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Volumn 3, Issue 5, 2008, Pages 517-524

Autophagy, an immunologic magic bullet: Mycobacterium tuberculosis phagosome maturation block and how to bypass it

Author keywords

Autophagy; Macrophage; Phagosome; Phosphoinositide; Rab; Tuberculosis

Indexed keywords

LIPOARABINOMANNAN; PHOSPHATIDYLINOSITOL 3 PHOSPHATE; RAB PROTEIN; RAB22A PROTEIN; UNCLASSIFIED DRUG; POLYPHOSPHOINOSITIDE;

EID: 55449089552     PISSN: 17460913     EISSN: None     Source Type: Journal    
DOI: 10.2217/17460913.3.5.517     Document Type: Review
Times cited : (55)

References (65)
  • 1
    • 0035798385 scopus 로고    scopus 로고
    • Evolution of the Rab family of small GTP-binding proteins
    • Pereira-Leal JB, Seabra MC: Evolution of the Rab family of small GTP-binding proteins. J. Mol. Biol. 313, 889-901 (2001).
    • (2001) J. Mol. Biol , vol.313 , pp. 889-901
    • Pereira-Leal, J.B.1    Seabra, M.C.2
  • 2
    • 0036129685 scopus 로고    scopus 로고
    • Molecular cloning and expression of a novel glycolipid sulfotransferase in Mycobacterium tuberculosis
    • Rivera-Marrero CA, Ritzenthaler JD, Newburn SA, Roman J, Cummings RD: Molecular cloning and expression of a novel glycolipid sulfotransferase in Mycobacterium tuberculosis. Microbiology 148, 783-792 (2002).
    • (2002) Microbiology , vol.148 , pp. 783-792
    • Rivera-Marrero, C.A.1    Ritzenthaler, J.D.2    Newburn, S.A.3    Roman, J.4    Cummings, R.D.5
  • 3
    • 0030960157 scopus 로고    scopus 로고
    • Arrest of mycobacterial phagosome maturation is caused by a block in vesicle fusion between stages controlled by Rab5 and Rab7
    • Via LE, Deretic D, Ulmer RJ, Hibler NS, Huber LA, Deretic V: Arrest of mycobacterial phagosome maturation is caused by a block in vesicle fusion between stages controlled by Rab5 and Rab7. J. Biol. Chem. 272, 13326-13331 (1997).
    • (1997) J. Biol. Chem , vol.272 , pp. 13326-13331
    • Via, L.E.1    Deretic, D.2    Ulmer, R.J.3    Hibler, N.S.4    Huber, L.A.5    Deretic, V.6
  • 4
    • 33748989856 scopus 로고    scopus 로고
    • Higher order Rab programming in phagolysosome biogenesis
    • Roberts EA, Chua J, Kyei GB, Deretic V: Higher order Rab programming in phagolysosome biogenesis. J. Cell Biol. 174, 923-929 (2006).
    • (2006) J. Cell Biol , vol.174 , pp. 923-929
    • Roberts, E.A.1    Chua, J.2    Kyei, G.B.3    Deretic, V.4
  • 6
    • 0028220231 scopus 로고    scopus 로고
    • Sturgill-Koszycki S, Schlesinger PH, Chakraborty P et al.: Lack of acidification in Mycobacterium phagosomes produced by exclusion of the vesicular proton-ATPase. Science 263, 678-681 (1994) (See comments: published erratum appears in Science 263[5152], 1359 [1994]).
    • Sturgill-Koszycki S, Schlesinger PH, Chakraborty P et al.: Lack of acidification in Mycobacterium phagosomes produced by exclusion of the vesicular proton-ATPase. Science 263, 678-681 (1994) (See comments: published erratum appears in Science 263[5152], 1359 [1994]).
  • 7
    • 24144442691 scopus 로고    scopus 로고
    • Rab conversion as a mechanism of progression from early to late endosomes
    • Rink J, Ghigo E, Kalaidzidis Y, Zerial M: Rab conversion as a mechanism of progression from early to late endosomes. Cell 122, 735-749 (2005).
    • (2005) Cell , vol.122 , pp. 735-749
    • Rink, J.1    Ghigo, E.2    Kalaidzidis, Y.3    Zerial, M.4
  • 8
    • 0035817635 scopus 로고    scopus 로고
    • Role of phosphatidylinositol 3-kinase and Rab5 effectors in phagosomal biogenesis and mycobacterial phagosome maturation arrest
    • Fratti RA, Backer JM, Gruenberg J, Corvera S, Deretic V: Role of phosphatidylinositol 3-kinase and Rab5 effectors in phagosomal biogenesis and mycobacterial phagosome maturation arrest. J. Cell Biol. 154, 631-644 (2001).
    • (2001) J. Cell Biol , vol.154 , pp. 631-644
    • Fratti, R.A.1    Backer, J.M.2    Gruenberg, J.3    Corvera, S.4    Deretic, V.5
  • 9
    • 2942628014 scopus 로고    scopus 로고
    • Acquisition of Hrs, an essential component of phagosomal maturation, is impaired by mycobacteria
    • Vieira OV, Harrison RE, Scott CC et al. Acquisition of Hrs, an essential component of phagosomal maturation, is impaired by mycobacteria. Mol. Cell. Biol. 24, 4593-4604 (2004).
    • (2004) Mol. Cell. Biol , vol.24 , pp. 4593-4604
    • Vieira, O.V.1    Harrison, R.E.2    Scott, C.C.3
  • 11
    • 0041467786 scopus 로고    scopus 로고
    • Mycobacterium's arrest of phagosome maturation in macrophages requires Rab5 activity and accessibility to iron
    • Kelley VA, Schorey JS: Mycobacterium's arrest of phagosome maturation in macrophages requires Rab5 activity and accessibility to iron. Mol. Biol. Cell 14, 3366-3377 (2003).
    • (2003) Mol. Biol. Cell , vol.14 , pp. 3366-3377
    • Kelley, V.A.1    Schorey, J.S.2
  • 12
    • 33751115464 scopus 로고    scopus 로고
    • Rab14 is critical for maintenance of Mycobacterium tuberculosis phagosome maturation arrest
    • Kyei GB, Vergne I, Chua J et al.: Rab14 is critical for maintenance of Mycobacterium tuberculosis phagosome maturation arrest. EMBO J. 25, 5250-5259 (2006).
    • (2006) EMBO J , vol.25 , pp. 5250-5259
    • Kyei, G.B.1    Vergne, I.2    Chua, J.3
  • 13
    • 0035494493 scopus 로고    scopus 로고
    • Distinct roles of class I and class III phosphatidylinositol 3-kinase in phagosome formation and maturation
    • Vieira OV, Botelho RJ, Rameh L et al.: Distinct roles of class I and class III phosphatidylinositol 3-kinase in phagosome formation and maturation. J. Cell Biol. 155, 19-25 (2001).
    • (2001) J. Cell Biol , vol.155 , pp. 19-25
    • Vieira, O.V.1    Botelho, R.J.2    Rameh, L.3
  • 14
    • 4344654141 scopus 로고    scopus 로고
    • Mycobacterium tuberculosis reprograms waves of phosphatidylinositol 3-phosphate on phagosomal organelles
    • Chua J, Deretic V: Mycobacterium tuberculosis reprograms waves of phosphatidylinositol 3-phosphate on phagosomal organelles. J. Biol. Chem. 279, 36982-36992 (2004).
    • (2004) J. Biol. Chem , vol.279 , pp. 36982-36992
    • Chua, J.1    Deretic, V.2
  • 16
    • 0034677007 scopus 로고    scopus 로고
    • 2+ signaling by Mycobacterium tuberculosis is associated with reduced phagosome-lysosome fusion and increased survival within human macrophages
    • 2+ signaling by Mycobacterium tuberculosis is associated with reduced phagosome-lysosome fusion and increased survival within human macrophages. J. Exp. Med. 191, 287-302 (2000).
    • (2000) J. Exp. Med , vol.191 , pp. 287-302
    • Malik, Z.A.1    Denning, G.M.2    Kusner, D.J.3
  • 18
    • 0035284908 scopus 로고    scopus 로고
    • Mycobacterium tuberculosis phagosomes exhibit altered calmodulin-dependent signal transduction: Contribution to inhibition of phagosome-lysosome fusion and intracellular survival in human macrophages
    • Malik ZA, Iyer SS, Kusner DJ: Mycobacterium tuberculosis phagosomes exhibit altered calmodulin-dependent signal transduction: contribution to inhibition of phagosome-lysosome fusion and intracellular survival in human macrophages. J. Immunol. 166, 3392-3401 (2001).
    • (2001) J. Immunol , vol.166 , pp. 3392-3401
    • Malik, Z.A.1    Iyer, S.S.2    Kusner, D.J.3
  • 20
    • 32344440349 scopus 로고    scopus 로고
    • Interaction and functional analyses of human VPS34/p150 phosphatidylinositol 3-kinase complex with Rab7
    • Stein MP, Cao C, Tessema M et al.: Interaction and functional analyses of human VPS34/p150 phosphatidylinositol 3-kinase complex with Rab7. Methods Enzymol. 403, 628-649 (2005).
    • (2005) Methods Enzymol , vol.403 , pp. 628-649
    • Stein, M.P.1    Cao, C.2    Tessema, M.3
  • 21
  • 22
    • 33748655254 scopus 로고    scopus 로고
    • Stewart GR, Patel J, Robertson BD, Rae A. Young DB: Mycobacterial mutants with defective control of phagosomal acidification. PLoS Pathog. 1, 269-278 (2005).
    • Stewart GR, Patel J, Robertson BD, Rae A. Young DB: Mycobacterial mutants with defective control of phagosomal acidification. PLoS Pathog. 1, 269-278 (2005).
  • 23
    • 33846847539 scopus 로고    scopus 로고
    • A mycobacterial gene involved in the synthesis of an outer cell envelope lipid is a key factor in prevention of phagosome maturation
    • Robinson N, Wolke M, Ernestus K, Plum G: A mycobacterial gene involved in the synthesis of an outer cell envelope lipid is a key factor in prevention of phagosome maturation. Infect. Immun. 75, 581-591 (2007).
    • (2007) Infect. Immun , vol.75 , pp. 581-591
    • Robinson, N.1    Wolke, M.2    Ernestus, K.3    Plum, G.4
  • 24
    • 0037627408 scopus 로고    scopus 로고
    • Mycobacterium tuberculosis glycosylated phosphatidylinositol causes phagosome maturation arrest
    • Fratti RA, Chua J, Vergne I, Deretic V: Mycobacterium tuberculosis glycosylated phosphatidylinositol causes phagosome maturation arrest. Proc. Natl Acad. Sci. USA 100, 5437-5442 (2003).
    • (2003) Proc. Natl Acad. Sci. USA , vol.100 , pp. 5437-5442
    • Fratti, R.A.1    Chua, J.2    Vergne, I.3    Deretic, V.4
  • 25
    • 25844508945 scopus 로고    scopus 로고
    • The human macrophage mannose receptor directs Mycobacterium tuberculosis lipoarabinomannan-mediated phagosome biogenesis
    • Kang PB, Azad AK, Torrelles JB et al.: The human macrophage mannose receptor directs Mycobacterium tuberculosis lipoarabinomannan-mediated phagosome biogenesis. J. Exp. Med. 202, 987-999 (2005).
    • (2005) J. Exp. Med , vol.202 , pp. 987-999
    • Kang, P.B.1    Azad, A.K.2    Torrelles, J.B.3
  • 26
    • 31844444593 scopus 로고    scopus 로고
    • Interaction of pathogenic mycobacteria with the host immune system
    • Houben EN, Nguyen L, Pieters J: Interaction of pathogenic mycobacteria with the host immune system. Curr Opin. Microbiol. 9, 76-85 (2006).
    • (2006) Curr Opin. Microbiol , vol.9 , pp. 76-85
    • Houben, E.N.1    Nguyen, L.2    Pieters, J.3
  • 28
    • 0029101901 scopus 로고
    • Integration of mycobacterial lipoarabinomannans into glycosylphosphatidylinositol-rich domains of lymphomonocytic cell plasma membranes
    • Ilangumaran S, Arni S, Poincelet M et al.: Integration of mycobacterial lipoarabinomannans into glycosylphosphatidylinositol-rich domains of lymphomonocytic cell plasma membranes. J. Immunol. 155, 1334-1342 (1995).
    • (1995) J. Immunol , vol.155 , pp. 1334-1342
    • Ilangumaran, S.1    Arni, S.2    Poincelet, M.3
  • 30
    • 0742288047 scopus 로고    scopus 로고
    • Mycobacterium tuberculosis phagosome maturation arrest: Mycobacterial phosphatidylinositol analog phosphatidylinositol mannoside stimulates early endosomal fusion
    • Vergne I, Fratti RA, Hill PJ, Chua J, Belisle J, Deretic V: Mycobacterium tuberculosis phagosome maturation arrest: mycobacterial phosphatidylinositol analog phosphatidylinositol mannoside stimulates early endosomal fusion. Mol. Biol. Cell 15, 751-760 (2004).
    • (2004) Mol. Biol. Cell , vol.15 , pp. 751-760
    • Vergne, I.1    Fratti, R.A.2    Hill, P.J.3    Chua, J.4    Belisle, J.5    Deretic, V.6
  • 31
    • 0034460958 scopus 로고    scopus 로고
    • Secretion of an acid phosphatase (SapM) by Mycobacterium tuberculosis that is similar to eukaryotic acid phosphatases
    • Saleh MT, Belisle JT: Secretion of an acid phosphatase (SapM) by Mycobacterium tuberculosis that is similar to eukaryotic acid phosphatases. J. Bacteriol. 182, 6850-6853 (2000).
    • (2000) J. Bacteriol , vol.182 , pp. 6850-6853
    • Saleh, M.T.1    Belisle, J.T.2
  • 32
    • 0016742008 scopus 로고
    • Phagosome-lysosome interactions in cultured macrophages infected with virulent tubercle bacilli. Reversal of the usual nonfusion pattern and observations on bacterial survival
    • Armstrong JA, Hart PD: Phagosome-lysosome interactions in cultured macrophages infected with virulent tubercle bacilli. Reversal of the usual nonfusion pattern and observations on bacterial survival. J. Exp. Med. 142, 1-16 (1975).
    • (1975) J. Exp. Med , vol.142 , pp. 1-16
    • Armstrong, J.A.1    Hart, P.D.2
  • 33
    • 34250716965 scopus 로고    scopus 로고
    • van der Wel N, Hava D, Houben D et al.: M. tuberculosis and M. leprae translocate from the phagolysosome to the cytosol in myeloid cells. Cell 129, 1287-1298 (2007).
    • van der Wel N, Hava D, Houben D et al.: M. tuberculosis and M. leprae translocate from the phagolysosome to the cytosol in myeloid cells. Cell 129, 1287-1298 (2007).
  • 34
    • 0021361257 scopus 로고
    • Disruption of phagosomal membranes of normal alveolar macrophages by the H37Rv strain of Mycobacterium tuberculosis. A correlate of virulence
    • Myrvik QN, Leake ES, Wright MJ: Disruption of phagosomal membranes of normal alveolar macrophages by the H37Rv strain of Mycobacterium tuberculosis. A correlate of virulence. Am. Rev. Respir. Dis. 129, 322-328 (1984).
    • (1984) Am. Rev. Respir. Dis , vol.129 , pp. 322-328
    • Myrvik, Q.N.1    Leake, E.S.2    Wright, M.J.3
  • 35
    • 34447102567 scopus 로고    scopus 로고
    • Survival of mycobacteria in macrophages is mediated by coronin 1-dependent activation of calcineurin
    • Jayachandran R, Sundaramurthy V, Gombaluzier B et al.: Survival of mycobacteria in macrophages is mediated by coronin 1-dependent activation of calcineurin. Cell 130, 37-50 (2007).
    • (2007) Cell , vol.130 , pp. 37-50
    • Jayachandran, R.1    Sundaramurthy, V.2    Gombaluzier, B.3
  • 36
    • 34548548443 scopus 로고    scopus 로고
    • Lipoamide dehydrogenase mediates retention of coronin-1 on BCG vacuoles, leading to arrest in phagosome maturation
    • Deghmane AE, Soulhine H, Bach H et al.: Lipoamide dehydrogenase mediates retention of coronin-1 on BCG vacuoles, leading to arrest in phagosome maturation. J. Cell Sci. 120, 2796-2806 (2007).
    • (2007) J. Cell Sci , vol.120 , pp. 2796-2806
    • Deghmane, A.E.1    Soulhine, H.2    Bach, H.3
  • 37
    • 0028909199 scopus 로고
    • Characterization of the Mycobacterium tuberculosis phagosome and evidence that phagosomal maturation is inhibited. j
    • Clemens DL, Horwitz MA: Characterization of the Mycobacterium tuberculosis phagosome and evidence that phagosomal maturation is inhibited. j. Exp. Med. 181, 257-270 (1995).
    • (1995) Exp. Med , vol.181 , pp. 257-270
    • Clemens, D.L.1    Horwitz, M.A.2
  • 38
    • 8344242220 scopus 로고    scopus 로고
    • Autophagy in health and disease: A double-edged sword
    • Shintani T, Klionsky DJ: Autophagy in health and disease: a double-edged sword. Science 306, 990-995 (2004).
    • (2004) Science , vol.306 , pp. 990-995
    • Shintani, T.1    Klionsky, D.J.2
  • 39
    • 12944308330 scopus 로고    scopus 로고
    • Eating oneself and uninvited guests; autophagy-related pathways in cellular defense
    • Levine B: Eating oneself and uninvited guests; autophagy-related pathways in cellular defense. Cell 120, 159-162 (2005).
    • (2005) Cell , vol.120 , pp. 159-162
    • Levine, B.1
  • 40
    • 11144245626 scopus 로고    scopus 로고
    • The role of autophagy during the early neonatal starvation period
    • Kuma A, Hatano M, Matsui M et al.: The role of autophagy during the early neonatal starvation period. Nature 432, 1032-1036 (2004).
    • (2004) Nature , vol.432 , pp. 1032-1036
    • Kuma, A.1    Hatano, M.2    Matsui, M.3
  • 42
    • 33749162486 scopus 로고    scopus 로고
    • Calpain-mediated cleavage of Atg5 switches autophagy to apoptosis
    • Yousefi S, Perozzo R, Schmid I et al.: Calpain-mediated cleavage of Atg5 switches autophagy to apoptosis. Nat. Cell Biol. 8, 1124-1132 (2006).
    • (2006) Nat. Cell Biol , vol.8 , pp. 1124-1132
    • Yousefi, S.1    Perozzo, R.2    Schmid, I.3
  • 43
    • 4544385218 scopus 로고    scopus 로고
    • Autophagy: Many paths to the same end
    • Cuervo AM: Autophagy: many paths to the same end. Mol. Cell. Biochem. 263, 55-72 (2004).
    • (2004) Mol. Cell. Biochem , vol.263 , pp. 55-72
    • Cuervo, A.M.1
  • 44
    • 8344247016 scopus 로고    scopus 로고
    • Autophagy defends cells against invading group A Streptococcus
    • Nakagawa I, Amano A, Mizushima N et al. Autophagy defends cells against invading group A Streptococcus. Science 306, 1037-1040 (2004).
    • (2004) Science , vol.306 , pp. 1037-1040
    • Nakagawa, I.1    Amano, A.2    Mizushima, N.3
  • 46
    • 10944253145 scopus 로고    scopus 로고
    • Autophagy is a defense mechanism inhibiting BCG and Mycobacterium tuberculosis survival in infected macrophages
    • Gutierrez MG, Master SS, Singh SB, Taylor GA, Colombo MI, Deretic V: Autophagy is a defense mechanism inhibiting BCG and Mycobacterium tuberculosis survival in infected macrophages. Cell 119, 753-766 (2004).
    • (2004) Cell , vol.119 , pp. 753-766
    • Gutierrez, M.G.1    Master, S.S.2    Singh, S.B.3    Taylor, G.A.4    Colombo, M.I.5    Deretic, V.6
  • 47
    • 12844275079 scopus 로고    scopus 로고
    • Endogenous MHC class II processing of a viral nuclear antigen after autophagy
    • Paludan C, Schmid D, Landthaler M et al.: Endogenous MHC class II processing of a viral nuclear antigen after autophagy. Science 307, 593-596 (2005).
    • (2005) Science , vol.307 , pp. 593-596
    • Paludan, C.1    Schmid, D.2    Landthaler, M.3
  • 48
    • 34250802980 scopus 로고    scopus 로고
    • Lysosomal killing of Mycobacterium mediated by ubiquitin-derived peptides is enhanced by autophagy
    • Alonso S, Pethe K, Russell DG, Purdy GE: Lysosomal killing of Mycobacterium mediated by ubiquitin-derived peptides is enhanced by autophagy. Proc. Natl Acad. Sci. USA 104, 6031-6036 (2007).
    • (2007) Proc. Natl Acad. Sci. USA , vol.104 , pp. 6031-6036
    • Alonso, S.1    Pethe, K.2    Russell, D.G.3    Purdy, G.E.4
  • 49
    • 33644816762 scopus 로고    scopus 로고
    • Cholesterol depletion in Mycobacterium avium-infected macrophages overcomes the block in phagosome maturation and leads to the reversible sequestration of viable mycobacteria in phagolysosome-derived autophagic vacuoles
    • de Chastellier C, Thilo L: Cholesterol depletion in Mycobacterium avium-infected macrophages overcomes the block in phagosome maturation and leads to the reversible sequestration of viable mycobacteria in phagolysosome-derived autophagic vacuoles. Cell. Microbiol. 8, 242-256 (2006).
    • (2006) Cell. Microbiol , vol.8 , pp. 242-256
    • de Chastellier, C.1    Thilo, L.2
  • 50
    • 2142752480 scopus 로고    scopus 로고
    • Cellular autophagy: Surrender, avoidance and subversion by microorganisms
    • Kirkegaard K, Taylor MP, Jackson WT: Cellular autophagy: surrender, avoidance and subversion by microorganisms. Nat. Rev, Microbiol. 2, 301-314 (2004).
    • (2004) Nat. Rev, Microbiol , vol.2 , pp. 301-314
    • Kirkegaard, K.1    Taylor, M.P.2    Jackson, W.T.3
  • 51
    • 12944303650 scopus 로고    scopus 로고
    • Growth factor regulation of autophagy and cell survival in the absence of apoptosis
    • Lum JJ, Bauer DE, Kong M et al.: Growth factor regulation of autophagy and cell survival in the absence of apoptosis. Cell 120, 237-248 (2005).
    • (2005) Cell , vol.120 , pp. 237-248
    • Lum, J.J.1    Bauer, D.E.2    Kong, M.3
  • 52
    • 32044465506 scopus 로고    scopus 로고
    • TOR signaling in growth and metabolism
    • Wullschleger S, Loewith R, Hall MN: TOR signaling in growth and metabolism. Cell 124, 471-484 (2006).
    • (2006) Cell , vol.124 , pp. 471-484
    • Wullschleger, S.1    Loewith, R.2    Hall, M.N.3
  • 53
    • 25144457455 scopus 로고    scopus 로고
    • Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy
    • Pattingre S, Tassa A, Qu X et al.: Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy. Cell 122, 927-939 (2005).
    • (2005) Cell , vol.122 , pp. 927-939
    • Pattingre, S.1    Tassa, A.2    Qu, X.3
  • 54
    • 33748506089 scopus 로고    scopus 로고
    • Human IRGM induces autophagy to eliminate intracellular mycobacteria
    • Singh SB, Davis AS, Taylor GA, Deretic V: Human IRGM induces autophagy to eliminate intracellular mycobacteria. Science 313, 1438-1441 (2006).
    • (2006) Science , vol.313 , pp. 1438-1441
    • Singh, S.B.1    Davis, A.S.2    Taylor, G.A.3    Deretic, V.4
  • 55
    • 33748444233 scopus 로고    scopus 로고
    • Vacuolar and plasma membrane stripping and autophagic elimination of Toxoplasma gondii primed effector macrophages
    • Ling YM, Shaw MH, Ayala C et al.: Vacuolar and plasma membrane stripping and autophagic elimination of Toxoplasma gondii primed effector macrophages. J. Exp. Med. 203, 2063-2071 (2006).
    • (2006) J. Exp. Med , vol.203 , pp. 2063-2071
    • Ling, Y.M.1    Shaw, M.H.2    Ayala, C.3
  • 56
    • 34347338690 scopus 로고    scopus 로고
    • Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility
    • Parkes M, Barrett JC, Prescott NJ et al.: Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility. Nat. Genet. 39, 830-832 (2007).
    • (2007) Nat. Genet , vol.39 , pp. 830-832
    • Parkes, M.1    Barrett, J.C.2    Prescott, N.J.3
  • 57
    • 34347357508 scopus 로고    scopus 로고
    • Association analysis of genetic variants in IL23R, ATG16L1 and 5p13.1 loci with Crohn's disease in Japanese patients
    • Yamazaki K, Onouchi Y, Takazoe M, Kubo M, Nakamura Y, Hata A: Association analysis of genetic variants in IL23R, ATG16L1 and 5p13.1 loci with Crohn's disease in Japanese patients. J. Hum. Genet. 52, 575-583 (2007).
    • (2007) J. Hum. Genet , vol.52 , pp. 575-583
    • Yamazaki, K.1    Onouchi, Y.2    Takazoe, M.3    Kubo, M.4    Nakamura, Y.5    Hata, A.6
  • 58
    • 34247566585 scopus 로고    scopus 로고
    • A nonsynonymous SNP in ATG16L1 predisposes to ileal Crohn's disease and is independent of CARD15 and IBD5
    • Prescott NJ, Fisher SA, Franke A et al.: A nonsynonymous SNP in ATG16L1 predisposes to ileal Crohn's disease and is independent of CARD15 and IBD5 Gastroenterology 132, 1665-1671 (2007).
    • (2007) Gastroenterology , vol.132 , pp. 1665-1671
    • Prescott, N.J.1    Fisher, S.A.2    Franke, A.3
  • 59
    • 0037711625 scopus 로고    scopus 로고
    • Cytoplasmic bacteria can be targets for autophagy
    • Rich KA, Burkett C, Webster P: Cytoplasmic bacteria can be targets for autophagy. Cell. Microbiol. 5, 455-468 (2003).
    • (2003) Cell. Microbiol , vol.5 , pp. 455-468
    • Rich, K.A.1    Burkett, C.2    Webster, P.3
  • 60
    • 33744958258 scopus 로고    scopus 로고
    • Autophagy controls Salmonella infection in response to damage to the Salmonella-containing vacuole
    • Birmingham CL, Smith AC, Bakowski MA, Yoshimori T, Brumell JH: Autophagy controls Salmonella infection in response to damage to the Salmonella-containing vacuole. J. Biol. Chem. 281. 11374-11383 (2006).
    • (2006) J. Biol. Chem , vol.281 , pp. 11374-11383
    • Birmingham, C.L.1    Smith, A.C.2    Bakowski, M.A.3    Yoshimori, T.4    Brumell, J.H.5
  • 61
    • 19344368318 scopus 로고    scopus 로고
    • Autophagy regulates programmed cell death during the plant innate immune response
    • Liu Y, Schiff M, Czymmek K, Talloczy Z, Levine B, Dinesh-Kumar SP: Autophagy regulates programmed cell death during the plant innate immune response. Cell 121, 567-577 (2005).
    • (2005) Cell , vol.121 , pp. 567-577
    • Liu, Y.1    Schiff, M.2    Czymmek, K.3    Talloczy, Z.4    Levine, B.5    Dinesh-Kumar, S.P.6
  • 62
    • 24744463111 scopus 로고    scopus 로고
    • Autophagy in innate and adaptive immunity
    • Deretic V: Autophagy in innate and adaptive immunity. Trends Immunol. 26, 523-528 (2005).
    • (2005) Trends Immunol , vol.26 , pp. 523-528
    • Deretic, V.1
  • 63
    • 33745357459 scopus 로고    scopus 로고
    • Autophagy as an immune defense mechanism
    • Deretic V: Autophagy as an immune defense mechanism. Curr. Opin. Immunol. 18, 375-382 (2006).
    • (2006) Curr. Opin. Immunol , vol.18 , pp. 375-382
    • Deretic, V.1
  • 64
    • 34248994604 scopus 로고    scopus 로고
    • Small molecules enhance autophagy and reduce toxicity in Huntington's disease models
    • Sarkar S, Perlstein EO. Imarisio S et al.: Small molecules enhance autophagy and reduce toxicity in Huntington's disease models. Nat. Chem. Biol. 3, 331-338 (2007).
    • (2007) Nat. Chem. Biol , vol.3 , pp. 331-338
    • Sarkar, S.1    Perlstein, E.O.2    Imarisio, S.3
  • 65
    • 33645542679 scopus 로고    scopus 로고
    • Mycobacterium tuberculosis inhibition of phagolysosome biogenesis and autophagy as a host defence mechanism
    • Deretic V, Singh S, Master S et al.: Mycobacterium tuberculosis inhibition of phagolysosome biogenesis and autophagy as a host defence mechanism. Cell. Microbiol. 8, 719-727 (2006).
    • (2006) Cell. Microbiol , vol.8 , pp. 719-727
    • Deretic, V.1    Singh, S.2    Master, S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.