Phorbol ester inhibition of rat gonadotropin-releasing hormone promoter activity: Role of Fos and Jun in the repression of transcription

Molecular Endocrinology

Volumn 10, Issue 1, 1996, Pages 35-44

  Bruder, Jan M ^a   Spaulding, Andrea J ^a   Wierman, Margaret E ^a  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GONADORELIN; PHORBOL ESTER;

ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; DNA FLANKING REGION; DNA SEQUENCE; ENZYME PHOSPHORYLATION; GENE DELETION; GENE EXPRESSION; GENE REPRESSION; GENETIC TRANSCRIPTION; HORMONE RECEPTOR INTERACTION; NEUROTRANSMITTER RELEASE; NONHUMAN; ONCOGENE C FOS; PRIORITY JOURNAL; PROMOTER REGION; RAT; TRANSCRIPTION REGULATION;

ANIMALS; BASE SEQUENCE; BINDING SITES; DNA; GENE EXPRESSION; GENES, FOS; GENES, JUN; GONADOTROPIN-RELEASING HORMONE; LEUCINE ZIPPERS; LUCIFERASES; MOLECULAR SEQUENCE DATA; PROMOTER REGIONS (GENETICS); RATS; RNA, MESSENGER; TETRADECANOYLPHORBOL ACETATE; TRANSCRIPTION FACTOR AP-1; TRANSCRIPTION, GENETIC; TRANSFECTION;

EID: 0030025215     PISSN: 08888809     EISSN: None     Source Type: Journal    
DOI: 10.1210/me.10.1.35     Document Type: Article

References (35)

1. Seeburg PH, Mason AJ, Stewart TA, Nikolics K 1987 The mammalian GnRH gene and its pivotal role in reproduction. Recent Prog Horm Res 43:69-95
2. Ojeda SR, Urbanski HF, Katz KH, Costa ME, Conn PM 1986 Activation of two different but complementary biochemical pathways stimulates release of hypothalamic luteinizing hormone-releasing hormone. Proc Natl Acad Sci USA 83:4932-4936
3. 2 secretion from median eminence nerve terminals in vitro. Brain Res Bull 15:657-659
4. Negro-Vilar A, Conte D, Valenca M 1986 Transmembrane signals mediating neural peptide secretion: role of protein kinase C activators and arachidonic acid metabolites in luteinizing hormone-releasing hormone secretion. Endocrinology 119:2796-2802
5. Negro-Vilar A, Valenca MM 1987 Transmembrane signals and neural peptide release: role of protein kinase C activators and arachidonic acid. Ann NY Acad Sci 494:146-149
6. Bruder JM, Krebs WD, Nett TM, Wierman ME 1992 Phorbol ester activation of the protein kinase C pathway inhibits gonadotropin-releasing hormone gene expression. Endocrinology 131:2552-2558
7. Bruder JM, Wierman ME 1994 Evidence for transcriptional inhibition of GnRH gene expression by phorbol ester at a proximal promoter region. Mol Cell Endocrinol 99:177-182
8. Yu K-L, Yeo TTS, Dong K-W, Jakubowski M, Lackner-Arkin C, Blum M, Roberts JL 1994 Second messenger regulation of mouse gonadotropin-releasing hormone gene expression in immortalized mouse hypothalamic GT1-3 cells. Mol Cell Endocrinol 102:85-92
9. Wetsel WC, Eraly SA, Whyte DB, Mellon PL 1993 Regulation of gonadotropin-releasing hormone by protein kinase-A and -C in immortalized hypothalamic neurons. Endocrinology 132:2360-2370
10. Nishizuka Y 1989 Studies and prospectives of the protein kinase C family for cellular regulation. Cancer 63:1892-1903
11. Nishizuka Y 1986 Studies and perspectives of protein kinase C. Science 233:305-312
12. Harrison SC 1991 A structural taxonomy of DNA-binding domains. Nature 353:715-719
13. Shuman JD, Vinson CR, McKnight SL 1990 Evidence of changes in protease sensitivity and subunit exchange rate on DNA binding by C/EBP. Science 249:771-774
14. Curran T, Franza BR Jr 1988 Fos and jun: the AP-1 connection. Cell 55:395-397
15. Rauscher FJI II, Voulalas PJ, Franza BR Jr, Curran T 1988 Fos and Jun bind cooperatively to the AP-1 site: reconstitution in vitro. Genes Dev 2:1687-1699
16. Gius D, Cao X, Rauscher FJI II, Cohen DR, Curran T, Sukhatme VP 1990 Transcriptional activation and repression of Fos are independent functions: the C terminus represses immediate-early gene expression via CArG elements. Mol Cell Biol 10:4243-4255
17. Gurney AL, Park EA, Giralt M, Liu J, Hanson RW 1992 Opposing actions of fos and jun on transcription of the phosphoenolpyruvate carboxykinase (GTP) gene. J Biol Chem 267:18133-18139
18. König H, Ponta H, Rahmsdorf U, Büscher M, Schönthal A, Rahmsdorf HJ, Herrlich P 1989 Autoregulation of fos: the dyad symmetry element as the major target of repression. EMBO J 8:2559-2566
19. SRF bound to the SRE. EMBO J 8:2567-2574
20. Sassone-Corsi P, Sisson JC, Verma IM 1988 Transcriptional autoregulation of the proto-oncogene fos. Nature 334:314-319
21. McBride K, Robitaille L, Tremblay S, Argentin S, Nemer M 1993 fos/jun repression of cardiac-specific transcription in quiescent and growth-stimulated myocytes is targeted at a tissue-specific cis element. Mol Cell Biol 13: 600-612
22. Wierman ME, Jacobsen BM, Kepa JK, Latzka MD, Radovick S, Chou J, Placental specific expression of the GnRH gene in SPA-209 human placental cells. Program of the The 77th Annual Meeting of The Endocrine Society, Washington, DC, 1995, p 3 (Abstract 668)
23. Gentz R, Rauscher FJI II, Abate C, Curran T 1989 Parallel association of fos and jun leucine zippers juxtaposes DNA binding domains. Science 243:1695-1699
24. Sonnenberg JL, Rauscher FJI I, Morgan JI, Curran T 1989 Regulation of proenkephalin by fos and jun. Science 246:1622-1625
25. Eraly SA, Mellon PL 1995 Regulation of gonadotropin-releasing hormone transcription by protein kinase C is mediated by evolutionary conserved promoter-proximal elements. Mol Endocrinol 9:848-859
26. Mellon PL, Windle JJ, Goldsmith PC, Padula CA, Roberts JL, Weiner RI 1990 Immortalization of hypothalamic GnRH neurons by genetically targeted tumorigenesis. Neuron 5:1-10
27. Feinberg AP, Vogelstein B 1983 A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity. Anal Biochem 132:6-13
28. Kepa JK, Wang C, Neeley CI, Raynolds MV, Gordon DF, Wood WM, Wierman ME 1992 Structure of the rat gonadotropin releasing hormone (rGnRH) gene promoter and functional analysis in hypothalamic cells. Nucleic Acids Res 20:1393-1399
29. Thomas PS 1980 Hybridization of denatured RNA and small DNA fragments transferred to nitrocellulose. Proc Natl Acad Sci USA 77:5201-5205
30. Wierman ME, Wang C 1990 Androgen selectively stimulates follicle-stimulating hormone-β mRNA levels after gonadotropin-releasing hormone antagonist administration. Biol Reprod 42:563-571
31. Kepa JK, Wang C, Neeley CI, Raynolds MV, Gordon DF, Wood WM, Wierman ME 1992 Structure of the rat gonadotropin releasing hormone (rGnRH) gene promoter and functional analysis in hypothalamic cells. Nucleic Acids Res 20:1393-1399
32. Maxwell IH, Harrison GS, Wood WM, Maxwell F 1989 A DNA cassette containing a trimerized SV40 polyadenylation signal which efficiently blocks spurious plasmid-initiated transcription. Biotechniques 7:276-280
33. Astruc ME, Chabret C, Bali P, Gagne D, Pons M 1995 Prolonged treatment of breast cancer cells with antiestrogens increased the activating protein-1-mediated response: involvement of the estrogen receptor. Endocrinology 136:824-832
34. Hoeffler JP, Meyer TE, Yun Y, Jameson JL, Habener JF 1988 Cyclic AMP-responsive DNA-binding protein: Structure based on a cloned placental cDNA. Science 24:1430-1433
35. Dignam JD, Lebovitz RM, Roeder RG 1983 Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res 11:1475-1489