Dominant-negative mutant of BIG2 an ARF-guanine nucleotide exchange factor specifically affects membrane trafficking from the trans-Golgi network through inhibiting membrane association of AP-1 and GGA coat proteins

Biochemical and Biophysical Research Communications

Volumn 294, Issue 2, 2002, Pages 254-260

  Shinotsuka, Chisa ^a,c   Waguri, Satoshi ^b   Wakasugi, Masaki ^b   Uchiyama, Yasuo ^b   Nakayama, Kazuhisa ^a  

^a UNIVERSITY OF TSUKUBA   (Japan)

^b OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^c NATIONAL CENTER FOR GERIATRICS AND GERONTOLOGY   (Japan)

Author keywords

ADP ribosylation factor; AP 1; BIG2; Endosome; GGA; Guanine nucleotide exchange factor; Mannose 6 phosphate receptor; Trans Golgi network

Indexed keywords

ADENOSINE DIPHOSPHATE RIBOSYLATION FACTOR; AP 1 PROTEIN; BIG2 PROTEIN; COAT PROTEIN; GGA PROTEIN; GUANINE NUCLEOTIDE EXCHANGE FACTOR; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; CYTOPLASM; GOLGI COMPLEX; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; TRANS GOLGI NETWORK;

ADAPTOR PROTEINS, VESICULAR TRANSPORT; ADP-RIBOSYLATION FACTORS; AMINO ACID SUBSTITUTION; ANIMALS; BIOLOGICAL TRANSPORT; BREFELDIN A; CARRIER PROTEINS; CELL LINE; COAT PROTEIN COMPLEX I; ENDOSOMES; GENES, DOMINANT; GUANINE NUCLEOTIDE EXCHANGE FACTORS; HELA CELLS; HEPATOCYTES; HUMANS; KIDNEY; MACROMOLECULAR SUBSTANCES; MEMBRANE PROTEINS; PROTEIN TRANSPORT; RATS; TRANS-GOLGI NETWORK; TRANSCRIPTION FACTOR AP-1; TRANSFECTION;

EID: 0036295057     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-291X(02)00456-4     Document Type: Article

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