WR-1065, the active metabolite of amifostine, mitigates radiation-induced delayed genomic instability

Free Radical Biology and Medicine

Volumn 45, Issue 12, 2008, Pages 1674-1681

  Dziegielewski, Jaroslaw ^a   Baulch, Janet E ^a   Goetz, Wilfried ^a   Coleman, Mitchell C ^b   Spitz, Douglas R ^b   Murley, Jeffrey S ^c   Grdina, David J ^c   Morgan, William F ^a  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF IOWA HOSPITALS AND CLINICS   (United States)

^c UNIVERSITY OF CHICAGO   (United States)

Author keywords

Amifostine; Delayed effects; Genomic instability; High LET radiation; Radio protection; WR 1065

Indexed keywords

2 (3 AMINOPROPYLAMINO)ETHANETHIOL; AMIFOSTINE; MANGANESE SUPEROXIDE DISMUTASE;

ARTICLE; CELL DEATH; CELL LEVEL; CELL PROTECTION; CHROMOSOME DAMAGE; CONTROLLED STUDY; DOSE RESPONSE; GENOMIC INSTABILITY; HUMAN; HUMAN CELL; IONIZING RADIATION; PRIORITY JOURNAL; PROGENY; RADIATION DOSE; RADIATION EXPOSURE; RADIATION PROTECTION;

AMIFOSTINE; CELL LINE, TUMOR; CELL SURVIVAL; COLORECTAL NEOPLASMS; DOSE-RESPONSE RELATIONSHIP, RADIATION; GENOMIC INSTABILITY; GREEN FLUORESCENT PROTEINS; HUMANS; MERCAPTOETHYLAMINES; MICRONUCLEUS TESTS; RADIATION TOLERANCE; RADIATION-PROTECTIVE AGENTS; SUPEROXIDE DISMUTASE; X-RAYS;

EID: 56349159491     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2008.09.004     Document Type: Article

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