Purification of an Fc-fusion biologic: Clearance of multiple product related impurities by hydrophobic interaction chromatography

Journal of Chromatography A

Volumn 1177, Issue 2, 2008, Pages 265-271

  Evans, David R H ^a   Macniven, Richard P ^a   Labanca, Marisa ^a   Walker, Joshua ^a   Notarnicola, Stephen M ^a  

^a BIOGEN   (United States)

Author keywords

Biologic; Butyl; Fc fusion; Hydrophobic interaction chromatography; Manufacturing

Indexed keywords

FUSION REACTIONS; HYDROPHOBICITY; ION CHROMATOGRAPHY; MONOMERS; PURIFICATION;

BUTYL CHROMATOGRAPHY; HYDROPHOBIC INTERACTION CHROMATOGRAPHY; STEP-ELUTION STRATEGY;

IMPURITIES;

HYBRID PROTEIN; IMMUNOGLOBULIN FC FRAGMENT;

ANALYTIC METHOD; ARTICLE; CHROMATOGRAPHY; ELUTION; FACTORIAL ANALYSIS; PARTICLE SIZE; PRIORITY JOURNAL; PURIFICATION;

ANIMALS; CHO CELLS; CHROMATOGRAPHY, AFFINITY; CHROMATOGRAPHY, LIQUID; CRICETINAE; CRICETULUS; CULTURE MEDIA, CONDITIONED; HYDROPHOBICITY; IMMUNOGLOBULIN FC FRAGMENTS; RECOMBINANT FUSION PROTEINS; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SEPHAROSE; STAPHYLOCOCCAL PROTEIN A;

EID: 37349019763     PISSN: 00219673     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chroma.2007.07.049     Document Type: Article

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