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Volumn 275, Issue 22, 2008, Pages 5458-5478

Gonadotropin-releasing hormone: Regulation of the GnRH gene

Author keywords

Estrogen; Follicle stimulating hormone; GnRH; Gonadotropin; Luteinizing hormone; PKC signalling; Progesterone; Promoter; Steroid hormone; Transcriptional regulation

Indexed keywords

ANDROGEN; CYCLIC AMP; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; ESTROGEN; G BOX BINDING FACTOR; GLUCOCORTICOID; GONADORELIN; GONADORELIN 1; GONADORELIN 2; GONADORELIN DERIVATIVE; GONADOTROPIN; INSULIN; MELATONIN; NUCLEIC ACID BINDING PROTEIN; OCTAMER TRANSCRIPTION FACTOR 1; PROGESTERONE; PROTEIN AP 1; PROTEIN AP 4; PROTEIN BRN2; PROTEIN DLX2; PROTEIN FOS; PROTEIN KINASE C; RETINOIC ACID RECEPTOR ALPHA; RETINOID X RECEPTOR ALPHA; SEX HORMONE; STEROID HORMONE; SYNAPTOTAGMIN I; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR GATA 4; TRANSCRIPTION FACTOR MSX1; UNCLASSIFIED DRUG;

EID: 54849421553     PISSN: 1742464X     EISSN: 17424658     Source Type: Journal    
DOI: 10.1111/j.1742-4658.2008.06676.x     Document Type: Short Survey
Times cited : (57)

References (137)
  • 1
    • 17044397637 scopus 로고    scopus 로고
    • Molecular biology of gonadotropin-releasing hormone (GnRH)-I, GnRH-II, and their receptors in humans
    • Cheng CK Leung PC (2005) Molecular biology of gonadotropin-releasing hormone (GnRH)-I, GnRH-II, and their receptors in humans. Endocr Rev 26, 283 306.
    • (2005) Endocr Rev , vol.26 , pp. 283-306
    • Cheng, C.K.1    Leung, P.C.2
  • 2
    • 34248347892 scopus 로고    scopus 로고
    • The effects of GABA on embryonic gonadotropin-releasing hormone neurons in rat hypothalamic primary culture
    • Fujioka H, Yamanouchi K, Akema T Nishihara M (2007) The effects of GABA on embryonic gonadotropin-releasing hormone neurons in rat hypothalamic primary culture. J Reprod Dev 53, 323 331.
    • (2007) J Reprod Dev , vol.53 , pp. 323-331
    • Fujioka, H.1    Yamanouchi, K.2    Akema, T.3    Nishihara, M.4
  • 3
    • 0034626937 scopus 로고    scopus 로고
    • The neurobiology of reproductive development
    • Ebling FJ Cronin AS (2000) The neurobiology of reproductive development. Neuroreport 11, R23 R33.
    • (2000) Neuroreport , vol.11
    • Ebling, F.J.1    Cronin, A.S.2
  • 4
    • 33344455517 scopus 로고    scopus 로고
    • Molecular and evolutionary characterization of the GnRH-II gene in the chicken: Distinctive genomic organization, expression pattern, and precursor sequence
    • Ikemoto T Park MK (2006) Molecular and evolutionary characterization of the GnRH-II gene in the chicken: distinctive genomic organization, expression pattern, and precursor sequence. Gene 368, 28 36.
    • (2006) Gene , vol.368 , pp. 28-36
    • Ikemoto, T.1    Park, M.K.2
  • 6
    • 24044447902 scopus 로고    scopus 로고
    • GnRHs and GnRH receptors
    • Millar RP (2005) GnRHs and GnRH receptors. Anim Reprod Sci 88, 5 28.
    • (2005) Anim Reprod Sci , vol.88 , pp. 5-28
    • Millar, R.P.1
  • 7
    • 0030886850 scopus 로고    scopus 로고
    • Examination of guinea pig luteinizing hormone-releasing hormone gene reveals a unique decapeptide and existence of two transcripts in the brain
    • Jimenez-Linan M, Rubin BS King JC (1997) Examination of guinea pig luteinizing hormone-releasing hormone gene reveals a unique decapeptide and existence of two transcripts in the brain. Endocrinology 138, 4123 4130.
    • (1997) Endocrinology , vol.138 , pp. 4123-4130
    • Jimenez-Linan, M.1    Rubin, B.S.2    King, J.C.3
  • 8
    • 0011305311 scopus 로고
    • Identification of the second gonadotropin-releasing hormone in chicken hypothalamus: Evidence that gonadotropin secretion is probably controlled by two distinct gonadotropin-releasing hormones in avian species
    • Miyamoto K, Hasegawa Y, Nomura M, Igarashi M, Kangawa K Matsuo H (1984) Identification of the second gonadotropin-releasing hormone in chicken hypothalamus: evidence that gonadotropin secretion is probably controlled by two distinct gonadotropin-releasing hormones in avian species. Proc Natl Acad Sci USA 81, 3874 3878.
    • (1984) Proc Natl Acad Sci USA , vol.81 , pp. 3874-3878
    • Miyamoto, K.1    Hasegawa, Y.2    Nomura, M.3    Igarashi, M.4    Kangawa, K.5    Matsuo, H.6
  • 10
    • 0029996717 scopus 로고    scopus 로고
    • GATA factors are essential for activity of the neuron-specific enhancer of the gonadotropin-releasing hormone gene
    • Lawson MA, Whyte DB Mellon PL (1996) GATA factors are essential for activity of the neuron-specific enhancer of the gonadotropin-releasing hormone gene. Mol Cell Biol 16, 3596 3605.
    • (1996) Mol Cell Biol , vol.16 , pp. 3596-3605
    • Lawson, M.A.1    Whyte, D.B.2    Mellon, P.L.3
  • 11
    • 0034455307 scopus 로고    scopus 로고
    • Regulation of gonadotropin-releasing hormone and its receptor gene expression by 17beta-estradiol in cultured human granulosa-luteal cells
    • Nathwani PS, Kang SK, Cheng KW, Choi KC Leung PC (2000) Regulation of gonadotropin-releasing hormone and its receptor gene expression by 17beta-estradiol in cultured human granulosa-luteal cells. Endocrinology 141, 1754 1763.
    • (2000) Endocrinology , vol.141 , pp. 1754-1763
    • Nathwani, P.S.1    Kang, S.K.2    Cheng, K.W.3    Choi, K.C.4    Leung, P.C.5
  • 12
    • 0032230256 scopus 로고    scopus 로고
    • Oct-1 binds promoter elements required for transcription of the GnRH gene
    • Eraly SA, Nelson SB, Huang KM Mellon PL (1998) Oct-1 binds promoter elements required for transcription of the GnRH gene. Mol Endocrinol 12, 469 481.
    • (1998) Mol Endocrinol , vol.12 , pp. 469-481
    • Eraly, S.A.1    Nelson, S.B.2    Huang, K.M.3    Mellon, P.L.4
  • 13
    • 0031910424 scopus 로고    scopus 로고
    • Retinoic acid regulates gonadotropin-releasing hormone (GnRH) release and gene expression in the rat hypothalamic fragments and GT1-1 neuronal cells in vitro
    • Cho S, Cho H, Geum D Kim K (1998) Retinoic acid regulates gonadotropin-releasing hormone (GnRH) release and gene expression in the rat hypothalamic fragments and GT1-1 neuronal cells in vitro. Brain Res Mol Brain Res 54, 74 84.
    • (1998) Brain Res Mol Brain Res , vol.54 , pp. 74-84
    • Cho, S.1    Cho, H.2    Geum, D.3    Kim, K.4
  • 14
    • 0034464904 scopus 로고    scopus 로고
    • The Otx2 homeoprotein regulates expression from the gonadotropin- releasing hormone proximal promoter
    • Kelley CG, Lavorgna G, Clark ME, Boncinelli E Mellon PL (2000) The Otx2 homeoprotein regulates expression from the gonadotropin-releasing hormone proximal promoter. Mol Endocrinol 14, 1246 1256.
    • (2000) Mol Endocrinol , vol.14 , pp. 1246-1256
    • Kelley, C.G.1    Lavorgna, G.2    Clark, M.E.3    Boncinelli, E.4    Mellon, P.L.5
  • 15
  • 16
    • 0027049778 scopus 로고
    • Immortalized hypothalamic GT1-7 neurons express functional gamma-aminobutyric acid type a receptors
    • Hales TG, Kim H, Longoni B, Olsen RW Tobin AJ (1992) Immortalized hypothalamic GT1-7 neurons express functional gamma-aminobutyric acid type A receptors. Mol Pharmacol 42, 197 202.
    • (1992) Mol Pharmacol , vol.42 , pp. 197-202
    • Hales, T.G.1    Kim, H.2    Longoni, B.3    Olsen, R.W.4    Tobin, A.J.5
  • 17
    • 0026543426 scopus 로고
    • Generation and synchronization of gonadotropin-releasing hormone (GnRH) pulses: Intrinsic properties of the GT1-1 GnRH neuronal cell line
    • Martinez de la EG, Choi AL Weiner RI (1992) Generation and synchronization of gonadotropin-releasing hormone (GnRH) pulses: intrinsic properties of the GT1-1 GnRH neuronal cell line. Proc Natl Acad Sci USA 89, 1852 1855.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 1852-1855
    • Martinez De La, E.G.1    Choi, A.L.2    Weiner, R.I.3
  • 19
    • 0033330381 scopus 로고    scopus 로고
    • Transgenics identify distal 5′- and 3′-sequences specifying gonadotropin-releasing hormone expression in adult mice
    • Pape JR, Skynner MJ, Allen ND Herbison AE (1999) Transgenics identify distal 5′- and 3′-sequences specifying gonadotropin-releasing hormone expression in adult mice. Mol Endocrinol 13, 2203 2211.
    • (1999) Mol Endocrinol , vol.13 , pp. 2203-2211
    • Pape, J.R.1    Skynner, M.J.2    Allen, N.D.3    Herbison, A.E.4
  • 20
    • 0037085359 scopus 로고    scopus 로고
    • Promoter sequences targeting tissue-specific gene expression of hypothalamic and ovarian gonadotropin-releasing hormone in vivo
    • Kim HH, Wolfe A, Smith GR, Tobet SA Radovick S (2002) Promoter sequences targeting tissue-specific gene expression of hypothalamic and ovarian gonadotropin-releasing hormone in vivo. J Biol Chem 277, 5194 5202.
    • (2002) J Biol Chem , vol.277 , pp. 5194-5202
    • Kim, H.H.1    Wolfe, A.2    Smith, G.R.3    Tobet, S.A.4    Radovick, S.5
  • 21
    • 0036186171 scopus 로고    scopus 로고
    • Identification of a discrete promoter region of the human GnRH gene that is sufficient for directing neuron-specific expression: A role for POU homeodomain transcription factors
    • Wolfe A, Kim HH, Tobet S, Stafford DE Radovick S (2002) Identification of a discrete promoter region of the human GnRH gene that is sufficient for directing neuron-specific expression: a role for POU homeodomain transcription factors. Mol Endocrinol 16, 435 449.
    • (2002) Mol Endocrinol , vol.16 , pp. 435-449
    • Wolfe, A.1    Kim, H.H.2    Tobet, S.3    Stafford, D.E.4    Radovick, S.5
  • 22
    • 0032565741 scopus 로고    scopus 로고
    • The GnRH promoter: Target of transcription factors, hormones, and signaling pathways
    • Nelson SB, Eraly SA Mellon PL (1998) The GnRH promoter: target of transcription factors, hormones, and signaling pathways. Mol Cell Endocrinol 140, 151 155.
    • (1998) Mol Cell Endocrinol , vol.140 , pp. 151-155
    • Nelson, S.B.1    Eraly, S.A.2    Mellon, P.L.3
  • 23
    • 0026553170 scopus 로고
    • Structure of the rat gonadotropin releasing hormone (rGnRH) gene promoter and functional analysis in hypothalamic cells
    • Kepa JK, Wang C, Neeley CI, Raynolds MV, Gordon DF, Wood WM Wierman ME (1992) Structure of the rat gonadotropin releasing hormone (rGnRH) gene promoter and functional analysis in hypothalamic cells. Nucleic Acids Res 20, 1393 1399.
    • (1992) Nucleic Acids Res , vol.20 , pp. 1393-1399
    • Kepa, J.K.1    Wang, C.2    Neeley, C.I.3    Raynolds, M.V.4    Gordon, D.F.5    Wood, W.M.6    Wierman, M.E.7
  • 24
    • 85003156705 scopus 로고
    • Identification of a major up-stream transcription start site for the human progonadotropin-releasing hormone gene used in reproductive tissues and cell lines
    • Dong KW, Yu KL Roberts JL (1993) Identification of a major up-stream transcription start site for the human progonadotropin-releasing hormone gene used in reproductive tissues and cell lines. Mol Endocrinol 7, 1654 1666.
    • (1993) Mol Endocrinol , vol.7 , pp. 1654-1666
    • Dong, K.W.1    Yu, K.L.2    Roberts, J.L.3
  • 25
    • 0029920309 scopus 로고    scopus 로고
    • Multiple transcription start sites for the GnRH gene in rhesus and cynomolgus monkeys: A non-human primate model for studying GnRH gene regulation
    • Dong KW, Duval P, Zeng Z, Gordon K, Williams RF, Hodgen GD, Jones G, Kerdelhue B Roberts JL (1996) Multiple transcription start sites for the GnRH gene in rhesus and cynomolgus monkeys: a non-human primate model for studying GnRH gene regulation. Mol Cell Endocrinol 117, 121 130.
    • (1996) Mol Cell Endocrinol , vol.117 , pp. 121-130
    • Dong, K.W.1    Duval, P.2    Zeng, Z.3    Gordon, K.4    Williams, R.F.5    Hodgen, G.D.6    Jones, G.7    Kerdelhue, B.8    Roberts, J.L.9
  • 26
    • 0025319890 scopus 로고
    • Isolation and characterization of the human gonadotropin-releasing hormone gene in the hypothalamus and placenta
    • Radovick S, Wondisford FE, Nakayama Y, Yamada M, Cutler GB Jr. Weintraub BD (1990) Isolation and characterization of the human gonadotropin-releasing hormone gene in the hypothalamus and placenta. Mol Endocrinol 4, 476 480.
    • (1990) Mol Endocrinol , vol.4 , pp. 476-480
    • Radovick, S.1    Wondisford, F.E.2    Nakayama, Y.3    Yamada, M.4    Cutler Jr., G.B.5    Weintraub, B.D.6
  • 27
    • 0028898975 scopus 로고
    • A neuron-specific enhancer targets expression of the gonadotropin- releasing hormone gene to hypothalamic neurosecretory neurons
    • Whyte DB, Lawson MA, Belsham DD, Eraly SA, Bond CT, Adelman JP Mellon PL (1995) A neuron-specific enhancer targets expression of the gonadotropin- releasing hormone gene to hypothalamic neurosecretory neurons. Mol Endocrinol 9, 467 477.
    • (1995) Mol Endocrinol , vol.9 , pp. 467-477
    • Whyte, D.B.1    Lawson, M.A.2    Belsham, D.D.3    Eraly, S.A.4    Bond, C.T.5    Adelman, J.P.6    Mellon, P.L.7
  • 28
    • 0029791973 scopus 로고    scopus 로고
    • Structure of the distal human gonadotropin releasing hormone (hGnrh) gene promoter and functional analysis in Gt1-7 neuronal cells
    • Kepa JK, Spaulding AJ, Jacobsen BM, Fang Z, Xiong X, Radovick S Wierman ME (1996) Structure of the distal human gonadotropin releasing hormone (hGnrh) gene promoter and functional analysis in Gt1-7 neuronal cells. Nucleic Acids Res 24, 3614 3620.
    • (1996) Nucleic Acids Res , vol.24 , pp. 3614-3620
    • Kepa, J.K.1    Spaulding, A.J.2    Jacobsen, B.M.3    Fang, Z.4    Xiong, X.5    Radovick, S.6    Wierman, M.E.7
  • 29
    • 0029832193 scopus 로고    scopus 로고
    • Cell-specific expression of the human gonadotropin-releasing hormone gene in transgenic animals
    • Wolfe AM, Wray S, Westphal H Radovick S (1996) Cell-specific expression of the human gonadotropin-releasing hormone gene in transgenic animals. J Biol Chem 271, 20018 20023.
    • (1996) J Biol Chem , vol.271 , pp. 20018-20023
    • Wolfe, A.M.1    Wray, S.2    Westphal, H.3    Radovick, S.4
  • 30
    • 0028877438 scopus 로고
    • The POU homeodomain transcription factor Oct-1 is essential for activity of the gonadotropin-releasing hormone neuron-specific enhancer
    • Clark ME Mellon PL (1995) The POU homeodomain transcription factor Oct-1 is essential for activity of the gonadotropin-releasing hormone neuron-specific enhancer. Mol Cell Biol 15, 6169 6177.
    • (1995) Mol Cell Biol , vol.15 , pp. 6169-6177
    • Clark, M.E.1    Mellon, P.L.2
  • 31
    • 0034458169 scopus 로고    scopus 로고
    • Transcription factors Oct-1 and C/EBPbeta (CCAAT/enhancer-binding protein-beta) are involved in the glutamate/nitric oxide/ cyclic-guanosine 5′-monophosphate-mediated repression of mediated repression of gonadotropin-releasing hormone gene expression
    • Belsham DD Mellon PL (2000) Transcription factors Oct-1 and C/EBPbeta (CCAAT/enhancer-binding protein-beta) are involved in the glutamate/nitric oxide/ cyclic-guanosine 5′-monophosphate-mediated repression of mediated repression of gonadotropin-releasing hormone gene expression. Mol Endocrinol 14, 212 228.
    • (2000) Mol Endocrinol , vol.14 , pp. 212-228
    • Belsham, D.D.1    Mellon, P.L.2
  • 32
    • 0033734710 scopus 로고    scopus 로고
    • Neuron-specific expression of the rat gonadotropin-releasing hormone gene is conferred by interactions of a defined promoter element with the enhancer in GT1-7 cells
    • Nelson SB, Lawson MA, Kelley CG Mellon PL (2000) Neuron-specific expression of the rat gonadotropin-releasing hormone gene is conferred by interactions of a defined promoter element with the enhancer in GT1-7 cells. Mol Endocrinol 14, 1509 1522.
    • (2000) Mol Endocrinol , vol.14 , pp. 1509-1522
    • Nelson, S.B.1    Lawson, M.A.2    Kelley, C.G.3    Mellon, P.L.4
  • 33
    • 0036842222 scopus 로고    scopus 로고
    • Neuron-restricted expression of the rat gonadotropin-releasing hormone gene is conferred by a cell-specific protein complex that binds repeated CAATT elements
    • Kelley CG, Givens ML, Rave-Harel N, Nelson SB, Anderson S Mellon PL (2002) Neuron-restricted expression of the rat gonadotropin-releasing hormone gene is conferred by a cell-specific protein complex that binds repeated CAATT elements. Mol Endocrinol 16, 2413 2425.
    • (2002) Mol Endocrinol , vol.16 , pp. 2413-2425
    • Kelley, C.G.1    Givens, M.L.2    Rave-Harel, N.3    Nelson, S.B.4    Anderson, S.5    Mellon, P.L.6
  • 35
    • 0030668697 scopus 로고    scopus 로고
    • Regulation of segmentation and segmental identity by Drosophila homeoproteins: The role of DNA binding in functional activity and specificity
    • Biggin MD McGinnis W (1997) Regulation of segmentation and segmental identity by Drosophila homeoproteins: the role of DNA binding in functional activity and specificity. Development 124, 4425 4433.
    • (1997) Development , vol.124 , pp. 4425-4433
    • Biggin, M.D.1    McGinnis, W.2
  • 36
    • 24744459873 scopus 로고    scopus 로고
    • The Groucho-related gene family regulates the gonadotropin-releasing hormone gene through interaction with the homeodomain proteins MSX1 and OCT1
    • Rave-Harel N, Miller NL, Givens ML Mellon PL (2005) The Groucho-related gene family regulates the gonadotropin-releasing hormone gene through interaction with the homeodomain proteins MSX1 and OCT1. J Biol Chem 280, 30975 30983.
    • (2005) J Biol Chem , vol.280 , pp. 30975-30983
    • Rave-Harel, N.1    Miller, N.L.2    Givens, M.L.3    Mellon, P.L.4
  • 38
    • 0032473352 scopus 로고    scopus 로고
    • Prep1, a novel functional partner of Pbx proteins
    • Berthelsen J, Zappavigna V, Mavilio F Blasi F (1998) Prep1, a novel functional partner of Pbx proteins. EMBO J 17, 1423 1433.
    • (1998) EMBO J , vol.17 , pp. 1423-1433
    • Berthelsen, J.1    Zappavigna, V.2    Mavilio, F.3    Blasi, F.4
  • 39
    • 33846619696 scopus 로고    scopus 로고
    • In vivo identification of a 107-base pair promoter element mediating neuron-specific expression of mouse gonadotropin-releasing hormone
    • Kim HH, Wolfe A, Cohen RN, Eames SC, Johnson AL, Wieland CN Radovick S (2007) In vivo identification of a 107-base pair promoter element mediating neuron-specific expression of mouse gonadotropin-releasing hormone. Mol Endocrinol 21, 457 471.
    • (2007) Mol Endocrinol , vol.21 , pp. 457-471
    • Kim, H.H.1    Wolfe, A.2    Cohen, R.N.3    Eames, S.C.4    Johnson, A.L.5    Wieland, C.N.6    Radovick, S.7
  • 40
    • 0028903873 scopus 로고
    • Signaling and transacting factors in the transcriptional inhibition of gonadotropin releasing hormone gene by human chorionic gonadotropin in immortalized hypothalamic GT1-7 neurons
    • Lei ZM Rao CV (1995) Signaling and transacting factors in the transcriptional inhibition of gonadotropin releasing hormone gene by human chorionic gonadotropin in immortalized hypothalamic GT1-7 neurons. Mol Cell Endocrinol 109, 151 157.
    • (1995) Mol Cell Endocrinol , vol.109 , pp. 151-157
    • Lei, Z.M.1    Rao, C.V.2
  • 41
    • 0030984897 scopus 로고    scopus 로고
    • Cis-Acting elements and trans-acting proteins in the transcriptional inhibition of gonadotropin-releasing hormone gene by human chorionic gonadotropin in immortalized hypothalamic GT1-7 neurons
    • Lei Z Rao CV (1997) cis-Acting elements and trans-acting proteins in the transcriptional inhibition of gonadotropin-releasing hormone gene by human chorionic gonadotropin in immortalized hypothalamic GT1-7 neurons. J Biol Chem 272, 14365 14371.
    • (1997) J Biol Chem , vol.272 , pp. 14365-14371
    • Lei, Z.1    Rao, C.V.2
  • 42
    • 0032230317 scopus 로고    scopus 로고
    • Multiple factors interacting at the GATA sites of the gonadotropin-releasing hormone neuron-specific enhancer regulate gene expression
    • Lawson MA, Buhain AR, Jovenal JC Mellon PL (1998) Multiple factors interacting at the GATA sites of the gonadotropin-releasing hormone neuron-specific enhancer regulate gene expression. Mol Endocrinol 12, 364 377.
    • (1998) Mol Endocrinol , vol.12 , pp. 364-377
    • Lawson, M.A.1    Buhain, A.R.2    Jovenal, J.C.3    Mellon, P.L.4
  • 43
    • 0027316033 scopus 로고
    • Regulation of gonadotropin-releasing hormone by protein kinase-A and -C in immortalized hypothalamic neurons
    • Wetsel WC, Eraly SA, Whyte DB Mellon PL (1993) Regulation of gonadotropin-releasing hormone by protein kinase-A and -C in immortalized hypothalamic neurons. Endocrinology 132, 2360 2370.
    • (1993) Endocrinology , vol.132 , pp. 2360-2370
    • Wetsel, W.C.1    Eraly, S.A.2    Whyte, D.B.3    Mellon, P.L.4
  • 44
    • 0030025215 scopus 로고    scopus 로고
    • Phorbol ester inhibition of rat gonadotropin-releasing hormone promoter activity: Role of Fos and Jun in the repression of transcription
    • Bruder JM, Spaulding AJ Wierman ME (1996) Phorbol ester inhibition of rat gonadotropin-releasing hormone promoter activity: role of Fos and Jun in the repression of transcription. Mol Endocrinol 10, 35 44.
    • (1996) Mol Endocrinol , vol.10 , pp. 35-44
    • Bruder, J.M.1    Spaulding, A.J.2    Wierman, M.E.3
  • 45
    • 27744474937 scopus 로고    scopus 로고
    • The protein kinase C pathway acts through multiple transcription factors to repress gonadotropin-releasing hormone gene expression in hypothalamic GT1-7 neuronal cells
    • Tang Q, Mazur M Mellon PL (2005) The protein kinase C pathway acts through multiple transcription factors to repress gonadotropin-releasing hormone gene expression in hypothalamic GT1-7 neuronal cells. Mol Endocrinol 19, 2769 2779.
    • (2005) Mol Endocrinol , vol.19 , pp. 2769-2779
    • Tang, Q.1    Mazur, M.2    Mellon, P.L.3
  • 46
    • 0032444364 scopus 로고    scopus 로고
    • Cellular mechanism of pulsatile LHRH release
    • Terasawa E (1998) Cellular mechanism of pulsatile LHRH release. Gen Comp Endocrinol 112, 283 295.
    • (1998) Gen Comp Endocrinol , vol.112 , pp. 283-295
    • Terasawa, E.1
  • 48
    • 0031873918 scopus 로고    scopus 로고
    • Release of luteinizing hormone-releasing hormone from enzymatically dispersed rat hypothalamic explants is pulsatile
    • Woller M, Nichols E, Herdendorf T Tutton D (1998) Release of luteinizing hormone-releasing hormone from enzymatically dispersed rat hypothalamic explants is pulsatile. Biol Reprod 59, 587 590.
    • (1998) Biol Reprod , vol.59 , pp. 587-590
    • Woller, M.1    Nichols, E.2    Herdendorf, T.3    Tutton, D.4
  • 49
    • 0032482947 scopus 로고    scopus 로고
    • Episodic gonadotropin-releasing hormone gene expression revealed by dynamic monitoring of luciferase reporter activity in single, living neurons
    • Nunez L, Faught WJ Frawley LS (1998) Episodic gonadotropin-releasing hormone gene expression revealed by dynamic monitoring of luciferase reporter activity in single, living neurons. Proc Natl Acad Sci USA 95, 9648 9653.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 9648-9653
    • Nunez, L.1    Faught, W.J.2    Frawley, L.S.3
  • 51
    • 30044449633 scopus 로고    scopus 로고
    • Identification of a novel OCT1 binding site that is necessary for the elaboration of pulses of rat GnRH promoter activity
    • Leclerc GM Boockfor FR (2005) Identification of a novel OCT1 binding site that is necessary for the elaboration of pulses of rat GnRH promoter activity. Mol Cell Endocrinol 245, 86 92.
    • (2005) Mol Cell Endocrinol , vol.245 , pp. 86-92
    • Leclerc, G.M.1    Boockfor, F.R.2
  • 52
    • 33847324069 scopus 로고    scopus 로고
    • Calcium influx and DREAM protein are required for GnRH gene expression pulse activity
    • Leclerc GM Boockfor FR (2007) Calcium influx and DREAM protein are required for GnRH gene expression pulse activity. Mol Cell Endocrinol 267, 70 79.
    • (2007) Mol Cell Endocrinol , vol.267 , pp. 70-79
    • Leclerc, G.M.1    Boockfor, F.R.2
  • 53
    • 0038649067 scopus 로고    scopus 로고
    • Functional cooperation between multiple regulatory elements in the untranslated exon 1 stimulates the basal transcription of the human GnRH-II gene
    • Cheng CK, Hoo RL, Chow BK Leung PC (2003) Functional cooperation between multiple regulatory elements in the untranslated exon 1 stimulates the basal transcription of the human GnRH-II gene. Mol Endocrinol 17, 1175 1191.
    • (2003) Mol Endocrinol , vol.17 , pp. 1175-1191
    • Cheng, C.K.1    Hoo, R.L.2    Chow, B.K.3    Leung, P.C.4
  • 54
    • 34249036100 scopus 로고    scopus 로고
    • Involvement of NF-kappaB subunit p65 and retinoic acid receptors, RARalpha and RXRalpha, in transcriptional regulation of the human GnRH II gene
    • Hoo RL, Chan KY, Leung FK, Lee LT, Leung PC Chow BK (2007) Involvement of NF-kappaB subunit p65 and retinoic acid receptors, RARalpha and RXRalpha, in transcriptional regulation of the human GnRH II gene. FEBS J 274, 2695 2706.
    • (2007) FEBS J , vol.274 , pp. 2695-2706
    • Hoo, R.L.1    Chan, K.Y.2    Leung, F.K.3    Lee, L.T.4    Leung, P.C.5    Chow, B.K.6
  • 55
    • 0034917627 scopus 로고    scopus 로고
    • Transcriptional regulation of the human GnRH II gene is mediated by a putative cAMP response element
    • Chen A, Laskar-Levy O, Ben-Aroya N Koch Y (2001) Transcriptional regulation of the human GnRH II gene is mediated by a putative cAMP response element. Endocrinology 142, 3483 3492.
    • (2001) Endocrinology , vol.142 , pp. 3483-3492
    • Chen, A.1    Laskar-Levy, O.2    Ben-Aroya, N.3    Koch, Y.4
  • 56
    • 0033038980 scopus 로고    scopus 로고
    • Negative regulation of gonadotropin-releasing hormone and gonadotropin-releasing hormone receptor gene expression by a gonadotrophin-releasing hormone agonist in the rat hypothalamus
    • Han YG, Kang SS, Seong JY, Geum D, Suh YH Kim K (1999) Negative regulation of gonadotropin-releasing hormone and gonadotropin-releasing hormone receptor gene expression by a gonadotrophin-releasing hormone agonist in the rat hypothalamus. J Neuroendocrinol 11, 195 201.
    • (1999) J Neuroendocrinol , vol.11 , pp. 195-201
    • Han, Y.G.1    Kang, S.S.2    Seong, J.Y.3    Geum, D.4    Suh, Y.H.5    Kim, K.6
  • 57
    • 0021814309 scopus 로고
    • Possible negative ultra-short loop feedback of luteinizing hormone releasing hormone (LHRH) in the ovariectomized rat
    • Bedran de Castro JC, Khorram O McCann SM (1985) Possible negative ultra-short loop feedback of luteinizing hormone releasing hormone (LHRH) in the ovariectomized rat. Proc Soc Exp Biol Med 179, 132 135.
    • (1985) Proc Soc Exp Biol Med , vol.179 , pp. 132-135
    • Bedran De Castro, J.C.1    Khorram, O.2    McCann, S.M.3
  • 59
    • 0023103796 scopus 로고
    • In vivo and in vitro examination of an autoregulatory mechanism for luteinizing hormone-releasing hormone
    • DePaolo LV, King RA Carrillo AJ (1987) In vivo and in vitro examination of an autoregulatory mechanism for luteinizing hormone-releasing hormone. Endocrinology 120, 272 279.
    • (1987) Endocrinology , vol.120 , pp. 272-279
    • Depaolo, L.V.1    King, R.A.2    Carrillo, A.J.3
  • 60
    • 0035002597 scopus 로고    scopus 로고
    • Autoregulation of the gonadotropin-releasing hormone (GnRH) system during puberty: Effects of antagonistic versus agonistic GnRH analogs in a female rat model
    • Roth C, Schricker M, Lakomek M, Strege A, Heiden I, Luft H, Munzel U, Wuttke W Jarry H (2001) Autoregulation of the gonadotropin-releasing hormone (GnRH) system during puberty: effects of antagonistic versus agonistic GnRH analogs in a female rat model. J Endocrinol 169, 361 371.
    • (2001) J Endocrinol , vol.169 , pp. 361-371
    • Roth, C.1    Schricker, M.2    Lakomek, M.3    Strege, A.4    Heiden, I.5    Luft, H.6    Munzel, U.7    Wuttke, W.8    Jarry, H.9
  • 61
    • 23444432857 scopus 로고
    • Gonadotropin releasing hormone inhibitory autofeedback by subproducts antagonist at N-methyl-D-aspartate receptors: A model of autocrine regulation of peptide secretion
    • Bourguignon JP, varez Gonzalez ML, Gerard A Franchimont P (1994) Gonadotropin releasing hormone inhibitory autofeedback by subproducts antagonist at N-methyl-D-aspartate receptors: a model of autocrine regulation of peptide secretion. Endocrinology 134, 1589 1592.
    • (1994) Endocrinology , vol.134 , pp. 1589-1592
    • Bourguignon, J.P.1    Varez Gonzalez, M.L.2    Gerard, A.3    Franchimont, P.4
  • 62
    • 0035114414 scopus 로고    scopus 로고
    • Differential regulation of two forms of gonadotropin-releasing hormone messenger ribonucleic acid in human granulosa-luteal cells
    • Kang SK, Tai CJ, Nathwani PS Leung PC (2001) Differential regulation of two forms of gonadotropin-releasing hormone messenger ribonucleic acid in human granulosa-luteal cells. Endocrinology 142, 182 192.
    • (2001) Endocrinology , vol.142 , pp. 182-192
    • Kang, S.K.1    Tai, C.J.2    Nathwani, P.S.3    Leung, P.C.4
  • 63
    • 0027167625 scopus 로고
    • Expression of gonadotropin-releasing hormone receptors and autocrine regulation of neuropeptide release in immortalized hypothalamic neurons
    • Krsmanovic LZ, Stojilkovic SS, Mertz LM, Tomic M Catt KJ (1993) Expression of gonadotropin-releasing hormone receptors and autocrine regulation of neuropeptide release in immortalized hypothalamic neurons. Proc Natl Acad Sci USA 90, 3908 3912.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 3908-3912
    • Krsmanovic, L.Z.1    Stojilkovic, S.S.2    Mertz, L.M.3    Tomic, M.4    Catt, K.J.5
  • 64
    • 0034463904 scopus 로고    scopus 로고
    • Role of gonadotropin-releasing hormone as an autocrine growth factor in human ovarian surface epithelium
    • Kang SK, Choi KC, Cheng KW, Nathwani PS, Auersperg N Leung PC (2000) Role of gonadotropin-releasing hormone as an autocrine growth factor in human ovarian surface epithelium. Endocrinology 141, 72 80.
    • (2000) Endocrinology , vol.141 , pp. 72-80
    • Kang, S.K.1    Choi, K.C.2    Cheng, K.W.3    Nathwani, P.S.4    Auersperg, N.5    Leung, P.C.6
  • 65
    • 33846173926 scopus 로고    scopus 로고
    • Regulation of type II luteinizing hormone-releasing hormone (LHRH-II) gene expression by the processed peptide of LHRH-I, LHRH-(1-5) in endometrial cells
    • Baldwin EL, Wegorzewska IN, Flora M Wu TJ (2007) Regulation of type II luteinizing hormone-releasing hormone (LHRH-II) gene expression by the processed peptide of LHRH-I, LHRH-(1-5) in endometrial cells. Exp Biol Med (Maywood) 232, 146 155.
    • (2007) Exp Biol Med (Maywood) , vol.232 , pp. 146-155
    • Baldwin, E.L.1    Wegorzewska, I.N.2    Flora, M.3    Wu, T.J.4
  • 66
    • 11144226953 scopus 로고    scopus 로고
    • Stimulation of luteinizing hormone-releasing hormone (LHRH) gene expression in GT1-7 cells by its metabolite, LHRH-(1-5)
    • Wu TJ, Mani SK, Glucksman MJ Roberts JL (2005) Stimulation of luteinizing hormone-releasing hormone (LHRH) gene expression in GT1-7 cells by its metabolite, LHRH-(1-5). Endocrinology 146, 280 286.
    • (2005) Endocrinology , vol.146 , pp. 280-286
    • Wu, T.J.1    Mani, S.K.2    Glucksman, M.J.3    Roberts, J.L.4
  • 67
    • 0027999075 scopus 로고
    • Novel presence of luteinizing hormone/human chorionic gonadotropin (hCG) receptors and the down-regulating action of hCG on gonadotropin-releasing hormone gene expression in immortalized hypothalamic GT1-7 neurons
    • Lei ZM Rao CV (1994) Novel presence of luteinizing hormone/human chorionic gonadotropin (hCG) receptors and the down-regulating action of hCG on gonadotropin-releasing hormone gene expression in immortalized hypothalamic GT1-7 neurons. Mol Endocrinol 8, 1111 1121.
    • (1994) Mol Endocrinol , vol.8 , pp. 1111-1121
    • Lei, Z.M.1    Rao, C.V.2
  • 68
    • 0028148727 scopus 로고
    • Expression and regulation of gonadotropin-releasing hormone (GnRH) and GnRH receptor messenger ribonucleic acids in human granulosa-luteal cells
    • Peng C, Fan NC, Ligier M, Vaananen J Leung PC (1994) Expression and regulation of gonadotropin-releasing hormone (GnRH) and GnRH receptor messenger ribonucleic acids in human granulosa-luteal cells. Endocrinology 135, 1740 1746.
    • (1994) Endocrinology , vol.135 , pp. 1740-1746
    • Peng, C.1    Fan, N.C.2    Ligier, M.3    Vaananen, J.4    Leung, P.C.5
  • 69
    • 33745105625 scopus 로고    scopus 로고
    • Differential regulation of two forms of gonadotropin-releasing hormone messenger ribonucleic acid by gonadotropins in human immortalized ovarian surface epithelium and ovarian cancer cells
    • Choi JH, Choi KC, Auersperg N Leung PC (2006) Differential regulation of two forms of gonadotropin-releasing hormone messenger ribonucleic acid by gonadotropins in human immortalized ovarian surface epithelium and ovarian cancer cells. Endocr Relat Cancer 13, 641 651.
    • (2006) Endocr Relat Cancer , vol.13 , pp. 641-651
    • Choi, J.H.1    Choi, K.C.2    Auersperg, N.3    Leung, P.C.4
  • 70
    • 0027304746 scopus 로고
    • Absence of androgen receptors in LHRH immunoreactive neurons
    • Huang X Harlan RE (1993) Absence of androgen receptors in LHRH immunoreactive neurons. Brain Res 624, 309 311.
    • (1993) Brain Res , vol.624 , pp. 309-311
    • Huang, X.1    Harlan, R.E.2
  • 71
    • 0031738481 scopus 로고    scopus 로고
    • Regulation of gonadotropin-releasing hormone (GnRH) gene expression by 5alpha-dihydrotestosterone in GnRH-secreting GT1-7 hypothalamic neurons
    • Belsham DD, Evangelou A, Roy D, Duc VL Brown TJ (1998) Regulation of gonadotropin-releasing hormone (GnRH) gene expression by 5alpha- dihydrotestosterone in GnRH-secreting GT1-7 hypothalamic neurons. Endocrinology 139, 1108 1114.
    • (1998) Endocrinology , vol.139 , pp. 1108-1114
    • Belsham, D.D.1    Evangelou, A.2    Roy, D.3    Duc, V.L.4    Brown, T.J.5
  • 72
    • 33645514445 scopus 로고    scopus 로고
    • Ligand-independent effects of estrogen receptor beta on mouse gonadotropin-releasing hormone promoter activity
    • Pak TR, Chung WC, Roberts JL Handa RJ (2006) Ligand-independent effects of estrogen receptor beta on mouse gonadotropin-releasing hormone promoter activity. Endocrinology 147, 1924 1931.
    • (2006) Endocrinology , vol.147 , pp. 1924-1931
    • Pak, T.R.1    Chung, W.C.2    Roberts, J.L.3    Handa, R.J.4
  • 73
    • 0028297150 scopus 로고
    • Glucocorticoid receptor-mediated repression of gonadotropin-releasing hormone promoter activity in GT1 hypothalamic cell lines
    • Chandran UR, Attardi B, Friedman R, Dong KW, Roberts JL DeFranco DB (1994) Glucocorticoid receptor-mediated repression of gonadotropin-releasing hormone promoter activity in GT1 hypothalamic cell lines. Endocrinology 134, 1467 1474.
    • (1994) Endocrinology , vol.134 , pp. 1467-1474
    • Chandran, U.R.1    Attardi, B.2    Friedman, R.3    Dong, K.W.4    Roberts, J.L.5    Defranco, D.B.6
  • 75
    • 0033237619 scopus 로고    scopus 로고
    • Estrogen directly represses gonadotropin-releasing hormone (GnRH) gene expression in estrogen receptor-alpha (ERalpha)- and ERbeta-expressing GT1-7 GnRH neurons
    • Roy D, Angelini NL Belsham DD (1999) Estrogen directly represses gonadotropin-releasing hormone (GnRH) gene expression in estrogen receptor-alpha (ERalpha)- and ERbeta-expressing GT1-7 GnRH neurons. Endocrinology 140, 5045 5053.
    • (1999) Endocrinology , vol.140 , pp. 5045-5053
    • Roy, D.1    Angelini, N.L.2    Belsham, D.D.3
  • 76
    • 0037328595 scopus 로고    scopus 로고
    • Differential regulation of gonadotropin-releasing hormone (GnRH)I and GnRHII messenger ribonucleic acid by gonadal steroids in human granulosa luteal cells
    • Khosravi S Leung PC (2003) Differential regulation of gonadotropin-releasing hormone (GnRH)I and GnRHII messenger ribonucleic acid by gonadal steroids in human granulosa luteal cells. J Clin Endocrinol Metab 88, 663 672.
    • (2003) J Clin Endocrinol Metab , vol.88 , pp. 663-672
    • Khosravi, S.1    Leung, P.C.2
  • 77
    • 0023749292 scopus 로고
    • Changes in cellular levels of messenger ribonucleic acid encoding gonadotropin-releasing hormone in the anterior hypothalamus of female rats during the estrous cycle
    • Zoeller RT Young WS III. (1988) Changes in cellular levels of messenger ribonucleic acid encoding gonadotropin-releasing hormone in the anterior hypothalamus of female rats during the estrous cycle. Endocrinology 123, 1688 1689.
    • (1988) Endocrinology , vol.123 , pp. 1688-1689
    • Zoeller, R.T.1    Young Iii., W.S.2
  • 78
    • 0030608936 scopus 로고    scopus 로고
    • Interaction of prostaglandin F2alpha and gonadotropin-releasing hormone on progesterone and estradiol production in human granulosa-luteal cells
    • Vaananen JE, Tong BL, Vaananen CM, Chan IH, Yuen BH Leung PC (1997) Interaction of prostaglandin F2alpha and gonadotropin-releasing hormone on progesterone and estradiol production in human granulosa-luteal cells. Biol Reprod 57, 1346 1353.
    • (1997) Biol Reprod , vol.57 , pp. 1346-1353
    • Vaananen, J.E.1    Tong, B.L.2    Vaananen, C.M.3    Chan, I.H.4    Yuen, B.H.5    Leung, P.C.6
  • 79
    • 0032746919 scopus 로고    scopus 로고
    • Estrogen receptor-mediated repression of gonadotropin-releasing hormone (gnRH) promoter activity in transfected CHO-K1 cells
    • Chen ZG, Yu KL, Zheng HM Dong KW (1999) Estrogen receptor-mediated repression of gonadotropin-releasing hormone (gnRH) promoter activity in transfected CHO-K1 cells. Mol Cell Endocrinol 158, 131 142.
    • (1999) Mol Cell Endocrinol , vol.158 , pp. 131-142
    • Chen, Z.G.1    Yu, K.L.2    Zheng, H.M.3    Dong, K.W.4
  • 80
    • 0035099655 scopus 로고    scopus 로고
    • Estradiol regulates gonadotropin-releasing hormone (GnRH) and its receptor gene expression and antagonizes the growth inhibitory effects of GnRH in human ovarian surface epithelial and ovarian cancer cells
    • Kang SK, Choi KC, Tai CJ, Auersperg N Leung PC (2001) Estradiol regulates gonadotropin-releasing hormone (GnRH) and its receptor gene expression and antagonizes the growth inhibitory effects of GnRH in human ovarian surface epithelial and ovarian cancer cells. Endocrinology 142, 580 588.
    • (2001) Endocrinology , vol.142 , pp. 580-588
    • Kang, S.K.1    Choi, K.C.2    Tai, C.J.3    Auersperg, N.4    Leung, P.C.5
  • 81
    • 0029874527 scopus 로고    scopus 로고
    • Evidence for estrogen receptor-mediated regulation of human gonadotropin-releasing hormone promoter activity in human placental cells
    • Dong KW, Chen ZG, Cheng KW Yu KL (1996) Evidence for estrogen receptor-mediated regulation of human gonadotropin-releasing hormone promoter activity in human placental cells. Mol Cell Endocrinol 117, 241 246.
    • (1996) Mol Cell Endocrinol , vol.117 , pp. 241-246
    • Dong, K.W.1    Chen, Z.G.2    Cheng, K.W.3    Yu, K.L.4
  • 82
    • 0026766885 scopus 로고
    • Estrogen negatively regulates rat gonadotropin releasing hormone (rGnRH) promoter activity in transfected placental cells
    • Wierman ME, Kepa JK, Sun W, Gordon DF Wood WM (1992) Estrogen negatively regulates rat gonadotropin releasing hormone (rGnRH) promoter activity in transfected placental cells. Mol Cell Endocrinol 86, 1 10.
    • (1992) Mol Cell Endocrinol , vol.86 , pp. 1-10
    • Wierman, M.E.1    Kepa, J.K.2    Sun, W.3    Gordon, D.F.4    Wood, W.M.5
  • 83
    • 85077345847 scopus 로고    scopus 로고
    • The transcription of the hGnRH-I and hGnRH-II genes in human neuronal cells is differentially regulated by estrogen
    • Chen A, Zi K, Laskar-Levy O Koch Y (2002) The transcription of the hGnRH-I and hGnRH-II genes in human neuronal cells is differentially regulated by estrogen. J Mol Neurosci 18, 67 76.
    • (2002) J Mol Neurosci , vol.18 , pp. 67-76
    • Chen, A.1    Zi, K.2    Laskar-Levy, O.3    Koch, Y.4
  • 84
    • 0030056831 scopus 로고    scopus 로고
    • Hormonal and neurotransmitter regulation of GnRH gene expression and related reproductive behaviors
    • Sagrillo CA, Grattan DR, McCarthy MM Selmanoff M (1996) Hormonal and neurotransmitter regulation of GnRH gene expression and related reproductive behaviors. Behav Genet 26, 241 277.
    • (1996) Behav Genet , vol.26 , pp. 241-277
    • Sagrillo, C.A.1    Grattan, D.R.2    McCarthy, M.M.3    Selmanoff, M.4
  • 85
    • 0032884132 scopus 로고    scopus 로고
    • Genomic and membrane actions of progesterone: Implications for reproductive physiology and behavior
    • Schumacher M, Coirini H, Robert F, Guennoun R El-Etr M (1999) Genomic and membrane actions of progesterone: implications for reproductive physiology and behavior. Behav Brain Res 105, 37 52.
    • (1999) Behav Brain Res , vol.105 , pp. 37-52
    • Schumacher, M.1    Coirini, H.2    Robert, F.3    Guennoun, R.4    El-Etr, M.5
  • 86
    • 0027162026 scopus 로고
    • The effects of a long-acting progestin on the hypothalamic-pituitary- ovarian axis in women with normal menstrual cycles
    • Poindexter AN III., Dildy GA, Brody SA, Snabes MC Brodyand SA (1993) The effects of a long-acting progestin on the hypothalamic-pituitary-ovarian axis in women with normal menstrual cycles. Contraception 48, 37 45.
    • (1993) Contraception , vol.48 , pp. 37-45
    • Poindexter Iii., A.N.1    Dildy, G.A.2    Brody, S.A.3    Snabes, M.C.4    Brodyand, S.A.5
  • 87
    • 0022617497 scopus 로고
    • In vitro LHRH release from superfused hypothalamus as a function of the rat estrous cycle: Effect of progesterone
    • Kim K Ramirez VD (1986) In vitro LHRH release from superfused hypothalamus as a function of the rat estrous cycle: effect of progesterone. Neuroendocrinology 42, 392 398.
    • (1986) Neuroendocrinology , vol.42 , pp. 392-398
    • Kim, K.1    Ramirez, V.D.2
  • 88
    • 0025094245 scopus 로고
    • Progesterone enhances the surge of luteinizing hormone by increasing the activation of luteinizing hormone-releasing hormone neurons
    • Lee WS, Smith MS Hoffman GE (1990) Progesterone enhances the surge of luteinizing hormone by increasing the activation of luteinizing hormone-releasing hormone neurons. Endocrinology 127, 2604 2606.
    • (1990) Endocrinology , vol.127 , pp. 2604-2606
    • Lee, W.S.1    Smith, M.S.2    Hoffman, G.E.3
  • 89
    • 0018947087 scopus 로고
    • Pulsatile secretion of luteinizing hormone: Differential suppression by ovarian steroids
    • Goodman RL Karsch FJ (1980) Pulsatile secretion of luteinizing hormone: differential suppression by ovarian steroids. Endocrinology 107, 1286 1290.
    • (1980) Endocrinology , vol.107 , pp. 1286-1290
    • Goodman, R.L.1    Karsch, F.J.2
  • 91
    • 0024306101 scopus 로고
    • Regulation of pro-gonadotropin-releasing hormone gene expression by sex steroids in the brain of male and female rats
    • Toranzo D, Dupont E, Simard J, Labrie C, Couet J, Labrie F Pelletier G (1989) Regulation of pro-gonadotropin-releasing hormone gene expression by sex steroids in the brain of male and female rats. Mol Endocrinol 3, 1748 1756.
    • (1989) Mol Endocrinol , vol.3 , pp. 1748-1756
    • Toranzo, D.1    Dupont, E.2    Simard, J.3    Labrie, C.4    Couet, J.5    Labrie, F.6    Pelletier, G.7
  • 93
    • 0024464692 scopus 로고
    • Progesterone increases messenger ribonucleic acid (mRNA) encoding luteinizing hormone releasing hormone (LHRH) level in the hypothalamus of ovariectomized estradiol-primed prepubertal rats
    • Kim K, Lee BJ, Park Y Cho WK (1989) Progesterone increases messenger ribonucleic acid (mRNA) encoding luteinizing hormone releasing hormone (LHRH) level in the hypothalamus of ovariectomized estradiol-primed prepubertal rats. Brain Res Mol Brain Res 6, 151 158.
    • (1989) Brain Res Mol Brain Res , vol.6 , pp. 151-158
    • Kim, K.1    Lee, B.J.2    Park, Y.3    Cho, W.K.4
  • 94
    • 0021070493 scopus 로고
    • In situ photolinked nuclear progesterone receptors of human breast cancer cells: Subunit molecular weights after transformation and translocation
    • Horwitz KB Alexander PS (1983) In situ photolinked nuclear progesterone receptors of human breast cancer cells: subunit molecular weights after transformation and translocation. Endocrinology 113, 2195 2201.
    • (1983) Endocrinology , vol.113 , pp. 2195-2201
    • Horwitz, K.B.1    Alexander, P.S.2
  • 95
    • 0033374783 scopus 로고    scopus 로고
    • The a and B isoforms of the human progesterone receptor: Two functionally different transcription factors encoded by a single gene
    • Giangrande PH McDonnell DP (1999) The A and B isoforms of the human progesterone receptor: two functionally different transcription factors encoded by a single gene. Recent Prog Horm Res 54, 291 313.
    • (1999) Recent Prog Horm Res , vol.54 , pp. 291-313
    • Giangrande, P.H.1    McDonnell, D.P.2
  • 96
    • 0034000089 scopus 로고    scopus 로고
    • The opposing transcriptional activities of the two isoforms of the human progesterone receptor are due to differential cofactor binding
    • Giangrande PH, Kimbrel EA, Edwards DP McDonnell DP (2000) The opposing transcriptional activities of the two isoforms of the human progesterone receptor are due to differential cofactor binding. Mol Cell Biol 20, 3102 3115.
    • (2000) Mol Cell Biol , vol.20 , pp. 3102-3115
    • Giangrande, P.H.1    Kimbrel, E.A.2    Edwards, D.P.3    McDonnell, D.P.4
  • 97
    • 14044250986 scopus 로고    scopus 로고
    • Differential role of progesterone receptor isoforms in the transcriptional regulation of human gonadotropin-releasing hormone I (GnRH I) receptor, GnRH I, and GnRH II
    • An BS, Choi JH, Choi KC Leung PC (2005) Differential role of progesterone receptor isoforms in the transcriptional regulation of human gonadotropin-releasing hormone I (GnRH I) receptor, GnRH I, and GnRH II. J Clin Endocrinol Metab 90, 1106 1113.
    • (2005) J Clin Endocrinol Metab , vol.90 , pp. 1106-1113
    • An, B.S.1    Choi, J.H.2    Choi, K.C.3    Leung, P.C.4
  • 98
    • 0028034494 scopus 로고
    • Steroid binding and metabolism in the luteinizing hormone-releasing hormone-producing neuronal cell line GT1-1
    • Poletti A, Melcangi RC, Negri-Cesi P, Maggi R Martini L (1994) Steroid binding and metabolism in the luteinizing hormone-releasing hormone-producing neuronal cell line GT1-1. Endocrinology 135, 2623 2628.
    • (1994) Endocrinology , vol.135 , pp. 2623-2628
    • Poletti, A.1    Melcangi, R.C.2    Negri-Cesi, P.3    Maggi, R.4    Martini, L.5
  • 99
    • 0031000789 scopus 로고    scopus 로고
    • Specific, nongenomic actions of steroid hormones
    • Wehling M (1997) Specific, nongenomic actions of steroid hormones. Annu Rev Physiol 59, 365 393.
    • (1997) Annu Rev Physiol , vol.59 , pp. 365-393
    • Wehling, M.1
  • 101
    • 0036842223 scopus 로고    scopus 로고
    • Differential regulation of gonadotropin-releasing hormone secretion and gene expression by androgen: Membrane versus nuclear receptor activation
    • Shakil T, Hoque AN, Husain M Belsham DD (2002) Differential regulation of gonadotropin-releasing hormone secretion and gene expression by androgen: membrane versus nuclear receptor activation. Mol Endocrinol 16, 2592 2602.
    • (2002) Mol Endocrinol , vol.16 , pp. 2592-2602
    • Shakil, T.1    Hoque, A.N.2    Husain, M.3    Belsham, D.D.4
  • 103
    • 33747070253 scopus 로고    scopus 로고
    • Glucocorticoid repression of the reproductive axis: Effects on GnRH and gonadotropin subunit mRNA levels
    • Gore AC, Attardi B DeFranco DB (2006) Glucocorticoid repression of the reproductive axis: effects on GnRH and gonadotropin subunit mRNA levels. Mol Cell Endocrinol 256, 40 48.
    • (2006) Mol Cell Endocrinol , vol.256 , pp. 40-48
    • Gore, A.C.1    Attardi, B.2    Defranco, D.B.3
  • 104
    • 0022263603 scopus 로고
    • A suppression of gonadotropin secretion by cortisol in castrated male rhesus monkeys (Macaca mulatta) mediated by the interruption of hypothalamic gonadotropin-releasing hormone release
    • Dubey AK Plant TM (1985) A suppression of gonadotropin secretion by cortisol in castrated male rhesus monkeys (Macaca mulatta) mediated by the interruption of hypothalamic gonadotropin-releasing hormone release. Biol Reprod 33, 423 431.
    • (1985) Biol Reprod , vol.33 , pp. 423-431
    • Dubey, A.K.1    Plant, T.M.2
  • 106
    • 0034895297 scopus 로고    scopus 로고
    • DHEA and its transformation into androgens and estrogens in peripheral target tissues: Intracrinology
    • Labrie F, Luu-The V, Labrie C Simard J (2001) DHEA and its transformation into androgens and estrogens in peripheral target tissues: intracrinology. Front Neuroendocrinol 22, 185 212.
    • (2001) Front Neuroendocrinol , vol.22 , pp. 185-212
    • Labrie, F.1    Luu-The, V.2    Labrie, C.3    Simard, J.4
  • 107
    • 0029992644 scopus 로고    scopus 로고
    • Dehydroepiandrosterone and dehydroepiandrosterone sulfate as neuroactive neurosteroids
    • Baulieu EE Robel P (1996) Dehydroepiandrosterone and dehydroepiandrosterone sulfate as neuroactive neurosteroids. J Endocrinol 150 (Suppl. S221 S239.
    • (1996) J Endocrinol , vol.150
    • Baulieu, E.E.1    Robel, P.2
  • 108
    • 0029074143 scopus 로고
    • Effects of dehydroepiandrosterone (DHEA) on GnRH gene expression in the rat brain as studied by in situ hybridization
    • Li S, Garcia de YE Pelletier G (1995) Effects of dehydroepiandrosterone (DHEA) on GnRH gene expression in the rat brain as studied by in situ hybridization. Peptides 16, 425 430.
    • (1995) Peptides , vol.16 , pp. 425-430
    • Li, S.1    Garcia De, Y.E.2    Pelletier, G.3
  • 109
    • 0038699383 scopus 로고    scopus 로고
    • Evidence that dehydroepiandrosterone, DHEA, directly inhibits GnRH gene expression in GT1-7 hypothalamic neurons
    • Cui H, Lin SY Belsham DD (2003) Evidence that dehydroepiandrosterone, DHEA, directly inhibits GnRH gene expression in GT1-7 hypothalamic neurons. Mol Cell Endocrinol 203, 13 23.
    • (2003) Mol Cell Endocrinol , vol.203 , pp. 13-23
    • Cui, H.1    Lin, S.Y.2    Belsham, D.D.3
  • 110
    • 0023901235 scopus 로고
    • Effect of food manipulation on the GnRH-LH-estradiol axis of young female rats
    • Bronson FH (1988) Effect of food manipulation on the GnRH-LH-estradiol axis of young female rats. Am J Physiol 254, R616 R621.
    • (1988) Am J Physiol , vol.254
    • Bronson, F.H.1
  • 112
    • 0025884362 scopus 로고
    • Suppression of pulsatile luteinizing hormone and testosterone secretion during short term food restriction in the adult male rhesus monkey (Macaca mulatta)
    • Cameron JL Nosbisch C (1991) Suppression of pulsatile luteinizing hormone and testosterone secretion during short term food restriction in the adult male rhesus monkey (Macaca mulatta). Endocrinology 128, 1532 1540.
    • (1991) Endocrinology , vol.128 , pp. 1532-1540
    • Cameron, J.L.1    Nosbisch, C.2
  • 113
    • 25844473390 scopus 로고    scopus 로고
    • Insulin regulation of GnRH gene expression through MAP kinase signaling pathways
    • Kim HH, DiVall SA, Deneau RM Wolfe A (2005) Insulin regulation of GnRH gene expression through MAP kinase signaling pathways. Mol Cell Endocrinol 242, 42 49.
    • (2005) Mol Cell Endocrinol , vol.242 , pp. 42-49
    • Kim, H.H.1    Divall, S.A.2    Deneau, R.M.3    Wolfe, A.4
  • 114
    • 34247622216 scopus 로고    scopus 로고
    • Egr-1 binds the GnRH promoter to mediate the increase in gene expression by insulin
    • DiVall SA, Radovick S Wolfe A (2007) Egr-1 binds the GnRH promoter to mediate the increase in gene expression by insulin. Mol Cell Endocrinol 270, 64 72.
    • (2007) Mol Cell Endocrinol , vol.270 , pp. 64-72
    • Divall, S.A.1    Radovick, S.2    Wolfe, A.3
  • 115
    • 0029812609 scopus 로고    scopus 로고
    • Luteinizing hormone deficiency and female infertility in mice lacking the transcription factor NGFI-A (Egr-1)
    • Lee SL, Sadovsky Y, Swirnoff AH, Polish JA, Goda P, Gavrilina G Milbrandt J (1996) Luteinizing hormone deficiency and female infertility in mice lacking the transcription factor NGFI-A (Egr-1). Science 273, 1219 1221.
    • (1996) Science , vol.273 , pp. 1219-1221
    • Lee, S.L.1    Sadovsky, Y.2    Swirnoff, A.H.3    Polish, J.A.4    Goda, P.5    Gavrilina, G.6    Milbrandt, J.7
  • 117
    • 0028018966 scopus 로고
    • Cloning and characterization of a mammalian melatonin receptor that mediates reproductive and circadian responses
    • Reppert SM, Weaver DR Ebisawa T (1994) Cloning and characterization of a mammalian melatonin receptor that mediates reproductive and circadian responses. Neuron 13, 1177 1185.
    • (1994) Neuron , vol.13 , pp. 1177-1185
    • Reppert, S.M.1    Weaver, D.R.2    Ebisawa, T.3
  • 118
    • 0029115639 scopus 로고
    • Molecular characterization of a second melatonin receptor expressed in human retina and brain: The Mel1b melatonin receptor
    • Reppert SM, Godson C, Mahle CD, Weaver DR, Slaugenhaupt SA Gusella JF (1995) Molecular characterization of a second melatonin receptor expressed in human retina and brain: the Mel1b melatonin receptor. Proc Natl Acad Sci USA 92, 8734 8738.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 8734-8738
    • Reppert, S.M.1    Godson, C.2    Mahle, C.D.3    Weaver, D.R.4    Slaugenhaupt, S.A.5    Gusella, J.F.6
  • 119
    • 0034752124 scopus 로고    scopus 로고
    • Cyclical regulation of GnRH gene expression in GT1-7 GnRH-secreting neurons by melatonin
    • Roy D, Angelini NL, Fujieda H, Brown GM Belsham DD (2001) Cyclical regulation of GnRH gene expression in GT1-7 GnRH-secreting neurons by melatonin. Endocrinology 142, 4711 4720.
    • (2001) Endocrinology , vol.142 , pp. 4711-4720
    • Roy, D.1    Angelini, N.L.2    Fujieda, H.3    Brown, G.M.4    Belsham, D.D.5
  • 120
    • 1542313846 scopus 로고    scopus 로고
    • Repression of gonadotropin-releasing hormone (GnRH) gene expression by melatonin may involve transcription factors COUP-TFI and C/EBP beta binding at the GnRH enhancer
    • Gillespie JM, Roy D, Cui H Belsham DD (2004) Repression of gonadotropin-releasing hormone (GnRH) gene expression by melatonin may involve transcription factors COUP-TFI and C/EBP beta binding at the GnRH enhancer. Neuroendocrinology 79, 63 72.
    • (2004) Neuroendocrinology , vol.79 , pp. 63-72
    • Gillespie, J.M.1    Roy, D.2    Cui, H.3    Belsham, D.D.4
  • 121
    • 0027143823 scopus 로고
    • Evidence that nitric oxide may mediate the ovarian steroid-induced luteinizing hormone surge: Involvement of excitatory amino acids
    • Bonavera JJ, Sahu A, Kalra PS Kalra SP (1993) Evidence that nitric oxide may mediate the ovarian steroid-induced luteinizing hormone surge: involvement of excitatory amino acids. Endocrinology 133, 2481 2487.
    • (1993) Endocrinology , vol.133 , pp. 2481-2487
    • Bonavera, J.J.1    Sahu, A.2    Kalra, P.S.3    Kalra, S.P.4
  • 122
    • 0027428648 scopus 로고
    • Nitric oxide regulates luteinizing hormone-releasing hormone secretion
    • Moretto M, Lopez FJ Negro-Vilar A (1993) Nitric oxide regulates luteinizing hormone-releasing hormone secretion. Endocrinology 133, 2399 2402.
    • (1993) Endocrinology , vol.133 , pp. 2399-2402
    • Moretto, M.1    Lopez, F.J.2    Negro-Vilar, A.3
  • 123
    • 0027485027 scopus 로고
    • Role of nitric oxide in the control of luteinizing hormone-releasing hormone release in vivo and in vitro
    • Rettori V, Belova N, Dees WL, Nyberg CL, Gimeno M McCann SM (1993) Role of nitric oxide in the control of luteinizing hormone-releasing hormone release in vivo and in vitro. Proc Natl Acad Sci USA 90, 10130 10134.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 10130-10134
    • Rettori, V.1    Belova, N.2    Dees, W.L.3    Nyberg, C.L.4    Gimeno, M.5    McCann, S.M.6
  • 124
    • 0030040751 scopus 로고    scopus 로고
    • NMDA and nitric oxide act through the cGMP signal transduction pathway to repress hypothalamic gonadotropin-releasing hormone gene expression
    • Belsham DD, Wetsel WC Mellon PL (1996) NMDA and nitric oxide act through the cGMP signal transduction pathway to repress hypothalamic gonadotropin-releasing hormone gene expression. EMBO J 15, 538 547.
    • (1996) EMBO J , vol.15 , pp. 538-547
    • Belsham, D.D.1    Wetsel, W.C.2    Mellon, P.L.3
  • 125
    • 0026354237 scopus 로고
    • Mitotic phosphorylation of the Oct-1 homeodomain and regulation of Oct-1 DNA binding activity
    • Segil N, Roberts SB Heintz N (1991) Mitotic phosphorylation of the Oct-1 homeodomain and regulation of Oct-1 DNA binding activity. Science 254, 1814 1816.
    • (1991) Science , vol.254 , pp. 1814-1816
    • Segil, N.1    Roberts, S.B.2    Heintz, N.3
  • 126
    • 0030610204 scopus 로고    scopus 로고
    • Retinoid X receptors
    • Rowe A (1997) Retinoid X receptors. Int J Biochem Cell Biol 29, 275 278.
    • (1997) Int J Biochem Cell Biol , vol.29 , pp. 275-278
    • Rowe, A.1
  • 127
    • 0035809805 scopus 로고    scopus 로고
    • A functional retinoic acid response element (RARE) is present within the distal promoter of the rat gonadotropin-releasing hormone (GnRH) gene
    • Cho S, Chung JJ, Choe Y, Choi HS, Han KD, Rhee K Kim K (2001) A functional retinoic acid response element (RARE) is present within the distal promoter of the rat gonadotropin-releasing hormone (GnRH) gene. Brain Res Mol Brain Res 87, 204 213.
    • (2001) Brain Res Mol Brain Res , vol.87 , pp. 204-213
    • Cho, S.1    Chung, J.J.2    Choe, Y.3    Choi, H.S.4    Han, K.D.5    Rhee, K.6    Kim, K.7
  • 128
    • 0035809810 scopus 로고    scopus 로고
    • 9-cis-Retinoic acid represses transcription of the gonadotropin-releasing hormone (GnRH) gene via proximal promoter region that is distinct from all-trans-retinoic acid response element
    • Cho S, Chung J, Han J, Ju LB, Han KD, Rhee K Kim K (2001) 9-cis-Retinoic acid represses transcription of the gonadotropin-releasing hormone (GnRH) gene via proximal promoter region that is distinct from all-trans-retinoic acid response element. Brain Res Mol Brain Res 87, 214 222.
    • (2001) Brain Res Mol Brain Res , vol.87 , pp. 214-222
    • Cho, S.1    Chung, J.2    Han, J.3    Ju, L.B.4    Han, K.D.5    Rhee, K.6    Kim, K.7
  • 129
    • 0029791821 scopus 로고    scopus 로고
    • Insulin-like growth factor I of peripheral origin acts centrally to accelerate the initiation of female puberty
    • Hiney JK, Srivastava V, Nyberg CL, Ojeda SR Dees WL (1996) Insulin-like growth factor I of peripheral origin acts centrally to accelerate the initiation of female puberty. Endocrinology 137, 3717 3728.
    • (1996) Endocrinology , vol.137 , pp. 3717-3728
    • Hiney, J.K.1    Srivastava, V.2    Nyberg, C.L.3    Ojeda, S.R.4    Dees, W.L.5
  • 130
    • 0025859755 scopus 로고
    • Insulin-like growth factor I: A possible metabolic signal involved in the regulation of female puberty
    • Hiney JK, Ojeda SR Dees WL (1991) Insulin-like growth factor I: a possible metabolic signal involved in the regulation of female puberty. Neuroendocrinology 54, 420 423.
    • (1991) Neuroendocrinology , vol.54 , pp. 420-423
    • Hiney, J.K.1    Ojeda, S.R.2    Dees, W.L.3
  • 131
    • 0029155722 scopus 로고
    • Modulation of anterior pituitary luteinizing hormone response to gonadotropin-releasing hormone by insulin-like growth factor I in vitro
    • Soldani R, Cagnacci A, Paoletti AM, Yen SS Melis GB (1995) Modulation of anterior pituitary luteinizing hormone response to gonadotropin-releasing hormone by insulin-like growth factor I in vitro. Fertil Steril 64, 634 637.
    • (1995) Fertil Steril , vol.64 , pp. 634-637
    • Soldani, R.1    Cagnacci, A.2    Paoletti, A.M.3    Yen, S.S.4    Melis, G.B.5
  • 132
    • 0028127104 scopus 로고
    • Insulin, insulin-like growth factor I (IGF-I) and IGF-II enhance basal and gonadotrophin-releasing hormone-stimulated luteinizing hormone release from rat anterior pituitary cells in vitro
    • Soldani R, Cagnacci A Yen SS (1994) Insulin, insulin-like growth factor I (IGF-I) and IGF-II enhance basal and gonadotrophin-releasing hormone-stimulated luteinizing hormone release from rat anterior pituitary cells in vitro. Eur J Endocrinol 131, 641 645.
    • (1994) Eur J Endocrinol , vol.131 , pp. 641-645
    • Soldani, R.1    Cagnacci, A.2    Yen, S.S.3
  • 133
    • 0031011236 scopus 로고    scopus 로고
    • Regulation of gonadotropin-releasing hormone (GnRH) gene expression by insulin-like growth factor I in a cultured GnRH-expressing neuronal cell line
    • Zhen S, Zakaria M, Wolfe A Radovick S (1997) Regulation of gonadotropin-releasing hormone (GnRH) gene expression by insulin-like growth factor I in a cultured GnRH-expressing neuronal cell line. Mol Endocrinol 11, 1145 1155.
    • (1997) Mol Endocrinol , vol.11 , pp. 1145-1155
    • Zhen, S.1    Zakaria, M.2    Wolfe, A.3    Radovick, S.4
  • 134
    • 0028990167 scopus 로고
    • Activation of central GABAA-but not of GABAB-receptors rapidly reduces pituitary LH release and GnRH gene expression in the preoptic/anterior hypothalamic area of ovariectomized rats
    • Leonhardt S, Seong JY, Kim K, Thorun Y, Wuttke W Jarry H (1995) Activation of central GABAA-but not of GABAB-receptors rapidly reduces pituitary LH release and GnRH gene expression in the preoptic/anterior hypothalamic area of ovariectomized rats. Neuroendocrinology 61, 655 662.
    • (1995) Neuroendocrinology , vol.61 , pp. 655-662
    • Leonhardt, S.1    Seong, J.Y.2    Kim, K.3    Thorun, Y.4    Wuttke, W.5    Jarry, H.6
  • 135
    • 0029042488 scopus 로고
    • Acute increase of GABAergic neurotransmission exerts a stimulatory effect on GnRH gene expression in the preoptic/anterior hypothalamic area of ovariectomized, estrogen- and progesterone-treated adult female rats
    • Kang SH, Seong JY, Cho S, Cho H Kim K (1995) Acute increase of GABAergic neurotransmission exerts a stimulatory effect on GnRH gene expression in the preoptic/anterior hypothalamic area of ovariectomized, estrogen- and progesterone-treated adult female rats. Neuroendocrinology 61, 486 492.
    • (1995) Neuroendocrinology , vol.61 , pp. 486-492
    • Kang, S.H.1    Seong, J.Y.2    Cho, S.3    Cho, H.4    Kim, K.5
  • 136
    • 0036970861 scopus 로고    scopus 로고
    • Role of gamma-aminobutyric acid neurons in the release of gonadotropin-releasing hormone in cultured rat embryonic olfactory placodes
    • Funabashi T, Daikoku S, Suyama K, Mitsushima D, Sano A Kimura F (2002) Role of gamma-aminobutyric acid neurons in the release of gonadotropin-releasing hormone in cultured rat embryonic olfactory placodes. Neuroendocrinology 76, 193 202.
    • (2002) Neuroendocrinology , vol.76 , pp. 193-202
    • Funabashi, T.1    Daikoku, S.2    Suyama, K.3    Mitsushima, D.4    Sano, A.5    Kimura, F.6
  • 137
    • 0031761388 scopus 로고    scopus 로고
    • Luteinizing hormone releasing hormone (LHRH) neurons maintained in nasal explants decrease LHRH messenger ribonucleic acid levels after activation of GABA(A) receptors
    • Fueshko SM, Key S Wray S (1998) Luteinizing hormone releasing hormone (LHRH) neurons maintained in nasal explants decrease LHRH messenger ribonucleic acid levels after activation of GABA(A) receptors. Endocrinology 139, 2734 2740.
    • (1998) Endocrinology , vol.139 , pp. 2734-2740
    • Fueshko, S.M.1    Key, S.2    Wray, S.3


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