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Volumn 107, Issue 5, 2008, Pages 1284-1293

Nerve growth factor regulates the expression of the cholinergic locus and the high-affinity choline transporter via the Akt/PKB signaling pathway

Author keywords

Acetylcholine; Choline acetyltransferase; Choline transporter; PC12 cells; Protein kinase B; Septum

Indexed keywords

ACETYLCHOLINE; CARRIER PROTEIN; CHOLINE ACETYLTRANSFERASE; CHOLINE TRANSPORTER; NERVE GROWTH FACTOR; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN KINASE B INHIBITOR; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

EID: 55849128946     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2008.05681.x     Document Type: Article
Times cited : (30)

References (52)
  • 1
    • 13944269898 scopus 로고    scopus 로고
    • The AKT/I kappa B kinase pathway promotes angiogenic/metastatic gene expression in colorectal cancer by activating nuclear factor-kappa B and beta-catenin
    • Agarwal A., Das K., Lerner N., Sathe S., Cicek M., Casey G. Sizemore N. (2005) The AKT/I kappa B kinase pathway promotes angiogenic/metastatic gene expression in colorectal cancer by activating nuclear factor-kappa B and beta-catenin. Oncogene 24, 1021 1031.
    • (2005) Oncogene , vol.24 , pp. 1021-1031
    • Agarwal, A.1    Das, K.2    Lerner, N.3    Sathe, S.4    Cicek, M.5    Casey, G.6    Sizemore, N.7
  • 2
    • 8144228424 scopus 로고    scopus 로고
    • PIKE/nuclear PI 3-kinase signaling mediates the antiapoptotic actions of NGF in the nucleus
    • Ahn J. Y., Rong R., Liu X. Ye K. (2004) PIKE/nuclear PI 3-kinase signaling mediates the antiapoptotic actions of NGF in the nucleus. EMBO J. 23, 3995 4006.
    • (2004) EMBO J. , vol.23 , pp. 3995-4006
    • Ahn, J.Y.1    Rong, R.2    Liu, X.3    Ye, K.4
  • 3
    • 0035210249 scopus 로고    scopus 로고
    • Molecular cloning and characterization of a murine hemicholinium-3- sensitive choline transporter
    • Apparsundaram S., Ferguson S. M. Blakely R. D. (2001) Molecular cloning and characterization of a murine hemicholinium-3-sensitive choline transporter. Biochem. Soc. Trans. 29, 711 716.
    • (2001) Biochem. Soc. Trans. , vol.29 , pp. 711-716
    • Apparsundaram, S.1    Ferguson, S.M.2    Blakely, R.D.3
  • 5
    • 0033198918 scopus 로고    scopus 로고
    • Activation of TrkA by nerve growth factor upregulates expression of the cholinergic gene locus but attenuates the response to ciliary neurotrophic growth factor
    • Berse B., Lopez-Coviella I. Blusztajn J. K. (1999) Activation of TrkA by nerve growth factor upregulates expression of the cholinergic gene locus but attenuates the response to ciliary neurotrophic growth factor. Biochem. J. 342, 301 308.
    • (1999) Biochem. J. , vol.342 , pp. 301-308
    • Berse, B.1    Lopez-Coviella, I.2    Blusztajn, J.K.3
  • 7
    • 0033773645 scopus 로고    scopus 로고
    • Opposing actions of phosphatidylinositol 3-kinase and glycogen synthase kinase-3beta in the regulation of HSF-1 activity
    • Bijur G. N. Jope R. S. (2000) Opposing actions of phosphatidylinositol 3-kinase and glycogen synthase kinase-3beta in the regulation of HSF-1 activity. J. Neurochem. 75, 2401 2408.
    • (2000) J. Neurochem. , vol.75 , pp. 2401-2408
    • Bijur, G.N.1    Jope, R.S.2
  • 8
    • 3042602081 scopus 로고    scopus 로고
    • Choline transporter 1 maintains cholinergic function in choline acetyltransferase haploinsufficiency
    • Brandon E. P., Mellott T., Pizzo D. P. et al. (2004) Choline transporter 1 maintains cholinergic function in choline acetyltransferase haploinsufficiency. J. Neurosci. 24, 5459 5466.
    • (2004) J. Neurosci. , vol.24 , pp. 5459-5466
    • Brandon, E.P.1    Mellott, T.2    Pizzo, D.P.3
  • 9
    • 2342565881 scopus 로고    scopus 로고
    • Advances in protein kinase B signalling: AKTion on multiple fronts
    • Brazil D. P., Yang Z. Z. Hemmings B. A. (2004) Advances in protein kinase B signalling: AKTion on multiple fronts. Trends Biochem. Sci. 29, 233 242.
    • (2004) Trends Biochem. Sci. , vol.29 , pp. 233-242
    • Brazil, D.P.1    Yang, Z.Z.2    Hemmings, B.A.3
  • 10
    • 33947699827 scopus 로고    scopus 로고
    • Differential regulation of the high affinity choline transporter and the cholinergic locus by cAMP signaling pathways
    • Brock M., Nickel A. C., Madziar B., Blusztajn J. K. Berse B. (2007) Differential regulation of the high affinity choline transporter and the cholinergic locus by cAMP signaling pathways. Brain Res. 1145, 1 10.
    • (2007) Brain Res. , vol.1145 , pp. 1-10
    • Brock, M.1    Nickel, A.C.2    Madziar, B.3    Blusztajn, J.K.4    Berse, B.5
  • 11
    • 0035369623 scopus 로고    scopus 로고
    • Transcription-dependent and -independent control of neuronal survival by the PI3K-Akt signaling pathway
    • Brunet A., Datta S. R. Greenberg M. E. (2001) Transcription-dependent and -independent control of neuronal survival by the PI3K-Akt signaling pathway. Curr. Opin. Neurobiol. 11, 297 305.
    • (2001) Curr. Opin. Neurobiol. , vol.11 , pp. 297-305
    • Brunet, A.1    Datta, S.R.2    Greenberg, M.E.3
  • 12
    • 0037205048 scopus 로고    scopus 로고
    • The phosphoinositide 3-kinase pathway
    • Cantley L. C. (2002) The phosphoinositide 3-kinase pathway. Science 296, 1655 1657.
    • (2002) Science , vol.296 , pp. 1655-1657
    • Cantley, L.C.1
  • 13
    • 33947306609 scopus 로고    scopus 로고
    • PIKE GTPase are phosphoinositide-3-kinase enhancers, suppressing programmed cell death
    • Chan C. B. Ye K. (2007) PIKE GTPase are phosphoinositide-3-kinase enhancers, suppressing programmed cell death. J. Cell Mol. Med. 11, 39 53.
    • (2007) J. Cell Mol. Med. , vol.11 , pp. 39-53
    • Chan, C.B.1    Ye, K.2
  • 16
    • 1342321750 scopus 로고    scopus 로고
    • PI 3-kinase, Akt and cell survival
    • Downward J. (2004) PI 3-kinase, Akt and cell survival. Semin. Cell. Dev. Biol. 15, 177 182.
    • (2004) Semin. Cell. Dev. Biol. , vol.15 , pp. 177-182
    • Downward, J.1
  • 18
    • 0009663357 scopus 로고
    • A multiple comparison procedure for comparing several treatments with a control
    • Dunnett C. W. (1955) A multiple comparison procedure for comparing several treatments with a control. J. Am. Stat. Assoc. 50, 1096 1121.
    • (1955) J. Am. Stat. Assoc. , vol.50 , pp. 1096-1121
    • Dunnett, C.W.1
  • 20
    • 48649088560 scopus 로고    scopus 로고
    • Intracellular signaling by Akt: Bound to be specific
    • Franke T. F. (2008) Intracellular signaling by Akt: bound to be specific. Sci. Signal. 1, pe29.
    • (2008) Sci. Signal. , vol.1
    • Franke, T.F.1
  • 21
    • 24744460940 scopus 로고    scopus 로고
    • Transcriptional regulation of neuronal genes and its effect on neural functions: Expression and function of forkhead transcription factors in neurons
    • Fukunaga K., Ishigami T. Kawano T. (2005) Transcriptional regulation of neuronal genes and its effect on neural functions: expression and function of forkhead transcription factors in neurons. J. Pharmacol. Sci. 98, 205 211.
    • (2005) J. Pharmacol. Sci. , vol.98 , pp. 205-211
    • Fukunaga, K.1    Ishigami, T.2    Kawano, T.3
  • 22
    • 1542328927 scopus 로고    scopus 로고
    • Structure, regulation and function of PKB/AKT - A major therapeutic target
    • Hanada M., Feng J. Hemmings B. A. (2004) Structure, regulation and function of PKB/AKT - a major therapeutic target. Biochim. Biophys. Acta 1697, 3 16.
    • (2004) Biochim. Biophys. Acta , vol.1697 , pp. 3-16
    • Hanada, M.1    Feng, J.2    Hemmings, B.A.3
  • 23
    • 11144222174 scopus 로고    scopus 로고
    • Inhibition of Akt kinase activity by a peptide spanning the betaA strand of the proto-oncogene TCL1
    • Hiromura M., Okada F., Obata T., Auguin D., Shibata T., Roumestand C. Noguchi M. (2004) Inhibition of Akt kinase activity by a peptide spanning the betaA strand of the proto-oncogene TCL1. J. Biol. Chem. 279, 53407 53418.
    • (2004) J. Biol. Chem. , vol.279 , pp. 53407-53418
    • Hiromura, M.1    Okada, F.2    Obata, T.3    Auguin, D.4    Shibata, T.5    Roumestand, C.6    Noguchi, M.7
  • 24
    • 28844434558 scopus 로고    scopus 로고
    • MTOR.RICTOR is the Ser473 kinase for Akt/protein kinase B in 3T3-L1 adipocytes
    • Hresko R. C. Mueckler M. (2005) mTOR.RICTOR is the Ser473 kinase for Akt/protein kinase B in 3T3-L1 adipocytes. J. Biol. Chem. 280, 40406 40416.
    • (2005) J. Biol. Chem. , vol.280 , pp. 40406-40416
    • Hresko, R.C.1    Mueckler, M.2
  • 25
    • 0034632791 scopus 로고    scopus 로고
    • 3-(Hydroxymethyl)-bearing phosphatidylinositol ether lipid analogues and carbonate surrogates block PI3-K, Akt, and cancer cell growth
    • Hu Y., Qiao L., Wang S., Rong S. B., Meuillet E. J., Berggren M., Gallegos A., Powis G. Kozikowski A. P. (2000) 3-(Hydroxymethyl)-bearing phosphatidylinositol ether lipid analogues and carbonate surrogates block PI3-K, Akt, and cancer cell growth. J. Med. Chem. 43, 3045 3051.
    • (2000) J. Med. Chem. , vol.43 , pp. 3045-3051
    • Hu, Y.1    Qiao, L.2    Wang, S.3    Rong, S.B.4    Meuillet, E.J.5    Berggren, M.6    Gallegos, A.7    Powis, G.8    Kozikowski, A.P.9
  • 26
    • 22544466382 scopus 로고    scopus 로고
    • Akt phosphorylation of p300 at Ser-1834 is essential for its histone acetyltransferase and transcriptional activity
    • Huang W. C. Chen C. C. (2005) Akt phosphorylation of p300 at Ser-1834 is essential for its histone acetyltransferase and transcriptional activity. Mol. Cell. Biol. 25, 6592 6602.
    • (2005) Mol. Cell. Biol. , vol.25 , pp. 6592-6602
    • Huang, W.C.1    Chen, C.C.2
  • 27
    • 33749076673 scopus 로고    scopus 로고
    • SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity
    • Jacinto E., Facchinetti V., Liu D., Soto N., Wei S., Jung S. Y., Huang Q., Qin J. Su B. (2006) SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity. Cell 127, 125 137.
    • (2006) Cell , vol.127 , pp. 125-137
    • Jacinto, E.1    Facchinetti, V.2    Liu, D.3    Soto, N.4    Wei, S.5    Jung, S.Y.6    Huang, Q.7    Qin, J.8    Su, B.9
  • 28
    • 0038578823 scopus 로고    scopus 로고
    • The PI-3 kinase/Akt pathway and T cell activation: Pleiotropic pathways downstream of PIP3
    • Kane L. P. Weiss A. (2003) The PI-3 kinase/Akt pathway and T cell activation: pleiotropic pathways downstream of PIP3. Immunol. Rev. 192, 7 20.
    • (2003) Immunol. Rev. , vol.192 , pp. 7-20
    • Kane, L.P.1    Weiss, A.2
  • 29
    • 0034044227 scopus 로고    scopus 로고
    • Neurotrophin signal transduction in the nervous system
    • Kaplan D. R. Miller F. D. (2000) Neurotrophin signal transduction in the nervous system. Curr. Opin. Neurobiol. 10, 381 391.
    • (2000) Curr. Opin. Neurobiol. , vol.10 , pp. 381-391
    • Kaplan, D.R.1    Miller, F.D.2
  • 30
    • 0037016513 scopus 로고    scopus 로고
    • Distribution of the high-affinity choline transporter in the human and macaque monkey spinal cord
    • Kobayashi Y., Okuda T., Fujioka Y., Matsumura G., Nishimura Y. Haga T. (2002) Distribution of the high-affinity choline transporter in the human and macaque monkey spinal cord. Neurosci. Lett. 317, 25 28.
    • (2002) Neurosci. Lett. , vol.317 , pp. 25-28
    • Kobayashi, Y.1    Okuda, T.2    Fujioka, Y.3    Matsumura, G.4    Nishimura, Y.5    Haga, T.6
  • 31
    • 0037419785 scopus 로고    scopus 로고
    • Novel PI analogues selectively block activation of the pro-survival serine/threonine kinase Akt
    • Kozikowski A. P., Sun H., Brognard J. Dennis P. A. (2003) Novel PI analogues selectively block activation of the pro-survival serine/threonine kinase Akt. J. Am. Chem. Soc. 125, 1144 1145.
    • (2003) J. Am. Chem. Soc. , vol.125 , pp. 1144-1145
    • Kozikowski, A.P.1    Sun, H.2    Brognard, J.3    Dennis, P.A.4
  • 34
    • 13444311821 scopus 로고    scopus 로고
    • Differential expression and regulation of the high-affinity choline transporter CHT1 and choline acetyltransferase in neurons of superior cervical ganglia
    • Lecomte M. J., De Gois S., Guerci A., Ravassard P., Faucon Biguet N., Mallet J. Berrard S. (2005) Differential expression and regulation of the high-affinity choline transporter CHT1 and choline acetyltransferase in neurons of superior cervical ganglia. Mol. Cell. Neurosci. 28, 303 313.
    • (2005) Mol. Cell. Neurosci. , vol.28 , pp. 303-313
    • Lecomte, M.J.1    De Gois, S.2    Guerci, A.3    Ravassard, P.4    Faucon Biguet, N.5    Mallet, J.6    Berrard, S.7
  • 35
    • 26444484932 scopus 로고    scopus 로고
    • Akt-induced promotion of cell-cycle progression at G(2)/M phase involves upregulation of NF-Y binding activity in PC12 cells
    • Lee S. R., Park J. H., Park E. K., Chung C. H., Kang S. S. Bang O. S. (2005) Akt-induced promotion of cell-cycle progression at G(2)/M phase involves upregulation of NF-Y binding activity in PC12 cells. J. Cell. Physiol. 205, 270 277.
    • (2005) J. Cell. Physiol. , vol.205 , pp. 270-277
    • Lee, S.R.1    Park, J.H.2    Park, E.K.3    Chung, C.H.4    Kang, S.S.5    Bang, O.S.6
  • 36
    • 0028920679 scopus 로고
    • Regulation of TrkA and ChAT expression in developing rat basal forebrain: Evidence that both exogenous and endogenous NGF regulate differentiation of cholinergic neurons
    • Li Y., Holtzman D. M., Kromer L. F., Kaplan D. R., Chua-Couzens J., Clary D. O., Knusel B. Mobley W. C. (1995) Regulation of TrkA and ChAT expression in developing rat basal forebrain: evidence that both exogenous and endogenous NGF regulate differentiation of cholinergic neurons. J. Neurosci. 15, 2888 2905.
    • (1995) J. Neurosci. , vol.15 , pp. 2888-2905
    • Li, Y.1    Holtzman, D.M.2    Kromer, L.F.3    Kaplan, D.R.4    Chua-Couzens, J.5    Clary, D.O.6    Knusel, B.7    Mobley, W.C.8
  • 37
    • 2342618936 scopus 로고    scopus 로고
    • Multiple roles of the PI3K/PKB (Akt) pathway in cell cycle progression
    • Liang J. Slingerland J. M. (2003) Multiple roles of the PI3K/PKB (Akt) pathway in cell cycle progression. Cell Cycle 2, 339 345.
    • (2003) Cell Cycle , vol.2 , pp. 339-345
    • Liang, J.1    Slingerland, J.M.2
  • 38
    • 13644262065 scopus 로고    scopus 로고
    • Regulation of cholinergic gene expression by nerve growth factor depends on the phosphatidylinositol-3′-kinase pathway
    • Madziar B., Lopez-Coviella I., Zemelko V. Berse B. (2005) Regulation of cholinergic gene expression by nerve growth factor depends on the phosphatidylinositol-3′-kinase pathway. J. Neurochem. 92, 767 779.
    • (2005) J. Neurochem. , vol.92 , pp. 767-779
    • Madziar, B.1    Lopez-Coviella, I.2    Zemelko, V.3    Berse, B.4
  • 39
    • 34250788809 scopus 로고    scopus 로고
    • AKT/PKB signaling: Navigating downstream
    • Manning B. D. Cantley L. C. (2007) AKT/PKB signaling: navigating downstream. Cell 129, 1261 1274.
    • (2007) Cell , vol.129 , pp. 1261-1274
    • Manning, B.D.1    Cantley, L.C.2
  • 40
    • 34248224881 scopus 로고    scopus 로고
    • Prenatal choline deficiency increases choline transporter expression in the septum and hippocampus during postnatal development and in adulthood in rats
    • Mellott T. J., Kowall N. W., Lopez-Coviella I. Blusztajn J. K. (2007) Prenatal choline deficiency increases choline transporter expression in the septum and hippocampus during postnatal development and in adulthood in rats. Brain Res. 1151, 1 11.
    • (2007) Brain Res. , vol.1151 , pp. 1-11
    • Mellott, T.J.1    Kowall, N.W.2    Lopez-Coviella, I.3    Blusztajn, J.K.4
  • 41
    • 33646791491 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase and glycogen synthase kinase 3 regulate estrogen receptor-mediated transcription in neuronal cells
    • Mendez P. Garcia-Segura L. M. (2006) Phosphatidylinositol 3-kinase and glycogen synthase kinase 3 regulate estrogen receptor-mediated transcription in neuronal cells. Endocrinology 147, 3027 3039.
    • (2006) Endocrinology , vol.147 , pp. 3027-3039
    • Mendez, P.1    Garcia-Segura, L.M.2
  • 42
    • 0033178646 scopus 로고    scopus 로고
    • Nerve growth factor increases the synthesis and release of acetylcholine and the expression of vesicular acetylcholine transporter in primary cultured rat embryonic septal cells
    • Oosawa H., Fujii T. Kawashima K. (1999) Nerve growth factor increases the synthesis and release of acetylcholine and the expression of vesicular acetylcholine transporter in primary cultured rat embryonic septal cells. J. Neurosci. Res. 57, 381 387.
    • (1999) J. Neurosci. Res. , vol.57 , pp. 381-387
    • Oosawa, H.1    Fujii, T.2    Kawashima, K.3
  • 43
    • 0032512135 scopus 로고    scopus 로고
    • NGF-induction of the expression of ChAT mRNA in PC12 cells and primary cultures of embryonic rat basal forebrain
    • Pongrac J. L. Rylett R. J. (1998) NGF-induction of the expression of ChAT mRNA in PC12 cells and primary cultures of embryonic rat basal forebrain. Brain Res. Mol. Brain Res. 62, 25 34.
    • (1998) Brain Res. Mol. Brain Res. , vol.62 , pp. 25-34
    • Pongrac, J.L.1    Rylett, R.J.2
  • 44
    • 26244464326 scopus 로고    scopus 로고
    • PKB/Akt induces transcription of enzymes involved in cholesterol and fatty acid biosynthesis via activation of SREBP
    • Porstmann T., Griffiths B., Chung Y. L., Delpuech O., Griffiths J. R., Downward J. Schulze A. (2005) PKB/Akt induces transcription of enzymes involved in cholesterol and fatty acid biosynthesis via activation of SREBP. Oncogene 24, 6465 6481.
    • (2005) Oncogene , vol.24 , pp. 6465-6481
    • Porstmann, T.1    Griffiths, B.2    Chung, Y.L.3    Delpuech, O.4    Griffiths, J.R.5    Downward, J.6    Schulze, A.7
  • 45
    • 13844312400 scopus 로고    scopus 로고
    • Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
    • Sarbassov D. D., Guertin D. A., Ali S. M. Sabatini D. M. (2005) Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science 307, 1098 1101.
    • (2005) Science , vol.307 , pp. 1098-1101
    • Sarbassov, D.D.1    Guertin, D.A.2    Ali, S.M.3    Sabatini, D.M.4
  • 47
    • 4143083694 scopus 로고    scopus 로고
    • Effects of NGF on acetylcholine, acetyl-CoA metabolism, and viability of differentiated and non-differentiated cholinergic neuroblastoma cells
    • Szutowicz A., Madziar B., Pawelczyk T., Tomaszewicz M. Bielarczyk H. (2004) Effects of NGF on acetylcholine, acetyl-CoA metabolism, and viability of differentiated and non-differentiated cholinergic neuroblastoma cells. J. Neurochem. 90, 952 961.
    • (2004) J. Neurochem. , vol.90 , pp. 952-961
    • Szutowicz, A.1    Madziar, B.2    Pawelczyk, T.3    Tomaszewicz, M.4    Bielarczyk, H.5
  • 48
    • 0030000182 scopus 로고    scopus 로고
    • Developmental age-dependent upregulation of choline acetyltransferase and vesicular acetylcholine transporter mRNA expression in neonatal rat septum by nerve growth factor
    • Tian X., Sun X. Suszkiw J. B. (1996) Developmental age-dependent upregulation of choline acetyltransferase and vesicular acetylcholine transporter mRNA expression in neonatal rat septum by nerve growth factor. Neurosci. Lett. 209, 134 136.
    • (1996) Neurosci. Lett. , vol.209 , pp. 134-136
    • Tian, X.1    Sun, X.2    Suszkiw, J.B.3
  • 50
    • 33846574233 scopus 로고    scopus 로고
    • Age-dependent loss of NGF signaling in the rat basal forebrain is due to disrupted MAPK activation
    • Williams B., Granholm A. C. Sambamurti K. (2007) Age-dependent loss of NGF signaling in the rat basal forebrain is due to disrupted MAPK activation. Neurosci. Lett. 413, 110 114.
    • (2007) Neurosci. Lett. , vol.413 , pp. 110-114
    • Williams, B.1    Granholm, A.C.2    Sambamurti, K.3
  • 51
    • 15044363028 scopus 로고    scopus 로고
    • Recent advances in the protein kinase B signaling pathway
    • Woodgett J. R. (2005) Recent advances in the protein kinase B signaling pathway. Curr. Opin. Cell Biol. 17, 150 157.
    • (2005) Curr. Opin. Cell Biol. , vol.17 , pp. 150-157
    • Woodgett, J.R.1
  • 52
    • 0030248402 scopus 로고    scopus 로고
    • Nerve growth factor and the neurotrophic factor hypothesis
    • Yuen E. C., Howe C. L., Li Y., Holtzman D. M. Mobley W. C. (1996) Nerve growth factor and the neurotrophic factor hypothesis. Brain Dev. 18, 362 368.
    • (1996) Brain Dev. , vol.18 , pp. 362-368
    • Yuen, E.C.1    Howe, C.L.2    Li, Y.3    Holtzman, D.M.4    Mobley, W.C.5


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