Pre-bled-young-rats in genotoxicity testing: A model for peripheral blood micronucleus assay

Regulatory Toxicology and Pharmacology

Volumn 52, Issue 2, 2008, Pages 147-157

  Vikram, A ^a   Tripathi, D N ^a   Pawar, A A ^a   Ramarao, P ^a   Jena, G B ^a  

^a NATIONAL INSTITUTE OF PHARMACEUTICAL EDUCATION AND RESEARCH NIPER   (India)

Author keywords

AZT; DEN; Genotoxicity; Micronucleus; MTX; Prior bleeding; QC; STZ

Indexed keywords

CLASTOGEN; DIETHYLNITROSAMINE; METHOTREXATE; QUERCETIN; STREPTOZOCIN; ZIDOVUDINE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLEEDING; BLOOD; BONE MARROW; CONTROLLED STUDY; GENOTOXICITY; MALE; MICRONUCLEUS TEST; MITOSIS INDEX; NEWBORN; NONHUMAN; PRIORITY JOURNAL; RAT; RETICULOCYTE; SENSITIVITY AND SPECIFICITY; TOXICITY TESTING;

ANIMALS; AREA UNDER CURVE; DIETHYLNITROSAMINE; DISEASE MODELS, ANIMAL; HEMORRHAGE; MALE; METHOTREXATE; MICE; MICRONUCLEUS TESTS; MUTAGENICITY TESTS; MUTAGENS; QUERCETIN; RATS; RATS, SPRAGUE-DAWLEY; RETICULOCYTES; STREPTOZOCIN; TIME FACTORS; ZIDOVUDINE;

ANIMALIA; MUS; RATTUS;

EID: 56149085569     PISSN: 02732300     EISSN: 10960295     Source Type: Journal    
DOI: 10.1016/j.yrtph.2008.07.005     Document Type: Article

References (63)

1. Armstrong M.J., and Galloway S.M. Micronuclei induced in peripheral blood of E mu-PIM-1 transgenic mice by chronic oral treatment with 2-acetylaminofluorene or benzene but not with diethyl-nitrosamine or 1,2-dichloroethane. Mutat. Res. 302 (1993) 61-70
2. Asanami S., Shimono K., Sawamoto O., Kurisu K., and Uejima M. The suitability of rat peripheral blood in subchronic studies for the micronucleus assay. Mutat. Res. 347 (1995) 73-78
3. Ayers K.M., Clive D., Tucker Jr. W.E., Hajian G., and de Miranda P. Nonclinical toxicology studies with zidovudine: genetic toxicity tests and carcinogenicity bioassays in mice and rats. Fundam. Appl. Toxicol. 32 (1996) 148-158
4. Barbisan L.F., Scolastici C., Miyamoto M., Salvadori D.M., Ribeiro L.R., da Eira A.F., and de Camargo J.L. Effects of crude extracts of Agaricus blazei on DNA damage and on rat liver carcinogenesis induced by diethylnitrosamine. Genet. Mol. Res. 2 (2003) 295-308
5. Bhunya S.P., and Jena G.B. The evaluation of clastogenic potential of trichloroacetic acid (TCA) in chick in vivo test system. Mutat. Res. 367 (1996) 254-259
6. Bolzan A.D., and Bianchi M.S. Genotoxicity of streptozotocin. Mutat. Res. 512 (2002) 121-134
7. Bolzan A.D., Bianchi N.O., and Bianchi M.S. Effects of antioxidants on streptozotocin-induced clastogenesis in mammalian and insect cells. Mutat. Res. 418 (1998) 35-42
8. Boots A.W., Li H., Schins R.P., Duffin R., Heemskerk J.W., Bast A., and Haenen G.R. The quercetin paradox. Toxicol. Appl. Pharmacol. 222 (2007) 89-96
9. Caria H., Chaveca T., Laires A., and Rueff J. Genotoxicity of quercetin in the micronucleus assay in mouse bone marrow erythrocytes, human lymphocytes, V79 cell line and identification of kinetochore-containing (CREST staining) micronuclei in human lymphocytes. Mutat. Res. 343 (1995) 85-94
10. Choudhury R.C., Ghosh S.K., and Palo A.K. Cytogenetic toxicity of methotrexate in mouse bone marrow. Environ. Toxicol. Pharmacol. 8 (2000) 191-196
11. Choudhury R.C., and Palo A.K. Modulatory effects of caffeine on methotrexate-induced cytogenotoxicity in mouse bone marrow. Environ. Toxicol. Pharmacol. 15 (2004) 79-85
12. da Silva J., Herrmann S.M., Heuser V., Peres W., Possa Marroni N., Gonzalez-Gallego J., and Erdtmann B. Evaluation of the genotoxic effect of rutin and quercetin by comet assay and micronucleus test. Food. Chem. Toxicol. 40 (2002) 941-947
13. De Boeck M., van der Leede B.J., Van Goethem F., De Smedt A., Steemans M., Lampo A., and Vanparys P. Flow cytometric analysis of micronucleated reticulocytes: time- and dose-dependent response of known mutagens in mice, using multiple blood sampling. Environ. Mol. Mutagen. 46 (2005) 30-42
14. Deng H., Zhang M., He J., Wu W., Jin L., Zheng W., Lou J., and Wang B. Investigating genetic damage in workers occupationally exposed to methotrexate using three genetic end-points. Mutagenesis 20 (2005) 351-357
15. Dertinger S.D., Bishop M.E., McNamee J.P., Hayashi M., Suzuki T., Asano N., Nakajima M., Saito J., Moore M., Torous D.K., and Macgregor J.T. Flow cytometric analysis of micronuclei in peripheral blood reticulocytes: I. Intra- and interlaboratory comparison with microscopic scoring. Toxicol. Sci. 94 (2006) 83-91
16. Diwan B.A., Riggs C.W., Logsdon D., Haines D.C., Olivero O.A., Rice J.M., Yuspa S.H., Poirier M.C., and Anderson L.M. Multiorgan transplacental and neonatal carcinogenicity of 3'-azido-3'-deoxythymidine in mice. Toxicol. Appl. Pharmacol. 161 (1999) 82-99
17. Edenharder R., Krieg H., Kottgen V., and Platt K.L. Inhibition of clastogenicity of benzo[a]pyrene and of its trans-7, 8-dihydrodiol in mice in vivo by fruits, vegetables, and flavonoids. Mutat. Res. 537 (2003) 169-181
18. Escobar P.A., Olivero O.A., Wade N.A., Abrams E.J., Nesel C.J., Ness R.B., Day R.D., Day B.W., Meng Q., O'Neill J.P., Walker D.M., Poirier M.C., Walker V.E., and Bigbee W.L. Genotoxicity assessed by the comet and GPA assays following in vitro exposure of human lymphoblastoid cells (H9) or perinatal exposure of mother-child pairs to AZT or AZT-3TC. Environ. Mol. Mutagen. 48 (2007) 330-343
19. Garcia-Gasca T., Fatell S., Villa-Trevino S., and Gonzalez de Mejia E. Effect of carotenoids against genotoxicity of diethylnitrosamine on rat hepatocytes. Toxicology In Vitro 12 (1998) 691-698
20. Harper S.B., Dertinger S.D., Bishop M.E., Lynch A.M., Lorenzo M., Saylor M., and MacGregor J.T. Flow cytometric analysis of micronuclei in peripheral blood reticulocytes III. An efficient method of monitoring chromosomal damage in the beagle dog. Toxicol. Sci. 100 (2007) 406-414
21. Harwood M., Danielewska-Nikiel B., Borzelleca J.F., Flamm G.W., Williams G.M., and Lines T.C. A critical review of the data related to the safety of quercetin and lack of evidence of in vivo toxicity, including lack of genotoxic/carcinogenic properties. Food Chem. Toxicol. 45 (2007) 2179-2205
22. Hayashi M., Kodama Y., Awogi T., Suzuki T., Asita A.O., and Sofuni T. The micronucleus assay using peripheral blood reticulocytes from mitomycin C- and cyclophosphamide-treated rats. Mutat. Res. 278 (1992) 209-213
23. Hayashi M., Tice R.R., MacGregor J.T., Anderson D., Blakey D.H., Kirsh-Volders M., Oleson Jr. F.B., Pacchierotti F., Romagna F., Shimada H., et al. In vivo rodent erythrocyte micronucleus assay. Mutat. Res. 312 (1994) 293-304
24. Heddle J.A., Cimino M.C., Hayashi M., Romagna F., Shelby M.D., Tucker J.D., Vanparys P., and MacGregor J.T. Micronuclei as an index of cytogenetic damage: past, present, and future. Environ. Mol. Mutagen. 18 (1991) 277-291
25. Hernandez-Ceruelos A., Madrigal-Bujaidar E., and de la Cruz C. Inhibitory effect of chamomile essential oil on the sister chromatid exchanges induced by daunorubicin and methyl methanesulfonate in mouse bone marrow. Toxicol. Lett. 135 (2002) 103-110
26. Higashikuni N., and Sutou S. An optimal, generalized sampling time of 30 +/- 6 h after double dosing in the mouse peripheral blood micronucleus test. Mutagenesis 10 (1995) 313-319
27. Hirai O., Miyamae Y., Fujino Y., Izumi H., Miyamoto A., and Noguchi H. Prior bleeding enhances the sensitivity of the in vivo micronucleus test. Mutat. Res. 264 (1991) 109-114
28. Holden H.E., Majeska J.B., and Studwell D. A direct comparison of mouse and rat bone marrow and blood as target tissues in the micronucleus assay. Mutat. Res. 391 (1997) 87-89
29. Hotchkiss C.E., Bishop M.E., Dertinger S.D., Slikker Jr. W., Moore M.M., and Macgregor J.T. Flow cytometric analysis of micronuclei in peripheral blood reticulocytes IV: an index of chromosomal damage in the rhesus monkey (Macaca mulatta). Toxicol. Sci. 102 (2008) 352-358
30. ICH, 1997. Hormonized triparite guideline S2B. Genotoxicity: a standard for genotoxicity testing of pharmaceuticals.
31. Jena G.B., and Bhunya S.P. Mutagenicity of an organophosphate insecticide acephate-an in vivo study in chicks. Mutagenesis 9 (1994) 319-324
32. Keshava C., Keshava N., Whong W.-Z., Nath J., and Ong T.-M. Inhibition of methotrexate-induced chromosomal damage by folinic acid in V79 cells. Mutat. Res. 397 (1998) 221-228
33. Kissling G.E., Dertinger S.D., Hayashi M., and MacGregor J.T. Sensitivity of the erythrocyte micronucleus assay: dependence on number of cells scored and inter-animal variability. Mutat. Res. 634 (2007) 235-240
34. Krishna G., Urda G., and Theiss J. Principles and practices of integrating genotoxicity evaluation into routine toxicology studies: a pharmaceutical industry perspective. Environ. Mol. Mutagen. 32 (1998) 115-120
35. Li J.C., and Kaminskas E. Accumulation of DNA strand breaks and methotrexate cytotoxicity. Proc. Natl. Acad. Sci. USA 81 (1984) 5694-5698
36. Liegibel U., Tinwell H., Callander R.D., Schmezer P., and Ashby J. Clastogenicity to the mouse bone marrow of the mouse germ cell genotoxin streptozotocin. Mutagenesis 7 (1992) 471-474
37. MacGregor J.T., Bishop M.E., McNamee J.P., Hayashi M., Asano N., Wakata A., Nakajima M., Saito J., Aidoo A., Moore M.M., and Dertinger S.D. Flow cytometric analysis of micronuclei in peripheral blood reticulocytes: II. An efficient method of monitoring chromosomal damage in the rat. Toxicol. Sci. 94 (2006) 92-107
38. Nito S., Kondo Y., Ono T., and Ariyuki F. In vitro micronucleus method with erythropoietin-differentiated erythrocytes. Mutat. Res. 175 (1986) 243-247
39. NTP. Toxicology and Carcinogenesis Studies on Quercetin. National Institute of Health. 409 (1992) 92-3140
40. OECD, 1997. OECD guidelines for the testing of chemicals: mamalian erythrocyte micronucleus test, guideline 474.
41. Olivero O.A. Mechanisms of genotoxicity of nucleoside reverse transcriptase inhibitors. Environ. Mol. Mutagen. 48 (2007) 215-223
42. Padmanabhan S., Tripathi D.N., Vikram A., Ramarao P., and Jena G.B. Cytotoxic and genotoxic effects of methotrexate in germ cells of male swiss mice. Mutat. Res. (2008)
43. Poirier M.C., Olivero O.A., Walker D.M., and Walker V.E. Perinatal genotoxicity and carcinogenicity of anti-retroviral nucleoside analog drugs. Toxicol Appl Pharmacol. 199 (2004) 151-161
44. Ramirez-Munoz M.P., Zuniga G., Torres-Bugarin O., Portilla E., Garcia-Martinez D., Ramos A., Cantu J.M., and Sanchez-Corona J. Evaluation of the micronucleus test in peripheral blood erythrocytes by use of the splenectomized model. Lab. Anim. Sci. 49 (1999) 418-420
45. Rietjens I.M., Boersma M.G., van der Woude H., Jeurissen S.M., Schutte M.E., and Alink G.M. Flavonoids and alkenylbenzenes: mechanisms of mutagenic action and carcinogenic risk. Mutat. Res. 574 (2005) 124-138
46. Russo G.L. Ins and outs of dietary phytochemicals in cancer chemoprevention. Biochem. Pharmacol. 74 (2007) 533-544
47. Schlegel R., and MacGregor J.T. The persistence of micronucleated erythrocytes in the peripheral circulation of normal and splenectomized Fischer 344 rats: implications for cytogenetic screening. Mutat. Res. 127 (1984) 169-174
48. Schmid W. The micronucleus test. Mutat. Res. 31 (1975) 9-15
49. Shuga J., Zhang J., Samson L.D., Lodish H.F., and Griffith L.G. In vitro erythropoiesis from bone marrow-derived progenitors provides a physiological assay for toxic and mutagenic compounds. Proc. Natl. Acad. Sci. USA 104 (2007) 8737-8742
50. Steinheider G., Neth R., and Marquardt H. Evaluation of nongenotoxic and genotoxic factors modulating the frequency of micronucleated erythrocytes in the peripheral blood of mice. Cell Biol. Toxicol. 1 (1985) 197-211
51. Suzuki H., Shirotori T., and Hayashi M. A liver micronucleus assay using young rats exposed to diethylnitrosamine: methodological establishment and evaluation. Cytogenet. Genome Res. 104 (2004) 299-303
52. Suzuki Y., Nagae Y., Ishikawa T., Watanabe Y., Nagashima T., Matsukubo K., and Shimizu H. Effect of erythropoietin on the micronucleus test. Environ. Mol. Mutagen. 13 (1989) 314-318
53. Suzuki Y., Nagae Y., Li J., Sakaba H., Mozawa K., Takahashi A., and Shimizu H. The micronucleus test and erythropoiesis. Effects of erythropoietin and a mutagen on the ratio of polychromatic to normochromatic erythrocytes (P/N ratio). Mutagenesis 4 (1989) 420-424
54. Tieppo J., Vercelino R., Dias A.S., Silva Vaz M.F., Silveira T.R., Marroni C.A., Marroni N.P., Henriques J.A., and Picada J.N. Evaluation of the protective effects of quercetin in the hepatopulmonary syndrome. Food.Chem. Toxicol. 11 (2007) 11
55. Tikoo K., Tamta A., Ali I.Y., Gupta J., and Gaikwad B. Tannic acid prevents azidothymidine (AZT) induced hepatotoxicity and genotoxicity along with change in expression of PARG and histone H3 acetylation. Toxcol. Lett. 177 (2008) 90-96
56. Udroiu I., Ieradi L.A., Cristaldi M., and Tanzarella C. Detection of clastogenic and aneugenic damage in newborn rats. Environ. Mol. Mutagen. 47 (2006) 320-324
57. Verna L., Whysner J., and Williams G.M. N-nitrosodiethylamine mechanistic data and risk assessment: bioactivation, DNA-adduct formation, mutagenicity, and tumor initiation. Pharmacol. Ther. 71 (1996) 57-81
58. Vikram A., Ramarao P., and Jena G. Prior bleeding enhances the sensitivity of peripheral blood and bone marrow micronucleus tests in rats. Mutagenesis 22 (2007) 287-291
59. Vikram A., Tripathi D.N., Ramarao P., and Jena G.B. Evaluation of streptozotocin genotoxicity in rats from different ages using the micronucleus assay. Regul. Toxicol. Pharmacol. 49 (2007) 238-244
60. Vikram A., Tripathi D.N., Ramarao P., and Jena G.B. Intervention of d-glucose ameliorates the toxicity of streptozotocin in accessory sex organs of rat. Toxicol. Appl. Pharmacol. 226 (2008) 84-93
61. Walker D.M., Malarkey D.E., Seilkop S.K., Ruecker F.A., Funk K.A., Wolfe M.J., Treanor C.P., Foley J.F., Hahn F.F., Hardisty J.F., and Walker V.E. Transplacental carcinogenicity of 3′-azido-3′-deoxythymidine in B6C3F1 mice and F344 rats. Environ. Mol. Mutagen. 48 (2007) 283-298
62. Witt K.L., Cunningham C.K., Patterson K.B., Kissling G.E., Dertinger S.D., Livingston E., and Bishop J.B. Elevated frequencies of micronucleated erythrocytes in infants exposed to zidovudine in utero and postpartum to prevent mother-to-child transmission of HIV. Environ. Mol. Mutagen. 48 (2007) 322-329
63. Witt K.L., Tice R.R., Wolfe G.W., and Bishop J.B. Genetic damage detected in CD-1 mouse pups exposed perinatally to 3′-azido-3′-deoxythymidine or dideoxyinosine via maternal dosing, nursing, and direct gavage: II. Effects of the individual agents compared to combination treatment. Environ. Mol. Mutagen. 44 (2004) 321-328