Plasma disposition, metabolism and excretion of the experimental antitumour agent 5,6-dimethylxanthenone-4-acetic acid in the mouse, rat and rabbit

Cancer Chemotherapy and Pharmacology

Volumn 43, Issue 4, 1999, Pages 323-330

  Kestell, Philip ^a   Paxton, James W ^a   Rewcastle, Gordon W ^a   Dunlop, Ingrid ^a   Baguley, Bruce C ^a  

^a UNIVERSITY OF AUCKLAND   (New Zealand)

Author keywords

Antitumour agents; Glucuronidation; Interspecies variation; Pharmacokinetics

Indexed keywords

5,6 DIMETHYLXANTHENONE 4 ACETIC ACID; ANTINEOPLASTIC AGENT; DRUG METABOLITE; GLUCURONIDE; XANTHONE 4 ACETIC ACID;

ANIMAL EXPERIMENT; ARTICLE; BOLUS INJECTION; COMPARTMENT MODEL; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DISPOSITION; DRUG EXCRETION; DRUG GLUCURONIDATION; DRUG METABOLISM; DRUG PROTEIN BINDING; DRUG URINE LEVEL; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INTRAVENOUS DRUG ADMINISTRATION; MALE; MASS SPECTROMETRY; MICHAELIS MENTEN KINETICS; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; RABBIT; RAT; SPECIES DIFFERENCE;

ANIMALS; ANTINEOPLASTIC AGENTS; BLOOD PROTEINS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DOSE-RESPONSE RELATIONSHIP, DRUG; INFUSIONS, INTRAVENOUS; INJECTIONS, INTRAVENOUS; MALE; METABOLIC CLEARANCE RATE; MICE; PROTEIN BINDING; RABBITS; RATS; RATS, SPRAGUE-DAWLEY; SPECIES SPECIFICITY; TIME FACTORS; XANTHENES; XANTHONES;

EID: 0033052183     PISSN: 03445704     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002800050902     Document Type: Article

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