A toxicologic and dermatologic assessment of cyclic and non-cyclic terpene alcohols when used as fragrance ingredients

Food and Chemical Toxicology

Volumn 46, Issue 11 SUPPL., 2008, Pages

  Belsito, D ^a   Bickers, D ^b   Bruze, M ^c   Calow, P ^d   Greim, H ^e   Hanifin, J M ^f   Rogers, A E ^g   Saurat, J H ^h   Sipes, I G ⁱ   Tagami, H ^j  

^a UNIVERSITY OF MISSOURI KANSAS CITY   (United States)

^b NewYork Presbyterian Hospital   (United States)

^c LUND UNIVERSITY HOSPITAL   (Sweden)

^d Environmental Assessment Institute   (Denmark)

^e TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^f OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^g BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^h GENEVA UNIVERSITY HOSPITALS   (Switzerland)

ⁱ UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

^j NONE   (Japan)

more..

Author keywords

[No Author keywords available]

Indexed keywords

2,6 DIMETHYL 3,5 OCTADIEN 2 OL; 3,7 DIMETHYL 1 OCTANOL; 3,7 DIMETHYL 4,6 OCTADIEN 3 OL; 3,7 DIMETHYLOCT 6 EN 3 OL; 3,7 DIMETHYLOCT 7 EN 1 OL; 4 CARVOMENTHENOL; 6,7 DIHYDROGERANIOL; ALCOHOL DERIVATIVE; BISABOLOL; BORNEOL; CARVEOL; CITRONELLOL; DEHYDROLINALOOL; FARNESOL; FRAGRANCE; GERANIOL; GERANYL LINALOOL; HYDROXYCITRONELLOL; ISOBORNEOL; LINALOOL; MUGUOL; MYRCENOL; NEROL; NEROLIDOL; OCIMENOL; RHODINOL; TERPENE DERIVATIVE; TETRAHYDROLINALOOL; TETRAHYDROMUGUOL; TETRAHYDROMYRCENOL; UNCLASSIFIED DRUG; PERFUME; TERPENE;

DERMIS; EPIDERMIS; HUMAN; NONHUMAN; REVIEW; SKIN ABSORPTION; SKIN TOXICITY; SUBCUTANEOUS TISSUE; TOXICITY TESTING; XENOBIOTIC METABOLISM; ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; CONTACT DERMATITIS; DRUG ADMINISTRATION ROUTE; MOUSE; RAT;

BACTERIA (MICROORGANISMS); ORYCTOLAGUS CUNICULUS;

ANIMALS; DERMATITIS, CONTACT; DRUG ADMINISTRATION ROUTES; HUMANS; MICE; MOLECULAR STRUCTURE; PERFUME; RATS; SKIN IRRITANCY TESTS; TERPENES;

EID: 55649115494     PISSN: 02786915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fct.2008.06.085     Document Type: Review

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257. RIFM (Research Institute for Fragrance Materials Inc.), 1978f. Acute toxicity studies on geranyl linalool. Unpublished Report from BASF, 9 June. Report Number 4454. RIFM, Woodcliff Lake, NJ, USA.
258. RIFM (Research Institute for Fragrance Materials Inc.), 1978g. Primary eye irritation test. Unpublished Report from Firmenich Incorporated, 21 September. Report Number 21397. RIFM, Woodcliff Lake, NJ, USA.
259. RIFM (Research Institute for Fragrance Materials Inc.), 1979a. Acute toxicity study in rats and rabbits. RIFM Report Number 1924, May 31. RIFM, Woodcliff Lake, NJ, USA.
260. RIFM (Research Institute for Fragrance Materials Inc.), 1979b. Report on human maximization studies. RIFM Report Number 1697, April to November. RIFM, Woodcliff Lake, NJ, USA.
261. RIFM (Research Institute for Fragrance Materials Inc.), 1979c. Local tolerance tests in the rabbit with farnesol. Unpublished Report from BASF, 10 August. Report Number 4459. RIFM, Woodcliff Lake, NJ, USA.
262. RIFM (Research Institute for Fragrance Materials Inc.), 1979d. Report on human maximization studies. RIFM Report Number 1775, March 7. RIFM, Woodcliff Lake, NJ, USA.
263. RIFM (Research Institute for Fragrance Materials, Inc.), 1979e. Repeated insult patch test of 6-isopropyl-2-isopropyl-2-decahydronaphthalenol in human subjects. Unpublished Report from Givaudan, 11 July. Report Number 18021. RIFM, Woodcliff Lake, NJ, USA.
264. RIFM (Research Institute for Fragrance Materials Inc.), 1979f. Acute dermal toxicity study. Unpublished Report from Firmenich Incorporated, 23 January. Report Number 21399. RIFM, Woodcliff Lake, NJ, USA.
265. RIFM (Research Institute for Fragrance Materials Inc.), 1979g. 29 Day percutaneous toxicity range finding with linalool in rats. RIFM Report Number 32943, May 22. RIFM, Woodcliff Lake, NJ, USA.
266. RIFM (Research Institute for Fragrance Materials Inc.), 1980a. A 90-day subacute dermal toxicity study with Linalool in rats. RIFM Report Number 4001, April 04. RIFM, Woodcliff Lake, NJ, USA.
267. RIFM (Research Institute for Fragrance Materials, Inc.), 1980b. Rat open application skin irritation test. Unpublished Report from Quest Inc., 25 September. Report Number 45420. RIFM, Woodcliff Lake, NJ, USA.
268. RIFM (Research Institute for Fragrance Materials Inc.), 1981a. Report on human maximization studies. RIFM Report Number 1792. March 18. (RIFM, Woodcliff Lake, NJ, USA.
269. RIFM (Research Institute for Fragrance Materials Inc.), 1981b. Determination of the oral LD50 in rats. Unpublished Report from IFF Incorporated, 14 December. Report Number 48369. RIFM, Woodcliff Lake, NJ, USA.
270. RIFM (Research Institute for Fragrance Materials Inc.), 1981c. Phototoxicity testing of fragrance materials. Unpublished Report from IFF, Incorporated, 9 March. Report Number 47075. RIFM, Woodcliff Lake, NJ, USA.
271. RIFM (Research Institute for Fragrance Materials Inc.), 1981d Acute toxicity studies with farnesol. Unpublished Report from IFF, Incorporated, 3 April. Report Number 4462. RIFM, Woodcliff Lake, NJ, USA.
272. RIFM (Research Institute for Fragrance Materials Inc.), 1982a. Acute toxicity studies. RIFM Report Number 1689, June 08. RIFM, Woodcliff Lake, NJ, USA,.
273. RIFM (Research Institute for Fragrance Materials Inc.), 1982b. Acute toxicity studies. RIFM Report Number 1689, September 29. RIFM, Woodcliff Lake, NJ, USA.
274. RIFM (Research Institute for Fragrance Materials Inc.), 1982c. Report on human maximization studies. RIFM Report Number 1643. RIFM, Woodcliff Lake, NJ, USA.
275. RIFM (Research Institute for Fragrance Materials Inc.), 1982d. Mutagenicity evaluation of linalool in the mouse lymphoma forward mutation assay. Report from Lorillard Tobacco Company, 31 August. Report Number 35826. RIFM, Woodcliff Lake, NJ, USA.
276. RIFM (Research Institute for Fragrance Materials Inc.), 1983a. Mutagenicity evaluation of linalool in the Ames Salmonella/microsome plate test. Unpublished Report from Lorillard Tobacco Company, 20 July. Report Number 35823. RIFM, Woodcliff Lake, NJ, USA.
277. RIFM (Research Institute for Fragrance Materials Inc.), 1983b. Mutagenicity evaluation of linalool in an in vitro cytogenetic assay measuring chromosome aberration frequencies in Chinese hamster ovary (CHO) cells. Unpublished Report from Lorillard Tobacco Company, 7 October. Report Number 35824. RIFM, Woodcliff Lake, NJ, USA.
278. RIFM (Research Institute for Fragrance Materials Inc.), 1983c. Maximization test in guinea pigs with farnesol. Unpublished Report from Dragoco, 3 February. Report Number 37812. RIFM, Woodcliff Lake, NJ, USA.
279. RIFM (Research Institute for Fragrance Materials Inc.), 1983d. Phototoxicity testing with farnesol. Unpublished Report from Dragoco Inc., 19 January. Report Number 37814. RIFM, Woodcliff Lake, NJ, USA.
280. RIFM (Research Institute for Fragrance Materials Inc.), 1983e. Photoallergenicity testing with farnesol. Unpublished Report from Dragoco Inc., 11 March. Report Number 37815. RIFM, Woodcliff Lake, NJ, USA.
281. RIFM (Research Institute for Fragrance Materials Inc.), 1983f. Farnesol 10% in vaseline: Acute dermal toxicity in rats. Unpublished Report from Dragaco Inc., 12 January. Report Number 37813. RIFM, Woodcliff Lake, NJ, USA.
282. RIFM (Research Institute for Fragrance Materials Inc.), 1984a. Primary skin irritation tests. RIFM Report Number 1795. RIFM, Woodcliff Lake, NJ, USA.
283. RIFM (Research Institute for Fragrance Materials Inc.), 1984b. Acute toxicity test. Unpublished Report from Quest International, 17 April. Report Number 46877, 17. RIFM, Woodcliff Lake, NJ, USA.
284. RIFM (Research Institute for Fragrance Materials Inc.), 1984c. Small volume eye irritation test. Unpublished Report from Quest International, 16 May. Report Number 46881. RIFM, Woodcliff Lake, NJ, USA.
285. RIFM (Research Institute for Fragrance Materials Inc.), 1984d. Guinea pig maximization test. Unpublished Report from Quest International, 20 January. Report Number 46883. RIFM, Woodcliff Lake, NJ, USA.
286. RIFM (Research Institute for Fragrance Materials Inc.), 1984e. Photoallergy test. Unpublished Report from Quest International, 11 June. Report Number 46879. RIFM, Woodcliff Lake, NJ, USA.
287. RIFM (Research Institute for Fragrance Materials Inc.), 1984f. Phototoxicity test. Unpublished Report from Quest International, 21 May. Report Number 46880. RIFM, Woodcliff Lake, NJ, USA.
288. RIFM (Research Institute for Fragrance Materials Inc.), 1984g. Guinea pig maximization test. Unpublished Report from Quest International, 20 January. Report Number 46882(RIFM, Woodcliff Lake, NJ, USA).
289. RIFM (Research Institute for Fragrance Materials Inc.), 1984h. Skin irritation test in rabbits. Unpublished Report from Quest International, 16 May. Report Number 46876. RIFM, Woodcliff Lake, NJ, USA.
290. RIFM (Research Institute for Fragrance Materials Inc.), 1984i. 14-day single dose subacute toxicity study in the rat with linalool. Unpublished Report from Lorillard Tobacco Company, January. Report Number 36660. RIFM, Woodcliff Lake, NJ, USA.
291. RIFM (Research Institute for Fragrance Materials Inc.), 1985a. Report on the study of the acute oral toxicity of 6,7-dihydrogeraniol in rats. Unpublished Report from BASF, 24 June. Report Number 3294. RIFM, Woodcliff Lake, NJ, USA.
292. RIFM (Research Institute for Fragrance Materials Inc.), 1985b. Primary skin irritation tests. RIFM Report Number 3099. RIFM, Woodcliff Lake, NJ, USA.
293. RIFM (Research Institute for Fragrance Materials Inc.), 1985c. Report on the study of the irritation on 6,7-dihydrogeraniol to the eye of the white rabbit based on the Draize method. Unpublished Report from BASF, 6 August. Report Number 3292. RIFM, Woodcliff Lake, NJ, USA.
294. RIFM (Research Institute for Fragrance Materials Inc.), 1985d. Report on the study of acute dermal toxicity of 6,7-dihydrogeraniol on rats. Unpublished Report from BASF, 24 June. Report Number 3293. RIFM, Woodcliff Lake, NJ, USA.
295. RIFM (Research Institute for Fragrance Materials Inc.), 1985f. Report on the study of the irritation on 6,7-dihydrogeraniol to the intact and abraded dorsal skin of the white rabbit based on Draize. Unpublished Report from BASF, 6 August. Report Number 3295. RIFM, Woodcliff Lake, NJ, USA.
296. RIFM (Research Institute for Fragrance Materials Inc.), 1985g. Maximization study of 6,7-dihydro-geraniol in human subjects. Unpublished Report from Fritzsche Dodge and Olcott, Inc., 18 June. Report Number 3296. RIFM, Woodcliff Lake, NJ, USA.
297. RIFM (Research Institute for Fragrance Materials Inc.), 1985h. Report on the maximization test for the sensitizing potential of 6,7-dihydrogeraniol in guinea pigs. Unpublished Report from BASF, 18 September. Report Number 3297. RIFM, Woodcliff Lake, NJ, USA.
298. RIFM (Research Institute for Fragrance Materials Inc.), 1985i. Report on human maximization studies. RIFM Report Number 1919, January 7. RIFM, Woodcliff Lake, NJ, USA.
299. RIFM (Research Institute for Fragrance Materials Inc.), 1985k. Ames test. Unpublished Report from Quest International, 29 August. Report Number 46878. RIFM, Woodcliff Lake, NJ, USA.
300. RIFM (Research Institute for Fragrance Materials, Inc.), 1985l. Determination of phototoxicity of geranodyle in guinea pigs. Unpublished Report from Givaudan, 1 October. Report Number 43447. RIFM, Woodcliff Lake, NJ, USA.
301. RIFM (Research Institute for Fragrance Materials, Inc.), 1985m. Determination of photoallergenicity of geranodyle in guinea pigs. Unpublished Report from Givaudan, 1 December. Report Number 43448. RIFM, Woodcliff Lake, NJ, USA.
302. RIFM (Research Institute for Fragrance Materials Inc.), 1986a. Acute dermal irritation study in rabbits. RIFM Report Number 5664. June 1986. RIFM, Woodcliff Lake, NJ, USA.
303. RIFM (Research Institute for Fragrance Materials Inc.), 1986b. Report on human maximization studies. RIFM Report Number 3100, January 15. RIFM, Woodcliff Lake, NJ, USA.
304. RIFM (Research Institute for Fragrance Materials Inc.), 1986c. Unscheduled DNA synthesis in rat primary hepatocytes. Report from Lorillard Tobacco Company, 5 May. Report Number 35825. RIFM, Woodcliff Lake, NJ, USA.
305. RIFM (Research Institute for Fragrance Materials Inc.), 1987a. Acute dermal irritation study in rabbits. RIFM Report Number 5667, August 1. RIFM, Woodcliff Lake, NJ, USA.
306. RIFM (Research Institute for Fragrance Materials Inc.), 1987b. Acute dermal irritation/corrosion test of nerol in the rabbit. Unpublished Report from BBA, 17 July. Report Number 15426. RIFM, Woodcliff Lake, NJ, USA.
307. RIFM (Research Institute for Fragrance Materials Inc.), 1987c. Acute dermal irritation/corrosion test of geraniol in the rabbit. Unpublished Report from BBA, 5 August. Report Number 15427. RIFM, Woodcliff Lake, NJ, USA.
308. RIFM (Research Institute for Fragrance Materials Inc.), 1987d. Delayed contact hypersensitivity study of myrtenol in guinea pigs. RIFM Report Number 5176, May 14. RIFM, Woodcliff Lake, NJ, USA.
309. RIFM (Research Institute for Fragrance Materials Inc.), 1987e. Report on human maximization studies. RIFM Report Number 5669, June 29. RIFM, Woodcliff Lake, NJ, USA.
310. RIFM (Research Institute for Fragrance Materials, Inc.), 1987f. Acute dermal irritation/corrosion test of geraniol in the rabbit. Unpublished Report from BBA, 17 July. Report Number 15428. RIFM, Woodcliff Lake, NJ, USA.
311. RIFM (Research Institute for Fragrance Materials, Inc.), 1987g. Geranodyle: Primary skin irritation test in rabbits. Unpublished Report from Givaudan, 1 August. Report Number 43446. RIFM, Woodcliff Lake, NJ, USA.
312. RIFM (Research Institute for Fragrance Materials, Inc.), 1987h. An acute dermal toxicity study with geranodyle on rats (Limit Test). Unpublished Report from Givaudan, 13 January. Report Number 43449January. RIFM, Woodcliff Lake, NJ, USA.
313. RIFM (Research Institute for Fragrance Materials, Inc.), 1987i. Primary eye irritation study with geranodyle. Unpublished Report from Givaudan, 3 June. Report Number 43445. RIFM, Woodcliff Lake, NJ, USA.
314. RIFM (Research Institute for Fragrance Materials Inc.), 1988a. Report on the acute irritation to the eye of the white rabbit. Unpublished Report from BASF, 14 November. Report Number 49356. RIFM, Woodcliff Lake, NJ, USA.
315. RIFM (Research Institute for Fragrance Materials Inc.), 1988b. Report on the acute dermal irritation/corrosion to the intact dorsal skin of the white rabbit. Unpublished Report from BASF, 14 November. Report Number 49357. RIFM, Woodcliff Lake, NJ, USA.
316. RIFM (Research Institute for Fragrance Materials Inc.), 1988c. Repeat insult patch tests with various compounds in humans. RIFM Report Number 6063, December, 13. RIFM, Woodcliff Lake, NJ, USA.
317. RIFM (Research Institute for Fragrance Materials Inc.), 1988d. Acute inhalation toxicity test of dehydrolinalool in rats. Unpublished Report from BASF, 20 June. Report Number 26075. RIFM, Woodcliff Lake, NJ, USA.
318. RIFM (Research Institute for Fragrance Materials Inc.), 1988e. Acute dermal irritation study. RIFM Report Number 9403, November. RIFM, Woodcliff Lake, NJ, USA.
319. RIFM (Research Institute for Fragrance Materials Inc.), 1989a. Acute dermal irritation/corrosion study on 3,7-dimethyl-1-octanol in rabbits. Unpublished Report from BBA, 1 February. Report Number 15622. RIFM, Woodcliff Lake, NJ, USA.
320. RIFM (Research Institute for Fragrance Materials Inc.), 1989b. Repeat insult patch test. RIFM Report Number 8514, January, 18. RIFM, Woodcliff Lake, NJ, USA.
321. RIFM (Research Institute for Fragrance Materials Inc.), 1989c. Reproductive and developmental toxicity screening test of Coriander Oil administered orally via gavage to Crl: Cd(tm) (sd) br female rats. Unpublished Report from Lorillard Tobacco Company, 12 April. Report Number 36124. RIFM, Woodcliff Lake, NJ, USA.
322. RIFM (Research Institute for Fragrance Materials Inc.), 1989d. Report on the study of dehydrolinalool in the Ames test (Standard plate test and preincubation test with Salmonella typhimurium). Unpublished Report from BASF, 14 March. Report Number 26074. RIFM, Woodcliff Lake, NJ, USA.
323. RIFM (Research Institute for Fragrance Materials Inc.), 1989e. Acute dermal irritation/corrosion study of dl-citronellol in rabbits. Unpublished Report from BBA, February. Report Number 12333. RIFM, Woodcliff Lake, NJ, USA.
324. RIFM (Research Institute for Fragrance Materials Inc.), 1989f. Report on the mutagenicity testing with farnesol. Unpublished Report from Dragoco, 14 July. Report Number 37820. RIFM, Woodcliff Lake, NJ, USA.
325. RIFM (Research Institute for Fragrance Materials Inc.), 1989g. Delayed contact hypersensitivity study of geraniol in guinea pigs (Maximization tests). Unpublished Report from Quest Incorporated, 15 December. Report Number 15429. RIFM, Woodcliff Lake, NJ, USA.
326. RIFM (Research Institute for Fragrance Materials Inc.), 1990a. A 28-day oral toxicity study of Coriander oil in rats. Unpublished Report from Lorillard Tobacco Company, 25 January. Report Number 36125. RIFM, Woodcliff Lake, NJ, USA.
327. RIFM (Research Institute for Fragrance Materials, Inc.), 1991a. Acute oral toxicity of cis-verbenol in rats. Unpublished Report from Bedoukian Research Incorporated, 14 June. Report Number 17241. RIFM, Woodcliff Lake, NJ, USA.
328. RIFM (Research Institute for Fragrance Materials, Inc.), 1991b. Primary skin irritation of cis-verbenol in rabbits. Unpublished Report from Bedoukian Research Incorporated, 14 June. Report Number 17242. RIFM, Woodcliff Lake, NJ, USA.
329. RIFM (Research Institute for Fragrance Materials, Inc.), 1992a. Guinea pig dermal sensitization of cis verbenol. Unpublished Report from Bedoukian Research Incorporated, 7 February. Report Number 17243.
330. RIFM (Research Institute for Fragrance Materials Inc.), 1992b. Linalool and Dehydrolinalool. Acute toxicity and local tolerance. Submission to EPA by Rhone-Poulenc, Inc., 11 September. Report Number 23272. RIFM, Woodcliff Lake, NJ, USA.
331. RIFM (Research Institute for Fragrance Materials Inc.), 1992c. Delayed contact hypersensitivity study of citronellol in guinea pigs (Buehler Technique). RIFM Report Number 17635, September 25. RIFM, Woodcliff Lake, NJ, USA.
332. RIFM (Research Institute for Fragrance Materials Inc.), 1992d. Delayed contact hypersensitivity study of geraniol in guinea pigs (Buehler Technique). RIFM Report Number 17636, September 28. RIFM, Woodcliff Lake, NJ, USA.
333. RIFM (Research Institute for Fragrance Materials Inc.), 1992e. Delayed contact hypersensitivity study of nerol in guinea pigs (Buehler Technique). RIFM Report Number 17637, September 25. RIFM, Woodcliff Lake, NJ, USA.
334. RIFM (Research Institute for Fragrance Materials Inc.), 1993a. Delayed contact hypersensitivity study of l-citronellol in guinea pigs (Buehler Technique). RIFM Report Number 20353, July 9. RIFM, Woodcliff Lake, NJ, USA.
335. RIFM (Research Institute for Fragrance Materials Inc.), 1994c. Mutagenicity test on linalool in the L5178YTK mouse lymphoma forward mutation assay with a confirmatory assay. Unpublished Report from Lorillard Tobacco Company, 3 March. Report Number 35827. RIFM, Woodcliff Lake, NJ, USA.
336. RIFM (Research Institute for Fragrance Materials Inc.), 1994d. Toxicology studies in the Guinea pig with l-n-Isopulegol. Unpublished Report from Takasago, 7 July. Report Number 34780. RIFM, Woodcliff Lake, NJ, USA.
337. RIFM (Research Institute for Fragrance Materials Inc.), 1995a. Maximization test in guinea pigs with farnesol. Unpublished Report from Dragoco, 6 July. Report Number 37818. RIFM, Woodcliff Lake, NJ, USA.
338. RIFM (Research Institute for Fragrance Materials Inc.), 1995b. Acute eye irritation/corrosion test of farnesol in rabbits. Unpublished Report from Dragoco, 6 July. Report Number 37817. RIFM, Woodcliff Lake, NJ, USA.
339. RIFM (Research Institute for Fragrance Materials Inc.), 1995c. Acute dermal irritation/corrosion test of farnesol in rabbits. Unpublished Report from Dragoco, 6 July. Report Number 37816. RIFM, Woodcliff Lake, NJ, USA.
340. RIFM (Research Institute for Fragrance Materials, Inc.), 1995d. Primary skin irritation study, phototoxicity study and delayed contact hypersensitivity test of geranodyle in guinea pigs. Private communication to FEMA. Unpublished Report from Y. Kajiura A. Kinosakie, 23 October. Report Number 43643. RIFM, Woodcliff Lake, NJ, USA.
341. RIFM (Research Institute for Fragrance Materials, Inc.), 1995e. Mutagenicity test of geranodyle. Private communication to FEMA. Unpublished Report from Y. Kajiura, 23 October. Report Number 43642. RIFM, Woodcliff Lake, NJ, USA.
342. RIFM (Research Institute for Fragrance Materials, Inc.), 1995f. Acute oral toxicity of geranodyle in the rat. Private communication to FEMA. Unpublished Report from Y. Kajiura A. Kinosaki, 17 October. Report Number 43641. RIFM, Woodcliff Lake, NJ, USA.
343. RIFM (Research Institute for Fragrance Materials Inc.), 1999a. Mutagenicity evaluation of 3,7-dimethyloct-6-en-3-ol in the Ames test. Unpublished Report from Givaudan, 20 October. Report Number 35739. RIFM, Woodcliff Lake, NJ, USA.
344. RIFM (Research Institute for Fragrance Materials Inc.), 1999b. Toxicology studies of tetrahydrolinalool in the guinea pig. Unpublished Report from Takasago, 5 August. Report Number 35061. RIFM, Woodcliff Lake, NJ, USA.
345. RIFM (Research Institute for Fragrance Materials Inc.), 1999c. Dermal irritation study in human volunteers with l-n-Isopulegol. Closed patch test. Unpublished Report from Takasago, 30 April. Report Number 34781. RIFM, Woodcliff Lake, NJ, USA.
346. RIFM (Research Institute for Fragrance Materials Inc.), 1999d. l-n-Isopulegol:rReverse mutation test "Ames test" with S. typhimurium and E. coli. Unpublished Report from Takasago, 30 April. Report Number 34782. RIFM, Woodcliff Lake, NJ, USA.
347. RIFM (Research Institute for Fragrance Materials Inc.), 1999e. Acute eye irritation/corrosion study in the rabbit. Unpublished Report from Haarmann and Reimer, 30 December. Report Number 36136. RIFM, Woodcliff Lake, NJ, USA.
348. RIFM (Research Institute for Fragrance Materials Inc.), 1999f. Toxicology studies of terpineol in the guinea pig. Unpublished Report from Takasago, 5 August. Report Number 35060. RIFM, Woodcliff Lake, NJ, USA.
349. RIFM (Research Institute for Fragrance Materials Inc.), 1999g. Geranodyle: Study of skin sensitization in albino guinea pigs; Maximization-Test. Unpublished Report from Givaudan, 16 December. Report Number 43443. RIFM, Woodcliff Lake, NJ, USA.
350. RIFM (Research Institute for Fragrance Materials Inc.), 2000a. Repeated insult patch test with geraniol. RIFM Report Number 36679, December 21. RIFM, Woodcliff Lake, NJ, USA.
351. RIFM (Research Institute for Fragrance Materials Inc.), 2000b. Repeated insult patch test with farnesol. Unpublished Report from Dragoco, 28 April. Report Number 35519. RIFM, Woodcliff Lake, NJ, USA.
352. RIFM (Research Institute for Fragrance Materials Inc.), 2000c. Repeated insult patch test with farnesol. Unpublished Report from Dragoco, 28 April. Report Number 35518. RIFM, Woodcliff Lake, NJ, USA.
353. RIFM (Research Institute for Fragrance Materials, Inc.), 2000d. Geranodyle: 28-Day oral toxicity (gavage) study in the Wistar rat. Unpublished Report from Givaudan, 21 March. Report Number 41536. RIFM, Woodcliff Lake, NJ, USA.
354. RIFM (Research Institute for Fragrance Materials, Inc.), 2000e. In vitro chromosome aberration assay in Chinese hamster V79 cells with geranodyle. Unpublished Report from Givaudan, 22 March. Report Number 43444. RIFM, Woodcliff Lake, NJ, USA.
355. RIFM (Research Institute for Fragrance Materials, Inc.), 2000f. An eye irritation study of geranodyle in rabbits. Unpublished Report from Takasago, 9 July. Report Number 50973. RIFM, Woodcliff Lake, NJ, USA.
356. RIFM (Research Institute for Fragrance Materials, Inc.,) 2001a. Acute toxicity study of myrtenol by oral administration to Sprague-Dawley rats. Unpublished Report from Dragoco, 26 March. Report Number 37779. RIFM, Woodcliff Lake, NJ, USA.
357. RIFM (Research Institute for Fragrance Materials Inc.), 2001b. Micronucleus test in bone marrow cells of the mouse with linalool. Unpublished Report from Hoffmann-LaRoche, 18 October. Private communication to FEMA. Report Number 38577. RIFM, Woodcliff Lake, NJ, USA.
358. RIFM (Research Institute for Fragrance Materials Inc.), 2001c. Local lymph node assay with geraniol. RIFM Report Number 37072, 9 May. RIFM, Woodcliff Lake, NJ, USA.
359. RIFM (Research Institute for Fragrance Materials Inc.), 2001d. Local lymph node assay with geraniol. RIFM Report Number 37071, 9 May. RIFM, Woodcliff Lake, NJ, USA.
360. RIFM (Research Institute for Fragrance Materials Inc.), 2001e. Local lymph node assay with geraniol. RIFM Report Number 37070, 9 May. RIFM, Woodcliff Lake, NJ, USA.
361. RIFM (Research Institute for Fragrance Materials Inc.), 2001f. Local lymph node assay with geraniol. RIFM Report Number 37069, 9 May. RIFM, Woodcliff Lake, NJ, USA.
362. RIFM (Research Institute for Fragrance Materials Inc.), 2002a. Modified primary dermal irritation test (MPDI) with dl-citronellol. RIFM Report Number 44234, August 14. RIFM, Woodcliff Lake, NJ, USA.
363. RIFM (Research Institute for Fragrance Materials Inc.), 2002b. Repeated insult patch test with geraniol. RIFM Report Number 44248, August 12. RIFM, Woodcliff Lake, NJ, USA.
364. RIFM (Research Institute for Fragrance Materials Inc.), 2003a. Modified primary dermal irritation test (MPDI) with dl-citronellol. RIFM Report Number 44232, March 18. RIFM, Woodcliff Lake, NJ, USA.
365. RIFM (Research Institute for Fragrance Materials Inc.), 2003b. Airborne levels of selected fragrance materials in a simulated bathroom. RIFM Report Number 41708, January 3. RIFM, Woodcliff Lake, NJ, USA.
366. RIFM (Research Institute for Fragrance Materials Inc.), 2003c. Local lymph node assay with geraniol. RIFM Report Number 43812, 17 December. RIFM, Woodcliff Lake, NJ, USA.
367. RIFM (Research Institute for Fragrance Materials Inc.), 2003d. Local lymph node assay with geraniol. RIFM Report Number 43811, 12 September. RIFM, Woodcliff Lake, NJ, USA.
368. RIFM (Research Institute for Fragrance Materials Inc.), 2004a. Repeated insult patch test with geraniol. RIFM Report Number 46888, August 09. RIFM, Woodcliff Lake, NJ, USA.
369. RIFM (Research Institute for Fragrance Materials Inc.), 2004b. Airborne Levels of Selected Fragrance Materials Following a Controlled Exposure to a Surrogate Fine Fragrance. RIFM Report Number 47425, December 3. RIFM, Woodcliff Lake, NJ, USA.
370. RIFM (Research Institute for Fragrance Materials Inc.), 2004c. Local Lymph Node Assay with farnesol. Unpublished Report from Symrise, 3 August. Report Number 47136. RIFM, Woodcliff Lake, NJ, USA.
371. RIFM (Research Institute for Fragrance Materials, Inc.), 2004d. Repeated insult patch test with farnesol. Unpublished Report from Symrise Inc., 16 December. Report Number 47190, RIFM, Woodcliff Lake, NJ, USA.
372. RIFM (Research Institute for Fragrance Materials Inc.), 2005a. Repeated insult patch test with dl-citronellol. RIFM Report Number 47277, January 6. RIFM, Woodcliff Lake, NJ, USA.
373. RIFM (Research Institute for Fragrance Materials Inc.), 2005b. Local Lymph Node Assay with dl-citronellol. RIFM Report Number 48752, January 28. RIFM, Woodcliff Lake, NJ, USA.
374. RIFM (Research Institute for Fragrance Materials Inc.), 2005c. Repeated insult patch test with cis-p-menthan-7-ol. Unpublished Report from Firmenich. Report Number 49734, 7 December. RIFM, Woodcliff Lake, NJ, USA.
375. RIFM (Research Institute for Fragrance Materials Inc.), 2006b. Developmental toxicity study with linalool (DRAFT). RIFM Report. RIFM, Woodcliff Lake, NJ, USA.
376. RIFM (Research Institute for Fragrance Materials Inc.), 2006c. In-vitro skin absorption study with linalool (DRAFT). RIFM Report. RIFM, Woodcliff Lake, NJ, USA.
377. RIFM (Research Institute for Fragrance Materials Inc.), 2006d. Sclareol and cedrol: Subchronic toxicity study (28 day repeated dose oral gavage study in rats). Unpublished Report to FEMA. Report Number 50942, 24 May. RIFM, Woodcliff Lake, NJ, USA.
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