Myocardin marks the earliest cardiac gene expression and plays an important role in heart development

Anatomical Record

Volumn 291, Issue 10, 2008, Pages 1200-1211

  Chen, Jian Fu ^a   Wang, Shusheng ^b   Wu, Qiulian ^a   Cao, Dongsun ^a   Nguyen, Thiha ^a   Chen, Yiping ^b   Wang, Da Zhi ^a  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

^b Tulane University   (United States)

Author keywords

Cardiac development; Chick embryos; Gene expression; Heart; Myocardin; SRF; Transcription factor

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; MYOCARDIN;

AMINO ACID SEQUENCE; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CHICK EMBRYO; CONTROLLED STUDY; EMBRYO; EMBRYO DEVELOPMENT; GENE ACTIVATION; GENE EXPRESSION; GENE OVEREXPRESSION; HEART DEVELOPMENT; HEART MUSCLE; MOLECULAR CLONING; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROMOTER REGION; REPORTER GENE; SMOOTH MUSCLE; SPECIES COMPARISON;

AMINO ACID SEQUENCE; ANIMALS; BIOLOGICAL MARKERS; CELLS, CULTURED; CHICK EMBRYO; EMBRYONIC DEVELOPMENT; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENES, REPORTER; HEART; HUMANS; MICE; MOLECULAR SEQUENCE DATA; MUSCLE, SMOOTH, VASCULAR; MYOCARDIUM; NUCLEAR PROTEINS; RANIDAE; TRANS-ACTIVATORS; TRANSFECTION;

EID: 54949154114     PISSN: 19328486     EISSN: 19328494     Source Type: Journal    
DOI: 10.1002/ar.20756     Document Type: Article

References (63)

1. Arceci RJ, King AA, Simon MC, Orkin SH, Wilson DB. 1993. Mouse GATA-4: a retinoic acid-inducible GATA-binding transcription factor expressed in endodermally derived tissues and heart. Mol Cell Biol 13:2235-2246.
2. Baldini A. 2002. DiGeorge syndrome: the use of model organisms to dissect complex genetics. Hum Mol Genet 11:2363-2369.
3. Basson CT, Bachinsky DR, Lin RC, Levi T, Elkins JA, Soults J, Grayzel D, Kroumpouzou E, Traill TA, Leblanc-Straceski J, Renault B, Kucherlapati R, Seidman JG, Seidman CE. 1997. Mutations in human TBX5 [corrected] cause limb and cardiac malformation in Holt-Oram syndrome. Nat Genet 15:30-35.
4. Black BL, Olson EN. 1998. Transcriptional control of muscle development by myocyte enhancer factor-2 (MEF2) proteins. Annu Rev Cell Dev Biol 14:167-196.
5. Brown DD, Binder O, Pagratis M, Parr BA, Conlon FL. 2003. Developmental expression of the Xenopus laevis Tbx20 orthologue. Dev Genes Evol 212:604-607.
6. Brown DD, Martz SN, Binder O, Goetz SC, Price BM, Smith JC, Conlon FL. 2005. Tbx5 and Tbx20 act synergistically to control vertebrate heart morphogenesis. Development 132:553-563.
7. Bruneau BG, Nemer G, Schmitt JP, Charron F, Robitaille L, Caron S, Conner DA, Gessler M, Nemer M, Seidman CE, Seidman JG. 2001. A murine model of Holt-Oram syndrome defines roles of the T-box transcription factor Tbx5 in cardiogenesis and disease. Cell 106:709-721.
8. Buckingham M, Meilhac S, Zaffran S. 2005. Building the mammalian heart from two sources of myocardial cells. Nat Rev Genet 6:826-835.
9. Bussen M, Petry M, Schuster-Gossler K, Leitges M, Gossler A, Kispert A. 2004. The T-box transcription factor Tbx18 maintains the separation of anterior and posterior somite compartments. Genes Dev 18:1209-1221.
10. Cai CL, Liang X, Shi Y, Chu PH, Pfaff SL, Chen J, Evans S. 2003. Isl1 identifies a cardiac progenitor population that proliferates prior to differentiation and contributes a majority of cells to the heart. Dev Cell 5:877-889.
11. Cao D, Wang Z, Zhang CL, Oh J, Xing W, Li S, Richardson JA, Wang DZ, Olson EN. 2005. Modulation of smooth muscle gene expression by association of histone acetyltransferases and deacetylases with myocardin. Mol Cell Biol 25:364-376.
12. Chen J, Kitchen CM, Streb JW, Miano JM. 2002. Myocardin: a component of a molecular switch for smooth muscle differentiation. J Mol Cell Cardiol 34:1345-1356.
13. Chen JF, Mandel EM, Thomson JM, Wu Q, Callis TE, Hammond SM, Conlon FL, Wang DZ. 2006. The role of microRNA-1 and microRNA-133 in skeletal muscle proliferation and differentiation. Nat Genet 38:228-233.
14. Chow N, Bell RD, Deane R, Streb JW, Chen J, Brooks A, Van Nostrand W, Miano JM, Zlokovic BV. 2007. Serum response factor and myocardin mediate arterial hypercontractility and cerebral blood flow dysregulation in Alzheimer's phenotype. Proc Natl Acad Sci USA 104:823-828.
15. Corson LB, Yamanaka Y, Lai KM, Rossant J. 2003. Spatial and temporal patterns of ERK signaling during mouse embryogenesis. Development 130:4527-4537.
16. Creemers EE, Sutherland LB, McAnally J, Richardson JA, Olson EN. 2006a. Myocardin is a direct transcriptional target of Mef2, Tead and Foxo proteins during cardiovascular development. Development 133:4245-4256.
17. Creemers EE, Sutherland LB, Oh J, Barbosa AC, Olson EN. 2006b. Coactivation of MEF2 by the SAP domain proteins myocardin and MASTR. Mol Cell 23:83-96.
18. Du KL, Ip HS, Li J, Chen M, Dandre F, Yu W, Lu MM, Owens GK, Parmacek MS. 2003. Myocardin is a critical serum response factor cofactor in the transcriptional program regulating smooth muscle cell differentiation. Mol Cell Biol 23:2425-2437.
19. Epstein JA. 2001. Developing models of DiGeorge syndrome. Trends Genet 17:S13-S17.
20. Hiroi Y, Kudoh S, Monzen K, Ikeda Y, Yazaki Y, Nagai R, Komuro I. 2001. Tbx5 associates with Nkx2-5 and synergistically promotes cardiomyocyte differentiation. Nat Genet 28:276-280.
21. Horb ME, Thomsen GH. 1999. Tbx5 is essential for heart development. Development 126:1739-1751.
22. Hu T, Yamagishi H, Maeda J, McAnally J, Yamagishi C, Srivastava D. 2004. Tbx1 regulates fibroblast growth factors in the anterior heart field through a reinforcing autoregulatory loop involving forkhead transcription factors. Development 131: 5491-5502.
23. Ip HS, Wilson DB, Heikinheimo M, Tang Z, Ting CN, Simon MC, Leiden JM, Parmacek MS. 1994. The GATA-4 transcription factor transactivates the cardiac muscle-specific troponin C promoter-enhancer in nonmuscle cells. Mol Cell Biol 14:7517-7526.
24. Kelley C, Blumberg H, Zon LI, Evans T. 1993. GATA-4 is a novel transcription factor expressed in endocardium of the developing heart. Development 118:817-827.
25. Kelly RG, Brown NA, Buckingham ME. 2001. The arterial pole of the mouse heart forms from Fgf10-expressing cells in pharyngeal mesoderm. Dev Cell 1:435-440.
26. Kirby ML. 2002. Molecular embryogenesis of the heart. Pediatr Dev Pathol 5:516-543.
27. Komuro I, Izumo S. 1993. Csx: a murine homeobox-containing gene specifically expressed in the developing heart. Proc Natl Acad Sci USA 90:8145-8149.
28. Kuo CT, Morrisey EE, Anandappa R, Sigrist K, Lu MM, Parmacek MS, Soudais C, Leiden JM. 1997. GATA4 transcription factor is required for ventral morphogenesis and heart tube formation. Genes Dev 11:1048-1060.
29. Li J, Zhu X, Chen M, Cheng L, Zhou D, Lu MM, Du K, Epstein JA, Parmacek MS. 2005. Myocardin-related transcription factor B is required in cardiac neural crest for smooth muscle differentiation and cardiovascular development. Proc Natl Acad Sci USA 102: 8916-8921.
30. Li QY, Newbury-Ecob RA, Terrett JA, Wilson DI, Curtis AR, Yi CH, Gebuhr T, Bullen PJ, Robson SC, Strachan T, Bonnet D, Lyonnet S, Young ID, Raeburn JA, Buckler AJ, Law DJ, Brook JD. 1997. Holt-Oram syndrome is caused by mutations in TBX5, a member of the Brachyury (T) gene family. Nat Genet 15:21-29.
31. Li S, Chang S, Qi X, Richardson JA, and Olson EN. 2006. Requirement of a myocardin-related transcription factor for development of mammary myoepithelial cells. Mol Cell Biol 26: 5797-5808.
32. Li S, Wang DZ, Wang Z, Richardson JA, Olson EN. 2003. The serum response factor coactivator myocardin is required for vascular smooth muscle development. Proc Natl Acad Sci USA 100: 9366-9370.
33. Lin Q, Schwarz J, Bucana C, Olson EN. 1997. Control of mouse cardiac morphogenesis and myogenesis by transcription factor MEF2C. Science 276:1404-1407.
34. Lints TJ, Parsons LM, Hartley L, Lyons I, Harvey RP. 1993. Nkx2.5: a novel murine homeobox gene expressed in early heart progenitor cells and their myogenic descendants. Development 119:969.
35. Liu ZP, Wang Z, Yanagisawa H, Olson EN. 2005. Phenotypic modulation of smooth muscle cells through interaction of Foxo4 and myocardin. Dev Cell 9:261-270.
36. Lyons I, Parsons LM, Hartley L, Li R, Andrews JE, Robb L, Harvey RP. 1995. Myogenic and morphogenetic defects in the heart tubes of murine embryos lacking the homeo box gene Nkx2-5. Genes Dev 9:1654-1666.
37. McKinsey TA, Zhang CL, Olson EN. 2002. MEF2: a calcium-dependent regulator of cell division, differentiation and death. Trends Biochem Sci 27:40-47.
38. Merscher S, Funke B, Epstein JA, Heyer J, Puech A, Lu MM, Xavier RJ, Demay MB, Russell RG, Factor S, Tokooya K, Jore BS, Lopez M, Pandita RK, Lia M, Carrion D, Xu H, Schorle H, Kobler JB, Scambler P, Wynshaw-Boris A, Skoultchi AI, Morrow BE, Kucherlapati R. 2001. TBX1 is responsible for cardiovascular defects in velo-cardio-facial/DiGeorge syndrome. Cell 104:619-629.
39. Molkentin JD, Lin Q, Duncan SA, Olson EN. 1997. Requirement of the transcription factor GATA4 for heart tube formation and ventral morphogenesis. Genes Dev 11:1061-1072.
40. Oh J, Richardson JA, Olson EN. 2005. Requirement of myocardin-related transcription factor-B for remodeling of branchial arch arteries and smooth muscle differentiation. Proc Natl Acad Sci USA 102:15122-15127.
41. Olson EN. 2002. A genetic blueprint for growth and development of the heart. Harvey Lect 98:41-64.
42. Olson EN. 2004. A decade of discoveries in cardiac biology. Nat Med 10:467-474.
43. Pipes GC, Creemers EE, and Olson EN. 2006. The myocardin family of transcriptional coactivators: versatile regulators of cell growth, migration, and myogenesis. Genes Dev 20:1545-1556.
44. Singh MK, Christoffels VM, Dias JM, Trowe MO, Petry M, Schuster-Gossler K, Burger A, Ericson J, Kispert A. 2005. Tbx20 is essential for cardiac chamber differentiation and repression of Tbx2. Development 132:2697-2707.
45. Small EM, Warkman AS, Wang DZ, Sutherland LB, Olson EN, Krieg PA. 2005. Myocardin is sufficient and necessary for cardiac gene expression in Xenopus. Development 132:987-997.
46. Srivastava D, Cserjesi P, Olson EN. 1995. A subclass of bHLH proteins required for cardiac morphogenesis. Science 270:1995-1999.
47. Srivastava D, Olson EN. 2000. A genetic blueprint for cardiac development. Nature 407:221-226.
48. Srivastava D, Thomas T, Lin Q, Kirby ML, Brown D, Olson EN. 1997. Regulation of cardiac mesodermal and neural crest development by the bHLH transcription factor, dHAND. Nat Genet 16:154-160.
49. Stennard FA, Costa MW, Lai D, Biben C, Furtado MB, Solloway MJ, McCulley DJ, Leimena C, Preis JI, Dunwoodie SL, Elliott DE, Prall OW, Black BL, Fatkin D, Harvey RP. 2005. Murine T-box transcription factor Tbx20 acts as a repressor during heart development, and is essential for adult heart integrity, function and adaptation. Development 132:2451-2462.
50. Sun Y, Boyd K, Xu W, Ma J, Jackson CW, Fu A, Shillingford JM, Robinson GW, Hennighausen L, Hitzler JK, Ma Z, Morris SW. 2006. Acute myeloid leukemia-associated Mkl1 (Mrtf-a) is a key regulator of mammary gland function. Mol Cell Biol 26:5809-5826.
51. Takeuchi JK, Mileikovskaia M, Koshiba-Takeuchi K, Heidt AB, Mori AD, Arruda EP, Gertsenstein M, Georges R, Davidson L, Mo R, Hui CC, Henkelman RM, Nemer M, Black BL, Nagy A, Bruneau BG. 2005. Tbx20 dose-dependently regulates transcription factor networks required for mouse heart and motoneuron development. Development 132:2463-2474.
52. Tanaka M, Chen Z, Bartunkova S, Yamasaki N, Izumo S. 1999. The cardiac homeobox gene Csx/Nkx2.5 lies genetically upstream of multiple genes essential for heart development. Development 126:1269-1280.
53. Ueyama T, Kasahara H, Ishiwata T, Nie Q, Izumo S. 2003. Myocardin expression is regulated by Nkx2.5, and its function is required for cardiomyogenesis. Mol Cell Biol 23:9222-9232.
54. von Both I, Silvestri C, Erdemir T, Lickert H, Walls JR, Henkelman RM, Rossant J, Harvey RP, Attisano L, Wrana JL. 2004. Foxh1 is essential for development of the anterior heart field. Dev Cell 7:331-345.
55. Waldo KL, Kumiski DH, Wallis KT, Stadt HA, Hutson MR, Platt DH, Kirby ML. 2001. Conotruncal myocardium arises from a secondary heart field. Development 128:3179-3188.
56. Wang D, Chang PS, Wang Z, Sutherland L, Richardson JA, Small E, Krieg PA, Olson EN. 2001. Activation of cardiac gene expression by myocardin, a transcriptional cofactor for serum response factor. Cell 105:851-862.
57. Wang DZ, Li S, Hockemeyer D, Sutherland L, Wang Z, Schratt G, Richardson JA, Nordheim A, Olson EN. 2002. Potentiation of serum response factor activity by a family of myocardin-related transcription factors. Proc Natl Acad Sci USA 99:14855-14860.
58. Wang DZ, Olson EN. 2004. Control of smooth muscle development by the myocardin family of transcriptional coactivators. Curr Opin Genet Dev 14:558-566.
59. Wang DZ, Reiter RS, Lin JL, Wang Q, Williams HS, Krob SL, Schultheiss TM, Evans S, Lin JJ. 1999. Requirement of a novel gene, Xin, in cardiac morphogenesis. Development 126:1281-1294.
60. Wang S, Yu X, Zhang T, Zhang X, Zhang Z, Chen Y. 2004a. Chick Pcl2 regulates the left-right asymmetry by repressing Shh expression in Hensen's node. Development 131:4381-4391.
61. Wang Z, Wang DZ, Hockemeyer D, McAnally J, Nordheim A, Olson EN. 2004b. Myocardin and ternary complex factors compete for SRF to control smooth muscle gene expression. Nature 428:185-189.
62. Wang Z, Wang DZ, Pipes GC, Olson EN. 2003. Myocardin is a master regulator of smooth muscle gene expression. Proc Natl Acad Sci USA 100:7129-7134.
63. Wei K, Che N, Chen F. 2007. Myocardin-related transcription factor B is required for normal mouse vascular development and smooth muscle gene expression. Dev Dyn 236:416-425.