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Azaelliptitoxin is the best well-known heterolignan for its biological activities. The generic name "heterolignan" was first introduced by Medarde et al., see: M. Medarde, R. Peláez-Lamamié de Clairac, F. Tomé, J. L. Lopez, A. San Feliciano, Arch. Pharm. 1995, 328, 403-407.
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56749157713
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(+)-(R)-Mosher's acid [(+)-(R)-MTPA] was used as chiral derivating agent.
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(+)-(R)-Mosher's acid [(+)-(R)-MTPA] was used as chiral derivating agent.
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In this reaction, the use of electron-donating alkyl protecting groups, such as the methyl group to give the dimethylamino moiety, led to the degradation of the reaction mixture probably by initial formation of the corresponding azafulvenium salt by removal of dimethylamine
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In this reaction, the use of electron-donating alkyl protecting groups, such as the methyl group to give the dimethylamino moiety, led to the degradation of the reaction mixture probably by initial formation of the corresponding azafulvenium salt by removal of dimethylamine.
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47
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Masked carbonyl groups are known to give cleaner reactions in several cases than the corresponding carbonyl groups, see: C. C. Silveira, A. S. Vieira, T. S. Kaufman, Tetrahedron Lett. 2006, 47, 7545-7549 and references cited therein.
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56749150615
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The coupling constant between the same hydrogen atoms in the 2-aza-4-methylepipodophyllotoxin is 1.8 Hz for the syn relationship, see ref.[18
-
[18]
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