxton, J.W.4
  • 63
    • 0033673590 scopus 로고    scopus 로고
    • Identification of the human liver cytochrome P450 isoenzyme responsible for the 6-methylhydroxylation of the novel anticancer drug 5,6-dimethylxanthenone-4-acetic acid
    • Zhou, S., Paxton, J.W., Tingle, M.D., Kestell, P. Identification of the human liver cytochrome P450 isoenzyme responsible for the 6-methylhydroxylation of the novel anticancer drug 5,6-dimethylxanthenone-4-acetic acid. Drug Metab Dispos 2000, 28(12): 1449-56.
    • (2000) Drug Metab Dispos , vol.28 , Issue.12 , pp. 1449-1456
    • Zhou, S.1    Paxton, J.W.2    Tingle, M.D.3    Kestell, P.4
  • 64
    • 33847157946 scopus 로고    scopus 로고
    • Pharmacokinetics of 5,6-dimethylxanthenone-4-acetic acid (AS1404), a novel vascular disrupting agent, in a phase 1 clinical trial
    • Jameson, M.B., Baguley, B.C., Kestell, P. et al. Pharmacokinetics of 5,6-dimethylxanthenone-4-acetic acid (AS1404), a novel vascular disrupting agent, in a phase 1 clinical trial. Cancer Chemother Pharmacol 2007, 59(5): 681-7.
    • (2007) Cancer Chemother Pharmacol , vol.59 , Issue.5 , pp. 681-687
    • Jameson, M.B.1    Baguley, B.C.2    Kestell, P.3
  • 65
    • 0038576231 scopus 로고    scopus 로고
    • 5,6-Dimethylxanthenone-4-acetic acid (DMXAA), a novel antivascular agent: Phase I clinical and pharmacokinetic study
    • Rustin, G.J.S., Bradley, C., Galbraith, S. et al. 5,6-Dimethylxanthenone-4-acetic acid (DMXAA), a novel antivascular agent: phase I clinical and pharmacokinetic study. Br J Cancer 2003, 88(8): 1160-7.
    • (2003) Br J Cancer , vol.88 , Issue.8 , pp. 1160-1167
    • Rustin, G.J.S.1    Bradley, C.2    Galbraith, S.3
  • 66
    • 33645659565 scopus 로고    scopus 로고
    • 5,6-Dimethylxanthenone-4-acetic acid in the treatment of refractory tumors: A Phase 1 safety study of a vascular disrupting agent
    • McKeage, M., Fong, P., Jeffery, M. et al. 5,6-Dimethylxanthenone-4-acetic acid in the treatment of refractory tumors: A Phase 1 safety study of a vascular disrupting agent. Clin Cancer Res 2006, 12(6): 1776-84.
    • (2006) Clin Cancer Res , vol.12 , Issue.6 , pp. 1776-1784
    • McKeage, M.1    Fong, P.2    Jeffery, M.3
  • 67
    • 56749183424 scopus 로고    scopus 로고
    • Update on survival in a phase Ib/II study of DMXAA (AS1404) combined with carboplatin and paclitaxel in non-small cell lung cancer (NSCLC)
    • Nov 7-10, Prague, Abst 40
    • Von Pawel, J., Reck, M., McKeague, M. Update on survival in a phase Ib/II study of DMXAA (AS1404) combined with carboplatin and paclitaxel in non-small cell lung cancer (NSCLC). Eur J Cancer Suppl [18th EORTC-NCI-AACR Symp Mol Targets Cancer Ther (Nov 7-10, Prague) 2006] 2006, 4(12): Abst 40.
    • (2006) Eur J Cancer Suppl [18th EORTC-NCI-AACR Symp Mol Targets Cancer Ther , vol.4 , Issue.12
    • Von Pawel, J.1    Reck, M.2    McKeague, M.3
  • 68
    • 56749133084 scopus 로고    scopus 로고
    • Update on randomised phase II study of DMXAA (ASA404) combined with carboplatin and paclitaxel in recurrent ovarian cancer
    • Sept 23-27, Barcelona, Abst 5028
    • Gabra, H., Jameson, M. Update on randomised phase II study of DMXAA (ASA404) combined with carboplatin and paclitaxel in recurrent ovarian cancer. Eur J Cancer Suppl [14th Eur Cancer Conf (ECCO) (Sept 23-27, Barcelona) 2007] 2007, 5(4): Abst 5028.
    • (2007) Eur J Cancer Suppl [14th Eur Cancer Conf (ECCO) , vol.5 , Issue.4
    • Gabra, H.1    Jameson, M.2
  • 70
    • 56749174837 scopus 로고    scopus 로고
    • An open-label, phase I trial of intravenous ASA404 administered in combination with paclitaxel and carboplatin in Japanese patients with non-small cell lung caner (NSCLC) (NCT00674102). ClinicalTrials.gov Web site, May 27, 2008.
    • An open-label, phase I trial of intravenous ASA404 administered in combination with paclitaxel and carboplatin in Japanese patients with non-small cell lung caner (NSCLC) (NCT00674102). ClinicalTrials.gov Web site, May 27, 2008.


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