A novel diol-derivative of chalcone produced by bioconversion, 3-(2,3-dihydroxyphenyl)-1-phenylpropan-1-one, activates PKA/MEK/ERK signaling and antagonizes Aβ-inhibition of the cascade in cultured rat CNS neurons

European Journal of Pharmacology

Volumn 600, Issue 1-3, 2008, Pages 10-17

  Al Rahim, Md ^a   Nakajima, Akira ^a   Misawa, Norihiko ^b   Shindo, Kazutoshi ^c   Adachi, Kyoko ^b   Shizuri, Yoshikazu ^b   Ohizumi, Yasushi ^a,d,e   Yamakuni, Tohru ^a  

^a TOHOKU UNIVERSITY   (Japan)

^b MARINE BIOTECHNOLOGY INSTITUTE   (Japan)

^c JAPAN WOMEN'S UNIVERSITY   (Japan)

^d YOKOHAMA COLLEGE OF PHARMACY   (Japan)

^e UNIVERSITY OF SHIZUOKA   (Japan)

Author keywords

A amyloid peptide ; Chalcone diol; CNS central nervous system neuronal culture; CREB cAMP response element binding protein ; ERK extracellular signal regulated kinase

Indexed keywords

3 (2,3 DIHYDROXYPHENYL) 1 PHENYLPROPAN 1 ONE; AMYLOID BETA PROTEIN; CHALCONE DERIVATIVE; CRE RECOMBINASE; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE 6; MITOGEN ACTIVATED PROTEIN KINASE KINASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BIOTRANSFORMATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; EMBRYO; ENZYME ACTIVATION; ESCHERICHIA COLI; NERVE CELL CULTURE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; ANIMALS; CELLS, CULTURED; CEREBRAL CORTEX; CYCLIC AMP; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DOSE-RESPONSE RELATIONSHIP, DRUG; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; MITOGEN-ACTIVATED PROTEIN KINASES; NEURONS; PHOSPHORYLATION; PROPIOPHENONES; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION; TIME FACTORS;

EID: 55949121306     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2008.09.046     Document Type: Article

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