The role of 5-HT1a and 5-HT2a receptors in attention and motor control: A mechanistic study in healthy volunteers

Psychopharmacology

Volumn 190, Issue 3, 2007, Pages 391-400

  Wingen, Marleen ^a   Kuypers, Kim P C ^a   Ramaekers, Johannes G ^a  

^a MAASTRICHT UNIVERSITY   (Netherlands)

Author keywords

Attention; Motor control; Serotonergic receptor manipulations

Indexed keywords

ESCITALOPRAM; KETANSERIN; PINDOLOL; PLACEBO; SEROTONIN 1A RECEPTOR; SEROTONIN 2A RECEPTOR; SEROTONIN UPTAKE INHIBITOR; CITALOPRAM; SEROTONIN ANTAGONIST;

ADULT; ALERTNESS; ARTICLE; ATTENTION; ATTENTION DISTURBANCE; COGNITION; CONTROLLED STUDY; DRUG EFFECT; DRUG RECEPTOR BINDING; FEMALE; HUMAN; MALE; MOTOR CONTROL; MOTOR PERFORMANCE; NORMAL HUMAN; PRIORITY JOURNAL; SELECTIVE ATTENTION; SINGLE DRUG DOSE; TASK PERFORMANCE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; DRUG ANTAGONISM; ORAL DRUG ADMINISTRATION; PHYSIOLOGY; PSYCHOMOTOR PERFORMANCE; RANDOMIZED CONTROLLED TRIAL; SLEEP;

ADMINISTRATION, ORAL; ADULT; ATTENTION; CITALOPRAM; COGNITION; CROSS-OVER STUDIES; DOUBLE-BLIND METHOD; FEMALE; HUMANS; KETANSERIN; MALE; PINDOLOL; PSYCHOMOTOR PERFORMANCE; RECEPTOR, SEROTONIN, 5-HT1A; RECEPTOR, SEROTONIN, 5-HT2A; SEROTONIN ANTAGONISTS; SEROTONIN UPTAKE INHIBITORS; SLEEP;

EID: 33846500206     PISSN: 00333158     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00213-006-0614-x     Document Type: Article

References (42)

1. Aellig WH, Narjes HH, Nuesch E, Oertle RJ, Devos JE, Pacha W (1981) A pharmacodynamic and pharmacokinetic comparison of pindolol 20 mg retard and a conventional tablet. Eur J Clin Pharmacol 20:179-183
2. Aronson S, Delgado P (2004) Escitalopram. Drugs Today (Bare) 40:121-131
3. Blokland A, Sik A, Lieben C (2005) Evaluation of DOI, 8-OH-DPAT, eticlopride and amphetamine on impulsive responding in a reaction time task in rats. Behav Pharmacol 16:93-100
4. Bond A, Lader M (1974) The use of analogue scales in rating subjective feelings. Br J Med Psychol 47:211-218
5. Bortolozzi A, Diaz Mataix L, Scorza MC, Celada P, Artigas F (2005) The activation of 5-HT receptors in prefrontal cortex enhances dopaminergic activity. J Neurochem 95:1597-1607
6. Carli M, Samanin R (2000) The 5-HT(1A) receptor agonist 8-OH-DPAT reduces rats' accuracy of attentional performance and enhances impulsive responding in a five-choice serial reaction time task: role of presynaptic 5-HT(1A) receptors. Psychopharmacology 149:259-268
7. Coull JT, Sahakian BJ, Middleton HC, Young AH, Park SB, McShane RH, Cowen PJ, Robbins TW (1995) Differential effects of clonidine, haloperidol, diazepam and tryptophan depletion on focused attention and attentional search. Psychopharmacology 121:222-230
8. de Wit H, Crean J, Richards JB (2000) Effects of d-amphetamine and ethanol on a measure of behavioral inhibition in humans. Behav Neurosci 114:830-837
9. de Wit H, Enggasser JL, Richards JB (2002) Acute administration of d-amphetamine decreases impulsivity in healthy volunteers. Neuropsychopharmacology 27:813-825
10. Di Matteo V, De Blasi A, Di Giulio C, Esposito E (2001) Role of 5-HT(2C) receptors in the control of central dopamine function. Trends Pharmacol Sci 22:229-232
11. Esposito E (2006) Serotonin-dopamin interaction as a focus of novel antidepressant drugs. Current Drug Targets 7:177-185
12. Harmer CJ, McTavish SFB, Clark L, Goodwin GM, Cowen PJ (2001) Tyrosine depletion attenuates dopamine function in healthy volunteers. Psychopharmacology 154:105-111
13. Harrison AA, Everitt BJ, Robbins TW (1997) Central 5-HT depletion enhances impulsive responding without affecting the accuracy of attentional performance: interactions with dopaminergic mechanisms. Psychopharmacology (Berl) 133:329-342
14. Harrison BJ, Olver JS, Norman TR, Burrows GD, Wesnes KA, Nathan PJ (2004) Selective effects of acute serotonin and catecholamine depletion on memory in healthy women. J Psychopharmacol 18:32-40
15. Hedner T, Persson B, Berglund G (1983) Ketanserin, a novel 5-hydroxytryptamine antagonist: monotherapy in essential hypertension. Br J Clin Pharmacol 16:121-125
16. Jex HR, McDonnell, JD, Phatak AV (1966) A "critical" tracking task for man-machine research related to the operators effective delay time. Part I: theory and experiments with a first order divergent controlled element. NASA CR-616, NASA Contractor Report. NASA CR:100-105
17. Koelega HS (1993) Stimulant drugs and vigilance performance: a review. Psychopharmacology (Berl) 111:1-16
18. Liechti ME, Saur MR, Gamma A, Hell D, Vollenweider FX (2000) Psychological and physiological effects on MDMA ("Ecstasy") after pretreatment with the 5-HT(2) antagonist ketanserin in healthy humans. Neurophychopharmacology 23:396-404
19. Logan GD (1994) On the ability to inhibit thought and action. In: Dagenbach D, Carr TH (eds) Inhibitory processes in attention, memory and language. Academic, San Diego
20. Lucas G, Spampinato U (2000) Role of striatal serotonin2A and serotonin2C receptor subtypes in the control of in vivo dopamine outflow in the rat striatum. J Neurochem 74:693-701
21. Mackworth NH (1950) Researches on the measurement of human performance. In: Sinaiko HW (ed) Selected papers on human factors in the design and use of control systems. Dover, New York, pp 174-331
22. Matrenza C, Hughes JM, Kemp AH, Wesnes KA, Harrison BJ, Nathan PJ (2004) Simultaneous depletion of serotonin and catecholamines impairs sustained attention in healthy female subjects without affecting learning and memory. J Psychopharmacol (Oxf) 18:21-31
23. Moskowitz H (1973) Laboratory studies of the effects of alcohol on some variables related to driving. J Saf Res 5:185-192
24. Mulder-Hajonides van der Meulen WREH (1981) Measurement of subjective sleep quality. Proceedings of the International European SleepCongress. Elsevier,Amsterdam,TheNetherlands
25. Nicholson AN, Pascoe PA (1990) Dopaminergic transmission and the sleep-wakefulness continuum in man. Neuropharmacology 29:411-417
26. O'Hanlon J, Robbe HWJ, Vermeeren A, VanLeeuwen C, Danjou PE (1998) Venlafaxine's effects on healthy volunteers' driving, psychomotor, and vigilance performance during 15-day fixed and incremental dosing regimens. J Clin Psychopharmacol 18:212-221
27. Pribram KH, McGuinness D (1975) Arousal, activation, and effort in the control of attention. Psychol Rev 82:116-149
28. Rabiner EA, Gunn RN, Wilkins MR, Sargent PA, Mocaer E, Sedman E, Cowen PJ, Grasby PM (2000) Drug action at the 5-HT(1A) receptor in vivo: autoreceptor and postsynaptic receptor occupancy examined with PET and [carbonyl-11C]WAY- 100635. Nucl Med Biol 27:509-513
29. Rabiner EA, Bhagwagar Z, Gunn RN, Sargent PA, Bench CJ, Cowen PJ, Grasby PM (2001) Pindolol augmentation of selective serotonin reuptake inhibitors: PET evidence that the dose used in clinical trials is too low. Am J Psychiatry 158:2080-2082
30. Rabiner EA, Bhagwagar Z, Gunn RN, Cowen PJ, Grasby PM (2004) Preferential 5-HT1A autoreceptor occupancy by pindolol is attenuated in depressed patients: effect of treatment or an endophenotype of depression? Neuropsychopharmacology 29:1688-1698
31. Ramaekers JG, Kuypers KPC (2006) Acute effects of 3,4- methylenedioxymethamphetamine (MDMA) on behavioral measures of impulsivity: alone and in combination with alcohol. Neuropsychopharmacology 31:1048-1055
32. Ramaekers JG, Muntjewerff ND, O'Hanlon JF (1995) A comparative study of acute and subchronic effects of dothiepin, fluoxetine and placebo on psychomotor and actual driving performance. Br J Pharmacol 39:397-404
33. Rasmussen K, McCreary AC, Shanks EA (2004) Attenuation of the effects of fluoxetine on serotonergic neuronal activity by pindolol in rats. Neurosci Lett 355:1-4
34. Riedel WJ, Eikmans K, Heldens A, Schmitt JA (2005) Specific serotonergic reuptake inhibition impairs vigilance performance acutely and after subchronic treatment. J Psychopharmacol (Oxf) 19:12-20
35. Robbins TW (1997) Arousal systems and attentional processes. Biol Psychol 45:57-71
36. Robbins TW (2000) Chemical neuromodulation of frontal-executive functions in humans and other animals. Exp Brain Res 133:130-138
37. Schmitt JA, Jorissen BL, Sobczak S, van Boxtel MP, Hogervorst E, Deutz NE, Riedel WJ (2000) Tryptophan depletion impairs memory consolidation but improves focussed attention in healthy young volunteers. J Psychopharmacol (Oxf) 14:21-29
38. Schmitt JA, Ramaekers JG, Kruizinga MJ, van Boxtel MP, Vuurman EF, Riedel WJ (2002) Additional dopamine reuptake inhibition attenuates vigilance impairment induced by serotonin reuptake inhibition in man. J Psychopharmacol (Oxf) 16:207-214
39. Soubrie P (1986) Reconciling the role of central serotonin neurons in human and animal behavior. Behav Brain Sci 9:319-364
40. Spoont MR (1992) Modulatory role of serotonin in neural information processing: implications for human psychopathology. Psychol Bull 112:330-350
41. Stroop JR (1935) Studies of interference in serial verbal reactions. J Exp Psychol 18:643-662
42. Wingen M, Bothmer J, Langer S, Ramaekers JG (2005) Actual driving performance and psychomotor function in healthy subjects after acute and subchronic treatment with escitalopram, mirtazapine, and placebo: a crossover trial. J Clin Psychiatry 66:436-443