Antioxidants modulate acute solar ultraviolet radiation-induced NF-κ-B activation in a human keratinocyte cell line

Free Radical Biology and Medicine

Volumn 26, Issue 1-2, 1999, Pages 174-183

  Saliou, Claude ^a,d   Kitazawa, Manabu ^b   McLaughlin, Laura ^a   Yang, Jian Ping ^c   Lodge, John K ^a   Tetsuka, Toshifumi ^c   Iwasaki, Keiji ^b   Cillard, Josiane ^d   Okamoto, Takashi ^c   Packer, Lester ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b AJINOMOTO CO INC   (Japan)

^c NAGOYA CITY UNIV MEDICAL SCHOOL   (Japan)

^d INSERM   (France)

Author keywords

Antioxidants; AP 1; Erythema; Free radical; Keratinocyte; NF B; Silymarin; Skin cancer; Ultraviolet radiation; Lipoic acid

Indexed keywords

ACETYLCYSTEINE; ANTIOXIDANT; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LACTATE DEHYDROGENASE; SILYMARIN; THIOCTIC ACID; TRANSCRIPTION FACTOR AP 1;

ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; ELECTROPHORETIC MOBILITY; GENE EXPRESSION; HUMAN; HUMAN CELL; KERATINOCYTE; PRIORITY JOURNAL; SKIN CANCER; SKIN DISEASE; ULTRAVIOLET RADIATION;

EID: 0009682067     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0891-5849(98)00212-3     Document Type: Article

References (55)

1. Streilein J.W. Photoimmunology of non-melanoma skin cancer. Leigh I.M., Newton Bishop J.A., Kripke M.L. Skin cancer. Vol. 26. 1996;207-217 Cold Spring Harbor Laboratory Press, Plainview, NY.
2. Hruza L.L., Pentland A.P. Mechanisms of UV-induced inflammation. J. Invest. Dermatol. 100:1993;35S-41S.
3. Beissert S., Granstein R.D. UV-induced cutaneous photobiology. Crit. Rev. Biochem. Mol. Biol. 31:1996;381-404.
4. Armstrong B.K., Kricker A. Epidemiology of sun exposure and skin cancer. Leigh I.M., Newton Bishop J.A., Kripke M.L. Skin cancer. Vol. 26. 1996;133-153 Cold Spring Harbor Laboratory Press, Plainview, NY.
5. Devary Y., Rosette C., Didonato J.A., Karin M. NF-kappa-B Activation by ultraviolet light not dependent on a nuclear signal. Science. 261:1993;1442-1445.
6. Baldwin A.S. The NF-kappa-B and I-kappa-B proteins - New discoveries and insights. Annu. Rev. Immunol. 14:1996;649-683.
7. Flohé L., Brigelius-Flohé R., Saliou C., Traber M., Packer L. Redox regulation of NF-κB activation. Free Radic. Biol. Med. 22:1997;1115-1126.
8. Okamoto T., Sakurada S., Yang J.P., Merin J.P. Regulation of NF-kappa B and disease control identification of a novel serine kinase and thioredoxin as effectors for signal transduction pathway for NF-kappa B activation . Curr. Top. Cell. Regul. 35:1997;149-161.
9. Sun Y., Oberley L.W. Redox regulation of transcriptional activators. Free Radic. Biol. Med. 21:1996;335-348.
10. Klement J.F., Rice N.R., Car B.D., Abbondanzo S.J., Powers G.D., Bhatt H., Chen C.H., Rosen C.A., Stewart C.L. I-kappa-B-alpha deficiency results in a sustained NF-kappa-B response and severe widespread dermatitis in mice. Mol. Cell. Biol. 16:1996;2341-2349.
11. Beg A.A., Sha W.C., Bronson R.T., Baltimore D. Constitutive NF-kappa-B activation, enhanced granulopoiesis, and neonatal lethality in I-kappa-B-alpha-deficient mice. Genes Dev. 9:1995;2736-2746.
12. Fisher G.J., Datta S.C., Talwar H.S., Wang Z.Q., Varani J., Kang S., Voorhees J.J. Molecular basis of sun-induced premature skin ageing and retinoid antagonism. Nature. 379:1996;335-339.
13. Simon M.M., Aragane Y., Schwarz A., Luger T.A., Schwarz T. UVB light induces nuclear factor kappa B (NF kappa B) activity independently from chromosomal DNA damage in cell-free cytosolic extracts. J. Invest. Dermatol. 102:1994;422-427.
14. Vile G.F., Tanew-Ilitschew A., Tyrrell R.M. Activation of NF-kappa B in human skin fibroblasts by the oxidative stress generated by UVA radiation. Photochem. Photobiol. 62:1995;463-468.
15. Fuchs J., Huflejt M.E., Rothfuss L.M., Wilson D.S., Carcamo G., Packer L. Impairment of enzymic and nonenzymic antioxidants in skin by UV-B irradiation. J. Invest. Dermatol. 93:1989;769-773.
16. Shindo Y., Witt E., Han D., Epstein W., Packer L. Enzymatic and non-enzymatic antioxidants in epidermis and dermis of human skin. J. Invest. Dermatol. 102:1994;122-124.
17. Tyrrell R.M., Pidoux M. Correlation between endogenous glutathione content and sensitivity of cultured human skin cells to radiation at defined wavelengths in the solar ultraviolet range. Photochem. Photobiol. 47:1988;405-412.
18. Weber C., Podda M., Rallis M., Thiele J.J., Traber M.G., Packer L. Efficacy of topically applied tocopherols and tocotrienols in protection of murine skin from oxidative damage induced by UV-irradiation. Free Radic. Biol. Med. 22:1997;761-769.
19. Ley R.D., Reeve V.E. Chemoprevention of ultraviolet radiation-induced skin cancer. Environ. Health Perspect. 105:1997;981-984.
20. Jurkiewicz B.A., Bissett D.L., Buettner G.R. Effect of topically applied tocopherol on ultraviolet radiation-mediated free radical damage in skin. J. Invest. Dermatol. 104:1995;484-488.
21. Scharffetter-Kochanek K., Wlaschek M., Brenneisen P., Schauen M., Bladschun R., Wenk J. UV-induced reactive oxygen species in photocarcinogenesis and photoaging. Biol. Chem. 378:1997;1247-1257.
22. Packer L., Witt E.H., Tritschler H.J. alpha-Lipoic acid as a biological antioxidant. Free Radic. Biol. Med. 19:1995;227-250.
23. Aruoma O.I., Halliwell B., Hoey B.M., Butler J. The antioxidant action of N-acetylcysteine its reaction with hydrogen peroxide, hydroxyl radical, superoxide, and hypochlorous acid . Free Radic. Biol. Med. 6:1989;593-597.
24. Leng-Peschlow E., Strenge-Hesse A. Die mariendistel (silybum marianum) und silymarin als lebertherapeutikum. Zeitschrift für Phytotherapie. 12:1991;162-174.
25. Han D., Handelman G., Marcocci L., Sen C.K., Roy S., Kobuchi H., Tritschler H.J., Flohé L., Packer L. Lipoic acid increases de novo synthesis of cellular glutathione by improving cystine utilization. Biofactors. 6:1997;321-338.
26. Halliwell B. Drug antioxidant effects a basis for drug selection? Drugs. 42:1991;569-605.
27. Valenzuela A., Aspillaga M., Vial S., Guerra R. Selectivity of silymarin on the increase of the glutathione content in different tissues of the rat. Planta Med. 55:1989;420-422.
28. Campos R., Garrido A., Guerra R., Valenzuela A. Silybin dihemisuccinate protects against glutathione depletion and lipid peroxidation induced by acetaminophen on rat liver. Planta Med. 55:1989;417-419.
29. Boukamp P., Petrussevska R.T., Breitkreutz D., Hornung J., Markham A., Fusenig N.E. Normal keratinization in a spontaneously immortalized aneuploid human keratinocyte cell line. J. Cell. Biol. 106:1988;761-771.
30. Olnes M.I., Kurl R.N. Isolation of nuclear extracts from fragile cells a simplified procedure applied to thymocytes . Biotechniques. 17:1994;828-829.
31. Garner M.M., Revzin A. A gel electrophoresis method for quantifying the binding of proteins to specific DNA regions application to components of the Escherichia coli lactose operon regulatory system . Nucleic Acids Res. 9:1981;3047-3060.
32. Sato T., Asamitsu K., Yang J.-P., Takahashi N., Tetsuka T., Yoneyama A., Kanagawa A., Okamoto T. Inhibition of human immunodeficiency virus type 1 replication by a bioavailable serine/threonine kinase inhibitor, fasudil hydrocholoride. AIDS Res. Hum. Retroviruses. 14:1998;293-298.
33. Schreck R., Albermann K., Baeuerle P.A. Nuclear factor kappa B an oxidative stress responsive transcription factor of eukaryotic cells . Free Radic. Res. Commun. 17:1992;221-237.
34. Ullrich S.E. The role of epidermal cytokines in the generation of cutaneous immune reactions and ultraviolet radiation-induced immune suppression. Photochem. Photobiol. 62:1995;389-401.
35. Gilmore T.D. Clinically Relevant findings [Editorial]. J. Clin. Invest. 100:1997;2935-2936.
36. Giard D.J., Aaronson S.A., Todaro G.J., Arnstein P., Kersey J.H., Dosik H., Parks W.P. In vitro cultivation of human tumors establishment of cell lines derived from a series of solid tumors . J. Natl. Cancer Inst. 51:1973;1417-1423.
37. Tobin D., Nilsson M., Toftgard R. Ras-independent activation of Rel-family transcription factors by UVB and TPA in cultured keratinocytes. Oncogene. 12:1996;785-793.
38. Sayre R.M., Kligman L.H. Discrepancies in the measurement of spectral sources. Photochem. Photobiol. 55:1992;141-144.
39. Agarwal R., Mukhtar H. Chemoprevention of photocarcinogenesis. Photochem. Photobiol. 63:1996;440-444.
40. Fuchs J., Milbradt R. Antioxidant inhibition of skin inflammation induced by reactive oxidants evaluation of the redox couple dihydrolipoate/lipoate . Skin Pharmacol. 7:1994;278-284.
41. Suzuki Y.J., Aggarwal B.B., Packer L. Alpha-lipoic acid is a potent inhibitor of NF-κB activation in human T cells. Biochem. Biophys. Res. Commun. 189:1992;1709-1715.
42. van den Broeke L.T., Beijersbergen van Henegouwen G.M.J. Topically applied N-acetylcysteine as a protector against UVB-induced systemic immunosuppression. J. Photochem. Photobiol. B Biol. 27:1995;61-65.
43. Steenvoorden D.P.T., Beijersbergen Van Henegouwen G.M.J. Cysteine derivatives protect against UV-induced reactive intermediates in human keratinocytes the role of glutathione synthesis . Photochem. Photobiol. 66:1997;665-671.
44. Mihm S., Ennen J., Pessara U., Kurth R., Dröge W. Inhibition of HIV-1 replication and NF-κB activity by cysteine and cysteine derivatives. AIDS. 5:1991;497-503.
45. Garmyn M., Degreef H. Suppression of UVB-induced c-fos and c-jun expression in human keratinocytes by N-acetylcysteine. J. Photochem. Photobiol. B: Biol. 37:1997;125-130.
46. Rice-Evans C.A., Miller N.J., Paganga G. Structure-antioxidant activity relationships of flavonoids and phenolic acids. Free Radic. Biol. Med. 20:1996;933-956.
47. Formica J.V., Regelson W. Review of the biology of quercetin and related bioflavonoids. Fd. Chem. Toxic. 33:1995;1061-1080.
48. Packer L., Saliou C., Droy-Lefaix M.T., Christen Y. Ginkgo biloba extract (EGb761) biological actions, antioxidant activity, and regulation of nitric oxide synthase . Packer L., Rice-Evans C. Flavonoids in health and disease. 1998;303-341 Marcel Dekker, Inc, New York.
49. Gerritsen M.E., Carley W.W., Ranges G.E., Shen C.P., Phan S.A., Ligon G.F., Perry C.A. Flavonoids inhibit cytokine-induced endothelial cell adhesion protein gene expression. Am. J. Pathol. 147:1995;278-292.
50. Bindoli A., Cavallini L., Siliprandi N. Inhibitory action of silymarin of lipid peroxide formation in rat liver mitochondria and microsomes. Biochem. Pharmacol. 26:1977;2405-2409.
51. Katiyar S.K., Korman N.J., Mukhtar H., Agarwal R. Protective effects of silymarin against photocarcinogenesis in a mouse skin model. J. Natl. Cancer Inst. 89:1997;556-566.
52. Bombardelli E., Spelta M., Della Loggia R., Sosa S., Tubaro A. Aging skin Protective effect of silymarin-PHYTOSOME . Fitoterapia. 62:1991;115-122.
53. Zi X., Mukhtar H., Agarwal R. Novel cancer chemopreventive effects of a flavonoid antioxidant silymarin inhibition of mRNA expression of an endogenous tumor promoter TNF alpha . Biochem. Biophys. Res. Commun. 239:1997;334-339.
54. Fiebrich F., Koch H. Silymarin, an inhibitor of prostaglandin synthetase. Experientia. 35:1979;1550-1552.
55. Yamamoto K., Arakawa T., Ueda N., Yamamoto S. Transcriptional roles of nuclear factor kappa-B and nuclear factor-interleukin-6 in the tumor necrosis factor alpha-dependent induction of cyclooxygenase-2 in MC3T3-E1 cells. J. Biol. Chem. 270:1995;31315-31320.