PIK3CA gene mutations in breast carcinoma in Malaysian patients

Cancer Genetics and Cytogenetics

Volumn 187, Issue 2, 2008, Pages 74-79

  Ching Shian Leong, Vincent ^a   Jabal, Mohd Faizal ^a   Leong, Pooi Pooi ^a   Abdullah, Maizaton Atmadini ^a   Gul, Yunus Alif ^a   Seow, Heng Fong ^a  

^a UNIVERSITY PUTRA MALAYSIA   (Malaysia)

Author keywords

[No Author keywords available]

Indexed keywords

GENOMIC DNA; PHOSPHATIDYLINOSITOL 3 KINASE;

ARTICLE; BREAST CARCINOMA; DNA EXTRACTION; GENE MUTATION; GENETIC ANALYSIS; HUMAN; HUMAN CELL; HUMAN TISSUE; MALAYSIA; NUCLEOTIDE SEQUENCE; PIK3CA GENE; PRIORITY JOURNAL; PROTEIN DOMAIN; SIGNAL TRANSDUCTION; SOMATIC MUTATION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; BREAST NEOPLASMS; CELL LINE, TUMOR; COLORECTAL NEOPLASMS; DNA MUTATIONAL ANALYSIS; HUMANS; MALAYSIA; MUTATION; NASOPHARYNGEAL NEOPLASMS; SIGNAL TRANSDUCTION;

EID: 56249147845     PISSN: 01654608     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cancergencyto.2008.07.005     Document Type: Article

References (29)

1. Cantley L.C. The phosphoinositide 3-kinase pathway. Science 296 (2002) 1655-1657
2. Vivanco I., and Sawyers C.L. The phosphatidylinositol 3-Kinase AKT pathway in human cancer. Nat Rev Cancer 2 (2002) 489-501
3. Bader A.G., Kang S., Zhao L., and Vogt P.K. Oncogenic PI3K deregulates transcription and translation. Nat Rev Cancer 5 (2005) 921-929
4. Samuels Y., Wang Z., Bardelli A., Silliman N., Ptak J., Szabo S., Yan H., Gazdar A., Powell S.M., Riggins G.J., Willson J.K., Markowitz S., Kinzler K.W., Vogelstein B., and Velculescu V.E. High frequency of mutations of the PIK3CA gene in human cancers. Science 304 (2004) 554
5. Karakas B., Bachman K.E., and Park B.H. Mutation of the PIK3CA oncogene in human cancers. Br J Cancer 94 (2006) 455-459
6. Hartmann C., Bartels G., Gehlhaar C., Holtkamp N., and von Deimling A. PIK3CA mutations in glioblastoma multiforme. Acta Neuropathol 109 (2005) 639-642
7. Wang Y., Helland A., Holm R., Kristensen G.B., and Borresen-Dale A.L. PIK3CA mutations in advanced ovarian carcinomas. Hum Mutat 25 (2005) 322
8. Maruyama N., Miyoshi Y., Taguchi T., Tamaki Y., Monden M., and Noguchi S. Clinicopathologic analysis of breast cancers with PIK3CA mutations in Japanese women. Clin Cancer Res 13 (2007) 408-414
9. Phillips W.A., Russell S.E., Ciavarella M.L., Choong D.Y., Montgomery K.G., Smith K., Pearson R.B., Thomas R.J., and Campbell I.G. Mutation analysis of PIK3CA and PIK3CB in esophageal cancer and Barrett's esophagus. Int J Cancer 118 (2006) 2644-2646
10. Kawano O., Sasaki H., Endo K., Suzuki E., Haneda H., Yukiue H., Kobayashi Y., Yano M., and Fujii Y. PIK3CA mutation status in Japanese lung cancer patients. Lung Cancer 54 (2006) 209-215
11. Kozaki K., Imoto I., Pimkhaokham A., Hasegawa S., Tsuda H., Omura K., and Inazawa J. PIK3CA mutation is an oncogenic aberration at advanced stages of oral squamous cell carcinoma. Cancer Sci 97 (2006) 1351-1358
12. Qiu W., Schonleben F., Li X., Ho D.J., Close L.G., Manolidis S., Bennett B.P., and Su G.H. PIK3CA mutations in head and neck squamous cell carcinoma. Clin Cancer Res 12 (2006) 1441-1446
13. Schonleben F., Qiu W., Ciau N.T., Ho D.J., Li X., Allendorf J.D., Remotti H.E., and Su G.H. PIK3CA mutations in intraductal papillary mucinous neoplasm/carcinoma of the pancreas. Clin Cancer Res 12 (2006) 3851-3855
14. Gallia G.L., Rand V., Siu I.M., Eberhart C.G., James C.D., Marie S.K., Oba-Shinjo S.M., Carlotti C.G., Caballero O.L., Simpson A.J., Brock M.V., Massion P.P., Carson Sr. B.S., and Riggins G.J. PIK3CA gene mutations in pediatric and adult glioblastoma multiforme. Mol Cancer Res 4 (2006) 709-714
15. Kita D., Yonekawa Y., Weller M., and Ohgaki H. PIK3CA alterations in primary (de novo) and secondary glioblastomas. Acta Neuropathol 113 (2007) 295-302
16. Aoki M., Batista O., Bellacosa A., Tsichlis P., and Vogt P.K. The akt kinase: molecular determinants of oncogenicity. Proc Natl Acad Sci USA 95 (1998) 14950-14955
17. Aoki M., Schetter C., Himly M., Batista O., Chang H.W., and Vogt P.K. The catalytic subunit of phosphoinositide 3-kinase: requirements for oncogenicity. J Biol Chem 275 (2000) 6267-6275
18. Kang S., Bader A.G., and Vogt P.K. Phosphatidylinositol 3-kinase mutations identified in human cancer are oncogenic. Proc Natl Acad Sci USA 102 (2005) 802-807
19. Ikenoue T., Kanai F., Hikiba Y., Obata T., Tanaka Y., Imamura J., Ohta M., Jazag A., Guleng B., Tateishi K., Asaoka Y., Matsumura M., Kawabe T., and Omata M. Functional analysis of PIK3CA gene mutations in human colorectal cancer. Cancer Res 65 (2005) 4562-4567
20. Isakoff S.J., Engelman J.A., Irie H.Y., Luo J., Brachmann S.M., Pearline R.V., Cantley L.C., and Brugge J.S. Breast cancer-associated PIK3CA mutations are oncogenic in mammary epithelial cells. Cancer Res 65 (2005) 10992-11000
21. Gymnopoulos M., Elsliger M.A., and Vogt P.K. Rare cancer-specific mutations in PIK3CA show gain of function. Proc Natl Acad Sci USA 104 (2007) 5569-5574
22. Tanaka Y., Kanai F., Tada M., Asaoka Y., Guleng B., Jazag A., Ohta M., Ikenoue T., Tateishi K., Obi S., Kawabe T., Yokosuka O., and Omata M. Absence of PIK3CA hotspot mutations in hepatocellular carcinoma in Japanese patients. Oncogene 25 (2006) 2950-2952
23. Or Y.Y., Hui A.B., To K.F., Lam C.N., and Lo K.W. PIK3CA mutations in nasopharyngeal carcinoma. Int J Cancer 118 (2006) 1065-1067
24. Shayesteh L., Lu Y., Kuo W.L., Baldocchi R., Godfrey T., Collins C., Pinkel D., Powell B., Mills G.B., and Gray J.W. PIK3CA is implicated as an oncogene in ovarian cancer. Nat Genet 21 (1999) 99-102
25. Byun D.S., Cho K., Ryu B.K., Lee M.G., Park J.I., Chae K.S., Kim H.J., and Chi S.G. Frequent monoallelic deletion of PTEN and its reciprocal associatioin with PIK3CA amplification in gastric carcinoma. Int J Cancer 104 (2003) 318-327
26. Kang S., Bader A.G., Zhao L., and Vogt P.K. Mutated PI 3-kinases: cancer targets on a silver platter. Cell Cycle 4 (2005) 578-581
27. Lee J.Y., Engelman J.A., and CantleyBiochemistry L.C. PI3K charges ahead. Science 317 (2007) 206-207
28. Miled N., Yan Y., Hon W.C., Perisic O., Zvelebil M., Inbar Y., Schneidman-Duhovny D., Wolfson H.J., Backer J.M., and Williams R.L. Mechanism of two classes of cancer mutations in the phosphoinositide 3-kinase catalytic subunit. Science 317 (2007) 239-242
29. Huang C.H., Mandelker D., Schmidt-Kittler O., Samuels Y., Velculescu V.E., Kinzler K.W., Vogelstein B., Gabelli S.B., and Amzel L.M. The structure of a human p110alpha/p85alpha complex elucidates the effects of oncogenic PI3Kalpha mutations. Science 318 (2007) 1744-1748