2,4-Dinitrophenol induces apoptosis in As4.1 juxtaglomerular cells through rapid depletion of GSH

Cell Biology International

Volumn 32, Issue 12, 2008, Pages 1536-1545

  Han, Yong Hwan ^a   Kim, Sung Zoo ^a   Kim, Suhn Hee ^a   Park, Woo Hyun ^a  

^a Chonbuk National University   (South Korea)

Author keywords

Calu 6; DNP; GSH; Mitochondria; ROS; ROS scavenger

Indexed keywords

2,4 DINITROPHENOL; CATALASE; GLUTATHIONE; HYDROGEN PEROXIDE; LIPOCORTIN 5; OXYGEN; REACTIVE OXYGEN METABOLITE; TIRON;

ANIMAL CELL; APOPTOSIS; ARTICLE; BINDING ASSAY; CELL DEATH; CONTROLLED STUDY; DNA CONTENT; FLOW CYTOMETRY; JUXTAGLOMERULAR CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; MOUSE; NONHUMAN; OUTCOME ASSESSMENT; PROTEIN DEPLETION;

2,4-DINITROPHENOL; ANIMALS; ANNEXIN A5; APOPTOSIS; CELL LINE, TUMOR; DNA; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; EPITHELIAL CELLS; GLUTATHIONE; JUXTAGLOMERULAR APPARATUS; MICE; MITOCHONDRIA; OXIDATIVE PHOSPHORYLATION; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES; TIME FACTORS; UNCOUPLING AGENTS; UP-REGULATION;

EID: 56149089553     PISSN: 10656995     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cellbi.2008.08.023     Document Type: Article

References (51)

1. 2-induced cell death in lung epithelial cells. Am J Physiol Lung Cell Mol Physiol 290 (2006) L978-L986
2. Ashkenazi A., and Dixit V.M. Death receptors: signaling and modulation. Science 281 (1998) 1305-1308
3. Baran C.P., Zeigler M.M., Tridandapani S., and Marsh C.B. The role of ROS and RNS in regulating life and death of blood monocytes. Curr Pharm Des 10 (2004) 855-866
4. Bass D.A., Parce J.W., Dechatelet L.R., Szejda P., Seeds M.C., and Thomas M. Flow cytometric studies of oxidative product formation by neutrophils: a graded response to membrane stimulation. J Immunol 130 (1983) 1910-1917
5. Budihardjo I., Oliver H., Lutter M., Luo X., and Wang X. Biochemical pathways of caspase activation during apoptosis. Ann Rev Cell Develop Biol 15 (1999) 269-290
6. Chen T.J., Jeng J.Y., Lin C.W., Wu C.Y., and Chen Y.C. Quercetin inhibition of ROS-dependent and -independent apoptosis in rat glioma C6 cells. Toxicology 223 (2006) 113-126
7. Cheng W.C., Berman S.B., Ivanovska I., Jonas E.A., Lee S.J., Chen Y., et al. Mitochondrial factors with dual roles in death and survival. Oncogene 25 (2006) 4697-4705
8. Coutts A.S., and La Thangue N. The p53 response during DNA damage: impact of transcriptional cofactors. Biochem Soc Symp (2006) 181-189
9. Dasmahapatra G., Rahmani M., Dent P., and Grant S. The tyrphostin adaphostin interacts synergistically with proteasome inhibitors to induce apoptosis in human leukemia cells through a reactive oxygen species (ROS)-dependent mechanism. Blood 107 (2006) 232-240
10. Dryer S.E., Dryer R.L., and Autor A.P. Enhancement of mitochondrial, cyanide-resistant superoxide dismutase in the livers of rats treated with 2,4-dinitrophenol. J Biol Chem 255 (1980) 1054-1057
11. Duan X., Bruneval P., Hammadeh R., Fresco R., Eble J.N., Clark J.I., et al. Metastatic juxtaglomerular cell tumor in a 52-year-old man. Am J Surg Pathol 28 (2004) 1098-1102
12. Erkkila K., Kyttanen S., Wikstrom M., Taari K., Hikim A.P., Swerdloff R.S., et al. Regulation of human male germ cell death by modulators of ATP production. Am J Physiol Endocrinol Metab 290 (2006) E1145-E1154
13. Estrela J.M., Ortega A., and Obrador E. Glutathione in cancer biology and therapy. Crit Rev Clin Lab Sci 43 (2006) 143-181
14. Futakawa N., Kondoh M., Ueda S., Higashimoto M., Takiguchi M., Suzuki S., et al. Involvement of oxidative stress in the synthesis of metallothionein induced by mitochondrial inhibitors. Biol Pharm Bull 29 (2006) 2016-2020
15. Gonzalez C., Sanz-Alfayate G., Agapito M.T., Gomez-Nino A., Rocher A., and Obeso A. Significance of ROS in oxygen sensing in cell systems with sensitivity to physiological hypoxia. Respir Physiol Neurobiol 132 (2002) 17-41
16. Han Y.H., Kim S.W., Kim S.H., Kim S.Z., and Park W.H. 2,4-dinitrophenol induces G1 phase arrest and apoptosis in human pulmonary adenocarcinoma Calu-6 cells. Toxicol In Vitro 22 (2008) 659-670
17. Han Y.H., Kim S.Z., Kim S.H., and Park W.H. Arsenic trioxide inhibits the growth of As4.1 juxtaglomerular cells via cell cycle arrest and caspase-independent apoptosis. Am J Physiol Renal Physiol 293 (2007) 511-520
18. 2 are an important factor maintaining mitochondria membrane potential of antimycin A-treated As4.1 juxtaglomerular cells. Biochem Pharmacol 73 (2007) 863-872
19. Hanstein W.G. Uncoupling of oxidative phosphorylation. Biochim Biophys Acta 456 (1976) 129-148
20. Hedley D.W., and Chow S. Evaluation of methods for measuring cellular glutathione content using flow cytometry. Cytometry 15 (1994) 349-358
21. Hengartner M.O. The biochemistry of apoptosis. Nature 407 (2000) 770-776
22. Higuchi Y. Glutathione depletion-induced chromosomal DNA fragmentation associated with apoptosis and necrosis. J Cell Mol Med 8 (2004) 455-464
23. Kadenbach B. Intrinsic and extrinsic uncoupling of oxidative phosphorylation. Biochim Biophys Acta 1604 (2003) 77-94
24. Kihara I., Kitamura S., Hoshino T., Seida H., and Watanabe T.A. hitherto unreported vascular tumor of the kidney: a proposal of "juxtaglomerular cell tumor". Acta Pathol Jpn 18 (1968) 197-206
25. Kim J.S., Cho E.W., Chung H.W., and Kim I.G. Effects of Tiron, 4,5-dihydroxy-1,3-benzene disulfonic acid, on human promyelotic HL-60 leukemia cell differentiation and death. Toxicology 223 (2006) 36-45
26. Kuruvilla S., Qualls Jr. C.W., Tyler R.D., Witherspoon S.M., Benavides G.R., Yoon L.W., et al. Effects of minimally toxic levels of carbonyl cyanide P-(trifluoromethoxy) phenylhydrazone (FCCP), elucidated through differential gene expression with biochemical and morphological correlations. Toxicol Sci 73 (2003) 348-361
27. Lakhani S.A., Masud A., Kuida K., Porter Jr. G.A., Booth C.J., Mehal W.Z., et al. Caspases 3 and 7: key mediators of mitochondrial events of apoptosis. Science 311 (2006) 847-851
28. Linsinger G., Wilhelm S., Wagner H., and Hacker G. Uncouplers of oxidative phosphorylation can enhance a Fas death signal. Mol Cell Biol 19 (1999) 3299-3311
29. Liu X., Yue P., Zhou Z., Khuri F.R., and Sun S.Y. Death receptor regulation and celecoxib-induced apoptosis in human lung cancer cells. J Natl Cancer Inst 96 (2004) 1769-1780
30. Macho A., Hirsch T., Marzo I., Marchetti P., Dallaporta B., Susin S.A., et al. Glutathione depletion is an early and calcium elevation is a late event of thymocyte apoptosis. J Immunol 158 (1997) 4612-4619
31. McFee R.B., Caraccio T.R., McGuigan M.A., Reynolds S.A., and Bellanger P. Dying to be thin: a dinitrophenol related fatality. Vet Hum Toxicol 46 (2004) 251-254
32. Mehmet H. Caspases find a new place to hide. Nature 403 (2000) 29-30
33. Miyoshi N., Oubrahim H., Chock P.B., and Stadtman E.R. Age-dependent cell death and the role of ATP in hydrogen peroxide-induced apoptosis and necrosis. Proc Natl Acad Sci USA 103 (2006) 1727-1731
34. Nohl H., Gille L., and Staniek K. Intracellular generation of reactive oxygen species by mitochondria. Biochem Pharmacol 69 (2005) 719-723
35. Poot M., Teubert H., Rabinovitch P.S., and Kavanagh T.J. De novo synthesis of glutathione is required for both entry into and progression through the cell cycle. J Cell Physiol 163 (1995) 555-560
36. 2): regulation of peroxiredoxin, catalase, and glutathione peroxidase via post-translational modification. Antioxid Redox Signal 7 (2005) 619-626
37. Robertson P.W., Klidjian A., Harding L.K., Walters G., Lee M.R., and Robb-Smith A.H. Hypertension due to a renin-secreting renal tumour. Am J Med 43 (1967) 963-976
38. Schnelldorfer T., Gansauge S., Gansauge F., Schlosser S., Beger H.G., and Nussler A.K. Glutathione depletion causes cell growth inhibition and enhanced apoptosis in pancreatic cancer cells. Cancer 89 (2000) 1440-1447
39. Shen H.M., and Liu Z.G. JNK signaling pathway is a key modulator in cell death mediated by reactive oxygen and nitrogen species. Free Radic Biol Med 40 (2006) 928-939
40. Shi Y. Mechanisms of caspase activation and inhibition during apoptosis. Mol Cell 9 (2002) 459-470
41. Sigmund C.D., Okuyama K., Ingelfinger J., Jones C.A., Mullins J.J., Kane C., et al. Isolation and characterization of renin-expressing cell lines from transgenic mice containing a renin-promoter viral oncogene fusion construct. J Biol Chem 265 (1990) 19,916-19,922
42. Simon H.U., Haj-Yehia A., and Levi-Schaffer F. Role of reactive oxygen species (ROS) in apoptosis induction. Apoptosis 5 (2000) 415-418
43. Stanley W.C., and Marzilli M. Metabolic therapy in the treatment of ischaemic heart disease: the pharmacology of trimetazidine. Fundam Clin Pharmacol 17 (2003) 133-145
44. Tikhaze A.K., Lankin V.Z., Zharova E.A., and Kolycheva S.V. Trimetazidine as indirect antioxidant. Bull Exp Biol Med 130 (2000) 951-953
45. Vier J., Gerhard M., Wagner H., and Hacker G. Enhancement of death-receptor induced caspase-8-activation in the death-inducing signalling complex by uncoupling of oxidative phosphorylation. Mol Immunol 40 (2004) 661-670
46. Wallach-Dayan S.B., Izbicki G., Cohen P.Y., Gerstl-Golan R., Fine A., and Breuer R. Bleomycin initiates apoptosis of lung epithelial cells by ROS but not by Fas/FasL pathway. Am J Physiol Lung Cell Mol Physiol 290 (2006) L790-L796
47. Watabe M., and Nakaki T. ATP depletion does not account for apoptosis induced by inhibition of mitochondrial electron transport chain in human dopaminergic cells. Neuropharmacology 52 (2007) 536-541
48. Wilcox C.S. Reactive oxygen species: roles in blood pressure and kidney function. Curr Hypertens Rep 4 (2002) 160-166
49. Wilcox C.S. Redox regulation of the afferent arteriole and tubuloglomerular feedback. Acta Physiol Scand 179 (2003) 217-223
50. Zafarullah M., Li W.Q., Sylvester J., and Ahmad M. Molecular mechanisms of N-acetylcysteine actions. Cell Mol Life Sci 60 (2003) 6-20
51. Zorov D.B., Juhaszova M., and Sollott S.J. Mitochondrial ROS-induced ROS release: an update and review. Biochim Biophys Acta 1757 (2006) 509-517