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Volumn 28, Issue 11, 2007, Pages 2305-2312

Transcription factor AP-2α represses both the mucin MUC4 expression and pancreatic cancer cell proliferation

Author keywords

[No Author keywords available]

Indexed keywords

APOMUCIN; CIS ACTING ELEMENT; CYCLIN DEPENDENT KINASE INHIBITOR 1B; MESSENGER RNA; MUCIN; MUCIN 4; TRANSCRIPTION FACTOR AP 2; TRANSCRIPTION FACTOR AP 2ALPHA; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG;

EID: 36249016867     PISSN: 01433334     EISSN: 14602180     Source Type: Journal    
DOI: 10.1093/carcin/bgm158     Document Type: Article
Times cited : (28)

References (37)
  • 1
    • 1842483164 scopus 로고    scopus 로고
    • Pancreatic intraepithelial neoplasia
    • Takaori,K. et al. (2004) Pancreatic intraepithelial neoplasia. Pancreas, 28, 257-262.
    • (2004) Pancreas , vol.28 , pp. 257-262
    • Takaori, K.1
  • 2
    • 33645734522 scopus 로고    scopus 로고
    • Targeting transcription factors for cancer gene therapy
    • Libermann,T.A. et al. (2006) Targeting transcription factors for cancer gene therapy. Curr. Gene Ther., 6, 17-33.
    • (2006) Curr. Gene Ther , vol.6 , pp. 17-33
    • Libermann, T.A.1
  • 3
    • 33746234890 scopus 로고    scopus 로고
    • The AP-2 family of transcription factors
    • Eckert,D. et al. (2005) The AP-2 family of transcription factors. Genome Biol., 6, 246.
    • (2005) Genome Biol , vol.6 , pp. 246
    • Eckert, D.1
  • 4
    • 0037163074 scopus 로고    scopus 로고
    • Transcription factor AP-2 interacts with the SUMO-conjugating enzyme UBC9 and is sumolated in vivo
    • Eloranda,J.J. et al. (2002) Transcription factor AP-2 interacts with the SUMO-conjugating enzyme UBC9 and is sumolated in vivo. J. Biol. Chem., 277, 30798-30804.
    • (2002) J. Biol. Chem , vol.277 , pp. 30798-30804
    • Eloranda, J.J.1
  • 5
    • 0034736585 scopus 로고    scopus 로고
    • Regulatory roles of AP-2 transcription factors in vertebrate development, apoptosis and cell-cycle control
    • Hilger-Eversheim,K. et al. (2000) Regulatory roles of AP-2 transcription factors in vertebrate development, apoptosis and cell-cycle control. Gene, 260, 1-12.
    • (2000) Gene , vol.260 , pp. 1-12
    • Hilger-Eversheim, K.1
  • 6
    • 0035821787 scopus 로고    scopus 로고
    • Dominant-negative transcription factor AP-2 augments SB-2 melanoma tumor growth in vivo
    • Gershenwald,J.E. et al. (2001) Dominant-negative transcription factor AP-2 augments SB-2 melanoma tumor growth in vivo. Oncogene, 20, 3363-3375.
    • (2001) Oncogene , vol.20 , pp. 3363-3375
    • Gershenwald, J.E.1
  • 7
    • 0032568937 scopus 로고    scopus 로고
    • Loss of AP-2 results in up-regulation of MCAM/MUC18 and an increase in tumour growth and metastasis of human melanoma cells
    • Jean,D. et al. (1998) Loss of AP-2 results in up-regulation of MCAM/MUC18 and an increase in tumour growth and metastasis of human melanoma cells. J. Biol. Chem., 273, 16501-16508.
    • (1998) J. Biol. Chem , vol.273 , pp. 16501-16508
    • Jean, D.1
  • 8
    • 3843146276 scopus 로고    scopus 로고
    • Suppression of invasion and peritoneal carcinomatosis of ovarian cancer cells by overexpression of AP-2alpha
    • Sumigama,S. et al. (2004) Suppression of invasion and peritoneal carcinomatosis of ovarian cancer cells by overexpression of AP-2alpha. Oncogene, 23, 5496-5504.
    • (2004) Oncogene , vol.23 , pp. 5496-5504
    • Sumigama, S.1
  • 9
    • 0037442825 scopus 로고    scopus 로고
    • Identification of HTF (HER2 transcription factor) as an AP-2 (activator protein-2) transcription factor and contribution of the HTF binding site to ERBB2 gene overexpression
    • Vernimmen,D. et al. (2003) Identification of HTF (HER2 transcription factor) as an AP-2 (activator protein-2) transcription factor and contribution of the HTF binding site to ERBB2 gene overexpression. Biochem. J., 370, 323-329.
    • (2003) Biochem. J , vol.370 , pp. 323-329
    • Vernimmen, D.1
  • 10
    • 0033105407 scopus 로고    scopus 로고
    • Complete sequence of the human mucin MUC4: A putative cell membrane-associated mucin
    • Moniaux,N. et al. (1999) Complete sequence of the human mucin MUC4: A putative cell membrane-associated mucin. Biochem. J., 338, 325-333.
    • (1999) Biochem. J , vol.338 , pp. 325-333
    • Moniaux, N.1
  • 11
    • 0033605267 scopus 로고    scopus 로고
    • Carraway,K.L.3rd et al. (1999) An intramembrane modulator of the ErbB2 receptor tyrosine kinase that potentiates neuregulin signaling. J. Biol. Chem., 274, 5263-5266.
    • Carraway,K.L.3rd et al. (1999) An intramembrane modulator of the ErbB2 receptor tyrosine kinase that potentiates neuregulin signaling. J. Biol. Chem., 274, 5263-5266.
  • 12
    • 0029162381 scopus 로고
    • In situ hybridization shows distinct patterns of mucin gene expression in normal, benign, and malignant pancreatic tissues
    • Balagué,C. et al. (1995) In situ hybridization shows distinct patterns of mucin gene expression in normal, benign, and malignant pancreatic tissues. Gastroenterology, 109, 953-964.
    • (1995) Gastroenterology , vol.109 , pp. 953-964
    • Balagué, C.1
  • 13
    • 0035678782 scopus 로고    scopus 로고
    • Mucin (MUC) gene expression in human pancreatic adenocarcinoma and chronic pancreatitis: A potential role of MUC4 as a tumour marker of diagnostic significance
    • Andrianafahanana,M. et al. (2001) Mucin (MUC) gene expression in human pancreatic adenocarcinoma and chronic pancreatitis: A potential role of MUC4 as a tumour marker of diagnostic significance. Clin. Cancer Res., 7, 4033-4040.
    • (2001) Clin. Cancer Res , vol.7 , pp. 4033-4040
    • Andrianafahanana, M.1
  • 14
    • 0036233702 scopus 로고    scopus 로고
    • MUC4 expression increases progressively in pancreatic intraepithelial neoplasia
    • Swartz,M.J. et al. (2002) MUC4 expression increases progressively in pancreatic intraepithelial neoplasia. Am. J. Clin. Pathol., 117, 791-796.
    • (2002) Am. J. Clin. Pathol , vol.117 , pp. 791-796
    • Swartz, M.J.1
  • 15
    • 23444448425 scopus 로고    scopus 로고
    • MUC4 expression is a novel prognostic factor in patients with invasive ductal carcinoma of the pancreas
    • Saitou,M. et al. (2005) MUC4 expression is a novel prognostic factor in patients with invasive ductal carcinoma of the pancreas. J. Clin. Pathol., 58, 845-852.
    • (2005) J. Clin. Pathol , vol.58 , pp. 845-852
    • Saitou, M.1
  • 16
    • 0035903173 scopus 로고    scopus 로고
    • Characterisation of human mucin gene MUC4 promoter: Importance of growth factors and proinflammatory cytokines for its regulation in pancreatic cancer cells
    • Perrais,M. et al. (2001) Characterisation of human mucin gene MUC4 promoter: Importance of growth factors and proinflammatory cytokines for its regulation in pancreatic cancer cells. J. Biol. Chem., 276 30923-30933.
    • (2001) J. Biol. Chem , vol.276 , pp. 30923-30933
    • Perrais, M.1
  • 17
    • 10744219516 scopus 로고    scopus 로고
    • Transcriptional regulation of human mucin MUC4 by bile acids in oesophagus cancer cells is promoter dependent and involves activation of phosphatidylinositol 3-kinase signalling pathway
    • Mariette,C. et al. (2004) Transcriptional regulation of human mucin MUC4 by bile acids in oesophagus cancer cells is promoter dependent and involves activation of phosphatidylinositol 3-kinase signalling pathway. Biochem. J., 377, 1-8.
    • (2004) Biochem. J , vol.377 , pp. 1-8
    • Mariette, C.1
  • 18
    • 8444227379 scopus 로고    scopus 로고
    • The murine Muc2 mucin gene is transcriptionally regulated by the zinc-finger GATA-4 transcription factor in intestinal cells
    • Van der Sluis,M. et al. (2004) The murine Muc2 mucin gene is transcriptionally regulated by the zinc-finger GATA-4 transcription factor in intestinal cells. Biochem. Biophys. Res. Commun., 325 952-960.
    • (2004) Biochem. Biophys. Res. Commun , vol.325 , pp. 952-960
    • Van der Sluis, M.1
  • 19
    • 14244254200 scopus 로고    scopus 로고
    • The antagonist regulation of the human MUC4 and ErbB-2 genes by the Ets protein PEA3 in pancreatic cancer cells: Implications for the proliferation/differentiation balance in the cells
    • Fauquette,V. et al. (2005) The antagonist regulation of the human MUC4 and ErbB-2 genes by the Ets protein PEA3 in pancreatic cancer cells: Implications for the proliferation/differentiation balance in the cells. Biochem. J., 386, 35-45.
    • (2005) Biochem. J , vol.386 , pp. 35-45
    • Fauquette, V.1
  • 20
    • 33846983600 scopus 로고    scopus 로고
    • Regulation of the human mucin MUC4 by taurodeoxycholic and taurochenodeoxycholic bile acids in oesophageal cancer cells is mediated by hepatocyte nuclear factor 1alpha
    • Piessen,G. et al. (2007) Regulation of the human mucin MUC4 by taurodeoxycholic and taurochenodeoxycholic bile acids in oesophageal cancer cells is mediated by hepatocyte nuclear factor 1alpha. Biochem. J., 402, 81-91.
    • (2007) Biochem. J , vol.402 , pp. 81-91
    • Piessen, G.1
  • 21
    • 25444502586 scopus 로고    scopus 로고
    • Activator protein 2alpha status determines the chemosensitivity of cancer cells: Implications in cancer chemotherapy
    • Wajapeyee,N. et al. (2005) Activator protein 2alpha status determines the chemosensitivity of cancer cells: Implications in cancer chemotherapy. Cancer Res., 65, 8628-8634.
    • (2005) Cancer Res , vol.65 , pp. 8628-8634
    • Wajapeyee, N.1
  • 22
    • 0028834524 scopus 로고
    • The K protein domain that recruits the IL-1 responsive K protein kinase lies adjacent to a cluster of c-Src and Vav SH3-binding sites. Implications that K protein acts as a docking platform
    • Van Seuningen,I. et al. (1995) The K protein domain that recruits the IL-1 responsive K protein kinase lies adjacent to a cluster of c-Src and Vav SH3-binding sites. Implications that K protein acts as a docking platform. J. Biol. Chem., 270, 26976-26985.
    • (1995) J. Biol. Chem , vol.270 , pp. 26976-26985
    • Van Seuningen, I.1
  • 23
    • 1642475141 scopus 로고    scopus 로고
    • Inhibition of MUC4 expression suppresses pancreatic tumour cell growth and metastasis
    • Singh,A.P. et al. (2004) Inhibition of MUC4 expression suppresses pancreatic tumour cell growth and metastasis. Cancer Res., 64 622-630.
    • (2004) Cancer Res , vol.64 , pp. 622-630
    • Singh, A.P.1
  • 24
    • 0013197528 scopus 로고    scopus 로고
    • Role and regulation of the thrombin receptor (PAR-1) in human melanoma
    • Tellez,C. et al. (2003) Role and regulation of the thrombin receptor (PAR-1) in human melanoma. Oncogene, 22, 3130-3137.
    • (2003) Oncogene , vol.22 , pp. 3130-3137
    • Tellez, C.1
  • 25
    • 0031012251 scopus 로고    scopus 로고
    • WAF1/CIP1 expression
    • WAF1/CIP1 expression. Nat. Genet, 15, 78-82.
    • (1997) Nat. Genet , vol.15 , pp. 78-82
    • Zeng, Y.X.1
  • 26
    • 34250341812 scopus 로고    scopus 로고
    • Loss of AP-2α results in deregulation of E-cadherin and MMP-9 and an increase in tumorigenicity of colon cancer cells in vivo
    • Schwartz,B. et al. (2007) Loss of AP-2α results in deregulation of E-cadherin and MMP-9 and an increase in tumorigenicity of colon cancer cells in vivo. Oncogene, 26, 4049-4058.
    • (2007) Oncogene , vol.26 , pp. 4049-4058
    • Schwartz, B.1
  • 27
    • 0036201658 scopus 로고    scopus 로고
    • Age related expression of werner's syndrome protein in selected tissues and coexpression of transcription factors
    • Motonaga,K. et al. (2002) Age related expression of werner's syndrome protein in selected tissues and coexpression of transcription factors. J. Clin. Pathol., 55, 195-199.
    • (2002) J. Clin. Pathol , vol.55 , pp. 195-199
    • Motonaga, K.1
  • 28
    • 0035542952 scopus 로고    scopus 로고
    • AP-2α transcription factor expression is associated with luminal differentiation and is lost in prostate cancer
    • Ruiz,M. et al. (2001) AP-2α transcription factor expression is associated with luminal differentiation and is lost in prostate cancer. Clin. Cancer Res., 7, 4086-4095.
    • (2001) Clin. Cancer Res , vol.7 , pp. 4086-4095
    • Ruiz, M.1
  • 29
    • 1242318509 scopus 로고    scopus 로고
    • Downregulation of Muc1 in MMTV-c-Neu tumours
    • Adriance,M.C. et al. (2004) Downregulation of Muc1 in MMTV-c-Neu tumours. Oncogene, 23, 697-705.
    • (2004) Oncogene , vol.23 , pp. 697-705
    • Adriance, M.C.1
  • 30
    • 0037160111 scopus 로고    scopus 로고
    • Tumour suppressor activity of AP-2α mediated through a direct interaction with p53
    • Mc Pherson,L.A. et al. (2002) Tumour suppressor activity of AP-2α mediated through a direct interaction with p53. J. Biol. Chem., 277, 45028-45033.
    • (2002) J. Biol. Chem , vol.277 , pp. 45028-45033
    • Mc Pherson, L.A.1
  • 31
    • 4644266467 scopus 로고    scopus 로고
    • Orthotopic transplantation models of pancreatic adenocarcinoma derived from cell lines and primary tumours and displaying varying metastatic activity
    • Loukopoulos,P. et al. (2004) Orthotopic transplantation models of pancreatic adenocarcinoma derived from cell lines and primary tumours and displaying varying metastatic activity. Pancreas, 29, 193-203.
    • (2004) Pancreas , vol.29 , pp. 193-203
    • Loukopoulos, P.1
  • 32
    • 10244226744 scopus 로고    scopus 로고
    • The effect of adenovirus expressing wild type p53 on 5 fluorouracil chemosensitivity is related to p53 status in pancreatic cancer cell lines
    • Eisold,S. et al. (2004) The effect of adenovirus expressing wild type p53 on 5 fluorouracil chemosensitivity is related to p53 status in pancreatic cancer cell lines. World J. Gastroenterol., 10, 3583-3589.
    • (2004) World J. Gastroenterol , vol.10 , pp. 3583-3589
    • Eisold, S.1
  • 33
    • 0033558373 scopus 로고    scopus 로고
    • Loss of p27Kip1 expression independently predicts poor prognosis for patients with resectable pancreatic adenocarcinoma
    • Lu,C.D. et al. (1999) Loss of p27Kip1 expression independently predicts poor prognosis for patients with resectable pancreatic adenocarcinoma. Cancer, 85, 1250-1260.
    • (1999) Cancer , vol.85 , pp. 1250-1260
    • Lu, C.D.1
  • 34
    • 19644388719 scopus 로고    scopus 로고
    • Pharmacologic inhibition of RAF-MEK-ERK signaling elicits pancreatic cancer cell cycle arrest through induced expression of p27Kip1
    • Gysin,S. et al. (2005) Pharmacologic inhibition of RAF-MEK-ERK signaling elicits pancreatic cancer cell cycle arrest through induced expression of p27Kip1. Cancer Res., 65, 4870-4880.
    • (2005) Cancer Res , vol.65 , pp. 4870-4880
    • Gysin, S.1
  • 35
    • 0030756064 scopus 로고    scopus 로고
    • Molecular cloning and characterization of the human p27Kip1 gene promoter
    • Minami,S. et al. (1997) Molecular cloning and characterization of the human p27Kip1 gene promoter. FEBS Lett., 411, 1-6.
    • (1997) FEBS Lett , vol.411 , pp. 1-6
    • Minami, S.1
  • 36
    • 0042941403 scopus 로고    scopus 로고
    • Targeted inactivation of p27kip1 is sufficient for large and small intestinal tumorigenesis in the mouse, which can be augmented by a western-style high-risk diet
    • Yang,W.C. et al. (2003) Targeted inactivation of p27kip1 is sufficient for large and small intestinal tumorigenesis in the mouse, which can be augmented by a western-style high-risk diet. Cancer Res. 63, 4990-4996.
    • (2003) Cancer Res , vol.63 , pp. 4990-4996
    • Yang, W.C.1
  • 37
    • 0036500996 scopus 로고    scopus 로고
    • Colorectal cancer in mice genetically deficent in the mucin Muc2
    • Velcich,A. et al. (2002) Colorectal cancer in mice genetically deficent in the mucin Muc2. Science, 295, 1726-1729.
    • (2002) Science , vol.295 , pp. 1726-1729
    • Velcich, A.1


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