Retrotrapezoid nucleus: A litmus test for the identification of central chemoreceptors

Experimental Physiology

Volumn 90, Issue 3, 2005, Pages 247-253

  Guyenet, Patrice G ^a,b   Stornetta, Ruth L ^a   Bayliss, Douglas A ^a   Mulkey, Daniel K ^a  

^a UNIVERSITY OF VIRGINIA   (United States)

^b UNIVERSITY OF VIRGINIA HEALTH SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBON DIOXIDE;

CELL NUCLEUS; CHEMORECEPTOR; CHEMOSENSITIVITY; GLIA CELL; HYPERCAPNIA; NERVE CELL; NONHUMAN; PH; RAPHE NUCLEUS; REGULATORY MECHANISM; RETROTRAPEZOID NUCLEUS; REVIEW; SEROTONINERGIC NERVE CELL; THEORY;

EID: 18844424364     PISSN: 09580670     EISSN: None     Source Type: Journal    
DOI: 10.1113/expphysiol.2004.029637     Document Type: Review

References (41)

1. + channel expressed in brainstem respiratory neurons. Respir Physiol 129, 159-174.
2. Chesler M (2003). Regulation and modulation of pH in the brain. Physiol Rev 83, 1183-1221.
3. Cream C, Li A & Nattie E (2002). The retrotrapezoid nucleus (RTN): local cytoarchitecture and afferent connections. Respir Physiol Neurobiol 130, 121-137.
4. 2 decreases membrane conductance and depolarizes neurons in the nucleus tractus solitarii. Exp Brain Res 76, 656-661.
5. Feldman JL, Mitchell GS & Nattie EE (2003). Breathing: rhythmicity, plasticity, chemosensitivity. Annu Rev Neurosci 26, 239-266.
6. Fukuda Y, Tojima H, Tanaka K & Chiba T (1993). Respiratory suppression by focal cooling of ventral medullary surface in anesthetized rats - functional and neuroanatomical correlate. Neurosci Lett 153, 177-180.
7. Kawai A, Ballantyne D, Muckenhoff K & Scheid P (1996). Chemosensitive medullary neurones in the brainstem - spinal cord preparation of the neonatal rat. J Physiol 492, 277-292.
8. Li A & Nattie EE (1997). Focal central chemoreceptor sensitivity in the RTN studied with a CO2 diffusion pipette in vivo. J Appl Physiol 83, 420-428.
9. 2 microdialysis in retrotrapezoid nucleus of the rat increases breathing in wakefulness but not in sleep. J Appl Physiol 87, 910-919.
10. Loeschcke HH (1982). Central chemosensitivity and the reaction theory. J Physiol 332, 1-24.
11. Ludwig MG, Vanek M, Guerini D, Gasser JA, Jones CE, Junker U, Hofstetter H, Wolf RM & Seuwen K (2003). Proton-sensing G-protein-coupled receptors. Nature 425, 93-98.
12. Millhorn DE & Eldridge FL (1986). Role of ventrolateral medulla in regulation of respiratory and cardiovascular systems. J Appl Physiol 61, 1249-1263.
13. Mitchell GS (2004). Back to the future: carbon dioxide receptors in the mammalian brain. Nat Neurosci 7, 1288-1290.
14. Montana V, Ni YC, Sunjara V, Hua X & Parpura V (2004). Vesicular glutamate transporter-dependent glutamate release from astrocytes. J Neurosci 24, 2633-2642.
15. Mulkey DL, Stornetta RL, Weston MC, Simmons JR, Parker A, Bayliss DA & Guyenet PG (2004). Respiratory control by ventral surface chemoreceptor neurons in rats. Nat Neurosci 7, 1361-1369.
16. 2, brainstem chemoreceptors and breathing. Prog Neurobiol 59, 299-331.
17. Nattie EE (2001). Central chemosensitivity, sleep, and wakefulness. Respir Physiol 129, 257-268.
18. 2 dialysis in the medullary raphe of the rat increases ventilation in sleep. J Appl Physiol 90, 1247-1257.
19. 2 dialysis in nucleus tractus solitarius region of rat increases ventilation in sleep and wakefulness. J Appl Physiol 92, 2119-2130.
20. Okada Y, Chen Z, Jiang W, Kuwana S & Eldridge FL (2002). Anatomical arrangement of hypercapnia-activatecl cells in the superficial ventral medulla of rats. J Appl Physiol 93, 427-439.
21. Pineda J & Aghajanian GK (1997). Carbon dioxide regulates the tonic activity of locus coeruleus neurons by modulating a proton- and polyamine-sensitive inward rectifier potassium current. Neuroscience 77, 723-743.
22. 2 and acid signaling in chemosensitive neurons. Am J Physiol Cell Physiol 287, C1493-C1526.
23. 2 of neurons in the rostral ventral medulla in vitro. J Neurophysiol 73, 933-944.
24. Richerson GB (2004). Serotonergic neurons as carbon dioxide sensors that maintain pH homeostasis. Nat Rev Neurosci 5, 449-461.
25. Richerson GB, Wang WG, Tiwari J & Bradley SR (2001). Chemo sensitivity of serotonergic neurons in the rostral ventral medulla. Respir Physiol 129, 175-189.
26. Rodman JR, Curran AK, Henderson KS, Dempsey JA & Smith CA (2001). Carotid body denervation in dogs: eupnea and the ventilatory response to hyperoxic hypercapnia. J Appl Physiol 91, 328-335.
27. 2 chemoreceptor neuron identification by c-fos immunocytochemistry. J Appl Physiol 73, 96-100.
28. Scheid P (2001). Central chemosensitivity. Respir Physiol Neurobiol 129, 1-278.
29. 2 chemoreceptors: a brief historical review. Respir Physiol 114, 17-24.
30. Smith JC, Morrison DE, Ellenberger HH, Otto MR & Feldman JL (1989). Brainstem projections to the major respiratory neuron populations in the medulla of the cat. J Comp Neurol 281, 69-96.
31. + chemoreception in the cat pre-Botzinger complex in vivo. J Appl Physiol 88, 1996-2007.
32. Spyer KM, Dale N & Gourine AV (2004). ATP is a key mediator of central and peripheral chemosensory transduction. Exp Physiol 89, 53-59.
33. Teppema LJ, Veening JG, Kranenburg A, Dahan A, Berkenbosch A & Olievier C (1997). Expression of c-fos in the rat brainstem after exposure to hypoxia and to normoxic and hyperoxic hypercapnia. J Comp Neurol 388, 169-190.
34. Veasey SC, Fornal CA, Metzler CW & Jacobs BL (1995). Response of serotonergic caudal rap he neurons in relation to specific motor activities in freely moving cats. J Neurosci 15, 5346-5359.
35. 2 and pH, and their role as chemostimulants in the isolated respiratory network of neonatal rats. J Physiol 499, 527-542.
36. Wang JQ, Kon J, Mogi C, Tobo M, Damirin A, Sato K et al. (2004). TDAG8 is a proton-sensing and psychosine-sensitive G-protein-coupled receptor. J Biol Chem 279, 45626-45633.
37. Washburn CP, Bayliss DA & Guyenet PG (2003). Cardiorespiratory neurons of the rat ventrolateral medulla contain TASK-1 and TASK-3 channel mRNA. Respir Physiol Neurobiol 138, 19-35.
38. + conductance. J Neurosci 22, 1256-1265.
39. + channels to central chemosensitivity in cultivated neurons of fetal rat medulla. J Neurophysiol 79, 2885-2894.
40. Weston MC, Stornetta RL & Guyenet PG (2004). Glutamatergic neuronal projections from the marginal layer of the rostral ventral medulla to the respiratory centers in rats. J Comp Neurol 473, 73-85.
41. Xu H, Cui N, Yang Z, Qu 2 & Jiang C (2000). Modulation of kir4.1 and kir5.1 by hypercapnia and intracellular acidosis. J Physiol 524, 725-735.