Molecular genetic studies of cognitive deficit in schizophrenia

Molecular Biology

Volumn 42, Issue 5, 2008, Pages 738-746

  Golimbet, V E ^a  

^a MENTAL HEALTH RESEARCH CENTER   (Russian Federation)

Author keywords

Cognitive disturbances; Dopamine; Gene polymorphism; Schizophrenia; Serotonin

Indexed keywords

EID: 55149108171     PISSN: 00268933     EISSN: 16083245     Source Type: Journal    
DOI: 10.1134/S0026893308050117     Document Type: Review

References (51)

1. S.R. Marder W. Fenton 2004 Measurement and treatment research to improve cognition in schizophrenia: NIMH MATRICS initiative to support the development of agents for improving cognition in schizophrenia Schizophr. Res. 72 5 9
2. A.K. Malhotra L.J. Kestler C. Mazzanti 2002 A functional polymorphism in the COMT gene and performance on a test of prefrontal cognition Am. J. Psychiatry. 159 652 654
3. J. Fossella T. Sommer J. Fan 2002 Assessing the molecular genetics of attention networks BMC Neurosci. 3 14 21
4. T.E. Goldberg M.F. Egan T. Gscheidle 2003 Executive subprocesses in working memory: relationship to catechol-O-methyltransferase Val158Met genotype and schizophrenia Arch. Gen. Psychiatry. 60 889 896
5. R.M. Bilder J. Volavka P. Czobor 2002 Neurocognitive correlates of the COMT Val(158)Met polymorphism in chronic schizophrenia Biol. Psychiatry. 52 701 707
6. G.E. Bruder J.G. Keilp H. Xu 2005 Catechol-O-methyltransferase (COMT) genotypes and working memory: Associations with differing cognitive operations Biol. Psychiatry. 58 901 907
7. C.E. Bearden A.F. Jawad D.R. Lynch 2004 Effects of a functional COMT polymorphism on prefrontal cognitive function in patients with 22q11.2 deletion syndrome Am. J. Psychiatry. 161 1700 1702
8. J.H. Barnett P.B. Jones T.W. Robbins U. Muller 2007 Effects of the catechol-O-methyltransferase Val158Met polymorphism on executive function: A meta-analysis of the Wisconsin Card Sort Test in schizophrenia and healthy controls Mol. Psychiatry. 12 502 509
9. A. Diamond L. Briand J. Fossella L. Gehlbach 2004 Genetic and neurochemical modulation of prefrontal cognitive functions in children Am. J. Psychiatry. 161 125 132
10. M.V. Alfimova V.E. Golimbet I.K. Gritsenko 2006 Interaction of dopaminergic system genes and cognitive functions in patients with schizophrenia, their relatives, and healthy persons from general population Zh. Nevrol. Psikhiatr. im. S.S. Korsakova. 106 57 63
11. D. Bartres-Faz C. Junque J.M. Serra-Grabulosa 2002 Dopamine DRD2 Taq I polymorphism associates with caudate nucleus volume and cognitive performance in memory impaired subjects Neurorept. 13 1121 1125
12. R. Rodriguez-Jimenez J. Hoenicka M.A. Jimenez-Arriero 2006 Performance in the Wisconsin Card Sorting Test and the C957T polymorphism of the DRD2 gene in healthy volunteers Neuropsychobiology. 54 166 170
13. G. Szekeres S. Keri A. Juhasz 2004 Role of dopamine D3 receptor (DRD3) and dopamine transporter (DAT) polymorphism in cognitive dysfunctions and therapeutic response to atypical antipsychotics in patients with schizophrenia Am. J. Med. Genet. B Neuropsychiatr. Genet. 124 1 5
14. N. Lowe A. Kirley Z. Hawi 2004 Joint analysis of the DRD5 marker concludes association with attention-deficit/hyperactivity disorder confined to the predominantly inattentive and combined subtypes Am. J. Hum. Genet. 74 348 356
15. V.E. Golimber M.V. Alfimova I.K. Gritsenko 2008 Association of dopamine receptor D5 gene polymorphism with specific features of voluntary attention in patients with schizophrenia and their relatives Byull. Eksp. Biol. Med. 145 71 73
16. R.Y. Chen P. Sham E.Y. Chen 2001 No association between T102C polymorphism of serotonin-2A receptor gene and clinical phenotypes of Chinese schizophrenic patients Psychiatry Res. 105 175 185
17. Golimbet V.E., Alfimova M.V., et al. 2006. Verbal memory deficit in schizophrenia as a possible endophenotype of the disease. In: Schizoaffective Disorder: New Research. Ed. Murray W.H. N.Y.: Nova Science Publ., 165-186.
18. A. Ucok H. Alpsan S. Cakir G. Saruhan-Direskeneli 2007 Association of a serotonin receptor 2A gene polymorphism with cognitive functions in patients with schizophrenia Am. J. Med. Genet. B Neuropsychiatr. Genet. 144 704 707
19. M. Reuter U. Ott D. Vaitl J. Hennig 2007 Impaired executive control is associated with a variation in the promoter region of the tryptophan hydroxylase 2 gene J. Cogn. Neurosci. 19 401 408
20. S.E. Harris H. Fox A.F. Wright 2006 The brainderived neurotrophic factor Val66Met polymorphism is associated with age-related change in reasoning skills Mol. Psychiatry. 11 505 513
21. J.K. Rybakowski A. Borkowska M. Skibinska 2006 Prefrontal cognition in schizophrenia and bipolar illness in relation to Val66Met polymorphism of the brain-derived neurotrophic factor gene Psychiatry Clin. Neurosci. 60 70 76
22. B.C. Ho P. Milev D.S. O'Leary 2006 Cognitive and magnetic resonance imaging brain morphometric correlates of brain-derived neurotrophic factor Val66Met gene polymorphism in patients with schizophrenia and healthy volunteers Arch. Gen. Psychiatry. 63 731 740
23. S.J. Tsai C.J. Hong Y.W. Yu T.J. Chen 2004 Association study of a brain-derived neurotrophic factor (BDNF) Val66Met polymorphism and personality trait and intelligence in healthy young females Neuropsychobiology. 49 13 16
24. M.V. Alfimova T.V. Lezheiko V.E. Golimbet 2008 Role of brain netrotrophic factor genetic polymorphism in processes of voluntary and involuntary attention and their pathology in schizophrenia Zh. Nevrol. Psikhiatr. im. S.S. Korsakova. 107 59 66
25. G. Donohoe D.W. Morris S. Clarke 2007 Variance in neurocognitive performance is associated with dysbindin-1 in schizophrenia: a preliminary study Neuropsychologia. 45 454 458
26. N.C. Stefanis T.A. Trikalinos D. Avramopoulos 2007 Impact of schizophrenia candidate genes on schizotypy and cognitive endophenotypes at the population level Biol. Psychiatry. 62 784 792
27. W. Hennah A. Tuulio-Henriksson T. Paunio 2005 A haplotype within the DISC1 gene is associated with visual memory functions in families with a high density of schizophrenia Mol. Psychiatry. 10 1097 1103
28. P.A. Thomson S.E. Harris J.M. Starr 2005 Association between genotype at an exonic SNP in DISC1 and normal cognitive aging Neurosci. Lett. 389 41 45
29. M.F. Egan T.E. Goldberg B.S. Kolachana 2001 Effect of COMT Val108/158Met genotype on frontal lobe function and risk schizophrenia Proc. Natl. Acad. Sci. USA. 98 6917 6922
30. S.J. Tsai Y.W. Yu T.J. Chen 2003 Association study of a functional catechol-O-methyltransferase-gene polymorphism and cognitive function in healthy females Neurosci. Lett. 338 123 126
31. V.A. Golimbet I.K. Gritsenko M.V. Alfimova 2006 Association study of COMT gene Val158Met polymorphism with auditory P300 and performance on neurocognitive tests in patients with schizophrenia and their relatives World J. Biol. Psychiatry. 7 238 245
32. E. Stip 2006 Cognition, schizophrenia and the effect of antipsychotics Encephale. 32 1 341 350
33. W.J. Muir M.L. Thomson P. McKeon 2001 Markers close to the dopamine D5 receptor gene (DRD5) show significant association with schizophrenia but not bipolar disorder Am. J. Med. Genet. 105 152 158
34. M. Wingen K.P. Kuypers J.G. Ramaekers 2007 The role of 5-HT1a and 5-HT2a receptors in attention and motor control: A mechanistic study in healthy volunteers Psychopharmacology (Berlin) 190 391 400
35. I. Hernandez B.P. Sokolov 2000 Abnormalities in 5-HT2A receptor mRNA expression in frontal cortex of chronic elderly schizophrenics with varying histories of neuroleptic treatment J. Neurosci. Res. 59 218 225
36. S.G. Potkin K. Fleming Y. Jin B. Gulasekaram 2001 Clozapine enhances neurocognition and clinical symptomatology more than standard neuroleptics J. Clin. Psychopharmacol. 21 479 483
37. M.V. Alfimova V.E. Golimbet N.G. Mityushina 2003 Polymorphism of the serotonin receptor type 2A (5-HTR2A) gene and verbal fluency in normalcy and in schizophrenia Mol. Biol. 37 68 73
38. O. Polesskaya B. Sokolov 2002 Differential expression of the "C" and "T" alleles of the 5-HTR2A receptor gene in the temporal cortex of normal individuals and schizophrenics J. Neurosci. Res. 67 812 822
39. Reuter M., Esslinger C., Montag C., et al. 2008. A functional variant of the tryptophan hydroxylase 2 gene impacts working memory: A genetic imaging study. Biol. Psychol. Jan 29.
40. M. Egan M. Kojima J. Callicott 2003 The BDNF Val66Met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function Cell. 112 257 269
41. P.R. Szeszko R. Lipsky C. Mentschel 2005 Brain-derived neurotrophic factor Val66Met polymorphism and volume of the hippocampal formation Mol. Psychiatry. 10 631 636
42. B. Funke C.T. Finn A.M. Plocik 2004 Association of the DTNBP1 locus with schizophrenia in a U.S. population Am. J. Hum. Genet. 75 891 898
43. A.J. Fallgatter M.J. Herrmann C. Hohoff 2006 DTNBP1 (dysbindin) gene variants modulate prefrontal brain function in healthy individuals Neuropsychopharmacology. 31 2002 2010
44. D.H. Blackwood M.F. Glabus J. Dunan 1999 Altered cerebral perfusion measured by SPECT in relatives of patients with schizophrenia: Correlations with memory and P300 Br. J. Psychiatry. 175 357 366
45. R. James R.R. Adams S. Christie 2004 Disrupted in Schizophrenia 1 (DISC1) is a multicompartmentalized protein that predominantly localizes to mitochondria Mol. Cell. Neurosci. 26 112 122
46. J.K. Millar B.S. Pickard S. Mackie 2005 DISC1 and PDE4B are interacting genetic factors in schizophrenia that regulate cAMP signaling Science. 310 1187 1191
47. T.E. Goldberg R.E. Straub J.H. Callicott 2006 The G72/G30 gene complex and cognitive abnormalities in schizophrenia Neuropsychopharmacology. 31 2022 2032
48. S. Papiol V. Molina A. Rosa 2007 Effect of interleukin-1beta gene functional polymorphism on dorsolateral prefrontal cortex activity in schizophrenic patients Am. J. Med. Genet. B Neuropsychiatr. Genet. 144 1090 1093
49. M. Reuter K. Peters K. Schroeter 2005 The influence of the dopaminergic system on cognitive functioning: A molecular genetic approach Behav. Brain Res. 16 93 99
50. T. Paunio A. Tuulio-Henriksson T. Hiekkalinna 2004 Search for cognitive trait components of schizophrenia reveals a locus for verbal learning and memory on 4q and for visual working memory on 2q Hum. Mol. Genet. 13 1693 1702
51. J.A. Apud D.R. Weinberger 2007 Treatment of cognitive deficits associated with schizophrenia: Potential role of catechol-O-methyltransferase inhibitors CNS Drugs. 21 535 557