Intracellular Mg2+ is a voltage-dependent pore blocker of HCN channels

American Journal of Physiology - Cell Physiology

Volumn 295, Issue 2, 2008, Pages

  Vemana, Sriharsha ^a   Pandey, Shilpi ^a   Larsson, H Peter ^a  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

Cysteine; Divalent block; Hyperpolarization activated current; Hyperpolarization activated cyclic nucleotide; Instantaneous currents; Inward rectifying

Indexed keywords

HYPERPOLARIZATION ACTIVATED CYCLIC NUCLEOTIDE GATED CHANNEL; ION CHANNEL; MAGNESIUM; UNCLASSIFIED DRUG; CYCLIC NUCLEOTIDE GATED CHANNEL; EDETIC ACID; HCN2 POTASSIUM CHANNEL; HYPERPOLARIZATION ACTIVATED CATION CHANNEL; HYPERPOLARIZATION-ACTIVATED CATION CHANNEL; POTASSIUM CHANNEL; SPERMIDINE; SPERMINE;

ANIMAL CELL; ARTICLE; BINDING SITE; CHANNEL GATING; CONTROLLED STUDY; ELECTROPHYSIOLOGY; HYPERPOLARIZATION; IC 50; MOLECULAR BIOLOGY; NONHUMAN; OOCYTE; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS; XENOPUS LAEVIS; ANIMAL; BIOLOGICAL MODEL; CELL MEMBRANE POTENTIAL; DOSE RESPONSE; DRUG EFFECT; FEMALE; GENETICS; INTRACELLULAR SPACE; METABOLISM; MOUSE; MUTATION; PATCH CLAMP; PHYSIOLOGY; TIME;

ANIMALS; BINDING SITES; CYCLIC NUCLEOTIDE-GATED CATION CHANNELS; DOSE-RESPONSE RELATIONSHIP, DRUG; EDETIC ACID; ELECTROPHYSIOLOGY; FEMALE; INTRACELLULAR SPACE; ION CHANNEL GATING; ION CHANNELS; MAGNESIUM; MEMBRANE POTENTIALS; MICE; MODELS, BIOLOGICAL; MUTAGENESIS, SITE-DIRECTED; MUTATION; OOCYTES; PATCH-CLAMP TECHNIQUES; POTASSIUM CHANNELS; SPERMIDINE; SPERMINE; TIME FACTORS; XENOPUS LAEVIS;

EID: 55949132130     PISSN: 03636143     EISSN: 15221563     Source Type: Journal    
DOI: 10.1152/ajpcell.00154.2008     Document Type: Article

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