Evidence for estrogenic contamination of the MAPK inhibitor PD98059

Endocrinology

Volumn 142, Issue 12, 2001, Pages 5390-5393

  Long, X ^a   Gize, E A ^a   Nephew, K ^a   Bigsby, R M ^a  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR;

ARTICLE; BINDING AFFINITY; BREAST CANCER; CANCER CELL CULTURE; CONCENTRATION RESPONSE; DOSE RESPONSE; DRUG EFFECT; DRUG RECEPTOR BINDING; ENZYME ACTIVATION; ENZYME ACTIVITY; ESTROGEN ACTIVITY; HORMONE SENSITIVITY; HUMAN; HUMAN CELL; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; REPORTER GENE;

BINDING, COMPETITIVE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG CONTAMINATION; ENZYME INHIBITORS; ESTRADIOL; ESTROGEN RECEPTOR ALPHA; ESTROGENS; FLAVONOIDS; MITOGEN-ACTIVATED PROTEIN KINASES; RECEPTORS, ESTROGEN; TUMOR CELLS, CULTURED;

EID: 0035210802     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/en.142.12.5390     Document Type: Article

References (13)

1. Cross-talk between peptide growth factor and estrogen receptor signaling pathways
2. Activation of the unliganded estrogen receptor by EGF involves the MAP kinase pathway and direct phosphorylation
3. AIB 1 is a conduit for kinase-mediated growth factor signaling to the estrogen receptor
4. Mitogen-activated protein kinase pathways
5. Inhibition of mitogen-activated protein kinase and phosphatidylinositol 3-kinase activity in MCF-7 cells prevents estrogen-induced mitogenesis
6. Estrogen modulation of prolactin gene expression requires an intact mitogen-activated protein kinase signal transduction pathway in cultured rat pituitary cells
7. Transcriptional activation of cathepsin D gene expression by growth factors
8. The 5′ flanking region of the pS2 gene contains a complex enhancer region responsive to oestrogens, epidermal growth factor, a tumour promoter (TPA), the c-Ha-ras oncoprotein and the c-jun protein
9. Studies of dehydroepiandrosterone (DHEA) with the human estrogen receptor in yeast
10. Detection of weak estrogenic flavonoids using a recombinant yeast strain and a modified MCF7 cell proliferation assay
11. Steroid receptor induction of gene transcription: A two-step model
12. Environmental estrogens induce transcriptionally active estrogen receptor dimers in yeast: Activity potentiated by the coactivator RIP140
13. Both Pit-1 and the estrogen receptor are required for estrogen responsiveness of the rat prolactin gene