The ARF exchange factors Gea1p and Gea2p regulate Golgi structure and function in yeast

Journal of Cell Science

Volumn 114, Issue 12, 2001, Pages 2241-2253

  Peyroche, Anne ^a   Courbeyrette, Régis ^a   Rambourg, Alain ^a   Jackson, Catherine L ^b  

^a CEA SACLAY   (France)

^b EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

Author keywords

ADP ribosylation factor (ARF); Brefeldin A (BFA); Golgi apparatus; GTP binding protein; Guanine nucleotide exchange factor (GEF); Sec7 domain; Secretory Pathway; Trafficking; Yeast

Indexed keywords

ADENOSINE DIPHOSPHATE RIBOSYLATION FACTOR; COAT PROTEIN COMPLEX I; GEA1P PROTEIN; GEA2P PROTEIN; GUANINE NUCLEOTIDE EXCHANGE FACTOR; GUANOSINE TRIPHOSPHATASE; UNCLASSIFIED DRUG;

ACCURACY; ARTICLE; CELL MEMBRANE TRANSPORT; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; GOLGI COMPLEX; MOLECULAR BIOLOGY; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN SECRETION; REGULATORY MECHANISM; SACCHAROMYCES CEREVISIAE; TEMPERATURE SENSITIVE MUTANT;

ADP-RIBOSYLATION FACTORS; ALLELES; AMINO ACID SEQUENCE; BREFELDIN A; CARBOXYPEPTIDASE C; CARBOXYPEPTIDASES; ENDOPLASMIC RETICULUM; FUNGAL PROTEINS; GOLGI APPARATUS; GUANINE NUCLEOTIDE EXCHANGE FACTORS; MANNOSYLTRANSFERASES; MEMBRANE GLYCOPROTEINS; MICROSCOPY, ELECTRON; MICROSCOPY, FLUORESCENCE; MOLECULAR SEQUENCE DATA; MUTATION; PROTEIN TRANSPORT; RECOMBINANT FUSION PROTEINS; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 0034943777     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (10)

1. Achstetter, T., Franzusoff, A., Field, C. and Schekman, R. (1988). SEC7 encodes an unusual, high molecular weight protein required for membrane traffic from the yeast Golgi apparatus. J. Biol Chem. 263, 11711-11717.
2. Boman, A. L. and Kahn, R. A. (1995). Arf proteins: the membrane traffic police? Trends Biochem. Sci. 20, 147-150.
3. Busch, M., Mayer, U. and Jürgens, G. (1996). Molecular analysis of the Arabidopsis pattern formation of gene GNOM: gene structure and intragenic complementation. Mol. Gen. Genet. 250, 681-691.
4. Chapman, R. E. and Munro, S. (1994). The functioning of the yeast Golgi apparatus requires an ER protein encoded by ANP1, a member of a new family of genes affecting the secretory pathway. EMBO J. 13, 4896-4907.
5. Chardin, P., Paris, S., Antonny, B., Robineau, S., Béraud-Dufour, S., Jackson, C. L. and Chabre, M. (1996). A human exchange factor for ARF contains Sec7- and pleckstrin-homology domains. Nature 384, 481-484.
6. Claude, A., Zhao, B. P., Kuziemsky, C. E., Dahan, S., Berger, S. J., Yan, J. P., Armold, A. D., Sullivan, E. M. and Melançon, P. (1999). GBF1. A novel Golgi-associated BFA-resistant guanine nucleotide exchange factor that displays specificity for ADP-ribosylation factor 5. J. Cell. Biol. 146, 71-84.
7. Dean, N. (1999). Asparagine-linked glycosylation in the yeast Golgi. Biochim. Biophys. Acta 1426, 309-322.
8. Deitz, S. B., Rambourg, A., Kepes, F. and Franzusoff, A. (2000). Sec7p Directs the transitions required for yeast Golgi biogenesis. Traffic 1, 172-183.
9. Donaldson, J. G., Finazzi, D. and Klausner, R. D. (1992). Brefeldin A inhibits Golgi membrane-catalysed exchange of guanine nucleotide onto ARF protein. Nature 360, 350-352.
10. Yan, J. P., Colon, M. E., Beebe, L. A. and Melançon, P. (1994). Isolation and characterization of mutant CHO cell lines with compartment-specific resistance to brefeldin A. J. Cell. Biol. 126, 65-75.