The development of new oximes and the evaluation of their reactivating therapeutic and neuroprotective efficacy against tabun

Mini-Reviews in Medicinal Chemistry

Volumn 8, Issue 11, 2008, Pages 1134-1143

  Kassa, Jiri ^a   Kuca, Kamil ^a,b   Karasova, Jana ^a   Musilek, Kamil ^a  

^a UNIVERSITY OF DEFENCE   (Czech Republic)

^b UNIVERSITY OF DEFENCE   (Czech Republic)

Author keywords

Acetylcholinesterase; Atropine; HI 6; K oximes; Mice; Obidoxime; Rats; Tabun

Indexed keywords

1 (4 CARBAMOYLPYRIDINIO) 1' (2 HYDROXYIMINOMETHYLPYRIDINIO)DIMETHYL ETHER; 1 (4 HYDROXYIMINOMETHYLPYRIDINIUM) 3 (4 CARBAMOYLPYRIDINIUM)BUTANE DIBROMIDE; 1 (4 HYDROXYIMINOMETHYLPYRIDINIUM) 3 (4 CARBAMOYLPYRIDINIUM)PROPANE DIBROMIDE; 1,4 BIS (4 HYDROXYIMINOMETHYLPYRIDINIUM)BUT 2 ENE DIBROMIDE; 1,4 BIS (4 HYDROXYIMINOMETHYLPYRIDINIUM)BUTANE DIBROMIDE; ACETYLCHOLINESTERASE; ANTIDOTE; ATROPINE; CHOLINERGIC RECEPTOR BLOCKING AGENT; CHOLINESTERASE REACTIVATOR; CYCLOSARIN; K 027; K 048; K 074; K 075; METHOXIME; OBIDOXIME; ORGANOPHOSPHORUS COMPOUND; OXIME DERIVATIVE; PRALIDOXIME; SOMAN; TABUN; TRIMEDOXIME; UNCLASSIFIED DRUG; NEUROPROTECTIVE AGENT; ORGANOPHOSPHATE; OXIME;

ARTICLE; CHEMICAL REACTION KINETICS; CHEMICAL WARFARE; CLINICAL EFFECTIVENESS; COMBINATION CHEMOTHERAPY; DRUG EFFICACY; DRUG MECHANISM; DRUG POTENCY; DRUG RESPONSE; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; ENZYME REACTIVATION; HUMAN; IN VITRO STUDY; IN VIVO STUDY; INTOXICATION; LD 50; MONOTHERAPY; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; SCREENING TEST; STRUCTURE ACTIVITY RELATION; TERRORISM; TOXICITY TESTING; ANIMAL; CHEMISTRY; DRUG ANTAGONISM; DRUG DESIGN; REVIEW; SYNTHESIS;

ANIMALS; ANTIDOTES; CHOLINESTERASE REACTIVATORS; DRUG DESIGN; HUMANS; NEUROPROTECTIVE AGENTS; OXIMES; PHOSPHORIC ACID ESTERS;

EID: 55249115613     PISSN: 13895575     EISSN: None     Source Type: Journal    
DOI: 10.2174/138955708785909871     Document Type: Article

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