Vitamin E attenuates myocardial oxidative stress induced by DHEA in rested and exercised rats

Journal of Applied Physiology

Volumn 80, Issue 2, 1996, Pages 486-490

  Goldfarb, A H ^a   McIntosh, M K ^a   Boyer, B T ^a  

^a UNIVERSITY OF NORTH CAROLINA AT GREENSBORO   (United States)

Author keywords

catalase; dehydroepiandrosterone; glutathione peroxidase; lipid peroxidation

Indexed keywords

ALPHA TOCOPHEROL; GLUTATHIONE PEROXIDASE; PRASTERONE;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; HEART MUSCLE METABOLISM; LIPID PEROXIDATION; MALE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; TREADMILL EXERCISE; VITAMIN INTAKE;

EID: 0030043905     PISSN: 87507587     EISSN: None     Source Type: Journal    
DOI: 10.1152/jappl.1996.80.2.486     Document Type: Article

References (30)

1. Alessio, H. M., and A. H. Goldfarb. Lipid peroxidation and scavenger enzymes during exercise: adaptive response to training. J. Appl. Physiol. 64: 1333-1336, 1988.
2. Alessio, H. M., A. H. Goldfarb, and R. G. Cutler. MDA content increases in fast- and slow-twitch skeletal muscle with intensity of exercise in a rat. Am. J. Physiol. 255 (Cell Physiol. 24): C874-C877, 1988.
3. Arkhipenko, Y. V., G. G. Konaovalova, L. M. Dzhaparidze, V. Z. Lankin, and V. B. Spirichev. Concentration of lipid peroxidation products and antioxidant enzyme activity in myocardium and liver of rats differing in vitamin E intake. Bull. Exp. Biol. Med. 106: 1697-T699, 1989.
4. Bears, R. F., and I. Sizer. A spectrophotometric method for measuring the breakdown of hydrogen peroxide by catalase. J. Biol. Chem. 195: 133-140, 1952.
5. Brady, P. S., L. J. Brady, and D. E. Ullrey. Selenium, vitamin E, and the response to swimming stress in the rat. J. Nutr. 109: 1103-1109, 1979.
6. Burton, G. W., and K. U. Ingold. Vitamin E as an in vitro and in vivo antioxidant. Vitamin E: biochemistry and health implications. Ann. NY Acad. Sci. 570: 7-22, 1989.
7. Cleary, M. P. The antiobesity effect of dehydroepiandrosterone in rats. Proc. Soc. Exp. Biol. Med. 196: 8-16, 1991.
8. Davies, K. J. A., A. T. Quintanilha, G. A. Brooks, and L. Packer. Free radicals and tissue damage produced by exercise. Biochem. Biophys. Res. Commun. 107: 1198-1205, 1982.
9. Dillard, C. J., E. E. Dumelin, and A. Tappel. Effect of dietary vitamin E on expiration of pentane and ethane by the rat. Lipids 12: 109-114, 1977.
10. Gohil, K., L. Packer, B. DeLumen, G. A. Brooks, and S. E. Terblanche. Vitamin E deficiency and vitamin C supplements: exercise and mitochondrial oxidation. J. Appl. Physiol. 60: 1986-1991, 1986.
11. Goldfarb, A. H., M. K. McIntosh, B. T. Boyer, and J. Fatouros. Vitamin E effects on indexes of lipid peroxidation in muscle from DHEA-treated and exercised rats. J. Appl. Physiol. 76: 1630-1635, 1994.
12. Gutteridge, J. M. C. Lipid peroxidation: some problems and concepts. In: Oxygen Radicals and Tissue Injury, edited by B. Halliwel. Bethesda, MD: Upjohn Symposium, 1988, p. 9-19.
13. Jenkins, R. R. Free radical chemistry; relationship to exercise. Sports Med. 5: 156-170, 1988.
14. Ji, L. L., R. Fu, and E. W. Mitchell. Glutathione and antioxidant enzymes in skeletal muscle: effects of fiber type and exercise intensity. J. Appl. Physiol. 73: 1854-1859, 1992.
15. Kanter, M. M., R. L. Hamlin, D. V. Unverferth, H. W. Davis, and A. J. Merola. Effect of exercise training on antioxidant enzymes and cardiotoxicity of doxorubin. J. Appl. Physiol. 59: 1298-1303, 1985.
16. Kumar, C. T., V. K. Reddy, M. Prasad, K. Thyagaraju, and P. Reddanna. Dietary supplementation of vitamin E protects heart tissue from exercise-induced oxidant stress. Mol. Cell. Biochem. 111: 109-115, 1992.
17. Lawrence, R., and R. Burk. Glutathione peroxidase activity in selenium-deficient rat liver. Biochem. Biophys. Res. Commun. 71: 952-958, 1976.
18. Link, G., A. Pinson, I. Kahane, and C. Hershko. Iron loading modifies the fatty acid composition of cultured rat myocardial cells and liposomal vesicles: effect of ascorbate and α-tocopherol on myocardial lipid peroxidation. J. Lab. Clin. Med. 114: 243-249, 1989.
19. Lowry, O. H., N. J. Rosenbrough, A. L. Farr, and R. J. Randall. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193: 265-275, 1951.
20. McIntosh, M. K., A. H. Goldfarb, L. Curtis, and P. Cote. Vitamin E alters hepatic antioxidant enzymes in rats treated with dehydroepiandrosterone (DHEA). J. Nutr. 123: 216-224, 1993.
21. McIntosh, M. K., A. H. Goldfarb, P. S. Cote, and K. Griffin. Vitamin E reduces peroxisomal fatty acid oxidation and indicators of oxidative stress in untrained, exercised rats treated with dehydroepiandrosterone (DHEA). J. Nutr. Biochem. 4: 298-303, 1993.
22. Packer, L. Vitamin E, physical exercise and tissue damage in animals. Med. Biol. 62: 105-109, 1984.
23. Phoenix, J., R. H. T Edwards, and M. T. Jackson. The effect of vitamin E analogues and long hydrocarbon chain compounds on calcium-induced muscle damage. A novel role for alpha-tocopherol. Biochem. Biophys. Acta 1097: 212-218, 1991.
24. Quintanilha, A. T. Effects of physical exercise and/or vitamin E on tissue oxidative metabolism. Biochem. Soc. Trans. 12: 403-404, 1984.
25. Salminen, A., H. Kainulainen, A. U. Arstila, and V. Vihko. Vitamin E deficiency and the susceptibility to lipid peroxidation of mouse cardiac and skeletal muscles. Acta Physiol. Scand. 122: 565-570, 1984.
26. Schauer, J. E., A. Schelin, P. Hanson, and F. W. Stratman. Dehydro-epiandrosterone and a beta-agonist energy transducers alter antioxidant enzyme systems: influence of chronic training and acute exercise in rats. Arch. Biochem. Biophys. 283: 503-511, 1990.
27. Sodin, B., Y. Hellsten-Westing, and F. S. Apple. Biochemical mechanisms for oxygen free radical formation during exercise. Sports Med. 10: 236-254, 1990.
28. Sumida, S., K. Tanaka, H. Kitao, and F. Nakadomo. Exercise-induced lipid peroxidation and leakage of enzymes before and after vitamin E supplementation. Int. J. Biochem. 21: 835-838, 1989.
29. Tagliaferro, A. R., J. R. Davis, S. Truchon, and N. Van Hamont. Effects of dehydroepiandrosterone acetate on metabolism, body weight, and composition of male and female rats. J. Nutr. 116: 1977-1983, 1986.
30. Tiidus, P. M., W. A. Behrens, R. Madere, J. J. Kim, and M. E. Houston. Effects of vitamin E and exercise training on tissue lipid peroxidation based on two methods of assessment. Nutr. Res. 13: 219-224, 1993.