메뉴 건너뛰기




Volumn 12, Issue 4, 2008, Pages 747-757

Genetic Determinants in Hepatic Fibrosis: From Experimental Models to Fibrogenic Gene Signatures in Humans

Author keywords

Cirrhosis; Fibrogenesis; Inbred mouse strains; Quantitative trait locus

Indexed keywords

ANGIOTENSIN; ANTIFIBROTIC AGENT; APOENZYME; CD14 ANTIGEN; CHEMOKINE RECEPTOR CCR5; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; DNA; GLUTATHIONE TRANSFERASE M1; GLYCOPROTEIN IB ALPHA; INTERLEUKIN 1 RECEPTOR; INTERLEUKIN 10; INTERLEUKIN 1BETA; MANGANESE SUPEROXIDE DISMUTASE; MONOCYTE CHEMOTACTIC PROTEIN 1; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR;

EID: 54949138100     PISSN: 10893261     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cld.2008.07.012     Document Type: Review
Times cited : (32)

References (53)
  • 1
    • 0031819504 scopus 로고    scopus 로고
    • The cell biology of liver fibrogenesis-an imbalance of proliferation, growth arrest and apoptosis of myofibroblasts
    • Gressner A.M. The cell biology of liver fibrogenesis-an imbalance of proliferation, growth arrest and apoptosis of myofibroblasts. Cell Tissue Res 292 (1998) 447-452
    • (1998) Cell Tissue Res , vol.292 , pp. 447-452
    • Gressner, A.M.1
  • 2
    • 15244356690 scopus 로고    scopus 로고
    • Mechanisms of disease: mechanisms of hepatic fibrosis and therapeutic implications
    • Friedman S.L. Mechanisms of disease: mechanisms of hepatic fibrosis and therapeutic implications. Nat Clin Pract Gastroenterol Hepatol 1 (2004) 98-105
    • (2004) Nat Clin Pract Gastroenterol Hepatol , vol.1 , pp. 98-105
    • Friedman, S.L.1
  • 3
    • 33744538682 scopus 로고    scopus 로고
    • Modern pathogenetic concepts of liver fibrosis suggest stellate cells and TGF-beta as major players and therapeutic targets
    • Gressner A.M., and Weiskirchen R. Modern pathogenetic concepts of liver fibrosis suggest stellate cells and TGF-beta as major players and therapeutic targets. J Cell Mol Med 10 (2006) 76-99
    • (2006) J Cell Mol Med , vol.10 , pp. 76-99
    • Gressner, A.M.1    Weiskirchen, R.2
  • 4
    • 40049097359 scopus 로고    scopus 로고
    • Liver cirrhosis
    • Schupan D., and Afdhal N.H. Liver cirrhosis. Lancet 371 (2008) 838-851
    • (2008) Lancet , vol.371 , pp. 838-851
    • Schupan, D.1    Afdhal, N.H.2
  • 6
    • 0030933395 scopus 로고    scopus 로고
    • Natural history of liver fibrosis progression in patients with chronic hepatitis C
    • Poynard T., Bedossa P., and Opolon P. Natural history of liver fibrosis progression in patients with chronic hepatitis C. Lancet 349 (1997) 825-832
    • (1997) Lancet , vol.349 , pp. 825-832
    • Poynard, T.1    Bedossa, P.2    Opolon, P.3
  • 7
    • 0036892365 scopus 로고    scopus 로고
    • Genome-wide analysis of hepatic fibrosis in inbred mice identifies the susceptibility locus Hfib1 on chromosome 15
    • Hillebrandt S., Goos C., Matern S., et al. Genome-wide analysis of hepatic fibrosis in inbred mice identifies the susceptibility locus Hfib1 on chromosome 15. Gastroenterology 123 (2002) 2041-2051
    • (2002) Gastroenterology , vol.123 , pp. 2041-2051
    • Hillebrandt, S.1    Goos, C.2    Matern, S.3
  • 8
    • 54949117061 scopus 로고    scopus 로고
    • Genetic determinants of complex liver diseases: mouse models and quantitative trait locus analysis
    • Rodés J., Benhamou J.P., Blei A., et al. (Eds), Blackwell Publishing, Oxford (UK)
    • Lammert F. Genetic determinants of complex liver diseases: mouse models and quantitative trait locus analysis. In: Rodés J., Benhamou J.P., Blei A., et al. (Eds). Textbook of hepatology: from basic science to clinical practice (2007), Blackwell Publishing, Oxford (UK) 371-383
    • (2007) Textbook of hepatology: from basic science to clinical practice , pp. 371-383
    • Lammert, F.1
  • 9
    • 1442301512 scopus 로고    scopus 로고
    • Ethnic differences in the prevalence of cryptogenic cirrhosis
    • Browning J.D., Kumar K.S., Saboorian M.H., et al. Ethnic differences in the prevalence of cryptogenic cirrhosis. Am J Gastroenterol 99 (2004) 292-298
    • (2004) Am J Gastroenterol , vol.99 , pp. 292-298
    • Browning, J.D.1    Kumar, K.S.2    Saboorian, M.H.3
  • 11
    • 34347337689 scopus 로고    scopus 로고
    • Combined genome scans for body stature in 6,602 European twins: evidence for common Caucasian loci
    • Perola M., Sammalisto S., Hiekkalinna T., et al. Combined genome scans for body stature in 6,602 European twins: evidence for common Caucasian loci. PLoS Genet 3 (2007) e97
    • (2007) PLoS Genet , vol.3
    • Perola, M.1    Sammalisto, S.2    Hiekkalinna, T.3
  • 12
    • 0030466376 scopus 로고    scopus 로고
    • Genetic predisposition to organ-specific endpoints of alcoholism
    • Reed T., Page W.F., Viken R.J., et al. Genetic predisposition to organ-specific endpoints of alcoholism. Alcohol Clin Exp Res 20 (1996) 1528-1533
    • (1996) Alcohol Clin Exp Res , vol.20 , pp. 1528-1533
    • Reed, T.1    Page, W.F.2    Viken, R.J.3
  • 13
    • 0036648981 scopus 로고    scopus 로고
    • From QTL to gene: the harvest begins
    • Korstanje R., and Paigen B. From QTL to gene: the harvest begins. Nat Genet 31 (2002) 235-236
    • (2002) Nat Genet , vol.31 , pp. 235-236
    • Korstanje, R.1    Paigen, B.2
  • 14
    • 30544436224 scopus 로고    scopus 로고
    • A combination of genetic polymorphisms increases the risk of progressive disease in chronic hepatitis C
    • Richardson M.M., Powell E.E., Barrie H.D., et al. A combination of genetic polymorphisms increases the risk of progressive disease in chronic hepatitis C. J Med Genet 42 (2005) e45
    • (2005) J Med Genet , vol.42
    • Richardson, M.M.1    Powell, E.E.2    Barrie, H.D.3
  • 15
    • 34548301514 scopus 로고    scopus 로고
    • A 7 gene signature identifies the risk of developing cirrhosis in patients with chronic hepatitis C
    • Huang H., Shiffman M.L., Friedman S., et al. A 7 gene signature identifies the risk of developing cirrhosis in patients with chronic hepatitis C. Hepatology 46 (2007) 297-306
    • (2007) Hepatology , vol.46 , pp. 297-306
    • Huang, H.1    Shiffman, M.L.2    Friedman, S.3
  • 16
    • 0028945864 scopus 로고
    • A miracle enough: the power of mice
    • Paigen K. A miracle enough: the power of mice. Nat Med 1 (1995) 215-220
    • (1995) Nat Med , vol.1 , pp. 215-220
    • Paigen, K.1
  • 17
    • 1542563409 scopus 로고    scopus 로고
    • Initial sequencing and comparative analysis of the mouse genome
    • Mouse Genome Sequencing Consortium. Initial sequencing and comparative analysis of the mouse genome. Nature 420 (2002) 520-562
    • (2002) Nature , vol.420 , pp. 520-562
    • Mouse Genome Sequencing Consortium1
  • 18
    • 0141456367 scopus 로고    scopus 로고
    • Mouse phenome project: understanding human biology through mouse genetics and genomics
    • Bogue M. Mouse phenome project: understanding human biology through mouse genetics and genomics. J Appl Physiol 95 (2003) 1335-1337
    • (2003) J Appl Physiol , vol.95 , pp. 1335-1337
    • Bogue, M.1
  • 19
    • 0030885185 scopus 로고    scopus 로고
    • Strain-specific differences in mouse hepatic wound healing are mediated by divergent T helper cytokine responses
    • Shi Z., Wakil A.E., and Rockey D.C. Strain-specific differences in mouse hepatic wound healing are mediated by divergent T helper cytokine responses. Proc Natl Acad Sci USA 94 (1997) 10663-10668
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 10663-10668
    • Shi, Z.1    Wakil, A.E.2    Rockey, D.C.3
  • 20
    • 23044477984 scopus 로고    scopus 로고
    • Complement factor 5 is a quantitative trait gene that modifies liver fibrogenesis in mice and humans
    • Hillebrandt S., Wasmuth H.E., Weiskirchen R., et al. Complement factor 5 is a quantitative trait gene that modifies liver fibrogenesis in mice and humans. Nat Genet 37 (2005) 835-843
    • (2005) Nat Genet , vol.37 , pp. 835-843
    • Hillebrandt, S.1    Wasmuth, H.E.2    Weiskirchen, R.3
  • 21
    • 33847363203 scopus 로고    scopus 로고
    • Models of liver fibrosis: exploring the dynamic nature of inflammation and repair in a solid organ
    • Iredale J.P. Models of liver fibrosis: exploring the dynamic nature of inflammation and repair in a solid organ. J Clin Invest 117 (2007) 539-548
    • (2007) J Clin Invest , vol.117 , pp. 539-548
    • Iredale, J.P.1
  • 22
    • 2542595537 scopus 로고    scopus 로고
    • Nomenclature of the finer branches of the biliary tree: canals, ductules, and ductular reactions in human livers
    • Roskams T.A., Theise N.D., Balabaud C., et al. Nomenclature of the finer branches of the biliary tree: canals, ductules, and ductular reactions in human livers. Hepatology 39 (2004) 1739-1745
    • (2004) Hepatology , vol.39 , pp. 1739-1745
    • Roskams, T.A.1    Theise, N.D.2    Balabaud, C.3
  • 23
    • 0018569464 scopus 로고
    • The effect of complete biliary obstruction on bile flow and bile acid excretion: postcholestatic choleresis in the rat
    • Accatino L., Contreras A., Fernandez S., et al. The effect of complete biliary obstruction on bile flow and bile acid excretion: postcholestatic choleresis in the rat. J Lab Clin Med 93 (1979) 706-717
    • (1979) J Lab Clin Med , vol.93 , pp. 706-717
    • Accatino, L.1    Contreras, A.2    Fernandez, S.3
  • 24
    • 23144461629 scopus 로고    scopus 로고
    • Comparison of murine cirrhosis models induced by hepatotoxin administration and common bile duct ligation
    • Chang M.L., Yeh C.T., Chang P.Y., et al. Comparison of murine cirrhosis models induced by hepatotoxin administration and common bile duct ligation. World J Gastroenterol 11 (2005) 4167-4172
    • (2005) World J Gastroenterol , vol.11 , pp. 4167-4172
    • Chang, M.L.1    Yeh, C.T.2    Chang, P.Y.3
  • 25
    • 33746544232 scopus 로고    scopus 로고
    • Combination of systemic thioacetamide (TAA) injections and ethanol feeding accelerates hepatic fibrosis in C3H/He mice and is associated with intrahepatic up regulation of MMP-2, VEGF and ICAM-1
    • Kornek M., Raskopf E., Guetgemann I., et al. Combination of systemic thioacetamide (TAA) injections and ethanol feeding accelerates hepatic fibrosis in C3H/He mice and is associated with intrahepatic up regulation of MMP-2, VEGF and ICAM-1. J Hepatol 45 (2006) 370-376
    • (2006) J Hepatol , vol.45 , pp. 370-376
    • Kornek, M.1    Raskopf, E.2    Guetgemann, I.3
  • 27
    • 0037359122 scopus 로고    scopus 로고
    • Kupffer cells are responsible for liver cirrhosis induced by carbon tetrachloride
    • Muriel P., and Escobar Y. Kupffer cells are responsible for liver cirrhosis induced by carbon tetrachloride. J Appl Toxicol 23 (2003) 103-108
    • (2003) J Appl Toxicol , vol.23 , pp. 103-108
    • Muriel, P.1    Escobar, Y.2
  • 28
    • 3042818975 scopus 로고    scopus 로고
    • Thioacetamide-induced intestinal-type cholangiocarcinoma in rat: an animal model recapitulating the multi-stage progression of human cholangiocarcinoma
    • Yeh C.N., Maitra A., Lee K.F., et al. Thioacetamide-induced intestinal-type cholangiocarcinoma in rat: an animal model recapitulating the multi-stage progression of human cholangiocarcinoma. Carcinogenesis 25 (2004) 631-636
    • (2004) Carcinogenesis , vol.25 , pp. 631-636
    • Yeh, C.N.1    Maitra, A.2    Lee, K.F.3
  • 29
    • 0031975307 scopus 로고    scopus 로고
    • Experimental strategies for the genetic dissection of complex traits in animal models
    • Darvasi A. Experimental strategies for the genetic dissection of complex traits in animal models. Nat Genet 18 (1998) 19-24
    • (1998) Nat Genet , vol.18 , pp. 19-24
    • Darvasi, A.1
  • 30
    • 15944376562 scopus 로고    scopus 로고
    • Strategies for mapping and cloning quantitative trait genes in rodents
    • Flint J., Valdar W., Shifman S., et al. Strategies for mapping and cloning quantitative trait genes in rodents. Nat Rev Genet 6 (2005) 271-286
    • (2005) Nat Rev Genet , vol.6 , pp. 271-286
    • Flint, J.1    Valdar, W.2    Shifman, S.3
  • 31
    • 33845732301 scopus 로고    scopus 로고
    • The mouse as a model for human biology: a resource guide for complex trait analysis
    • Peters L.L., Robledo R.F., Bult C.J., et al. The mouse as a model for human biology: a resource guide for complex trait analysis. Nat Rev Genet 8 (2007) 58-69
    • (2007) Nat Rev Genet , vol.8 , pp. 58-69
    • Peters, L.L.1    Robledo, R.F.2    Bult, C.J.3
  • 32
    • 0242291131 scopus 로고    scopus 로고
    • The nature and identification of quantitative trait loci: a community's view
    • The Complex Trait Consortium. The nature and identification of quantitative trait loci: a community's view. Nat Rev Genet 4 (2003) 911-916
    • (2003) Nat Rev Genet , vol.4 , pp. 911-916
    • The Complex Trait Consortium1
  • 33
    • 0037324768 scopus 로고    scopus 로고
    • Mouse models for genetic dissection of polygenic gastrointestinal diseases
    • Hillebrandt S., Matern S., and Lammert F. Mouse models for genetic dissection of polygenic gastrointestinal diseases. Eur J Clin Invest 33 (2003) 155-160
    • (2003) Eur J Clin Invest , vol.33 , pp. 155-160
    • Hillebrandt, S.1    Matern, S.2    Lammert, F.3
  • 34
    • 0035164656 scopus 로고    scopus 로고
    • Map Manager QTX, cross-platform software for genetic mapping
    • Manly K.F., Cudmore Jr. R.H., and Meer J.M. Map Manager QTX, cross-platform software for genetic mapping. Mamm Genome 12 (2001) 930-932
    • (2001) Mamm Genome , vol.12 , pp. 930-932
    • Manly, K.F.1    Cudmore Jr., R.H.2    Meer, J.M.3
  • 35
    • 15044344834 scopus 로고    scopus 로고
    • Mapping expression in randomized rodent genomes
    • Broman K.W. Mapping expression in randomized rodent genomes. Nat Genet 37 (2005) 209-210
    • (2005) Nat Genet , vol.37 , pp. 209-210
    • Broman, K.W.1
  • 36
    • 0024508964 scopus 로고
    • Mapping Mendelian factors underlying quantitative traits using RFLP linkage maps
    • Lander E.S., and Botstein D. Mapping Mendelian factors underlying quantitative traits using RFLP linkage maps. Genetics 121 (1989) 185-199
    • (1989) Genetics , vol.121 , pp. 185-199
    • Lander, E.S.1    Botstein, D.2
  • 37
    • 0028877463 scopus 로고
    • Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results
    • Lander E., and Kruglyak L. Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. Nat Genet 11 (1995) 241-247
    • (1995) Nat Genet , vol.11 , pp. 241-247
    • Lander, E.1    Kruglyak, L.2
  • 38
    • 0028151261 scopus 로고
    • Empirical threshold values for quantitative trait mapping
    • Churchill G.A., and Doerge R.W. Empirical threshold values for quantitative trait mapping. Genetics 138 (1994) 963-971
    • (1994) Genetics , vol.138 , pp. 963-971
    • Churchill, G.A.1    Doerge, R.W.2
  • 39
    • 54949108885 scopus 로고    scopus 로고
    • Identification of multiple interacting quantitative trait loci (QTL) for hepatic fibrosis in mice
    • Hillebrandt S., Sauerbruch T., and Lammert F. Identification of multiple interacting quantitative trait loci (QTL) for hepatic fibrosis in mice. Gastroenterology 130 (2006) A427
    • (2006) Gastroenterology , vol.130
    • Hillebrandt, S.1    Sauerbruch, T.2    Lammert, F.3
  • 40
    • 54949126254 scopus 로고    scopus 로고
    • The chemokine CXCL9 (MIG) is a genetic modifier of liver fibrogenesis in chronic hepatitis C
    • Wasmuth H.E., Wiederholt T., Dahl E., et al. The chemokine CXCL9 (MIG) is a genetic modifier of liver fibrogenesis in chronic hepatitis C. Hepatology 44 (2006) 568A
    • (2006) Hepatology , vol.44
    • Wasmuth, H.E.1    Wiederholt, T.2    Dahl, E.3
  • 41
    • 54949149440 scopus 로고    scopus 로고
    • The CC chemokine RANTES (CCL5) mediates liver fibrosis in mice and humans
    • Berres M.L., Rüland A., Moreno Zaldivar M., et al. The CC chemokine RANTES (CCL5) mediates liver fibrosis in mice and humans. Z Gastroenterol (2008) 46
    • (2008) Z Gastroenterol , pp. 46
    • Berres, M.L.1    Rüland, A.2    Moreno Zaldivar, M.3
  • 42
    • 20044394908 scopus 로고    scopus 로고
    • Use of a dense single nucleotide polymorphism map for in silico mapping in the mouse
    • Pletcher M.T., McClurg P., Batalov S., et al. Use of a dense single nucleotide polymorphism map for in silico mapping in the mouse. PLoS Biol 2 (2004) e393
    • (2004) PLoS Biol , vol.2
    • Pletcher, M.T.1    McClurg, P.2    Batalov, S.3
  • 43
    • 33846535231 scopus 로고    scopus 로고
    • An integrated in silico gene mapping strategy in inbred mice
    • Cervino A.C., Darvasi A., Fallahi M., et al. An integrated in silico gene mapping strategy in inbred mice. Genetics 175 (2007) 321-333
    • (2007) Genetics , vol.175 , pp. 321-333
    • Cervino, A.C.1    Darvasi, A.2    Fallahi, M.3
  • 44
    • 0035827344 scopus 로고    scopus 로고
    • In silico mapping of complex disease-related traits in mice
    • Grupe A., Germer S., Usuka J., et al. In silico mapping of complex disease-related traits in mice. Science 292 (2001) 1915-1918
    • (2001) Science , vol.292 , pp. 1915-1918
    • Grupe, A.1    Germer, S.2    Usuka, J.3
  • 45
    • 1542515172 scopus 로고    scopus 로고
    • From genotypes to haplotypes in hepatobiliary diseases: one plus one equals (sometimes) more than two
    • Wasmuth H.E., Matern S., and Lammert F. From genotypes to haplotypes in hepatobiliary diseases: one plus one equals (sometimes) more than two. Hepatology 39 (2004) 604-607
    • (2004) Hepatology , vol.39 , pp. 604-607
    • Wasmuth, H.E.1    Matern, S.2    Lammert, F.3
  • 46
    • 24944473560 scopus 로고    scopus 로고
    • Genetic studies to identify hepatic fibrosis genes and SNPs in human populations
    • Day C.P. Genetic studies to identify hepatic fibrosis genes and SNPs in human populations. Methods Mol Med 117 (2005) 315-331
    • (2005) Methods Mol Med , vol.117 , pp. 315-331
    • Day, C.P.1
  • 47
    • 79959503826 scopus 로고    scopus 로고
    • The International HapMap Project
    • The International HapMap Consortium. The International HapMap Project. Nature 426 (2003) 789-796
    • (2003) Nature , vol.426 , pp. 789-796
    • The International HapMap Consortium1
  • 48
    • 0347419933 scopus 로고    scopus 로고
    • Genetische Risikofaktoren der Fibrogenese bei chronischen Lebererkrankungen
    • Wasmuth H.E., Lammert F., and Matern S. Genetische Risikofaktoren der Fibrogenese bei chronischen Lebererkrankungen. Med Klin 98 (2003) 754-762
    • (2003) Med Klin , vol.98 , pp. 754-762
    • Wasmuth, H.E.1    Lammert, F.2    Matern, S.3
  • 50
    • 35648963655 scopus 로고    scopus 로고
    • Biomarkers of hepatic fibrosis, fibrogenesis and genetic pre-disposition pending between fiction and reality
    • Gressner O.A., Weiskirchen R., and Gressner A.M. Biomarkers of hepatic fibrosis, fibrogenesis and genetic pre-disposition pending between fiction and reality. J Cell Mol Med 11 (2007) 1031-1051
    • (2007) J Cell Mol Med , vol.11 , pp. 1031-1051
    • Gressner, O.A.1    Weiskirchen, R.2    Gressner, A.M.3
  • 51
    • 36349010904 scopus 로고    scopus 로고
    • Hemochromatosis genotypes and risk of 31 disease endpoints: meta-analyses including 66,000 cases and 226,000 controls
    • Ellervik C., Birgens H., Tybjaerg-Hansen A., et al. Hemochromatosis genotypes and risk of 31 disease endpoints: meta-analyses including 66,000 cases and 226,000 controls. Hepatology 46 (2007) 1071-1080
    • (2007) Hepatology , vol.46 , pp. 1071-1080
    • Ellervik, C.1    Birgens, H.2    Tybjaerg-Hansen, A.3
  • 52
    • 36349011285 scopus 로고    scopus 로고
    • Genomewide genetic association studies in hepatology: the end of searching for the needle in the haystack?
    • Hellerbrand C., and Wasmuth H.E. Genomewide genetic association studies in hepatology: the end of searching for the needle in the haystack?. Hepatology 46 (2007) 1661-1663
    • (2007) Hepatology , vol.46 , pp. 1661-1663
    • Hellerbrand, C.1    Wasmuth, H.E.2
  • 53
    • 40849096166 scopus 로고    scopus 로고
    • The road to genome-wide association studies
    • Kruglyak L. The road to genome-wide association studies. Nat Rev Genet 9 (2008) 314-318
    • (2008) Nat Rev Genet , vol.9 , pp. 314-318
    • Kruglyak, L.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.