6-Phenyl-4,5-dihydro-3(2H)-pyridazinones. A Series of Hypotensive Agents

Journal of Medicinal Chemistry

Volumn 17, Issue 3, 1974, Pages 273-281

  Curran, William V ^a   Ross, Adma ^a  

^a WYETH RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIHYPERTENSIVE AGENT; PYRIDAZINONE DERIVATIVE;

BLOOD PRESSURE; CHROMATOGRAPHY; DRUG ANALYSIS; DRUG SCREENING; DRUG SYNTHESIS; HYPERTENSION; RAT; STRUCTURE ACTIVITY RELATION; THEORETICAL STUDY;

ANIMAL; ANTIHYPERTENSIVE AGENTS; BLOOD PRESSURE; DOGS; HAPLORHINI; HEMORRHAGE; MICE; PYRIDAZINES; RATS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0015955381     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm00249a004     Document Type: Article

References (18)

1. T. L. Jacobs, Heterocycl. Compounds, 6, 101 (1957).
2. M. Tisier and B. Stanovnik, Advan. Heterocycl. Chem., 9, 211 (1968).
3. A. G. Peto and G. Olah, in “Friedel-Crafts and Related Reactions,” Vol. III, Interscience, New York, N. Y., 1963. p 535.
4. E. Berliner, Org. React., 5, 290 (1949).
5. D. K. Genge and J. J. Triverdi, J. Indian Chem. Soc. 36, 598 (1959).
6. L. Friedman and H. Schechter, J. Org. Chem., 26, 2522 (1961).
7. M. S. Newman and H. Boden. J. Org. Chem., 26, 2525 (1961).
8. E. L. Martin, J. Amer. Chem. Soc., 58, 1438(1936).
9. J. A. Marshall and S. F. Brady, J. Org. Chem., 35, 4068 (1970).
10. E. A. Stack, R. P. Brundage, and L. T. Fletcher, J. Amer. Chem. Soc., 73, 1117 (1953).
11. G. Bachmann, British Patent 1, 168, 291 (Oct 22, 1969).
12. J. R. Cummings, A. M. Welter, J. L. Grace, Jr., and L. M. Lipchuck, J. Pharmacol. Exp. Ther., 161, 88 (1968).
13. G. Bachmann and A. Amann, U. S. Patent 3, 475, 431 (Oct 28, 1969).
14. G. Bachmann and A. Amann, British Patent 1, 164, 139 (Sept 17, 1969).
15. J. P. English, R. C. Clapp, Q. P. Cole, and J. Krapcho, J. Amer. Chem. Soc., 67, 2263 (1945).
16. E. A. Steck and F. C. Nachod, J. Amer. Chem. Soc., 79, 4408 (1957).
17. R. E. Lutz, P. S. Bailey, C.-K. Dien, and J. W. Rinker, J. Amer. Chem. Soc., 75, 5039 (1953).
18. H. M. Holava, Jr., and R. A. Partyka, J. Med. Chem., 14, 262(1971).