Induction of hepatotoxicity by sanguinarine is associated with oxidation of protein thiols and disturbance of mitochondrial respiration

Journal of Applied Toxicology

Volumn 28, Issue 8, 2008, Pages 945-956

  Choy, Cheuk Sing ^a,b   Cheah, Khoot Peng ^a   Chiou, Hung Yi ^b   Li, Joe Sharg ^a   Liu, Yung Hung ^a   Yong, Seet Foong ^a   Chiu, Wen Ta ^c   Liao, Jiunn Wang ^d   Hu, Chien Ming ^a  

^a TAIPEI MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^b TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^c TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^d NATIONAL CHUNG HSING UNIVERSITY   (Taiwan)

Author keywords

Hepatotoxicity; Lipid peroxidation; Mitochondria; Oxygen consumption; Protein thiol; Reactive oxygen species; Sanguinarine

Indexed keywords

ACETYLCYSTEINE; ADENOSINE TRIPHOSPHATE; ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; DITHIOTHREITOL; GLUTATHIONE; LACTATE DEHYDROGENASE; REACTIVE OXYGEN METABOLITE; SANGUINARINE; THIOL; TRIACYLGLYCEROL;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CELL DEATH; CELL VACUOLE; CONTROLLED STUDY; CYTOTOXICITY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DNA FRAGMENTATION; LACTATE DEHYDROGENASE BLOOD LEVEL; LIPID PEROXIDATION; LIPID STORAGE; LIVER CELL; LIVER INJURY; LIVER TOXICITY; MALE; MITOCHONDRIAL RESPIRATION; MOUSE; NONHUMAN; OXIDATION; OXIDATIVE STRESS; OXYGEN CONSUMPTION; PRIORITY JOURNAL; RAT; RESPIRATORY CHAIN; TRIACYLGLYCEROL BLOOD LEVEL;

ADENOSINE TRIPHOSPHATE; ANIMALS; APOPTOSIS; BENZOPHENANTHRIDINES; CARDIOTONIC AGENTS; CELLS, CULTURED; DNA FRAGMENTATION; FLOW CYTOMETRY; HEPATITIS, TOXIC; ISOQUINOLINES; LIPID PEROXIDATION; LIVER; MALE; MEMBRANE POTENTIALS; MICE; MICE, INBRED ICR; MITOCHONDRIA, LIVER; OXIDATIVE STRESS; OXYGEN CONSUMPTION; PROTEINS; RATS; RATS, WISTAR; REACTIVE OXYGEN SPECIES; SULFHYDRYL COMPOUNDS;

ARGEMONE MEXICANA; MUS; RATTUS;

EID: 55549096414     PISSN: 0260437X     EISSN: 10991263     Source Type: Journal    
DOI: 10.1002/jat.1360     Document Type: Article

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