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Volumn 1033, Issue , 2004, Pages 79-91

Therapeutic effects of L-carnitine and propionyl-L-carnitine on cardiovascular diseases: A review

Author keywords

Levocarnitine; Myocardial ischemia; Myocardial metabolism; Propionyl L carnitine

Indexed keywords

ACETYL COENZYME A; CARNITINE; COENZYME A; LACTIC ACID; PROPIONYLCARNITINE; PYRUVATE DEHYDROGENASE; VALPROIC ACID;

EID: 10644296223     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1196/annals.1320.007     Document Type: Conference Paper
Times cited : (204)

References (84)
  • 1
    • 0025561023 scopus 로고
    • Primary and secondary disorders of carnitine metabolism
    • DE VIVO, D.C. & I. TEIN. 1990. Primary and secondary disorders of carnitine metabolism. Int. Pediatr. 5: 134-141.
    • (1990) Int. Pediatr. , vol.5 , pp. 134-141
    • De Vivo, D.C.1    Tein, I.2
  • 3
    • 0019433391 scopus 로고
    • Effects of carnitine isomers on fatty acid metabolism in ischemic swine hearts
    • LIEDTKE, A.J., H. NELLIS & L.F. WHITESELL. 1981. Effects of carnitine isomers on fatty acid metabolism in ischemic swine hearts. Circ. Res. 48: 859-866.
    • (1981) Circ. Res. , vol.48 , pp. 859-866
    • Liedtke, A.J.1    Nellis, H.2    Whitesell, L.F.3
  • 4
    • 0020211816 scopus 로고
    • Metabolic and mechanical effects using L- and D-carnitine in working swine hearts
    • LIEDTKE, A.J., H. NELLIS, L.F. WHITESELL & C.Q. MAHAR. 1982. Metabolic and mechanical effects using L- and D-carnitine in working swine hearts. Am. J. Physiol. 243: H691-H697.
    • (1982) Am. J. Physiol. , vol.243
    • Liedtke, A.J.1    Nellis, H.2    Whitesell, L.F.3    Mahar, C.Q.4
  • 5
    • 0141910712 scopus 로고
    • Clinical study of efficacy of L-carnitine and metabolic observations in exercise physiology
    • Pergamon. New York
    • ANGELINI, C., L. VERGANI, L. COSTA et al. 1986. Clinical study of efficacy of L-carnitine and metabolic observations in exercise physiology. In Clinical Aspects of Human Carnitine Deficiency, p. 38. Pergamon. New York.
    • (1986) Clinical Aspects of Human Carnitine Deficiency , pp. 38
    • Angelini, C.1    Vergani, L.2    Costa, L.3
  • 6
    • 0022262822 scopus 로고
    • Effects of L-carnitine loading on the aerobic and anaerobic performance of endurance athletes
    • MARCONI, C., G. SASSI, A. CARPINELLI & P. CERRETELLI. 1985. Effects of L-carnitine loading on the aerobic and anaerobic performance of endurance athletes. Eur. J. Appl. Physiol. 54: 131-135.
    • (1985) Eur. J. Appl. Physiol. , vol.54 , pp. 131-135
    • Marconi, C.1    Sassi, G.2    Carpinelli, A.3    Cerretelli, P.4
  • 7
    • 0018409955 scopus 로고
    • Improved pacing tolerance of the ischemic human myocardium after administration of carnitine
    • THOMSEN, J.H., A.L. SHUG, V.U. YAP et al. 1979. Improved pacing tolerance of the ischemic human myocardium after administration of carnitine. Am. J. Cardiol. 43: 300-306.
    • (1979) Am. J. Cardiol. , vol.43 , pp. 300-306
    • Thomsen, J.H.1    Shug, A.L.2    Yap, V.U.3
  • 8
    • 0021349010 scopus 로고
    • The metabolic effects of L-carnitine in angina pectoris
    • FERRARI, R., F. CUCCHINI & O. VISIOLI. 1984. The metabolic effects of L-carnitine in angina pectoris. Int. J. Cardiol. 5: 213-216.
    • (1984) Int. J. Cardiol. , vol.5 , pp. 213-216
    • Ferrari, R.1    Cucchini, F.2    Visioli, O.3
  • 9
    • 10644287151 scopus 로고
    • Effects of high doses of L-carnitine on myocardial lactate balance during pacing-induced ischemia in aging subjects
    • REFORZO, G., P.L. DE ANDREIS BESSONE, F. REBAUDO & M. TIBALDI. 1986. Effects of high doses of L-carnitine on myocardial lactate balance during pacing-induced ischemia in aging subjects. Curr. Ther. Res. 40: 374-383.
    • (1986) Curr. Ther. Res. , vol.40 , pp. 374-383
    • Reforzo, G.1    De Andreis Bessone, P.L.2    Rebaudo, F.3    Tibaldi, M.4
  • 10
    • 0020061970 scopus 로고
    • Effect of carnitine on serum HDL-cholesterol: Report of two cases
    • ROSSI, C.S. & N. SILIPRANDI. 1982. Effect of carnitine on serum HDL-cholesterol: report of two cases. Johns Hopkins Med. J. 150: 51-54.
    • (1982) Johns Hopkins Med. J. , vol.150 , pp. 51-54
    • Rossi, C.S.1    Siliprandi, N.2
  • 11
    • 0021055183 scopus 로고
    • Statistical evaluation of long-term L-carnitine therapy in hyperlipoproteinaemias
    • POLA, P., P. TONDI, A. DAL LAGO et al. 1983. Statistical evaluation of long-term L-carnitine therapy in hyperlipoproteinaemias. Drugs Exp. Clin. Res. 12: 925-935.
    • (1983) Drugs Exp. Clin. Res. , vol.12 , pp. 925-935
    • Pola, P.1    Tondi, P.2    Dal Lago, A.3
  • 12
    • 0021143420 scopus 로고
    • Effects of L-carnitine on exercise tolerance in patients with stable angina pectoris
    • KAMIKAWA, T., Y. SUZUKI, A. KOBAYASHI et al. 1984. Effects of L-carnitine on exercise tolerance in patients with stable angina pectoris. Jpn. Heart J. 25: 587-597.
    • (1984) Jpn. Heart J. , vol.25 , pp. 587-597
    • Kamikawa, T.1    Suzuki, Y.2    Kobayashi, A.3
  • 13
    • 0008903043 scopus 로고
    • Improved exercise tolerance after administration of carnitine
    • KOLOLCHAROEN, P., J. NAPPI, P. PEDUZZI et al. 1981. Improved exercise tolerance after administration of carnitine. Curr. Ther. Res. 30: 753-764.
    • (1981) Curr. Ther. Res. , vol.30 , pp. 753-764
    • Kololcharoen, P.1    Nappi, J.2    Peduzzi, P.3
  • 14
    • 0023892981 scopus 로고
    • Bicycle ergometer and echocardiographic study in healthy subjects and patients with angina pectoris after administration of L-carnitine: Semiautomatic computerized analysis of M-mode tracings
    • CANALE, C., V. TERRACHINI, A. BIAGINI et al. 1988. Bicycle ergometer and echocardiographic study in healthy subjects and patients with angina pectoris after administration of L-carnitine: semiautomatic computerized analysis of M-mode tracings. Int. J. Clin. Pharmacol. Ther. Toxicol. 26: 221-224.
    • (1988) Int. J. Clin. Pharmacol. Ther. Toxicol. , vol.26 , pp. 221-224
    • Canale, C.1    Terrachini, V.2    Biagini, A.3
  • 15
    • 0023905696 scopus 로고
    • Increases in walking distance in patients with peripheral vascular disease treated with L-carnitine: A double-blind, cross-over study
    • BREVETTI, G., M. CHIARIELLO, G. FERULANO et al. 1988. Increases in walking distance in patients with peripheral vascular disease treated with L-carnitine: a double-blind, cross-over study. Circulation 77: 767-773.
    • (1988) Circulation , vol.77 , pp. 767-773
    • Brevetti, G.1    Chiariello, M.2    Ferulano, G.3
  • 16
    • 10644291980 scopus 로고
    • The pink sheet
    • FDA. 1989. The pink sheet. FDA Reports 51: 7-9.
    • (1989) FDA Reports , vol.51 , pp. 7-9
  • 17
    • 0021053314 scopus 로고
    • Medium-chain acyl-CoA dehydrogenase deficiency in children with non-ketotic hypoglycemia and low carnitine levels
    • STANLEY, C.A., D.E. HALE & P.M. COATES. 1983. Medium-chain acyl-CoA dehydrogenase deficiency in children with non-ketotic hypoglycemia and low carnitine levels. Pediatr. Res. 17: 877-884.
    • (1983) Pediatr. Res. , vol.17 , pp. 877-884
    • Stanley, C.A.1    Hale, D.E.2    Coates, P.M.3
  • 18
    • 0021238320 scopus 로고
    • L-Carnitine enhances excretion of propionyl coenzyme A as propionylcarnitine in propionic acidemia
    • ROE, C.R., D.S. MILLINGTON, D.A. MAITBY et al. 1984. L-Carnitine enhances excretion of propionyl coenzyme A as propionylcarnitine in propionic acidemia. J. Clin. Invest. 73: 1785-1788.
    • (1984) J. Clin. Invest. , vol.73 , pp. 1785-1788
    • Roe, C.R.1    Millington, D.S.2    Maitby, D.A.3
  • 19
    • 0021710439 scopus 로고
    • Urinary excretion of L-carnitine and acylcarnitines by patients with disorders of organic acid metabolism: Evidence for secondary insufficiency of L-carnitine
    • CHALMEAR, R.A., R.C. ROE, C.E. STACEY & C.L. HOPPEL. 1984. Urinary excretion of L-carnitine and acylcarnitines by patients with disorders of organic acid metabolism: evidence for secondary insufficiency of L-carnitine. Pediatr. Res. 18: 1325-1328.
    • (1984) Pediatr. Res. , vol.18 , pp. 1325-1328
    • Chalmear, R.A.1    Roe, R.C.2    Stacey, C.E.3    Hoppel, C.L.4
  • 20
    • 0025949325 scopus 로고
    • The clinical use of carnitine for the treatment of organic acidurias
    • WINTER, S.C., M.Z. ELINOR, H. VANCE et al. 1991. The clinical use of carnitine for the treatment of organic acidurias. Int. Pediatr. 6: 62-65.
    • (1991) Int. Pediatr. , vol.6 , pp. 62-65
    • Winter, S.C.1    Elinor, M.Z.2    Vance, H.3
  • 21
    • 0022589460 scopus 로고
    • Direct identification of propionyl-carnitine in propionic acidemia: Biochemical and clinical results of oral carnitine supplementation
    • DURAN, M., D. KETTING, J.E. BECKERING et al. 1986. Direct identification of propionyl-carnitine in propionic acidemia: biochemical and clinical results of oral carnitine supplementation. J. Inherited Metab. Dis. 9: 202-207.
    • (1986) J. Inherited Metab. Dis. , vol.9 , pp. 202-207
    • Duran, M.1    Ketting, D.2    Beckering, J.E.3
  • 22
    • 0020428817 scopus 로고
    • L-Carnitine for methylmalonic aciduria
    • SECCOMBE, D.W., F. SNYDER & H.G. PARSONS. 1982. L-Carnitine for methylmalonic aciduria. Lancet 1982: 1401.
    • (1982) Lancet , vol.1982 , pp. 1401
    • Seccombe, D.W.1    Snyder, F.2    Parsons, H.G.3
  • 23
    • 0020893303 scopus 로고
    • Quantitative assessment of carnitine loss during hemodialysis and hemofibrillation
    • LESCHKE, M., K.W. RUMPF, T. EISENHAUER et al. 1983. Quantitative assessment of carnitine loss during hemodialysis and hemofibrillation. Kidney Int. 24: 143-146.
    • (1983) Kidney Int. , vol.24 , pp. 143-146
    • Leschke, M.1    Rumpf, K.W.2    Eisenhauer, T.3
  • 24
    • 0020544896 scopus 로고
    • Correlation between increased serum and tissue L-carnitine levels and improved muscle symptoms in hemodialyzed patients
    • BELLINGHIERI, G., V. SAVICA, A. MALLAMA et al. 1983. Correlation between increased serum and tissue L-carnitine levels and improved muscle symptoms in hemodialyzed patients. Am. J. Clin. Nutr. 38: 523-531.
    • (1983) Am. J. Clin. Nutr. , vol.38 , pp. 523-531
    • Bellinghieri, G.1    Savica, V.2    Mallama, A.3
  • 25
    • 0020692868 scopus 로고
    • Endocrine metabolic effects of L-carnitine in patients on regular dialysis treatment
    • ALBERTAZZI, A., P. CAPELLI, B. DI PAOLO et al. 1982. Endocrine metabolic effects of L-carnitine in patients on regular dialysis treatment. Proc. EDTA 19: 302-307.
    • (1982) Proc. EDTA , vol.19 , pp. 302-307
    • Albertazzi, A.1    Capelli, P.2    Di Paolo, B.3
  • 26
    • 0019990891 scopus 로고
    • La carnicina nel trattamento dei crampi muscolari nei pazienti in emodialisi periodica
    • DI MARCO, V., V. GINARDI, E. DELL'SIRA et al. 1982. La carnicina nel trattamento dei crampi muscolari nei pazienti in emodialisi periodica. Policlinico, Sezione Medica 89: 104-110.
    • (1982) Policlinico, Sezione Medica , vol.89 , pp. 104-110
    • Di Marco, V.1    Ginardi, V.2    Dell'sira, E.3
  • 27
    • 0018939237 scopus 로고
    • Carnitine in haemodialysis patients
    • AUBIA, J., J. MASRAMON, J. LHOVERAS et al. 1980. Carnitine in haemodialysis patients. Lancet 1980: 1028.
    • (1980) Lancet , vol.1980 , pp. 1028
    • Aubia, J.1    Masramon, J.2    Lhoveras, J.3
  • 28
    • 0020352877 scopus 로고
    • Beneficial effects of L-carnitine in post-dialysis syndrome
    • CASCIANI, C.V., U. CARUSO, E. CRAVOTTO et al. 1982. Beneficial effects of L-carnitine in post-dialysis syndrome. Curr. Ther. Res. 32: 116-126.
    • (1982) Curr. Ther. Res. , vol.32 , pp. 116-126
    • Casciani, C.V.1    Caruso, U.2    Cravotto, E.3
  • 29
    • 0025152162 scopus 로고
    • Multicenter trial of L-carnitine in maintenance hemodialysis patients. II. Clinical and biochemical effects
    • AHMAD, S., H.T. ROBERTSON, T.A. GOLPER et al. 1990. Multicenter trial of L-carnitine in maintenance hemodialysis patients. II. Clinical and biochemical effects. Kidney Int. 38: 912-918.
    • (1990) Kidney Int. , vol.38 , pp. 912-918
    • Ahmad, S.1    Robertson, H.T.2    Golper, T.A.3
  • 30
    • 0019946715 scopus 로고
    • Effects of L-carnitine on arrhythmias during hemodialysis
    • SUZUKI, Y., M. NARITA & N. YAMAKAZI. 1982. Effects of L-carnitine on arrhythmias during hemodialysis. Jpn. Heart J. 23: 349-358.
    • (1982) Jpn. Heart J. , vol.23 , pp. 349-358
    • Suzuki, Y.1    Narita, M.2    Yamakazi, N.3
  • 31
    • 0001630397 scopus 로고
    • Long-term carnitine treatment of chronic anemia of patients with end-stage renal failure
    • TROVATO, G.M., V. GINARDI, V. DI MARCO et al. 1987. Long-term carnitine treatment of chronic anemia of patients with end-stage renal failure. Curr. Ther. Res. 31: 1042-1049.
    • (1987) Curr. Ther. Res. , vol.31 , pp. 1042-1049
    • Trovato, G.M.1    Ginardi, V.2    Di Marco, V.3
  • 32
    • 0020592202 scopus 로고
    • Favorable effects of L-carnitine treatment on hypertriglyceridemia in hemodialysis patients: Decisive role of low levels of high-density lipoprotein-cholesterol
    • VACHA, G.M., G. GIOCELLI, N. SILIPRANDI & M. CORSI. 1983. Favorable effects of L-carnitine treatment on hypertriglyceridemia in hemodialysis patients: decisive role of low levels of high-density lipoprotein-cholesterol. Am. J. Clin. Nutr. 38: 532-540.
    • (1983) Am. J. Clin. Nutr. , vol.38 , pp. 532-540
    • Vacha, G.M.1    Giocelli, G.2    Siliprandi, N.3    Corsi, M.4
  • 33
    • 0019941501 scopus 로고
    • Carnitine deficiency and hyperammonemia associated with valproic acid therapy
    • OHTANI, Y., F. ENDO & I. MATSUDA. 1980. Carnitine deficiency and hyperammonemia associated with valproic acid therapy. J. Pediatr. 101: 782-785.
    • (1980) J. Pediatr. , vol.101 , pp. 782-785
    • Ohtani, Y.1    Endo, F.2    Matsuda, I.3
  • 34
    • 0023135810 scopus 로고
    • Valproic acid hepatic fatalities: A retrospective review
    • DREIFFUS, F.E., N. SANTILLI, D.H. LANGER et al. 1987. Valproic acid hepatic fatalities: a retrospective review. Neurology 37: 379-385.
    • (1987) Neurology , vol.37 , pp. 379-385
    • Dreiffus, F.E.1    Santilli, N.2    Langer, D.H.3
  • 35
    • 0026448556 scopus 로고
    • A child with valproic acid-associated carnitine deficiency and carnitine-responsive cardiac dysfunction
    • BRATTON, S.L., A.L. GARDEN, T.P. BOHAN et al. 1992. A child with valproic acid-associated carnitine deficiency and carnitine-responsive cardiac dysfunction. J. Child Neurol. 7: 413-416.
    • (1992) J. Child Neurol. , vol.7 , pp. 413-416
    • Bratton, S.L.1    Garden, A.L.2    Bohan, T.P.3
  • 36
    • 0025124082 scopus 로고
    • Effects of valproic acid on the urea cycle and carnitine metabolsim
    • CASTRO-CAGO, M., I. NOVO & S. RODRIGUEZ-SEGADE. 1990. Effects of valproic acid on the urea cycle and carnitine metabolsim. Int. Pediatr. 5: 54-57.
    • (1990) Int. Pediatr. , vol.5 , pp. 54-57
    • Castro-Cago, M.1    Novo, I.2    Rodriguez-Segade, S.3
  • 37
    • 0025196395 scopus 로고
    • Valproate-induced hepatotoxicity: Protective effect of L-carnitine supplementation
    • SUGIMOTO, T., N. NISHIDA, K. MURAKAMI et al. 1990. Valproate-induced hepatotoxicity: protective effect of L-carnitine supplementation. Jpn. J. Psychiatry Neurol. 44: 387-388.
    • (1990) Jpn. J. Psychiatry Neurol. , vol.44 , pp. 387-388
    • Sugimoto, T.1    Nishida, N.2    Murakami, K.3
  • 38
    • 0020486895 scopus 로고
    • Myocardial carnitine deficiency in acute myocardial infarction
    • SPAGNOLI, L.G., M. CORSI, S. VILLASCHI et al. 1982. Myocardial carnitine deficiency in acute myocardial infarction. Lancet 1982: 1419-1420.
    • (1982) Lancet , vol.1982 , pp. 1419-1420
    • Spagnoli, L.G.1    Corsi, M.2    Villaschi, S.3
  • 39
    • 0020477960 scopus 로고
    • Myocardial carnitine deficiency in chronic heart failure
    • SUZUKI, Y. 1982. Myocardial carnitine deficiency in chronic heart failure. Lancet 1982: 116.
    • (1982) Lancet , vol.1982 , pp. 116
    • Suzuki, Y.1
  • 40
    • 0025735666 scopus 로고
    • The therapeutic potential of carnitine in cardiovascular disorders
    • PEPINE, C.J. 1992. The therapeutic potential of carnitine in cardiovascular disorders. Clin. Ther. 13: 3-22.
    • (1992) Clin. Ther. , vol.13 , pp. 3-22
    • Pepine, C.J.1
  • 41
    • 0024309861 scopus 로고
    • High doses of L-carnitine in acute myocardial infarction: Metabolic and antiarrhythmic effects
    • RIZZON, P., C. BIASCO & F. BOSCIA. 1989. High doses of L-carnitine in acute myocardial infarction: metabolic and antiarrhythmic effects. Eur. Heart J. 10: 502-508.
    • (1989) Eur. Heart J. , vol.10 , pp. 502-508
    • Rizzon, P.1    Biasco, C.2    Boscia, F.3
  • 42
    • 0029101882 scopus 로고
    • Effects of L-carnitine administration on left ventricular remodelling after acute anterior myocardial infarction (the CEDIM trial)
    • ILICETO, S., D. SCRUTINIO, P. BRUZZI et al. 1995. Effects of L-carnitine administration on left ventricular remodelling after acute anterior myocardial infarction (the CEDIM trial). J. Am. Coll. Cardiol. 26: 380-387.
    • (1995) J. Am. Coll. Cardiol. , vol.26 , pp. 380-387
    • Iliceto, S.1    Scrutinio, D.2    Bruzzi, P.3
  • 43
    • 0023905696 scopus 로고
    • Increases in walking distance in patients with peripheral vascular disease treated with L-carnitine: A double blind, cross-over study
    • BREVETTI, G., M. CHIARIELLO, G. FERULANO et al. 1988. Increases in walking distance in patients with peripheral vascular disease treated with L-carnitine: a double blind, cross-over study. Circulation 77: 767-773
    • (1988) Circulation , vol.77 , pp. 767-773
    • Brevetti, G.1    Chiariello, M.2    Ferulano, G.3
  • 44
    • 0012751011 scopus 로고
    • Short-term hemodynamic effects of intravenous propionyl-L-carnitine in anesthetized dogs
    • CEVESE, A., F. SCHENA & G. CEROTTI. 1989. Short-term hemodynamic effects of intravenous propionyl-L-carnitine in anesthetized dogs. Cardiologia 34: 95-101.
    • (1989) Cardiologia , vol.34 , pp. 95-101
    • Cevese, A.1    Schena, F.2    Cerotti, G.3
  • 45
    • 0025794242 scopus 로고
    • Short-term hemodynamic effects of intravenous propionyl-L-carnitine in anesthetized dogs
    • CEVESE, A., F. SCHENA & G. CERUTTI. 1991. Short-term hemodynamic effects of intravenous propionyl-L-carnitine in anesthetized dogs. Cardiovasc. Drugs Ther. 5(suppl. II): 45-56.
    • (1991) Cardiovasc. Drugs Ther. , vol.5 , Issue.2 SUPPL. , pp. 45-56
    • Cevese, A.1    Schena, F.2    Cerutti, G.3
  • 46
    • 0012694212 scopus 로고
    • Effetti emodinamici e sul circolo coronarico della propionyl-L-carnitina
    • CHIDDO, A., S. MUSCI, A. BORTOME et al. 1989. Effetti emodinamici e sul circolo coronarico della propionyl-L-carnitina. Cardiologia 54(suppl. 1): 111-117.
    • (1989) Cardiologia , vol.54 , Issue.1 SUPPL. , pp. 111-117
    • Chiddo, A.1    Musci, S.2    Bortome, A.3
  • 47
    • 0025778491 scopus 로고
    • Hemodynamic study of intravenous propionyl-L-carnitine in patients with ischemic heart disease and normal left ventricular function
    • CHIDDO, A., A. GAGLIONE, S. MUSCI et al. 1991. Hemodynamic study of intravenous propionyl-L-carnitine in patients with ischemic heart disease and normal left ventricular function. Cardiovasc. Drugs Ther. 5(suppl. I): 107-112.
    • (1991) Cardiovasc. Drugs Ther. , vol.5 , Issue.1 SUPPL. , pp. 107-112
    • Chiddo, A.1    Gaglione, A.2    Musci, S.3
  • 48
    • 0028271988 scopus 로고
    • Anaplerotic effect of propionyl-L-carnitine in rat heart mitochondria
    • TASSANI, V., L. CATTAPAN, L. MAGNANIMI et al. 1994. Anaplerotic effect of propionyl-L-carnitine in rat heart mitochondria. Biochem. Biophys. Res. Commun. 199: 949-953.
    • (1994) Biochem. Biophys. Res. Commun. , vol.199 , pp. 949-953
    • Tassani, V.1    Cattapan, L.2    Magnanimi, L.3
  • 49
    • 0023655089 scopus 로고
    • Substrate-induced alteration of high energy phosphate metabolism and contractile function in the perfused heart
    • ZWEIER, J.L. & E. JACOBUS. 1987. Substrate-induced alteration of high energy phosphate metabolism and contractile function in the perfused heart. J. Biol. Chem. 262: 8015-8021.
    • (1987) J. Biol. Chem. , vol.262 , pp. 8015-8021
    • Zweier, J.L.1    Jacobus, E.2
  • 50
    • 0026529819 scopus 로고
    • Prolonged propionyl-L-carnitine pretreatment of rabbit: Biochemical, hemodynamic, and electrophysiological effects on myocardium
    • FERRARI, R., F. DI LISA, J.W. DE JONG et al. 1992. Prolonged propionyl-L-carnitine pretreatment of rabbit: biochemical, hemodynamic, and electrophysiological effects on myocardium. J. Mol. Cell. Cardiol. 24: 219-232.
    • (1992) J. Mol. Cell. Cardiol. , vol.24 , pp. 219-232
    • Ferrari, R.1    Di Lisa, F.2    De Jong, J.W.3
  • 51
    • 0025729592 scopus 로고
    • Lack of correlation between the antiarrhythmic effect of L-propionylcarnitine on reoxygenation-induced arrhythmias and its electrophysiological properties
    • BARBIERI, M., P.U. CARBONIN, E. CERBAI et al. 1991. Lack of correlation between the antiarrhythmic effect of L-propionylcarnitine on reoxygenation-induced arrhythmias and its electrophysiological properties. Br. J. Pharmacol. 102: 73-78.
    • (1991) Br. J. Pharmacol. , vol.102 , pp. 73-78
    • Barbieri, M.1    Carbonin, P.U.2    Cerbai, E.3
  • 52
    • 0025764972 scopus 로고
    • Effect of propionyl-L-carnitine on mechanical function of isolated rabbit heart
    • FERRARI, R., E. PASINI, E. CONDORELLI et al. 1991. Effect of propionyl-L-carnitine on mechanical function of isolated rabbit heart. Cardiovasc. Drugs Ther. 5: 17-24.
    • (1991) Cardiovasc. Drugs Ther. , vol.5 , pp. 17-24
    • Ferrari, R.1    Pasini, E.2    Condorelli, E.3
  • 53
    • 0012660346 scopus 로고
    • Effect of L-carnitine derivatives on lipid peroxidation of cardiac mitochondria
    • FERRARI, R., A. CARGNONI, C. CECONI et al. 1990. Effect of L-carnitine derivatives on lipid peroxidation of cardiac mitochondria. Soc. Ital. Biochim. 2: 200.
    • (1990) Soc. Ital. Biochim. , vol.2 , pp. 200
    • Ferrari, R.1    Cargnoni, A.2    Ceconi, C.3
  • 54
    • 0021284516 scopus 로고
    • The surprising heart: A review of recent progress in cardiac electrophysiology
    • NOBLE, D. 1984. The surprising heart: a review of recent progress in cardiac electrophysiology. J. Physiol. 353: 1-50.
    • (1984) J. Physiol. , vol.353 , pp. 1-50
    • Noble, D.1
  • 55
    • 0027463073 scopus 로고
    • Beneficial effect of carnitine on mechanical recovery of rat hearts reperfused after a transient period of global ischemia is accompanied by a stimulation of glucose oxidation
    • BRODERICK, T.L., H.A. QUINNEY, C.C. BARKER et al. 1993. Beneficial effect of carnitine on mechanical recovery of rat hearts reperfused after a transient period of global ischemia is accompanied by a stimulation of glucose oxidation. Circulation 87: 972-981.
    • (1993) Circulation , vol.87 , pp. 972-981
    • Broderick, T.L.1    Quinney, H.A.2    Barker, C.C.3
  • 56
    • 0025995772 scopus 로고
    • Protection of the reperfused heart by L-propionylcarnitine
    • LEIPALA, J.A., R. BHATNAGAR, E. PINEDA et al. 1991. Protection of the reperfused heart by L-propionylcarnitine. J. Appl. Physiol. 71: 1518-1522.
    • (1991) J. Appl. Physiol. , vol.71 , pp. 1518-1522
    • Leipala, J.A.1    Bhatnagar, R.2    Pineda, E.3
  • 57
    • 85047675973 scopus 로고
    • Protection of the ischaemic myocardium by L-propionylcarnitine: Effects on the recovery of cardiac output after ischaemia and reperfusion, carnitine transport, and fatty acid oxidation
    • PAULSON, D.J., J. TRAXLER, M. SCHMIDT et al. 1986. Protection of the ischaemic myocardium by L-propionylcarnitine: effects on the recovery of cardiac output after ischaemia and reperfusion, carnitine transport, and fatty acid oxidation. Cardiovasc. Res. 20: 536-541.
    • (1986) Cardiovasc. Res. , vol.20 , pp. 536-541
    • Paulson, D.J.1    Traxler, J.2    Schmidt, M.3
  • 58
    • 0026740173 scopus 로고
    • Haemodynamic and metabolic activities of propionyl-L-carnitine in rats with pressure overload cardiac hypertrophy
    • YANG, X.P., M. SAMAJA, E. ENGLISH et al. 1992. Haemodynamic and metabolic activities of propionyl-L-carnitine in rats with pressure overload cardiac hypertrophy. J. Cardiovasc. Pharmacol. 20: 88-98.
    • (1992) J. Cardiovasc. Pharmacol. , vol.20 , pp. 88-98
    • Yang, X.P.1    Samaja, M.2    English, E.3
  • 59
    • 0028277666 scopus 로고
    • Propionyl-L-carnitine prevents myocardial mechanical alterations due to pressure overload in rats
    • MICHELETTI, R., G. GIACALONE, M. CANEPARI et al. 1994. Propionyl-L-carnitine prevents myocardial mechanical alterations due to pressure overload in rats. Am. J. Physiol. 266: H2190-H2197.
    • (1994) Am. J. Physiol. , vol.266
    • Micheletti, R.1    Giacalone, G.2    Canepari, M.3
  • 60
    • 0027536958 scopus 로고
    • Propionyl-L-carnitine limits chronic ventricular dilatation after myocardial infarction in rats
    • MICHELETTI, R., A. SCHIAVONE, E. ENGLISH et al. 1993. Propionyl-L-carnitine limits chronic ventricular dilatation after myocardial infarction in rats. Am. J. Physiol. 264: H1111-H1117.
    • (1993) Am. J. Physiol. , vol.264
    • Micheletti, R.1    Schiavone, A.2    English, E.3
  • 61
    • 0012696604 scopus 로고
    • Propionyl-L-carnitine ameliorates myocyte performance after infarction
    • LI, P., R. MICHELETTI, C. PARK et al. 1994. Propionyl-L-carnitine ameliorates myocyte performance after infarction [abstract]. Can. J. Cardiol. 10: 85.
    • (1994) Can. J. Cardiol. , vol.10 , pp. 85
    • Li, P.1    Micheletti, R.2    Park, C.3
  • 62
    • 0027058819 scopus 로고
    • Effect of propionyl-L-carnitine on experimental induced cardiomyopathy in rats
    • PASINI, E., L. COMINI, R. FERRARI et al. 1992. Effect of propionyl-L-carnitine on experimental induced cardiomyopathy in rats. Am. J. Cardiovasc. Pathol. 4: 216-222.
    • (1992) Am. J. Cardiovasc. Pathol. , vol.4 , pp. 216-222
    • Pasini, E.1    Comini, L.2    Ferrari, R.3
  • 63
    • 0021008583 scopus 로고
    • Cardiac sarcoplasmic reticulum in insulin- or carnitine-treated diabetic rats
    • LOPASCHUCK, G.D., A.G. TAHILIANI, R.V.S.U. VADLAMUDI et al. 1983. Cardiac sarcoplasmic reticulum in insulin- or carnitine-treated diabetic rats. Am. J. Physiol. 245: H969-H976.
    • (1983) Am. J. Physiol. , vol.245
    • Lopaschuck, G.D.1    Tahiliani, A.G.2    Vadlamudi, R.V.S.U.3
  • 64
    • 0021206426 scopus 로고
    • Exercise intolerance in patients with chronic heart failure: Role of impaired skeletal muscle nutritive flow
    • WILSON, J.R., J.L. MARTIN, D. SCHWARTZ et al. 1984. Exercise intolerance in patients with chronic heart failure: role of impaired skeletal muscle nutritive flow. Circulation 69: 1079-1087.
    • (1984) Circulation , vol.69 , pp. 1079-1087
    • Wilson, J.R.1    Martin, J.L.2    Schwartz, D.3
  • 65
    • 0022628696 scopus 로고
    • Symptoms limiting exercise in chronic heart failure
    • LIPKIN, D.P. & F.A. POOLE-WILSON. 1986. Symptoms limiting exercise in chronic heart failure. BMJ 292: 1030-1031.
    • (1986) BMJ , vol.292 , pp. 1030-1031
    • Lipkin, D.P.1    Poole-Wilson, F.A.2
  • 66
    • 0027524995 scopus 로고
    • Factors contributing to exercise limitation of heart failure
    • WILSON, J.R. & M.D. MANCINI. 1993. Factors contributing to exercise limitation of heart failure. J. Am. Coll. Cardiol. 22: 93A-98A.
    • (1993) J. Am. Coll. Cardiol. , vol.22
    • Wilson, J.R.1    Mancini, M.D.2
  • 67
    • 0030297870 scopus 로고    scopus 로고
    • Exercise limitation in chronic heart failure: Central role of the periphery
    • CLARK, A.L., F.A. POOLE-WILSON & A.J.S. COATS. 1996. Exercise limitation in chronic heart failure: central role of the periphery. J. Am. Coll. Cardiol. 28: 1092-1102.
    • (1996) J. Am. Coll. Cardiol. , vol.28 , pp. 1092-1102
    • Clark, A.L.1    Poole-Wilson, F.A.2    Coats, A.J.S.3
  • 68
    • 0024432116 scopus 로고
    • Relation between central and peripheral hemodynamics during exercise in patients with chronic heart failure
    • SULLIVAN, M.J., J.D. KNIGHT, M.B. HIGGINBOTHAM et al. 1989. Relation between central and peripheral hemodynamics during exercise in patients with chronic heart failure. Circulation 80: 769-781.
    • (1989) Circulation , vol.80 , pp. 769-781
    • Sullivan, M.J.1    Knight, J.D.2    Higginbotham, M.B.3
  • 69
    • 4243383047 scopus 로고
    • Limb uptake of substrate in patients with congestive heart failure (CHF)
    • FERRARI, R., E. PASINI, F. DE GIULI et al. 1994. Limb uptake of substrate in patients with congestive heart failure (CHF) [abstract]. Can. J. Cardiol. 10(suppl. A): 73A.
    • (1994) Can. J. Cardiol. , vol.10 , Issue.SUPPL. A
    • Ferrari, R.1    Pasini, E.2    De Giuli, F.3
  • 70
    • 0030754419 scopus 로고    scopus 로고
    • Skeletal muscle function at low work level as a model for daily activities in patients with chronic heart failure
    • OPASICH, C., E. PASINI, R. AQUILANI et al. 1997. Skeletal muscle function at low work level as a model for daily activities in patients with chronic heart failure. Eur. Heart J. 18: 1626-1631.
    • (1997) Eur. Heart J. , vol.18 , pp. 1626-1631
    • Opasich, C.1    Pasini, E.2    Aquilani, R.3
  • 71
    • 0023905696 scopus 로고
    • Increases in walking distance in patients with peripheral vascular disease treated with L-carnitine: A double blind, cross-over study
    • BREVETTI, G., M. CHIARIELLO, G. FERULANO et al. 1988. Increases in walking distance in patients with peripheral vascular disease treated with L-carnitine: a double blind, cross-over study. Circulation 77: 767-783.
    • (1988) Circulation , vol.77 , pp. 767-783
    • Brevetti, G.1    Chiariello, M.2    Ferulano, G.3
  • 72
    • 0030444753 scopus 로고    scopus 로고
    • Changes in energy metabolism of calf muscle in patients with intermittent claudication assessed by 31 pMRS: A phase II open study
    • TAYLOR, D.J., A. AMATO, U. HANDS et al. 1996. Changes in energy metabolism of calf muscle in patients with intermittent claudication assessed by 31 pMRS: a phase II open study. Vasc. Med. 1: 241-245.
    • (1996) Vasc. Med. , vol.1 , pp. 241-245
    • Taylor, D.J.1    Amato, A.2    Hands, U.3
  • 73
    • 0028849885 scopus 로고
    • Propionyl-L-carnitine in intermittent claudication: Double-blind, placebo-controlled, dose-titration, multicenter study
    • BREVETTI, G., S. PERNA, C. SABBÀ et al. 1995. Propionyl-L- carnitine in intermittent claudication: double-blind, placebo-controlled, dose-titration, multicenter study. J. Am. Coll. Cardiol. 26: 1411-1416.
    • (1995) J. Am. Coll. Cardiol. , vol.26 , pp. 1411-1416
    • Brevetti, G.1    Perna, S.2    Sabbà, C.3
  • 74
    • 0035369894 scopus 로고    scopus 로고
    • Propionyl-L-carnitine improves exercise performance and functional status in patients with claudication
    • HIATT, W.R., J.G. REGENSTEINER, M.A. CREAGER et al. 2001. Propionyl-L-carnitine improves exercise performance and functional status in patients with claudication. Am. J. Med. 110: 616-622.
    • (2001) Am. J. Med. , vol.110 , pp. 616-622
    • Hiatt, W.R.1    Regensteiner, J.G.2    Creager, M.A.3
  • 75
    • 0033230534 scopus 로고    scopus 로고
    • European multicenter study on propionyl-L-carnitine in intermittent claudication
    • BREVETTI, G., C. DIEHM & D. LAMBERT. 1999. European multicenter study on propionyl-L-carnitine in intermittent claudication. J. Am. Coll. Cardiol. 34: 1618-1624.
    • (1999) J. Am. Coll. Cardiol. , vol.34 , pp. 1618-1624
    • Brevetti, G.1    Diehm, C.2    Lambert, D.3
  • 76
    • 0031717287 scopus 로고    scopus 로고
    • Acute and chronic effects of propionyl-L-carnitine on the hemodynamics, exercise capacity, and hormones in patients with congestive heart failure
    • ANAND, I., Y. CHANDRASHEKAR, F. DE GIULI et al. 1998. Acute and chronic effects of propionyl-L-carnitine on the hemodynamics, exercise capacity, and hormones in patients with congestive heart failure. Cardiovasc. Drugs Ther. 12: 291-299.
    • (1998) Cardiovasc. Drugs Ther. , vol.12 , pp. 291-299
    • Anand, I.1    Chandrashekar, Y.2    De Giuli, F.3
  • 77
    • 0028662376 scopus 로고
    • Efficacy of L-propionyl-carnitine treatment in patients with left ventricular dysfunction
    • CAPONNETTO, S., C. CANALE, M.A. MASPERONE et al. 1994. Efficacy of L-propionyl-carnitine treatment in patients with left ventricular dysfunction. Eur. Heart J. 15: 1167-1173.
    • (1994) Eur. Heart J. , vol.15 , pp. 1167-1173
    • Caponnetto, S.1    Canale, C.2    Masperone, M.A.3
  • 78
    • 0026725961 scopus 로고
    • Control study on the therapeutic efficacy of propionyl-L-carnitine in patients with congestive heart failure
    • MANCINI, M., S. RENGO, M. LINGETTI et al. 1992. Control study on the therapeutic efficacy of propionyl-L-carnitine in patients with congestive heart failure. Arzneim. Forsch. 42: 1101-1104.
    • (1992) Arzneim. Forsch. , vol.42 , pp. 1101-1104
    • Mancini, M.1    Rengo, S.2    Lingetti, M.3
  • 79
    • 0012696961 scopus 로고
    • Cytokines in end stage congestive heart failure: Effect of propionyl-L-carnitine
    • BACHETTI, T., A. CORTI, G. CASSANI et al. 1994. Cytokines in end stage congestive heart failure: effect of propionyl-L-carnitine. Eur. Heart J. 15: 1267-1273.
    • (1994) Eur. Heart J. , vol.15 , pp. 1267-1273
    • Bachetti, T.1    Corti, A.2    Cassani, G.3
  • 80
    • 0029117828 scopus 로고
    • Tumor necrosis factor soluble receptors in patients with various degrees of congestive heart failure
    • FERRARI, R., T. BACHETTI, R. CONFORTINI et al. 1995. Tumor necrosis factor soluble receptors in patients with various degrees of congestive heart failure. Circulation 92: 1479-1486.
    • (1995) Circulation , vol.92 , pp. 1479-1486
    • Ferrari, R.1    Bachetti, T.2    Confortini, R.3
  • 81
    • 0032029131 scopus 로고    scopus 로고
    • Tumor necrosis factor in CHF: A double facet cytokine
    • FERRARI, R. 1998. Tumor necrosis factor in CHF: a double facet cytokine. Cardiovasc. Res. 37: 554-559.
    • (1998) Cardiovasc. Res. , vol.37 , pp. 554-559
    • Ferrari, R.1
  • 82
    • 0033539585 scopus 로고    scopus 로고
    • Serum from patients with severe heart failure downregulates enol and is proapopiotic - Role of tumor necrosis factor-α
    • AGNOLETTI, L., S. CURELLO, T. BACHETTI et al. 1999. Serum from patients with severe heart failure downregulates enol and is proapopiotic - role of tumor necrosis factor-α. Circulation 100: 1983-1991.
    • (1999) Circulation , vol.100 , pp. 1983-1991
    • Agnoletti, L.1    Curello, S.2    Bachetti, T.3
  • 83
    • 0025286817 scopus 로고
    • Elevated circulating level of tumor necrosis factor in severe chronic heart failure
    • LEVINE, B., J. KALMAN, L. MAYER et al. 1991. Elevated circulating level of tumor necrosis factor in severe chronic heart failure. N. Engl. J. Med. 323: 236-241.
    • (1991) N. Engl. J. Med. , vol.323 , pp. 236-241
    • Levine, B.1    Kalman, J.2    Mayer, L.3
  • 84
    • 0032927528 scopus 로고    scopus 로고
    • Study on propionyl-L-carnitine in chronic heart failure
    • THE INVESTIGATORS OF THE STUDY ON PROPIONYL-L-CARNITINE IN CHRONIC HEART FAILURE. 1999. Study on propionyl-L-carnitine in chronic heart failure. Eur. Heart J. 20: 70-76.
    • (1999) Eur. Heart J. , vol.20 , pp. 70-76


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