A novel finding that Streptomyces clavuligerus can produce the antibiotic clavulanic acid using olive oil as a sole carbon source

Journal of Applied Microbiology

Volumn 105, Issue 6, 2008, Pages 2058-2064

  Efthimiou, G ^a   Thumser, A E ^a   Avignone Rossa, C A ^a  

^a UNIVERSITY OF SURREY   (United Kingdom)

Author keywords

Carbon source; Clavulanic acid; Glycerol; Lipids; Macromolecular composition; Olive oil; Streptomyces clavuligerus

Indexed keywords

BACTERIA; BATCH CELL CULTURE; CARBON; ECONOMIC AND SOCIAL EFFECTS; FERMENTATION; MACROMOLECULES; OLIVE OIL; PHYSIOLOGY; UNSATURATED FATTY ACIDS;

ACID PRODUCTION; ACID YIELDS; BATCH CULTURE; CARBON SOURCE; CLAVULANIC ACID; FOOD OIL; LIPID CONTENT; MACROMOLECULAR COMPOSITION; SOLE CARBON SOURCE; STREPTOMYCES CLAVULIGERUS;

GLYCEROL;

CLAVULANIC ACID; GLYCEROL; OLIVE OIL;

ALCOHOL; ANTIBIOTICS; BIOREACTOR; BIOTECHNOLOGY; CARBON; CATABOLISM; HERB; LIPID; PHYSIOLOGY; PROTEIN; VEGETABLE OIL;

ARTICLE; BACTERIAL GROWTH; BACTERIAL METABOLISM; BACTERIUM CULTURE; BIOREACTOR; CARBON SOURCE; CATABOLISM; CHEMICAL COMPOSITION; CONTROLLED STUDY; CULTURE MEDIUM; DRUG SYNTHESIS; ENERGY RESOURCE; MACROMOLECULE; NONHUMAN; QUANTITATIVE ANALYSIS; REPRODUCIBILITY; STREPTOMYCES CLAVULIGERUS;

STREPTOMYCES CLAVULIGERUS;

EID: 56649115980     PISSN: 13645072     EISSN: 13652672     Source Type: Journal    
DOI: 10.1111/j.1365-2672.2008.03975.x     Document Type: Article

References (30)

1. Aharonowitz, Y. Demain, A.L. (1978) Carbon catabolite regulation of cephalosporin production in Streptomyces clavuligerus. Antimicrob Agents Chemother 14, 159 164.
2. Banchio, C. Gramajo, H.C. (1997) Medium- and long-chain fatty acid uptake and utilization by Streptomyces coelicolor A3(2): first characterization of a gram-positive bacterial system. Microbiology 143, 2439 2447.
3. Bird, A.E., Bellis, J.M. Gasson, B.C. (1982) Spectrophotometric assay of clavulanic acid by reaction with imidazole. Analyst 107, 1241 1245.
4. Bushell, M.E., Kirk, S., Zhao, H. Avignone-Rossa, C.A. (2006) Manipulation of the physiology of clavulanic acid biosynthesis with the aid of metabolic flux analysis. Enzyme Microb Technol 39, 149 157.
5. Cavanagh, M.E., Ison, A.P., Lilly, M.D., Carley-Smith, S.W. Edwards, J. (1994) The utilization of lipids during Streptomyces fermentations. Trans Inst Chem Eng 72, 14 16.
6. Chen, K.C., Lin, H.Y., Wu, J.Y. Hwang, S.C. (2003) Enhancement of clavulanic acid production in Streptomyces clavuligerus with ornithine feeding. Enzyme Microb Technol 32, 152 156.
7. Choi, D. Cho, K. (2004) Effect of carbon source consumption rate on lincomycin production from Streptomyces lincolnensis. J Microbiol Biotechnol 14, 532 539.
8. Davidson, A. (1992) Quantitative microbial physiology of Streptomyces coelicolor A3 (2). PhD Thesis, University of Glasgow, UK.
9. Dubois, M., Gilles, K.A., Hamilton, J.K., Rebers, P.A. Smith, F. (1956) Colorimetric method for determination of sugars and related substances. Anal Chem 28, 350 356.
10. Garcia-Dominguez, M., Martin, J.F. Liras, P. (1989) Characterization of sugar uptake in wild-type Streptomyces clavuligerus, which is impaired in glucose uptake, and in a glucose-utilizing mutant. J Bacteriol 171, 6808 6814.
11. Hamedi, J., Malekzadeh, F. Niknam, V. (2002) Improved production of erythromycin by Saccharopolyspora erythraea by various plant oils. Biotechnol Lett 24, 697 700.
12. Hartree, E.F. (1972) Determination of protein: a modification of the Lowry method that gives a linear photometric response. Anal Biochem 48, 422 427.
13. Harwood, J. Aparicio, R. (2000) Handbook of Olive Oil: Analysis and Properties. Gaithersburg, MD, USA : Aspen Publishers Inc.
14. Izard, J. Limberger, R.J. (2003) Rapid screening method for quantitation of bacterial cell lipids from whole cells. J Microbiol Methods 55, 411 418.
15. Jacques, C. (2004) Modelling of metabolic pathways for Saccharopolyspora erythraea using flux balance analysis. PhD Thesis, University College London, UK.
16. Jones, A.M. Porter, M.A. (1998) Vegetable oils in fermentation: beneficial effects of low-level supplementation. J Ind Microbiol Biotechnol 21, 203 207.
17. Large, K.P., Ison, A.P. Williams, D.J. (1998) The effect of agitation rate on lipid utilisation and clavulanic acid production in Streptomyces clavuligerus. J Biotechnol 63, 111 119.
18. Lee, P.C. Ho, C.C. (1996) Production of clavulanic acid and cephamycin C by Streptomyces clavuligerus in palm-oil medium. World J Microbiol Biotechnol 12, 73 75.
19. Maranesi, G.L., Baptista-Neto, A., Hokka, C.O. Badino, A.C. (2005) Utilisation of vegetable oil in the production of clavulanic acid by Streptomyces clavuligerus ATCC 27064. World J Microbiol Biotechnol 21, 509 514.
20. Mayer, A.F. Deckwer, W.D. (1996) Simultaneous production and decomposition of clavulanic acid during Streptomyces clavuligerus cultivations. Appl Microbiol Biotechnol 45, 41 46.
21. Ortiz, S.C.A., Hokka, C.O. Badino, A.C. (2007) Utilization of soybean derivatives on clavulanic acid production by Streptomyces clavuligerus. Enzyme Microb Technol 40, 1071 1077.
22. Parrou, J.L. Francois, J. (1997) A simplified procedure for a rapid and reliable assay of both glycogen and trehalose in whole yeast cells. Anal Biochem 248, 186 188.
23. Peacock, L., Ward, J., Ratledge, C., Dickinson, F.M. Ison, A. (2003) How Streptomyces lividans uses oils and sugars as mixed substrates. Enzyme Microb.Technol. 32, 157 166.
24. Roels, J.A. (1983) Energetics and Kinetics in Biotechnology. Amsterdam, the Netherlands : Elsevier Science & Technology.
25. Roubos, J.A. (2002) Bioprocess modelling and optimization; fed-batch clavulanic acid production by Streptomyces. PhD Thesis, Delft University of Technology, the Netherlands.
26. Shahab, N., Flett, F., Oliver, S.G. Butler, P.R. (1996) Growth rate control of protein and nucleic acid content in Streptomyces coelicolor A3(2) and Escherichia coli B/r. Microbiology 142, 1927 1935.
27. von Stockar, U., Maskow, T., Liu, J., Marison, I.W. Patiño, R. (2006) Thermodynamics of microbial growth and metabolism: an analysis of the current situation. J Biotechnol 121, 517 533.
28. Teodoro, J.C., Baptista-Neto, A., Cruz-Hernández, I.L., Hokka, C.O. Badino, A.C. (2006) Influence of feeding conditions on clavulanic acid production in fed-batch cultivation with medium containing glycerol. Appl Microbiol Biotechnol 72, 450 455.
29. Valdez, F., González-Cerón, G., Kieser, H.M. Servín-González, L. (1999) The Streptomyces coelicolor A3(2) lipAR operon encodes an extracellular lipase and a new type of transcriptional regulator. Microbiology 145, 2365 2374.
30. Westerhof, H. Kholodenko, B. (2004) Metabolic engineering. In Metabolic Engineering in the Post-Genomic Era ed. Westerhof, H. Kholodenko, B. pp. 1 35. Norfolk, UK : Horizon Bioscience.