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Volumn 10, Issue 9, 2008, Pages 530-537

Molecular biology of pancreatic cancer

Author keywords

Cyclins; EGFr; K ras; Pancreatic cancer; STAT3; TGF

Indexed keywords

GENETIC PREDISPOSITION; GENETICS; HUMAN; MOLECULAR BIOLOGY; PANCREAS TUMOR; REVIEW;

EID: 56149100868     PISSN: 1699048X     EISSN: 16993055     Source Type: Journal    
DOI: 10.1007/s12094-008-0247-6     Document Type: Article
Times cited : (9)

References (63)
  • 1
    • 33847387472 scopus 로고    scopus 로고
    • Kras(g12d) and smad4/dpc4 haploinsufficiency cooperate to induce mucinous cystic neoplasms and invasive adenocarcinoma of the pancreas
    • Izeradjene K, Combs C, Best M et al (2007) Kras(G12D) and Smad4/Dpc4 haploinsufficiency cooperate to induce mucinous cystic neoplasms and invasive adenocarcinoma of the pancreas. Cancer Cell 11:229-243
    • (2007) Cancer Cell , vol.11 , pp. 229-243
    • Izeradjene, K.1    Combs, C.2    Best, M.3
  • 2
  • 3
    • 9144266295 scopus 로고    scopus 로고
    • Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse
    • Hingorani SR, Petricoin EF, Maitra A et al (2003) Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse. Cancer Cell 4:437-450
    • (2003) Cancer Cell , vol.4 , pp. 437-450
    • Hingorani, S.R.1    Petricoin, E.F.2    Maitra, A.3
  • 4
    • 19344362405 scopus 로고    scopus 로고
    • Trp53r172h and krasg12d cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice
    • Hingorani SR, Wang L, Multani AS et al (2005) Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice. Cancer Cell 7:469-483
    • (2005) Cancer Cell , vol.7 , pp. 469-483
    • Hingorani, S.R.1    Wang, L.2    Multani, A.S.3
  • 5
    • 33645824724 scopus 로고    scopus 로고
    • Both p16(ink4a) and the p19(arf)-p53 pathway constrain progression of pancreatic adenocarcinoma in the mouse
    • Bardeesy N, Aguirre AJ, Chu GC et al (2006) Both p16(Ink4a) and the p19(Arf)-p53 pathway constrain progression of pancreatic adenocarcinoma in the mouse. Proc Natl Acad Sci USA 103:5947-5952
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 5947-5952
    • Bardeesy, N.1    Aguirre, A.J.2    Chu, G.C.3
  • 6
    • 0346455774 scopus 로고    scopus 로고
    • Activated kras and ink4a/arf deficiency cooperate to produce metastatic pancreatic ductal adenocarcinoma
    • Aguirre J, Bardeesy N, Sinha M et al (2003) Activated Kras and Ink4a/Arf deficiency cooperate to produce metastatic pancreatic ductal adenocarcinoma. Genes Dev 17:3112-3126
    • (2003) Genes Dev , vol.17 , pp. 3112-3126
    • Aguirre, J.1    Bardeesy, N.2    Sinha, M.3
  • 7
    • 52149123619 scopus 로고    scopus 로고
    • Core signaling pathways in human pancreatic cancers revealed by global genomic analyses
    • DOI10.1126/Science.1164368
    • Jones S, Zhang X, Parsons DW et al (2008) Core signaling pathways in human pancreatic cancers revealed by global genomic analyses. Science DOI10.1126/Science. 1164368
    • (2008) Science
    • Jones, S.1    Zhang, X.2    Parsons, D.W.3
  • 8
    • 42149192000 scopus 로고    scopus 로고
    • Activated kras, but not hras or nras, may initiate tumors of endodermal origin via stem cell expansion
    • Quinlan MP, Quatela SE, Philips MR et al (2008) Activated Kras, but not Hras or Nras, may initiate tumors of endodermal origin via stem cell expansion. Mol Cell Biol 28:2659-2674
    • (2008) Mol Cell Biol , vol.28 , pp. 2659-2674
    • Quinlan, M.P.1    Quatela, S.E.2    Philips, M.R.3
  • 9
    • 44649114063 scopus 로고    scopus 로고
    • Oncogenic kras induces progenitor cell expansion and malignant transformation in zebrafish exocrine pancreas
    • Park SW, Davison JM, Rhee J et al (2008) Oncogenic KRAS induces progenitor cell expansion and malignant transformation in zebrafish exocrine pancreas. Gastroenterology 134:2080-2090
    • (2008) Gastroenterology , vol.134 , pp. 2080-2090
    • Park, S.W.1    Davison, J.M.2    Rhee, J.3
  • 10
    • 54949125004 scopus 로고    scopus 로고
    • Analysis of ccn2 promoter activity in panc-1 cells: Regulation by ras/mek/erk
    • Pickles M, Leask A (2007) Analysis of CCN2 promoter activity in PANC-1 cells: regulation by ras/MEK/ERK. J Cell Commun Signal 1:85-90
    • (2007) J Cell Commun Signal , vol.1 , pp. 85-90
    • Pickles, M.1    Leask, A.2
  • 11
    • 33745078936 scopus 로고    scopus 로고
    • Connective tissue growth factor-specific antibody attenuates tumor growth, metastasis, and angiogenesis in an orthotopic mouse model of pancreatic cancer
    • Aikawa T, Gunn J, Spong SM et al (2006) Connective tissue growth factor-specific antibody attenuates tumor growth, metastasis, and angiogenesis in an orthotopic mouse model of pancreatic cancer. Mol Cancer Ther 5:1108-1116
    • (2006) Mol Cancer Ther , vol.5 , pp. 1108-1116
    • Aikawa, T.1    Gunn, J.2    Spong, S.M.3
  • 12
    • 34347253037 scopus 로고    scopus 로고
    • Oncogenic kras activates hedgehog signaling pathway in pancreatic cancer cells
    • Ji Z, Mei FC, Xie J et al (2007) Oncogenic KRAS activates hedgehog signaling pathway in pancreatic cancer cells. J Biol Chem 282:14048-14055
    • (2007) J Biol Chem , vol.282 , pp. 14048-14055
    • Ji, Z.1    Mei, F.C.2    Xie, J.3
  • 13
    • 33750504838 scopus 로고    scopus 로고
    • Cyclin e expression and outcome in pancreatic ductal adenocarcinoma
    • Skalicky DA, Kench JG, Segara D et al (2006) Cyclin E expression and outcome in pancreatic ductal adenocarcinoma. Cancer Epidemiol Biomarkers Prev 15:1941-1947
    • (2006) Cancer Epidemiol Biomarkers Prev , vol.15 , pp. 1941-1947
    • Skalicky, D.A.1    Kench, J.G.2    Segara, D.3
  • 14
    • 0036110390 scopus 로고    scopus 로고
    • Cyclin d regulates fgfr-1 isoforms iiic and iiib (isoform iiic enhances and fgfr1-iiib inhibits pancreatic cancer cell growth
    • Biankin AV, Biankin SA, Kench JG et al (2002) Cyclin D regulates FGFR-1 isoforms IIIc and IIIb (isoform IIIc enhances and FGFR1-IIIb inhibits pancreatic cancer cell growth. Gut 50:861-868
    • (2002) Gut , vol.50 , pp. 861-868
    • Biankin, A.V.1    Biankin, S.A.2    Kench, J.G.3
  • 15
    • 55949100561 scopus 로고    scopus 로고
    • Exon iii splicing of fibroblast growth factor receptor 1 is modulated by growth factors and cyclin d1
    • Chen G, Wang J, Liu Z et al (2008) Exon III splicing of fibroblast growth factor receptor 1 is modulated by growth factors and cyclin D1. Pancreas 37:159-164
    • (2008) Pancreas , vol.37 , pp. 159-164
    • Chen, G.1    Wang, J.2    Liu, Z.3
  • 16
    • 34547932065 scopus 로고    scopus 로고
    • Solid pseudopapillary neoplasms of the pancreas show an interruption of the wnt-signaling pathway and express gene products of 11q
    • Tiemann K, Heitling U, Kosmahl M et al (2007) Solid pseudopapillary neoplasms of the pancreas show an interruption of the Wnt-signaling pathway and express gene products of 11q. Mod Pa-thol 20:955-960
    • (2007) Mod Pa-thol , vol.20 , pp. 955-960
    • Tiemann, K.1    Heitling, U.2    Kosmahl, M.3
  • 17
    • 9144224192 scopus 로고    scopus 로고
    • Ink4/arf germline alterations in pancreatic cancer patients
    • Ghiorzo P, Pastorino L, Bonelli L et al (2004) INK4/ARF germline alterations in pancreatic cancer patients. Ann Oncol 15:70-78
    • (2004) Ann Oncol , vol.15 , pp. 70-78
    • Ghiorzo, P.1    Pastorino, L.2    Bonelli, L.3
  • 18
    • 0032222915 scopus 로고    scopus 로고
    • Novel germline p16(ink4) allele (asp145cys) in a family with multiple pancreatic carcinomas. Mutations in brief no. 148
    • Moskaluk CA, Hruban H, Lietman A et al (1998) Novel germline p16(INK4) allele (Asp145Cys) in a family with multiple pancreatic carcinomas. Mutations in brief no. 148. Hum Mutat 12:70
    • (1998) Hum Mutat , vol.12 , pp. 70
    • Moskaluk, C.A.1    Hruban, H.2    Lietman, A.3
  • 19
    • 0028308492 scopus 로고
    • P53 mutations in pancreatic carcinoma and evidence of common involvement of homocopolymer tracts in dna microdeletions
    • Redston MS, Caldas C, Seymour AB et al (1994) p53 mutations in pancreatic carcinoma and evidence of common involvement of homocopolymer tracts in DNA microdeletions. Cancer Res 54: 3025-3033
    • (1994) Cancer Res , vol.54 , pp. 3025-3033
    • Redston, M.S.1    Caldas, C.2    Seymour, A.B.3
  • 20
    • 53049095294 scopus 로고    scopus 로고
    • Suppression of inhibitor of differentiation 2, a target of mutant p53, is required for gain-of-function mutations
    • Yan W, Liu G, Scoumanne A et al (2008) Suppression of inhibitor of differentiation 2, a target of mutant p53, is required for gain-of-function mutations. Cancer Res 68:6789-6796
    • (2008) Cancer Res , vol.68 , pp. 6789-6796
    • Yan, W.1    Liu, G.2    Scoumanne, A.3
  • 21
    • 34547686211 scopus 로고    scopus 로고
    • The role of the dna damage checkpoint pathway in intraductal papillary mucinous neoplasms of the pancreas
    • Miyasaka Y, Nagai E, Yamaguchi H et al (2007) The role of the DNA damage checkpoint pathway in intraductal papillary mucinous neoplasms of the pancreas. Clin Cancer Res 13:4371-4377
    • (2007) Clin Cancer Res , vol.13 , pp. 4371-4377
    • Miyasaka, Y.1    Nagai, E.2    Yamaguchi, H.3
  • 22
    • 0038179900 scopus 로고    scopus 로고
    • Molecular profiling of pancreatic adenocarcinoma and chronic pancreatitis identifies multiple genes differentially regulated in pancreatic cancer
    • Logsdon CD, Simeone DM, Binkley C et al (2003) Molecular profiling of pancreatic adenocarcinoma and chronic pancreatitis identifies multiple genes differentially regulated in pancreatic cancer. Cancer Res 63:2649-2657
    • (2003) Cancer Res , vol.63 , pp. 2649-2657
    • Logsdon, C.D.1    Simeone, D.M.2    Binkley, C.3
  • 23
    • 4544269166 scopus 로고    scopus 로고
    • Enhanced expression of 14-3-3sigma in pancreatic cancer and its role in cell cycle regulation and apoptosis
    • Guweidhi A, Kleeff J, Giese N et al (2004) Enhanced expression of 14-3-3sigma in pancreatic cancer and its role in cell cycle regulation and apoptosis. Carcinogenesis 25:1575-1585
    • (2004) Carcinogenesis , vol.25 , pp. 1575-1585
    • Guweidhi, A.1    Kleeff, J.2    Giese, N.3
  • 24
    • 0032014216 scopus 로고    scopus 로고
    • Human smad3 and smad4 are sequence-specific transcription activators
    • Zawel L, Dai JL, Buckhaults P et al (1998) Human Smad3 and Smad4 are sequence-specific transcription activators. Mol Cell 1:611-617
    • (1998) Mol Cell , vol.1 , pp. 611-617
    • Zawel, L.1    Dai, J.L.2    Buckhaults, P.3
  • 25
    • 0036848885 scopus 로고    scopus 로고
    • Suppression of tumorigenesis and induction of p15(ink4b) by smad4/dpc4 in human pancreatic cancer cells
    • Peng B, Fleming JB, Breslin T et al (2002) Suppression of tumorigenesis and induction of p15(ink4b) by Smad4/DPC4 in human pancreatic cancer cells. Clin Cancer Res 8:3628-3638
    • (2002) Clin Cancer Res , vol.8 , pp. 3628-3638
    • Peng, B.1    Fleming, J.B.2    Breslin, T.3
  • 26
    • 49249095430 scopus 로고    scopus 로고
    • Inhibition of stat3 tyr705 phosphorylation by smad4 suppresses transforming growth factor beta-mediated invasion and metastasis in pancreatic cancer cells
    • Zhao S, Venkatasubbarao K, Lazor JW et al (2008) Inhibition of STAT3 Tyr705 phosphorylation by Smad4 suppresses transforming growth factor beta-mediated invasion and metastasis in pancreatic cancer cells. Cancer Res 68:4221-4228
    • (2008) Cancer Res , vol.68 , pp. 4221-4228
    • Zhao, S.1    Venkatasubbarao, K.2    Lazor, J.W.3
  • 27
    • 6044241807 scopus 로고    scopus 로고
    • The correlation between cytoplasmic overexpression of epidermal growth factor receptor and tumor aggressiveness: Poor prognosis in patients with pancreatic ductal adenocarcinoma
    • Ueda S, Ogata S, Tsuda H et al (2004) The correlation between cytoplasmic overexpression of epidermal growth factor receptor and tumor aggressiveness: poor prognosis in patients with pancreatic ductal adenocarcinoma. Pancreas 29: e1-8
    • (2004) Pancreas , vol.29
    • Ueda, S.1    Ogata, S.2    Tsuda, H.3
  • 28
    • 34249933404 scopus 로고    scopus 로고
    • Erlotinib plus gemcitabine compared with gemcitabine alone in patients with advanced pancreatic cancer: A phase iii trial of the national cancer institute of canada clinical trials group
    • Moore MJ, Goldstein D, Hamm J et al (2007) Erlotinib plus gemcitabine compared with gemcitabine alone in patients with advanced pancreatic cancer: a phase III trial of the National Cancer Institute of Canada Clinical Trials Group. J Clin Oncol 25:1960-1966
    • (2007) J Clin Oncol , vol.25 , pp. 1960-1966
    • Moore, M.J.1    Goldstein, D.2    Hamm, J.3
  • 29
    • 34548205213 scopus 로고    scopus 로고
    • Concomitant pancreatic activation of kras(g12d) and tgfa results in cystic papillary neoplasms reminiscent of human ipmn
    • Siveke JT, Einwächter H, Sipos B et al (2007) Concomitant pancreatic activation of Kras(G12D) and Tgfa results in cystic papillary neoplasms reminiscent of human IPMN. Cancer Cell 12: 266-279
    • (2007) Cancer Cell , vol.12 , pp. 266-279
    • Siveke, J.T.1    Einwächter, H.2    Sipos, B.3
  • 30
    • 0242690240 scopus 로고    scopus 로고
    • Murine pancreatic tumor cell line td2 bears the characteristic pattern of genetic changes with two independently amplified gene loci
    • Schreiner B, Greten FR, Baur DM et al (2003) Murine pancreatic tumor cell line TD2 bears the characteristic pattern of genetic changes with two independently amplified gene loci. Oncogene 22:6802-6809
    • (2003) Oncogene , vol.22 , pp. 6802-6809
    • Schreiner, B.1    Greten, F.R.2    Baur, D.M.3
  • 31
    • 33947322389 scopus 로고    scopus 로고
    • Epidermal growth factor receptor (egfr) is highly conserved in pancreatic cancer
    • Tzeng CW, Frolov A, Frolova N et al (2007) Epidermal growth factor receptor (EGFR) is highly conserved in pancreatic cancer. Surgery 141:464-469
    • (2007) Surgery , vol.141 , pp. 464-469
    • Tzeng, C.W.1    Frolov, A.2    Frolova, N.3
  • 32
    • 35248866321 scopus 로고    scopus 로고
    • Egfr genomic gain and aberrant pathway signaling in pancreatic cancer patients
    • Tzeng CW, Frolov A, Frolova N et al (2007) EGFR genomic gain and aberrant pathway signaling in pancreatic cancer patients. J Surg Res 143: 20-26
    • (2007) J Surg Res , vol.143 , pp. 20-26
    • Tzeng, C.W.1    Frolov, A.2    Frolova, N.3
  • 33
    • 3042743983 scopus 로고    scopus 로고
    • Genomic dna-chip hybridization reveals a higher incidence of genomic amplifications in pancreatic cancer than conventional comparative genomic hybridization and leads to the identification of novel candidate genes
    • Holzmann K, Kohlhammer H, Schwaenen C et al (2004) Genomic DNA-chip hybridization reveals a higher incidence of genomic amplifications in pancreatic cancer than conventional comparative genomic hybridization and leads to the identification of novel candidate genes. Cancer Res 64: 4428-4433
    • (2004) Cancer Res , vol.64 , pp. 4428-4433
    • Holzmann, K.1    Kohlhammer, H.2    Schwaenen, C.3
  • 34
    • 33645748963 scopus 로고    scopus 로고
    • Transforming growth factor alpha expression drives constitutive epidermal growth factor receptor pathway activation and sensitivity to gefitinib (iressa) in human pancreatic cancer cell lines
    • Pino MS, Shrader M, Baker CH et al (2006) Transforming growth factor alpha expression drives constitutive epidermal growth factor receptor pathway activation and sensitivity to gefitinib (Iressa) in human pancreatic cancer cell lines. Cancer Res 66:3802-3812
    • (2006) Cancer Res , vol.66 , pp. 3802-3812
    • Pino, M.S.1    Shrader, M.2    Baker, C.H.3
  • 35
    • 33846220461 scopus 로고    scopus 로고
    • Epidermal growth factor receptor kinase domain mutations in esophageal and pancreatic adenocarcinomas
    • Kwak EL, Jankowski J, Thayer SP et al (2006) Epidermal growth factor receptor kinase domain mutations in esophageal and pancreatic adenocarcinomas. Clin Cancer Res 12:4283-4287
    • (2006) Clin Cancer Res , vol.12 , pp. 4283-4287
    • Kwak, E.L.1    Jankowski, J.2    Thayer, S.P.3
  • 36
    • 34548128023 scopus 로고    scopus 로고
    • Activation of the epidermal growth factor signalling pathway by tissue plasminogen activator in pancreas cancer cells
    • Hurtado M, Lozano JJ, Castellanos E et al (2007) Activation of the epidermal growth factor signalling pathway by tissue plasminogen activator in pancreas cancer cells. Gut 56:1266-1274
    • (2007) Gut , vol.56 , pp. 1266-1274
    • Hurtado, M.1    Lozano, J.J.2    Castellanos, E.3
  • 37
    • 43149117047 scopus 로고    scopus 로고
    • Characterization of the cxcr4 signaling in pancreatic cancer cells
    • Billadeau DD, Chatterjee S, Bramati P et al (2006) Characterization of the CXCR4 signaling in pancreatic cancer cells. Int J Gastrointest Cancer 37:110-119
    • (2006) Int J Gastrointest Cancer , vol.37 , pp. 110-119
    • Billadeau, D.D.1    Chatterjee, S.2    Bramati, P.3
  • 38
    • 28644440697 scopus 로고    scopus 로고
    • Involvement of mmp-7 in invasion of pancreatic cancer cells through activation of the egfr mediated mekerk signal transduction pathway
    • Tan X, Egami H, Abe M et al (2005) Involvement of MMP-7 in invasion of pancreatic cancer cells through activation of the EGFR mediated MEKERK signal transduction pathway. J Clin Pathol 58:1242-1248
    • (2005) J Clin Pathol , vol.58 , pp. 1242-1248
    • Tan, X.1    Egami, H.2    Abe, M.3
  • 39
    • 24344473824 scopus 로고    scopus 로고
    • Correlation of translocation of tight junction protein zonula occludens-1 and activation of epidermal growth factor receptor in the regulation of invasion of pancreatic cancer cells
    • Takai E, Tan X, Tamori Y et al (2005) Correlation of translocation of tight junction protein Zonula occludens-1 and activation of epidermal growth factor receptor in the regulation of invasion of pancreatic cancer cells. Int J Oncol 27: 645-651
    • (2005) Int J Oncol , vol.27 , pp. 645-651
    • Takai, E.1    Tan, X.2    Tamori, Y.3
  • 40
    • 42349093818 scopus 로고    scopus 로고
    • Coordinated epidermal growth factor receptor pathway gene overexpression predicts epidermal growth factor receptor inhibitor sensitivity in pancreatic cancer
    • Jimeno A, Tan AC, Coffa J et al (2008) Coordinated epidermal growth factor receptor pathway gene overexpression predicts epidermal growth factor receptor inhibitor sensitivity in pancreatic cancer. Cancer Res 68:2841-2849
    • (2008) Cancer Res , vol.68 , pp. 2841-2849
    • Jimeno, A.1    Tan, A.C.2    Coffa, J.3
  • 41
    • 52649173202 scopus 로고    scopus 로고
    • Proteasome inhibition activates epidermal growth factor receptor (egfr) and egfr-independent mitogenic kinase signaling pathways in pancreatic cancer cells
    • Sloss CM, Wang F, Liu R et al (2008) Proteasome inhibition activates epidermal growth factor receptor (EGFR) and EGFR-independent mitogenic kinase signaling pathways in pancreatic cancer cells. Clin Cancer Res 14:5116-5123
    • (2008) Clin Cancer Res , vol.14 , pp. 5116-5123
    • Sloss, C.M.1    Wang, F.2    Liu, R.3
  • 42
    • 0344873744 scopus 로고    scopus 로고
    • Autocrine-mediated erbb-2 kinase activation of stat3 is required for growth factor independence of pancreatic cancer cell lines
    • DeArmond D, Brattain MG, Jessup JM et al (2003) Autocrine-mediated ErbB-2 kinase activation of STAT3 is required for growth factor independence of pancreatic cancer cell lines. Oncogene 22:7781-7795
    • (2003) Oncogene , vol.22 , pp. 7781-7795
    • DeArmond, D.1    Brattain, M.G.2    Jessup, J.M.3
  • 43
    • 34548291991 scopus 로고    scopus 로고
    • Overexpression of erbb2 in the exocrine pancreas induces an inflammatory response but not increased proliferation
    • Algül H, Wagner M, Lesina M et al (2007) Overexpression of ErbB2 in the exocrine pancreas induces an inflammatory response but not increased proliferation. Int J Cancer 121:1410-1416
    • (2007) Int J Cancer , vol.121 , pp. 1410-1416
    • Algül, H.1    Wagner, M.2    Lesina, M.3
  • 44
    • 33748361817 scopus 로고    scopus 로고
    • Inactivation of akt by the epidermal growth factor receptor inhibitor erlotinib is mediated by her-3 in pancreatic and colorectal tumor cell lines and contributes to erlotinib sensitivity
    • Buck E, Eyzaguirre A, Haley JD et al (2006) Inactivation of Akt by the epidermal growth factor receptor inhibitor erlotinib is mediated by HER-3 in pancreatic and colorectal tumor cell lines and contributes to erlotinib sensitivity. Mol Cancer Ther 5:2051-2059
    • (2006) Mol Cancer Ther , vol.5 , pp. 2051-2059
    • Buck, E.1    Eyzaguirre, A.2    Haley, J.D.3
  • 45
    • 3042561471 scopus 로고    scopus 로고
    • Tumor hypoxia correlates with metastatic tumor growth of pancreatic cancer in an orthotopic murine model
    • Büchler P, Reber HA, Lavey RS et al (2004) Tumor hypoxia correlates with metastatic tumor growth of pancreatic cancer in an orthotopic murine model. J Surg Res 120:295-303
    • (2004) J Surg Res , vol.120 , pp. 295-303
    • Büchler, P.1    Reber, H.A.2    Lavey, R.S.3
  • 46
    • 0037134709 scopus 로고    scopus 로고
    • Clinical application of antiangiogenic therapy: Microvessel density, what it does and doesn't tell us
    • Hlatky L, Hahnfeldt P, Folkman J (2002) Clinical application of antiangiogenic therapy: microvessel density, what it does and doesn't tell us. J Natl Cancer Inst 94:883-893
    • (2002) J Natl Cancer Inst , vol.94 , pp. 883-893
    • Hlatky, L.1    Hahnfeldt, P.2    Folkman, J.3
  • 47
    • 0034657029 scopus 로고    scopus 로고
    • High expression of vascular endothelial growth factor is associated with liver metastasis and a poor prognosis for patients with ductal pancreatic adenocarcinoma
    • Seo Y, Baba H, Fukuda T et al (2000) High expression of vascular endothelial growth factor is associated with liver metastasis and a poor prognosis for patients with ductal pancreatic adenocarcinoma. Cancer 88:2239-2245
    • (2000) Cancer , vol.88 , pp. 2239-2245
    • Seo, Y.1    Baba, H.2    Fukuda, T.3
  • 48
    • 0036894180 scopus 로고    scopus 로고
    • Vegf-rii influences the prognosis of pancreatic cancer
    • Büchler P, Reber HA, Büchler MW et al (2002) VEGF-RII influences the prognosis of pancreatic cancer. Ann Surg 236:738-749
    • (2002) Ann Surg , vol.236 , pp. 738-749
    • Büchler, P.1    Reber, H.A.2    Büchler, M.W.3
  • 49
    • 0842268386 scopus 로고    scopus 로고
    • Aberrant expression of neuropilin-1 and -2 in human pancreatic cancer cells
    • Fukahi K, Fukasawa M, Neufeld G et al (2004) Aberrant expression of neuropilin-1 and -2 in human pancreatic cancer cells. Clin Cancer Res 10: 581-590
    • (2004) Clin Cancer Res , vol.10 , pp. 581-590
    • Fukahi, K.1    Fukasawa, M.2    Neufeld, G.3
  • 50
    • 33644975393 scopus 로고    scopus 로고
    • Anti-angiogenesis therapy in pancreatic carcinoma
    • Saif MW (2006) Anti-angiogenesis therapy in pancreatic carcinoma. JOP 7:163-173
    • (2006) JOP , vol.7 , pp. 163-173
    • Saif, M.W.1
  • 51
    • 34547662268 scopus 로고    scopus 로고
    • Overexpression of pdgf-bb decreases colorectal and pancreatic cancer growth by increasing tumor pericyte content
    • McCarty MF, Somcio RJ, Stoeltzing O et al (2007) Overexpression of PDGF-BB decreases colorectal and pancreatic cancer growth by increasing tumor pericyte content. J Clin Invest 117: 2114-2122
    • (2007) J Clin Invest , vol.117 , pp. 2114-2122
    • McCarty, M.F.1    Somcio, R.J.2    Stoeltzing, O.3
  • 52
    • 34247853560 scopus 로고    scopus 로고
    • An antibody directed against pdgf receptor beta enhances the antitumor and the anti-angiogenic activities of an anti-vegf receptor 2 antibody
    • Shen J, Vil MD, Zhang H et al (2007) An antibody directed against PDGF receptor beta enhances the antitumor and the anti-angiogenic activities of an anti-VEGF receptor 2 antibody. Biochem Biophys Res Commun 357:1142-1147
    • (2007) Biochem Biophys Res Commun , vol.357 , pp. 1142-1147
    • Shen, J.1    Vil, M.D.2    Zhang, H.3
  • 53
    • 2642547301 scopus 로고    scopus 로고
    • Inflammatory cells contribute to the generation of an angiogenic phenotype in pancreatic ductal adenocarcinoma
    • Esposito I, Menicagli M, Funel N et al (2004) Inflammatory cells contribute to the generation of an angiogenic phenotype in pancreatic ductal adenocarcinoma. J Clin Pathol 57:630-636
    • (2004) J Clin Pathol , vol.57 , pp. 630-636
    • Esposito, I.1    Menicagli, M.2    Funel, N.3
  • 54
    • 0035902805 scopus 로고    scopus 로고
    • Enhanced vegf production and decreased immunogenicity induced by tgf-beta 1 promote liver metastasis of pancreatic cancer
    • Teraoka H, Sawada T, Nishihara T et al (2001) Enhanced VEGF production and decreased immunogenicity induced by TGF-beta 1 promote liver metastasis of pancreatic cancer. Br J Cancer 85:612-617
    • (2001) Br J Cancer , vol.85 , pp. 612-617
    • Teraoka, H.1    Sawada, T.2    Nishihara, T.3
  • 55
    • 47949099628 scopus 로고    scopus 로고
    • Modes of resistance to anti-angiogenic therapy
    • Bergers G, Hanahan D (2008) Modes of resistance to anti-angiogenic therapy. Nat Rev Cancer 8:592-603
    • (2008) Nat Rev Cancer , vol.8 , pp. 592-603
    • Bergers, G.1    Hanahan, D.2
  • 56
    • 45549106185 scopus 로고    scopus 로고
    • Mutational analyses of multiple oncogenic pathways in intraductal papillary mucinous neoplasms of the pancreas
    • Schönleben F, Allendorf JD, Qiu W et al (2008) Mutational analyses of multiple oncogenic pathways in intraductal papillary mucinous neoplasms of the pancreas. Pancreas 36:168-172
    • (2008) Pancreas , vol.36 , pp. 168-172
    • Schönleben, F.1    Allendorf, J.D.2    Qiu, W.3
  • 57
    • 43349105069 scopus 로고    scopus 로고
    • Pik3ca, kras, and braf mutations in intraductal papillary mucinous neoplasm/carcinoma (ipmn/c) of the pancreas
    • Schönleben F, Qiu W, Remotti HE et al (2008) PIK3CA, KRAS, and BRAF mutations in intraductal papillary mucinous neoplasm/carcinoma (IPMN/C) of the pancreas. Langenbecks Arch Surg 393:289-296
    • (2008) Langenbecks Arch Surg , vol.393 , pp. 289-296
    • Schönleben, F.1    Qiu, W.2    Remotti, H.E.3
  • 58
    • 42649125571 scopus 로고    scopus 로고
    • Differential effects of oncogenic k-ras and nras on proliferation, differentiation and tumor progression in the colon
    • Haigis KM, Kendall KR, Wang Y et al (2008) Differential effects of oncogenic K-Ras and NRas on proliferation, differentiation and tumor progression in the colon. Nat Genet 40:600-608
    • (2008) Nat Genet , vol.40 , pp. 600-608
    • Haigis, K.M.1    Kendall, K.R.2    Wang, Y.3
  • 59
    • 34447126386 scopus 로고    scopus 로고
    • Neurotensin is a versatile modulator of in vitro human pancreatic ductal adenocarcinoma cell (pdac) migration
    • Mijatovic T, Gailly P, Mathieu V et al (2007) Neurotensin is a versatile modulator of in vitro human pancreatic ductal adenocarcinoma cell (PDAC) migration. Cell Oncol 29:315-326
    • (2007) Cell Oncol , vol.29 , pp. 315-326
    • Mijatovic, T.1    Gailly, P.2    Mathieu, V.3
  • 60
    • 34249335357 scopus 로고    scopus 로고
    • Fbox protein skp2, an oncogene up-regulated in pdac, is transcriptionally regulated by the pi3k/akt1 pathway in pdac cells
    • Reichert M, Saur D, Hamacher R et al (2007) Fbox protein SKP2, an oncogene up-regulated in PDAC, is transcriptionally regulated by the PI3K/AKT1 pathway in PDAC cells. Cancer Res 67:4149-4156
    • (2007) Cancer Res , vol.67 , pp. 4149-4156
    • Reichert, M.1    Saur, D.2    Hamacher, R.3
  • 61
    • 42349112613 scopus 로고    scopus 로고
    • Muc1 expression is regulated by dna methylation and histone h3 lysine 9 modification in cancer cells
    • Yamada N, Nishida Y, Tsutsumida H et al (2008) MUC1 expression is regulated by DNA methylation and histone H3 lysine 9 modification in cancer cells. Cancer Res 68:2708-2716
    • (2008) Cancer Res , vol.68 , pp. 2708-2716
    • Yamada, N.1    Nishida, Y.2    Tsutsumida, H.3
  • 62
    • 33748482616 scopus 로고    scopus 로고
    • Muc2 expression is regulated by histone h3 modification and dna methylation in pancreatic cancer
    • Yamada N, Hamada T, Goto M et al (2006) MUC2 expression is regulated by histone H3 modification and DNA methylation in pancreatic cancer. Int J Cancer 119:1850-1857
    • (2006) Int J Cancer , vol.119 , pp. 1850-1857
    • Yamada, N.1    Hamada, T.2    Goto, M.3
  • 63
    • 36249016867 scopus 로고    scopus 로고
    • Ap-2alpha is an important in vivo negative regulator of muc4 expression in human pancreatic tissue and that ap-2alpha may play a tumoursuppressive role in pancreatic dac
    • Fauquette V, Aubert S, Groux-Degroote S et al (2007) AP-2alpha is an important in vivo negative regulator of MUC4 expression in human pancreatic tissue and that AP-2alpha may play a tumoursuppressive role in pancreatic DAC. Carcinogenesis 28:2305-2312
    • (2007) Carcinogenesis , vol.28 , pp. 2305-2312
    • Fauquette, V.1    Aubert, S.2    Groux-Degroote, S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.