Dehydroepiandrosterone modulates antioxidant enzymes and Akt signaling in healthy Wistar rat hearts

Journal of Steroid Biochemistry and Molecular Biology

Volumn 112, Issue 1-3, 2008, Pages 138-144

  Jacob, Maria H V M ^a   Janner, Daiane da R ^a   Belló Klein, Adriane ^a   Llesuy, Susana F ^b   Ribeiro, Maria F M ^a  

^a FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

^b Programa de Radicales Libres em Biologia   (Argentina)

Author keywords

Akt; DHEA; Heart; Oxidative stress

Indexed keywords

4 HYDROXYNONENAL; CATALASE; GLUTATHIONE TRANSFERASE; MEMBRANE LIPID; PRASTERONE; PROTEIN KINASE B; SUPEROXIDE DISMUTASE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CHEMOLUMINESCENCE; CONTROLLED STUDY; DOSE RESPONSE; DRUG MECHANISM; ENZYME ACTIVITY; HEART MUSCLE; LIPID PEROXIDATION; MALE; MOUSE; NONHUMAN; OXIDATIVE STRESS; SIGNAL TRANSDUCTION; TISSUE HOMOGENATE; WESTERN BLOTTING;

ANIMALS; CATALASE; DEHYDROEPIANDROSTERONE SULFATE; ENZYME ACTIVATION; LIPID PEROXIDATION; MALE; MYOCARDIUM; OXIDATIVE STRESS; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, WISTAR; SIGNAL TRANSDUCTION; SUPEROXIDE DISMUTASE;

RATTUS; RATTUS NORVEGICUS;

EID: 55349088199     PISSN: 09600760     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jsbmb.2008.09.008     Document Type: Article

References (40)

1. Celebi F., Yilmaz I., Aksoy H., Gümüs M., Taysi S., and Oren D. Dehydroepiandrosterone prevents oxidative injury in obstructive jaundice in rats. J. Int. Med. Res. 32 4 (2004) 400-405
2. Kim S.K., and Novak R.F. The role of intracellular signaling in insulin-mediated regulation of drug metabolizing enzyme gene and protein expression. Pharmacol. Ther. 113 1 (2007) 88-120
3. Jiang Y., Miyazaki T., Honda A., Hirayama T., Yoshida S., Tanaka N., and Matsuzaki Y. Apoptosis and inhibition of the phosphatidylinositol 3-kinase/Akt signaling pathway in the anti-proliferative actions of dehydroepiandrosterone. J. Gastroenterol. 40 5 (2005) 490-497
4. Simoncini T., Mannella P., Fornari L., Varone G., Caruso A., and Genazzani A.R. Dehydroepiandrosterone modulates endothelial nitric oxide synthesis via direct genomic and nongenomic mechanisms. Endocrinology 144 8 (2003) 3449-3455
5. Eich D.M., Nestler J.E., Johnson D.E., Dworkin G.H., Ko D., Wechsler A.S., and Hess M.L. Inhibition of accelerated coronary atherosclerosis with dehydroepiandrosterone in the heterotopic rabbit model of cardiac transplantation. Circulation 87 1 (1993) 261-269
6. Chistopher-Hennings J., Kurzman I.D., Haffa A.L., Kemnitz J.W., and Macewen E.G. The effect of high fat diet and dehydroepiandrosterone (DHEA) administration in rhesus monkey. In Vivo 9 5 (1995) 415-420
7. Schumacher M., Akwa Y., Guennoun R., Robert F., Labombarda F., Désarnaud F., Robel P., De Nicola A.F., and Baulieu E.E. Steroids synthesis and metabolism in the nervous system: trophic and protective effects. J. Neurocytol. 29 (2000) 307-326
8. Baulieu E.E., and Robel P. Dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEAS) as neuroactive neurosteroids. Proc. Natl. Acad. Sci. U.S.A. 95 (1998) 1089-1091
9. Arnlöv J., Pencina M.J., Amin S., Nam B.H., Benjamin E.J., Murabito J.M., Wang T.J., Knapp P.E., D'Agostino Sr. R.B., Bhasin S., and Vasan R.S. Endogenous sex hormones and cardiovascular disease incidence in men. Ann. Intern. Med. 145 3 (2006) 176-184
10. Khaw K.T. Dehydroepiandrosterone, dehydroepiandrosterone sulphate and cardiovascular disease. J. Endocrinol. 150 (1996) S149-S153
11. Yoshimura M. Cardiac aldosterone. Nippon Rinsho 64 5 (2006) 837-842
12. Goldfarb A.H., McIntosh M.K., and Boyer B.T. Vitamin E attenuates myocardial oxidative stress induced by DHEA in rested and exercised rats. J. Appl. Physiol. 80 2 (1996) 486-490
13. Mastrocola R., Aragno M., Betteto S., Brignardello E., Catalano M., Danni O., and Boccuzzi G. Pro-oxidant effect of dehydroepiandrosterone in rats is mediated by PPAR activation. Life Sci. 73 3 (2003) 289-299
14. Simoncini T., and Genazzani A.R. Non-genomic actions of sex steroids hormones. Eur. J. Endocrinol. 148 (2003) 281-292
15. Valko M., Leibfritz D., Moncol J., Cronin M.T.D., Manzur M., and Telser J. Free radicals and antioxidants in normal physiological functions and human disease. Int. J. Biochem. Cell Biol. 39 (2007) 44-84
16. Dröge W. The plasma redox state and ageing. Ageing Res. Rev. 1 2 (2002) 257-278
17. Tanaka T., Nakamura H., Yodoi J., and Bloom E.T. Redox regulation of the signaling pathways leading to eNOS phosphorylation. Free Radic. Biol. Med. 38 9 (2005) 1231-1242
18. Mullonkal C.J., and Toledo-Pereyra L.H. Akt in ischemia and reperfusion. J. Invest. Surg. 20 3 (2007) 195-203
19. DeBosch B., Treskov I., Lupu T.S., Weinheimer C., Kovacs A., Courtois M., and Muslin A.J. Akt1 is required for physiological cardiac growth. Circulation 113 17 (2006) 2097-2104
20. Kibaly C., Meyer L., Patte-Mensah C., and Mensah-Nyagan A.G. Biochemical and functional evidence for the control of pain mechanisms by dehydroepiandrosterone endogenously synthesized in the spinal cord. FASEB J. 22 1 (2008) 93-104
21. Labrie F., Luu-The V., Martel C., Chernomoretz A., Calvo E., Morissette J., and Labrie C. Dehydroepiandrosterone (DHEA) is an anabolic steroid like dihydrotestosterone (DHT), the most potent natural androgen, and tetrahydrogestrinone (THG). J. Steroid Biochem. Mol. Biol. 100 (2006) 52-58
22. Llesuy S.F., Milei J., Molina H., Boveris A., and Milei S. Comparison of lipid peroxidation and myocardial damage induced by adriamycin and 4′-epiadriamycin mice. Tumori 71 (1985) 241-249
23. Gonzalez-Flecha B., Llesuy S.F., and Boveris A. Hydroperoxide-initiated chemiluminescence: an assay for oxidative stress in biopsies of heart, liver and muscle. Free Radic. Biol. Med. 10 (1991) 93-100
24. Marklund S.L. Pyrogallol autoxidation. In: Greenwald R.A. (Ed). Handbook of Methods for Oxygen Radical Research (1985), CRC Press, Boca Raton, FL 243-247
25. Aebi H. Catalase in vitro. Methods Enzymol. 105 (1984) 121-126
26. Mannervick B., and Gluthenberg C. Glutathione transferase (human placenta). Methods Enzymol. 77 (1981) 231-235
27. Bradford M.M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72 (1976) 248-254
28. Lowry O.H., Rosebrough A.L., Farr A.L., and Randall R. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193 (1951) 265-275
29. Khan S.A. Effects of dehydroepiandrosterone (DHEA) on ubiquinone and catalase in the livers of male F-344 rats. Biol. Pharm. Bull. 28 7 (2005) 1301-1303
30. López O., Hernández A.F., Rodrigo L., Gil F., Pena G., Serrano J.L., Parrón T., Villanueva E., and Pla A. Changes in antioxidant enzymes in humans with long-term exposure to pesticides. Toxicol. Lett. 171 3 (2007) 146-153
31. Aksoy Y., Yapanoglu T., Aksou H., and Yildirim A.K. The effect of dehydroepiandrosterone on renal ischemia-reperfusion-induced oxidative stress in rabbits. Urol. Res. 32 3 (2004) 93-96
32. Pelissier M.A., Trap C., Malewiak M.I., and Morfin R. Antioxidant effects of dehydroepiandrosterone and 7-α-hydroxy-dehydroepiandrosterone in the rat colon, intestine and liver. Steroids 69 (2004) 137-144
33. Pastore A., Federici G., Bertini E., and Piemonte F. Analysis of glutathione: implication in redox and detoxification. Clin. Chim. Acta 333 1 (2003) 19-39
34. Uchida K. 4-Hydroxy-2-nonenal: a product and mediator of oxidative stress. Prog. Lipid Res. 42 4 (2003) 318-343
35. Nakashima I., Liu W., Akhand A.A., Takeda K., Kawamoto Y., Kato M., and Suzuki H. 4-Hydroxynonenal triggers multistep signal transduction cascades for suppression of cellular functions. Mol. Aspects Med. 24 4-5 (2003) 231-238
36. Liu D., Si H., Reynolds K.A., Zhen W., Jia Z., and Dillon J.S. Dehydroepiandrosterone protects vascular endothelial cells against apoptosis through a galphai protein-dependent activation of phosphatidylinositol 3-kinase-Akt and regulation of antiapoptotic Bcl-2 expression. Endocrinology 148 7 (2007) 3068-3076
37. Wang X., McCullogh K.D., Franke T.F., and Holbrook N.J. Epidermal growth factor receptor-dependent Akt activation by oxidative stress enhances cell survival. J. Biol. Chem. 275 19 (2000) 14624-14631
38. R.P. Guedes, A.S.R. Araujo, D. Janner, A. Belló-Klein, M.F. Ribeiro, W.A. Partata, Increase in reactive oxygen species and activation of Akt signaling pathway in naturopathic pain, Cell. Mol. Neurobiol., 2008, doi:101007/s10571-008-9279-9.
39. Cai H., Li Z., Davis M.E., Kanner W., Harrison D.G., and Dudley S.C. Akt-dependent phosphorylation of serine 1179 and mitogen-activated protein kinase kinase/extracellular signal-regulated kinase 1/2 cooperatively mediate activation of the endothelial nitric-oxide synthase by hydrogen peroxide. Mol. Pharmacol. 63 (2003) 325-331
40. Araujo A.S., Enzveiler A.T., Schenkel P., Fernandes T.R., Ribeiro M.F., Partata W.A., Llesuy S., and Belló-Klein A. Oxidative stress activates insulin-like growth factor I receptor protein expression, mediating cardiac hypertrophy induced by thyroxine. Mol. Cell. Biochem. 303 1-2 (2007) 89-95