Ketamine-induced cardiac depression is associated with increase in [Mg2+]i and activation of p38 MAP kinase and ERK 1/2 in guinea pig

Biochemical and Biophysical Research Communications

Volumn 349, Issue 2, 2006, Pages 716-722

  Kim, Shang Jin ^a   Kang, Hyung Sub ^a   Lee, Mun Young ^a   Lee, Sei Jin ^b   Seol, Jea Won ^a   Park, Sang Yeol ^a   Kim, In Shik ^a   Kim, Nam Soo ^a   Kim, Sung Zoo ^a   Kwak, Yong Geun ^a   Kim, Jin Shang ^a  

^a Chonbuk National University   (South Korea)

^b Korea Basic Science Institute (KBSI)   (South Korea)

Author keywords

Cardiac depression; ERK 1 2; Intracellular magnesium ion; Ketamine; p38 MAP kinase

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; FURAPTRA; KETAMINE; MAGNESIUM ION; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL LEVEL; CONTROLLED STUDY; DOSE RESPONSE; DRUG ANTAGONISM; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME ANALYSIS; GUINEA PIG; HEART DISEASE; HEART LEFT VENTRICLE PRESSURE; HEART MUSCLE CELL; HEART PERFUSION; HEART RATE; ISOLATED HEART; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ANIMALS; CYTOPLASM; DOSE-RESPONSE RELATIONSHIP, DRUG; EXCITATORY AMINO ACID ANTAGONISTS; FLAVONOIDS; GUINEA PIGS; HEART; IMIDAZOLES; KETAMINE; MAGNESIUM; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MYOCARDIUM; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PYRIDINES;

CAVIA; CAVIA PORCELLUS;

EID: 33748426309     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2006.08.082     Document Type: Article

References (29)

1. Aya A.G., Robert E., Bruelle P., Lefrant J.Y., Juan J.M., Peray P., Eledjam J.J., and de La Coussaye J.E. Effects of ketamine on ventricular conduction, refractoriness, and wavelength: potential antiarrhythmic effects: a high-resolution epicardial mapping in rabbit hearts. Anesthesiology 87 (1997) 1417-1427
2. Hara Y., Tamagawa M., and Nakaya H. The effects of ketamine on conduction velocity and maximum rate of rise of action potential upstroke in guinea pig papillary muscles: comparison with quinidine. Anesth. Analg. 79 (1994) 687-693
3. Graf B.M., Vicenzi M.N., Martin E., Bosnjak Z.J., and Stowe D.F. Ketamine has stereospecific effects in the isolated perfused guinea pig heart. Anesthesiology 82 (1995) 1426-1437
4. Yeh F.C., Tzeng C.C., Chang C.L., and Chen H.I. The direct cardiac effects of ketamine studied on the intact isolated rabbit heart. Acta Anaesthesiol. Sin. 32 (1994) 209-212
5. Cook D.J., Carton E.G., and Housmans R.R. Mechanism of the positive inotropic effect of ketamine in isolated ferret ventricular papillary muscle. Anesthesiology 74 (1991) 880-888
6. Endou M., Hattori Y., Nakaya H., Gotoh Y., and Kanno M. Electrophysiologic mechanisms responsible for inotropic responses to ketamine in guinea pig and rat myocardium. Anesthesiology 76 (1992) 409-418
7. Riou B., Viars P., and Lecarpentier Y. Effects of ketamine on the cardiac papillary muscle of normal hamsters and those with cardiomyopathy. Anesthesiology 73 (1990) 910-918
8. Suzer O., Suzer A., Aykac Z., and Ozuner Z. Direct cardiac effects in isolated perfused rat hearts measured at increasing concentrations of morphine, alfentanil, fentanyl, ketamine, etomidate, thiopentone, midazolam and propofol. Eur. J. Anaesthesiol. 15 (1998) 480-485
9. Waxman K., Shoemaker W.C., and Lippmann M. Cardiovascular effects of anesthetic induction with ketamine. Anesth. Analg. 59 (1980) 355-358
10. Pagel P.S., Kampine J.P., Schmeling W.T., and Warltier D.C. Ketamine depresses myocardial contractility as evaluated by the preload recruitable stroke work relationship in chronically instrumented dogs with autonomic nervous system blockade. Anesthesiology 76 (1992) 564-572
11. Kunst G., Martin E., Graf B.M., Hagl S., and Vahl C.F. Actions of ketamine and its isomers on contractility and calcium transients in human myocardium. Anesthesiology 90 (1999) 1363-13671
12. 2+ transients and contraction in rat ventricular myocytes at supraclinical concentrations. Anesthesiology 88 (1998) 781-791
13. Maguire M.E., and Cowan J.A. Magnesium chemistry and biochemistry. BioMetals 15 (2002) 203-210
14. Chakraborti S., Chakraborti T., Mandal M., Mandal A., Das S., and Ghosh S. Protective role of magnesium in cardiovascular diseases: a review. Mol. Cell. Biochem. 238 (2002) 163-179
15. Grubbs R.D. Intracellular magnesium and magnesium buffering. Biometals 15 (2002) 251-259
16. Iseri L.T., and French J.H. Magnesium: nature's physiologic calcium blocker. Am. Heart J. 108 (1984) 188-193
17. McGuigan J.A.S., Elder H.Y., Gunzel D., and Schlue W.R. Magnesium homeostasis in heart; a critical reappraisal. J. Clin. Basic Cardiol. 5 (2002) 5-22
18. Romani A.M., and Scarpa A. Regulation of cellular magnesium. Front. Biosci. 5 (2000) 720-734
19. 2+ efflux is related to MAP kinase activation in the heart. Biochem. Biophys. Res. Commun. 333 (2005) 1132-1138
20. 2+ uptake in mouse distal convoluted tubule cells. Biochem. Biophys. Res. Commun. 341 (2006) 742-748
21. Su B., and Karin M. Mitogen-activated protein kinase cascades and regulation of gene expression. Curr. Opin. Immunol. 8 (1996) 402-411
22. Idvall J., Ahlgren I., Aronsen KR., and Stenberg P. Ketamine infusions: pharmacokinetics and clinical effects. Br. J. Anaesth. 51 (1979) 1167-1173
23. Orser B., Smith D., Henderson S., and Gelb A. Magnesium deficiency increases ketamine sensitivity in rats. Can. J. Anaesth. 44 (1997) 883-890
24. Shapira Y., Lam A.M., Artru A.A., Eng C., and Soltow L. Ketamine alters calcium and magnesium in brain tissue following experimental head trauma in rats. J. Cereb. Blood Flow. Metab. 13 (1993) 962-968
25. Ko S.H., Lee S.K., Han Y.J., Choe H., Kwak Y.G., Chae S.W., Cho K.P., and Song H.S. Blockade of myocardial ATP-sensitive potassium channels by ketamine. Anesthesiology 87 (1997) 68-74
26. Edwards G., and Weston A.H. The pharmacology of ATP-sensitive potassium channels. Annu. Rev. Pharmacol. Toxicol. 33 (1993) 597-637
27. Waas W.F., and Dalby D.N. Physiological concentrations of divalent magnesium ion activate the serine/threonine specific protein kinase ERK2. Biochemistry 42 (2003) 2960-2970
28. Liao P., Wang S.Q., Wang S., Zheng M., Zheng M., Zhang S.J., Cheng H., Wang Y., and Xiao R.P. p38 Mitogen-activated protein kinase mediates a negative inotropic effect in cardiac myocytes. Circ. Res. 90 (2002) 190-196
29. Boulom V., Lee H.W., Zhao L., and Eghbali-Webb M. Stimulation of DNA synthesis, activation of mitogen-activated protein kinase ERK2 and nuclear accumulation of c-fos in human aortic smooth muscle cells by ketamine. Cell Prolif. 35 (2002) 155-165