Role of the Src homology 2 domains and interdomain regions in ZAP-70 phosphorylation and enzymatic activity

European Journal of Biochemistry

Volumn 266, Issue 3, 1999, Pages 1166-1173

  Magistrelli, Giovanni ^a,c   Bosotti, Roberta ^a   Valsasina, Barbara ^a   Visco, Carlo ^a   Perego, Rita ^a   Toma, Salvatore ^a   Acuto, Oreste ^b   Isacchi, Antonella ^a  

^a PFIZER INC   (United States)

^b INSTITUT PASTEUR   (France)

^c INSTITUT DE RECHERCHE PIERRE FABRE   (France)

Author keywords

Kinase activity; Phosphorylation; SH2; TCR; ZAP 70

Indexed keywords

LINK PROTEIN; PHENYLALANINE; PROTEIN TYROSINE KINASE; T LYMPHOCYTE RECEPTOR; TYROSINE;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; CELL STRAIN COS1; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME SUBSTRATE; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; MUTATION; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PHOSPHORYLATION; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION;

ANIMALS; BINDING SITES; CATALYTIC DOMAIN; COS CELLS; HUMANS; JURKAT CELLS; MUTATION; PHOSPHORYLATION; PROTEIN-TYROSINE KINASES; RECEPTORS, ANTIGEN, T-CELL; RECOMBINANT PROTEINS; SIGNAL TRANSDUCTION; SRC HOMOLOGY DOMAINS; TRANSFECTION; TYROSINE; ZAP-70 PROTEIN-TYROSINE KINASE;

EID: 0033572977     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1432-1327.1999.00973.x     Document Type: Article

References (40)

1. 1. Chan, A.C., van Oers, N.S., Tran, A., Turka, A.L., Law, C.L., Ryan, J.C., Clark, E.A. & Weiss, A. (1994) Differential expression of ZAP-70 and Syk protein tyrosine kinases, and the role of this family of protein kinases in TCR signaling. J. Immunol. 152, 4758-4766.
2. 2. Chan, A.C., Iwashima, M., Turck, C.W. & Weiss, A. (1992) ZAP-70: a 70 kd protein-tyrosine kinase that associates with the TCR ζ chain. Cell 71, 649-662.
3. 3. Taniguchi, T., Kobayashi, T., Kondo, J., Takahashi, K., Nakamura, H., Suzuki, J., Nagai, K., Yamada, T., Nakamura, S. & Yamamura, H. (1991) Molecular cloning of a porcine gene Syk that encodes a 72-kDa protein-tyrosine kinase showing high susceptibility to proteolysis. J. Biol. Chem. 266, 15790-15796.
4. 4. Thome, M. & Acuto, O. (1995) Molecular mechanism of T-cell activation: role of protein tyrosine kinases in antigen receptor-mediated signal transduction. Res. Immunol. 146, 291-307.
5. 5. Irving, B.A., Chan, A.C. & Weiss, A. (1993) Functional characterization of a signal transducing motif present in the T cell antigen receptor ζ chain. J. Exp. Med. 177, 1093-1103.
6. 6. Reth, M. (1989) Antigen receptor tail clue. Nature 338, 383-384.
7. 7. Iwashima, M., Irving, B.A., van Oers, N.S., Chan, A.C. & Weiss, A. (1994) Sequential interactions of the TCR with two distinct cytoplasmic tyrosine kinases. Science 263, 1136-1139.
8. 8. Strauss, D.B. & Weiss, A. (1993) The CD3 chains of the T cell antigen receptor associate with the ZAP-70 tyrosine kinase and are tyrosine phosphorylated after receptor stimulation. J. Exp. Med. 178, 1523-1530.
9. 9. Chan, A.C., Irving, B.A., Fraser, J.D. & Weiss, A. (1991) The ζ chain is associated with a tyrosine kinase and upon T-cell antigen receptor stimulation associates with ZAP-70, a 70-kDa tyrosine phosphoprotein. Proc. Natl Acad. Sci. USA 88, 9166-9170.
10. 10. Hatada, M.H., Lu, X., Laird, E.R., Green, J., Morgenstern, J.P., Lou, M., Marr, C.S., Phillips, T.B., Ram, M.K., Theriault, K., Zoller, M.J. & Karas, J.L. (1995) Molecular basis for interaction of the protein tyrosine kinase ZAP-70 with the T-cell receptor. Nature 377, 32-38.
11. 11. Grazioli, L., Germain, V., Weiss, A. & Acuto, O. (1998) Anti-peptide antibodies detect conformational changes of the inter-SH2 domain of ZAP-70 due to binding to the zeta chain and to intramolecular interactions. J. Biol. Chem. 273, 8916-8921.
12. 12. Chan, A.C., Dalton, M., Johnson, M.R., Kong, G.H., Wang, T., Thoma, R. & Kurosaki, T. (1995) Activation of ZAP-70 kinase activity by phosphorylation of tyrosine 493 is required for lymphocyte antigen receptor function. EMBO J. 14, 2499-2508.
13. 13. Neumeister, E.N., Zhu, Y., Richard, S., Terhost, C., Chan, A.C. & Shaw, A.S. (1995) Binding of ZAP-70 to phosphorylated T-cell receptor ζ and η enhances its autophosphorylation and generates specific binding sites for SH2 domain-containing proteins. Mol. Cell. Biol. 15, 3171-3178.
14. 14. Pacini, S., Ulivieri, C., Di Somma, M.M., Isacchi, A., Lanfrancone, L., Pelicci, P.G., Telfold, J.L. & Baldari, C.T. (1998) Tyrosine 474 of ZAP-70 is required for association with the Shc adaptor and for T-cell antigen receptor-dependent gene activation. J. Biol. Chem. 273, 20487-20493.
15. 15. Lupher, M.L. Jr, Reedquist, K.A., Myake, S., Langdon, W.Y. & Band, H. (1996) A novel phosphotyrosine-binding domain in the N-terminal transforming region of Cbl interacts directly and selectively with ZAP-70 in T cells. J. Biol. Chem. 271, 24063-24068.
16. 16. Plas, D.R., Johnson, R., Pingel, J.T., Matthews, R.J., Dalton, M., Roy, G., Chan, A.C. & Thomas, M.L. (1996) Direct regulation of ZAP-70 by SHP-1 in T cell antigen receptor signaling. Science 272, 1173-1176.
17. 17. Duplay, P., Thome, M., Herve, F. & Acuto, O. (1994) p561ck interacts via its src homology 2 domain with the ZAP-70 kinase. J. Exp. Med. 179, 1163-1172.
18. 18. Watts, J.D., Affolter, M., Krebs, D.L., Wange, R.L., Samelson, L.E. & Aebersold, R. (1994) Identification by electrospray ionization mass spectrometry of the sites of tyrosine phosphorylation induced in activated Jurkat T cells on the protein tyrosine kinase ZAP-70. J. Biol. Chem. 269, 29520-29529.
19. 19. Kong, G., Dalton, M., Wardenburg, J.B., Straus, D., Kurosaki, T. & Chan, A.C. (1996) Distinct tyrosine phosphorylation sites in ZAP-70 mediate activation and negative regulation of antigen receptor function. Mol. Cell Biol. 16, 5026-5035.
20. 20. Mège, D., Di Bartolo, V., Germain, V., Tuosto, L., Michel, F. & Acuto, O. (1996) Mutation of tyrosine 492/493 in the kinase domain of ZAP-70 affects multiple T-cell receptor signaling pathways. J. Biol. Chem. 271, 32644-33265.
21. 21. Wange, R.L., Guitian, R., Isakov, N., Watts, J.D., Aebersold, R. & Samelson, L.E. (1995) Activating and inhibitory mutations in adjacent tyrosines in the kinase domain of ZAP-70. J. Biol. Chem. 270, 18730-18733.
22. 22. Zhao, Q. & Weiss, A. (1996) Enhancement of lymphocyte responsiveness by a gain-of-function mutation of ZAP-70. Mol. Cell. Biol. 16, 6765-6774.
23. 23. Zeitlmann, L., Knorr, T., Knoll, M., Romeo, C., Sirim, P. & Kolanus, W. (1998) T cell activation induced by novel gain-of-function mutants of Syk and ZAP-70. J. Biol. Chem. 273, 15445-15452.
24. 24. Di Bartolo, V., Mege, D., Germain, V., Pelosi, M., Dufour, E., Pascussi, J., Magistrelli, G., Isacchi, A. & Acuto, O. (1999) Tyrosine 319, a newly identified phosphorylation site of ZAP-70, plays a critical role in T cell antigen receptor signaling. J. Biol. Chem. 274, 6285-6294.
25. 25. Pelosi, M., Di Bartolo, V., Mounier, V., Mege, D., Pascussi, J.M., Dufour, E., Blondel, A. & Acuto, O. (1999) Tyrosine 319 in the interdomain B of ZAP-70 is a binding site for the Src homology 2 domain of Lck. J. Biol. Chem. 274, 14229-14237.
26. 26. Fernandez, J., Andrews, L. & Mische, S.M. (1994) An improved procedure for enzymatic digestion of polyvinylidene difluoride-bound proteins for internal sequence analysis. Anal. Biochem. 218, 112-117.
27. 27. Isakov, N., Wange, R.L., Watts, J.D., Aebersold, R. & Samelson, L.E. (1996) Purification and characterization of human ZAP-70 protein-tyrosine kinase from a baculovirus expression system. J. Biol. Chem 271, 15753-15761.
28. 28. Watts, J.D., Brabb, T., Bures, E.J., Wange, R.L., Samelson, L.E. & Aebersold, R. (1996) Identification and characterization of a substrate specific for the T cell protein tyrosine kinase ZAP-70. FEBS Lett. 398, 217-222.
29. 29. Backer, J.M., Myers, M.G. Jr, Shoelson, S.E., Chin, D.J., Sun, X.J., Miralpeix, M., Hu, P., Margolis, B., Skolnik, E.Y., Schlessinger, J. & White, M.F. (1992) Phosphatidylinositol 3′-kinase is activated by association with IRS-1 during insulin stimulation. EMBO J. 11, 3469-3479.
30. 30. Lechleider, R.J., Sugimoto, S., Bennet, A.M., Kashishian, A.S., Cooper, J.A., Shoelson, S.E., Walsh, C.T. & Neel, B.G. (1993) Activation of the SH2-containing phosphotyrosine phosphatase SH-PTP2 by its binding site, phosphotyrosine 1009, on the human platelet-derived growth factor receptor. J. Biol. Chem. 268, 21478-21481.
31. 31. Shoelson, S.E., Sivaraja, M., Williams, K.P., Hu, P., Schlessinger, J. & Weiss, M.A. (1993) Specific phosphopeptide binding regulates a conformational change in the PI 3-kinase SH2 domain associated with enzyme activation. EMBO J. 12, 795-802.
32. 32. Martin. A., Tsui, H.W., Shulman, M.J., Isenman, D. & Tsui, F.W. (1999) Murine SHP-1 splice variants with altered Src homology 2 (SH2) domains. Implications for the sh2-mediated intramolecular regulation of shp-1. J. Biol. Chem. 274, 21725-21734.
33. 33. Shiue, L., Zoller, M.J. & Brugge, J.S. (1995) Syk is activated by phosphotyrosine-containing peptides representing the tyrosine-based activation motifs of the high affinity receptor for IgE. J. Biol. Chem. 270, 10498-10502.
34. 34. Rowley, R.B., Burkhardt, A.L., Chao, H.G., Matsueda, G.R. & Bolen, J.B. (1995) Syk protein-tyrosine kinase is regulated by tyrosine-phosphorylated Ig α/Ig β immunoreceptor tyrosine activation motif binding and autophosphorylation. J. Biol. Chem. 270, 11590-11594.
35. 35. Kimura, T., Sakamoto, H., Appella, E. & Siraganian, R.P. (1996) Conformational changes induced in the protein tyrosine kinase p72syk by tyrosine phosphorylation or by binding of phosphorylated immunoreceptor tyrosine-based activation motif peptides. Mol. Cell. Biol. 16, 1471-1478.
36. 36. Lo Grasso, P.V., Hawkins, J., Frank, L.J., Wisniewski, D. & Marcy, A. (1996) Mechanism of activation for ZAP-70 catalytic activity. Proc. Natl Acad. Sci. USA 93, 12165-12170.
37. 37. Meng, W., Sawasdikosol, S., Burakoff, S.J. & Eck, M.J. (1999) Structure of the amino-terminal domain of Cbl complexed to its binding site on ZAP-70 kinase. Nature 398, 84-90.
38. 38. Lupher, M.L. Jr, Songyang, Z., Shoelson, S.E., Cantley, L.C. & Band, H. (1997) The Cbl phosphotyrosine-binding domain selects a D (N/D) XpY motif and binds to the Tyr292 negative regulatory phosphorylation site of ZAP-70. J. Biol Chem. 272, 33140-33144.
39. 39. Deckert, M., Tartare-Deckert, S., Couture, C., Mustelin, T. & Altman, A. (1996) Functional and physical interactions of Syk family kinases with the Vav proto-oncogene product. Immunity 5, 591-604.
40. 40. Zhao, Q., Williams, B.L., Abraham, R.T. & Weiss, A. (1999) Interdomain B in ZAP-70 regulates but is not required for ZAP-70 signaling function in lymphocytes. Mol. Cell. Biol. 19, 948-956.