GABA-mediated neurotransmission in the nucleus of the solitary tract alters resting ventilation following exposure to chronic hypoxia in conscious rats

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 291, Issue 5, 2006, Pages

  Chung, Sean ^a   Ivy, Gwen O ^a   Reid, Stephen G ^a  

^a UNIVERSITY OF TORONTO   (Canada)

Author keywords

aminobutyric acid; Control of breathing; Plethysmography

Indexed keywords

3 AMINOPROPYL(DIETHOXYMETHYL)PHOSPHINIC ACID; 4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID A RECEPTOR BLOCKING AGENT; 4 AMINOBUTYRIC ACID B RECEPTOR BLOCKING AGENT; BICUCULLINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY PLETHYSMOGRAPHY; BREATHING; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; HYPOBARISM; HYPOXIA; MALE; NEUROTRANSMISSION; NONHUMAN; PRIORITY JOURNAL; RAT; SOLITARY TRACT NUCLEUS; TIDAL VOLUME;

ANIMALS; ANOXIA; BICUCULLINE; GABA ANTAGONISTS; GAMMA-AMINOBUTYRIC ACID; MALE; ORGANOPHOSPHORUS COMPOUNDS; PULMONARY VENTILATION; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, GABA; RESPIRATORY MECHANICS; REST; SOLITARY NUCLEUS; SYNAPTIC TRANSMISSION;

EID: 33751170700     PISSN: 03636119     EISSN: 15221490     Source Type: Journal    
DOI: 10.1152/ajpregu.00645.2005     Document Type: Article

References (38)

1. Aaron EA and Powell FL. Effects of chronic hypoxia on hypoxic ventilatory response in awake rats. J Appl Physiol 74: 1635-1640, 1993.
2. Bisgard GE and Neubauer JA. Peripheral and central effects of hypoxia. In: Regulation of Breathing, edited by Dempsey, JA and Pack AI. New York: Marcel Dekker, 1995, p. 617-618.
3. Burton MD and Kazemi H. Neurotransmitters in central respiratory control. Respir Physiol 122: 111-121, 2000.
4. Chitravanshi VC, Kachroo A, and Sapru HN. A midline area in the nucleus commissuralis of NTS mediates the phrenic nerve response to carotid chemoreceptor stimulation. Brain Res 662: 127-133, 1994.
5. Dempsey JA and Forster HV. Mediation of ventilatory adaptations. Physiol Rev 62: 262-346, 1982.
6. Drorbaugh JE and Fenn WO. A barometric method of measuring ventilation in newborn infants. Pediatrics 16: 81-89, 1955.
7. Dwinell MR and Powell FL. Chronic hypoxia enhances the phrenic nerve response to arterial chemoreceptor stimulation in anesthetized rats. J Appl Physiol 87: 817-23, 1999.
8. Feldman JL, Mitchell GS, and Nattie GE. Breathing: rhythmicity plasticity chemosensitivity. Annu Rev Neurosci 26: 239-66, 2003.
9. Finley JCW and Katz DM. The central organization of carotid body efferent projections to the brainstem of the rat. Brain Res 572: 108-116, 1992.
10. Forster HV, and Dempsey JA Ventilatory Adaptations In: Regulation of Breathing, edited by Hornbein TF. New York: Marcel Dekker, 1981, p. 845-904.
11. Hedner J, Hedner T, Wessberg P, and Jonason J. An analysis of the mechanism by which γ-aminobutyric acid depresses ventilation in the rat. J Appl Physiol 56: 849-856, 1984.
12. Hoop B, Beagle JL, Maher TJ, and Kazemi H. Brainstem amino acid neurotransmitters and hypoxic ventilatory response. Respir Physiol 118: 117-129, 1999.
13. Housley GD, Martin-Body RL, Dawson NJ, and Sinclair JD. Brain stem projections of the glossopharyngeal nerve and its carotid sinus branch in the rat. Neuroscience 22: 237-50, 1987.
14. Housley GD and Sinclair JD. Localization by kainic acid lesions of neurons transmitting the carotid chemoreceptor stimulus for respiration in rats. J Physiol 406: 99-114, 1988.
15. Hsieh YH, Siegal RE, and Dick TE. Pontine GABAergic pathways: role and plasticity in the hypoxic ventilatory response. Respir Physiol Neurobiol 143: 141-153, 2004.
16. Jacky JP. A plethysmograph for long-term measurement of ventilation in unrestrained animals. J Appl Physiol 45: 644-647, 1978.
17. Kazemi H and Hoop B. Glutamic acid and γ-aminobutyric acid neurotransmitters in central control of breathing. J Appl Physiol 70: 1-7, 1991.
18. Lin TB, Lo MJ, Huang CY, Ting H, and Lee SD. GABAergic modulation of ventilatory response to acute and sustained hypoxia in obese Zucker rats. Int J Obesity 29, 188-195, 2005.
19. Machado BH and Bonagamba LGB. Cardiovascular responses to microinjection of trans-(±)-ACPD into the NTS were similar in conscious and chloralose-anesthetized rats. Braz J Med Biol Res 31: 573-579, 1998.
20. Malan A. Ventilation measured by whole body plethysmography in hibernating animals and poikilotherms. Respir Physiol 17: 32-44, 1973.
21. McCrimmon DR, Zuperku EJ, Hayashi F, Dogas Z, Hinrichsen CF, Stuth EA, Tonkovic-Capin M, Krolo M, and Hopp FA. Modulation of the synaptic drive to respiratory premotor and motor neurons. Respir Physiol 110: 161-176, 1997.
22. Mizusawa A, Ogawa H, Kikuchi Y, Hida W, Kurosawa H, Okabe S, Takishima T, and Shirato K. In vivo release of glutamate in nucleus tractus solitarii of the rat during hypoxia. J Physiol 478: 55-65, 1994.
23. Mortola JP and Frappell PB. On the barometric method for measurement of ventilation, and its use in small animals. Can J Physiol 76: 937-944, 1998.
24. Núñez-Abades P, Morillo AM, and Pásaro R. Brainstem connections of the rat ventral respiratory subgroups: afferent projections. J Auton Nerv Syst 42: 99-118, 1993.
25. Powell FL, Dwinell MR, and Aaron EA. Measuring ventilatory acclimatization to hypoxia: comparative aspects. Respir Physiol 122: 271-284, 2000.
26. Powell FL, Milsom WK, and Mitchell GS. Time domains of the hypoxic ventilatory response. Respir Physiol 112: 123-145, 1998.
27. Reid SG and Powell FL. The effects of systemic NMDA receptor blockade on ventilatory acclimatization to hypoxia. J Appl Physiol 99: 2108-2114, 2005.
28. Sato M, Severinghaus JW, Powell FL, Xu FD, and Spellman MJ Jr. Augmented hypoxic ventilatory response in men at altitude. J Appl Physiol 73: 101-107, 1992.
29. Soto-Arape I, Burton M, and Kazemi H. Central neurotransmitters and the hypoxic ventilatory response. Am J Respir Crit Care Med 151: 1113-1120, 1995.
30. Suzuki M, Nishina M, Nakamura S, and Maruyama K. Endogenous GABA in the commissural subnucleus of the NTS inhibits the carotid chemoreceptor reflex via GABA-A receptors in rats. J Neural Transm 110: 211-218, 2003.
31. Tabata M, Kurosawa H, Kikuchi Y, Hida W, Ogawa H, Okabe S, Tun Y, Hattori T, and Shirato K. Role of GABA within the nucleus tractus solitarii in the hypoxic ventilatory decline of awake rats. Am J Physiol Regul Integr Comp Physiol 281: R1411-R1419, 2001.
32. Tolstykh G, Belugin S, and Mifflin S. Responses to GABA(A) receptor activation are altered in NTS neurons isolated from chronic hypoxic rats. Brain Res 1006: 107-113, 2004.
33. Trippenbach T. Baclofen-induced block of the Hering-Breuer expiratory-promoting reflex in rats. Can J Physiol Pharmacol 73: 706-713, 1995.
34. Vardhan A, Kachroo A, and Sapru NH. Excitatory amino acid receptors in commissural nucleus of the NTS mediate carotid chemoreceptor responses. Am J Physiol Regul Integr Comp Physiol 264: R41-R50, 1993.
35. Wasserman AM, Ferreira M Jr, Sahibzada N, Hernandez YM, and Gillis RA. GABA-mediated neurotransmission in the ventrolateral NTS plays a role in respiratory regulation in the rat. Am J Physiol Regul Integr Comp Physiol 283: R1423-R1441, 2002.
36. Weil JV. Ventilatory control at high altitude. In: Handbook of Physiology. The Respiratory System. Control of Breathing. Bethesda, MD: Am. Physiol. Soc., 1986, sect. 3, vol. II, chapt. 21, p.703-728.
37. Yamada KA, Norman WP, Hamosh P, and Gillis RA. Medullary ventral surface GABA receptors affect respiratory and cardiovascular function. Brain Res 248: 71-78, 1982.
38. Zec N and Kinney HC. Anatomic relationships of the human nucleus of the solitary tract in the medulla oblongata: a DiI labelling study. Auton Neurosci 105: 131-44, 2003.