Delayed cytoprotection after enhancement of Sod2 (MnSOD) gene expression in SA-NH mouse sarcoma cells exposed to WR-1065, the active metabolite of amifostine

Radiation Research

Volumn 158, Issue 1, 2002, Pages 101-109

  Murley, Jeffrey S ^a   Kataoka, Yasushi ^a   Weydert, Christine J ^a   Oberley, Larry W ^a   Grdina, David J ^a  

^a UNIVERSITY OF CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 (3 AMINOPROPYLAMINO)ETHANETHIOL; AMIFOSTINE; MANGANESE SUPEROXIDE DISMUTASE;

ANIMAL CELL; ARTICLE; CELL PROTECTION; CELL SURVIVAL; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA PROBE; ELECTROPHORESIS; GENE EXPRESSION; MOUSE; NONHUMAN; NORTHERN BLOTTING; PRIORITY JOURNAL; RADIATION PROTECTION; SARCOMA CELL; X IRRADIATION;

EID: 0036306828     PISSN: 00337587     EISSN: None     Source Type: Journal    
DOI: 10.1667/0033-7587(2002)158[0101:DCAEOS]2.0.CO;2     Document Type: Article

References (36)

1. Amifostine: An update on its clinical status as a cytoprotectant in patients with cancer receiving chemotherapy or radiotherapy and its potential therapeutic application in myelodysplastic syndrome
2. Society of Clinical Oncology clinical practice guidelines for the use of chemotherapy and radiotherapy protectants
3. Chemopreventive activity of oltipraz
4. Antioxidant and redox regulation of gene transcription
5. Redox regulation of NF-κB activation
6. WR1065, an active metabolite of amifostine, affects phosphorylation of topoisomerase IIα leading to changes in enzyme activity and cell cycle progression in CHO AA 8 cells
7. Radioprotectants
8. Activation of NFκB and MnSOD gene expression by free radical scavengers in human microvascular endothelial cells
9. Activation of NF-κB and elevation of MnSOD gene expression by thiol reducing agents in lung adenocarcinoma (A549) cells
10. Thiol modulation of TNFα and IL-I induced MnSOD gene expression and activation of NF-αB
11. Oltipraz stimulates the transcription of the manganese superoxide dismutase gene in rat hepatocytes
12. Function and activation of NF-κB in the immune system
13. Superoxide radical and superoxide dismutases
14. Overexpression of manganese superoxide dismutase in DU 145 human prostate carcinoma cells has multiple effects on cell phenotype
15. Manganese superoxide dismutase in disease
16. Clair, Suppression of fibrosarcoma metastases by elevated expression of manganese superoxide dismutase
17. Transfection and expression of MnSOD cDNA decreases tumor malignancy of human oral squamous carcinoma SCC-25 cells
18. Amifostine inhibits hematopoietic progenitor cell apoptosis by activating NF-κB/Rel transcription factors
19. Amifostine: Mechanisms of action underlying cytoprotection and chemoprevention
20. Binding of the aminothiol WR 1065 to transcription factors influences cellular response to anticancer drugs
21. Inhibition of spontaneous metastases formation by amifostine
22. Protective roles of cytokines against radiation: Induction of mitochondrial MnSOD
23. Overexpression of mitochondrial manganese superoxide dismutase promotes the survival of tumor cells exposed to interleukin-1, tumor necrosis factor, selected anticancer drugs, and ionizing radiation
24. Role of antioxidant enzymes on ionizing radiation resistance
25. Manganese superoxide dismutase-plasmid/liposome (MnSOD-PL) administration protects mice from esophagitis associated with fractionated radiation
26. Overexpression of mitochondrial manganese superoxide dismutase protects against radiation-induced cell death in the human hepatocellular carcinoma cell line HLE
27. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
28. Cleavage of structural proteins during the assembly of the head of bacteriophage T4
29. Assay of superoxide dismutase activity in tumor tissue
30. Chemoprevention with WR-2721 and its metabolites
31. Differential activation of nuclear transcription factor KB, gene expression, and protein levels by amifostine's free thiol in human microvascular endothelial and glioma cells
32. Cytoprotection by WR-1065, the active form of amifostine, is independent of p 53 status in human malignant glioma cell lines
33. Thiol and disulfide metabolites of the radiation protector and potential chemopreventive agent WR-2721 are linked to both its anti-cytotoxic and anti-mutagenic mechanisms of action
34. The effect of the radioprotector WR-2721 and WR-1065 on mitochondrial lipid peroxidation
35. Amifostine: An update on its clinical status as a cytoprotectant in patients with cancer receiving chemotherapy or radiotherapy and its potential therapeutic application in myelodysplastic syndrome
36. Use of amifostine in hematologic malignancies, myelodysplastic syndrome, and acute leukemia