Regulation of gonadotropin-releasing hormone (GnRH) gene expression by 5α-dihydrotestosterone in GnRH-secreting GT1-7 hypothalamic neurons

Endocrinology

Volumn 139, Issue 3, 1998, Pages 1108-1114

  Belsham, Denise D ^a   Evangelou, Andreas ^a   Roy, Deboleena ^a   Le, Duc Vinh ^b   Brown, Theodore J ^a  

^a UNIVERSITY OF TORONTO   (Canada)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN RECEPTOR; ANDROSTANOLONE; GONADORELIN;

ANIMAL CELL; ARTICLE; GENE EXPRESSION REGULATION; HORMONAL REGULATION; HORMONE ACTION; HORMONE BINDING; HYPOTHALAMUS; IMMUNOBLOTTING; MOUSE; NERVE CELL; NONHUMAN; PRIORITY JOURNAL; RECEPTOR AFFINITY;

EID: 0031738481     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/endo.139.3.5846     Document Type: Article

References (55)

1. Yen SSC 1991 Hypothalamic Gonadotropin-Releasing Hormone: Basic and Clinical Aspects. Raven Press, New York, pp 245-280
2. Kelly MJ, Ronnekleiv OK, Eskay RL 1984 Identification of estrogen-responsive LHRH neurons in the guinea pig hypothalamus. Brain Res Bull 12:399-407
3. Moss RL, Dudley CA 1984 Molecular aspects of the interaction between estrogen and the membrane excitability of hypothalamic nerve cells. Prog Brain Res 61:3-22
4. Shivers BD, Harlan RE, Morrell JI, Pfaff DW 1983 Absence of oestradiol concentration in cell nuclei of LHRH-immunoreactive neurones. Nature 304:345-347
5. Herbison AE, Theodosis DT 1992 Localization of oestrogen receptors in preoptic neurons containing neurotensin but not tyrosine hydroxylase, cholecystokinin or luteinizing hormone-releasing hormone in the male and female rat. Neuroscience 50:283-298
6. Watson REJ, Langub MCJ, Landis JW 1992 Further evidence that most luteinizing hormone-releasing hormone neurons are not directly estrogen-responsive: simultaneous localization of luteinizing hormone and estrogen receptor immunoreactivity in the guinea-pig brain. J Neuroendocrinol 4:311-317
7. Lehman MN, Karsch FJ 1993 Do gonadotropin-releasing hormone, tyrosine hydroxylase-, and β-endorphin-immunoreactive neurons contain estrogen receptors? A double label immunocytochemical study in Suffolk ewe. Endocrinology 133:887-895
8. King JC, Tai DW, Hanna IK, Pfeiffer A, Haas P, Ronsheim PM, Mitchell SC, Turcotte JC, Blaustein JD 1995 A subgroup of LHRH neurons in guinea pigs with progestin receptors is centrally positioned within the total population of LHRH neurons. Neuroendocrinology 61:265-275
9. Huang X, Harlan RE 1993 Absence of androgen receptors in LHRH immunoreactive neurons. Brain Res 624:309-311
10. Kalra PS, Kalra SP 1986 Steroidal modulation of the regulatory neuropoptides: luteinizing hormone releasing hormone, neuropeptide Y and endogenous opiod peptides. J Steroid Biochem 25:733-740
11. Negro-Vilar A, Advis JP, Ojeda SR, McCann SM 1982 Pulsatile luteinizing hormone (LH) patterns in ovariectomized rats: involvement of norepinephrine and dopamine in the release of LH-releasing hormone and LH. Endocrinology 111:932-938
12. Nazian SJ, Landon CS, Muffly KE, Cameron DF 1994 Opioid inhibition of adrenergic and dopaminergic but not serotonergic stimulation of luteinizing hormone releasing hormone release from immortalized hypothalamic neurons. Mol Cell Neurosci 5:642-648
13. Barraclough CA 1992 Neural control of the synthesis and release of luteinizing hormone-releasing hormone. Ciba Found Symp 168:233-246
14. Donoso AO, Lopez FJ, Negro-Vilar A 1992 Cross-talk between excitatory and inhibitory amino acids in the regulation of luteinizing hormone-releasing hormone secretion. Endocrinology 131:1559-1561
15. Brown TJ, MacLusky NJ, Leranth C, Shanabrough M, Naftolin F 1990 Progestin receptor containing neurons in the guinea pig hypothalamus: afferent connections, neurotransmitter content, and morphological characteristics. Mol Cell Neurosci 1:58-77
16. Leranth C, MacLusky NJ, Brown TJ, Chen EC, Redmond DEJ, Naftolin F 1992 Transmitter content and afferent connections of estrogen-sensitive progestin receptor-containing neurons in the primate hypothalamus. Neuroendocrinology 55:667-682
17. Horvath TL, Naftolin F, Leranth C 1993 Luteinizing hormone-releasing hormone and γ-aminobutyric acid neurons in the medial preoptic area are synaptic targets of dopamine axons originating in anterior periventricular areas. J Neuroendocrinol 5:71-79
18. Schwanzel-Fukuda M, Jorgenson KL, Bergen HT, Weesner GD, Pfaff DW 1992 Biology of normal luteinizing hormone-releasing hormone neurons during and after their migration from olfactory placode. Endocr Rev 13:623-634
19. Mellon PL, Windle JJ, Goldsmith P, Pedula C, Roberts J, Weiner RI 1990 Immortalization of hypothalamic GnRH neurons by genetically targeted tumorigenesis. Neuron 5:1-10
20. Wetsel WC 1995 Immortalized hypothalamic luteinizing hormone-releasing hormone (LHRH) neurons: a new tool for dissecting the molecular and cellular basis of LHRH physiology. Cell Mol Neurobiol 15:43-78
21. Wierman ME, Bruder JM, Kepa JK 1995 Regulation of gonadotropin-releasing hormone (GnRH) gene expression in hypothalamic neuronal cells. Cell Mol Neurobiol 15:79-88
22. Clark ME, Lawson MA, Belsham DD, Eraly SA, Mellon PL 1997 Molecular Aspects of GnRH Gene Expression. JAI Press, Greenwich, Connecticut, pp 1-30
23. Gore AC, Roberts JL 1997 Regulation of gonadotropin-releasing hormone gene expression in vivo and in vitro. Front Neuroendocrinol 18:209-245
24. Poletti A, Melcangi RC, Negri-Cesi P, Maggi R, Martini L 1994 Steroid binding and metabolism in the luteinizing hormone-releasing hormone-producing neuronal cell line GT1-1. Endocrinology 135:2623-2628
25. Yeh S, Chang C 1996 Cloning and characterization of a specific coactivator, ARA70, for the androgen receptor in human prostate cells. Proc Natl Acad Sci USA 93:5517-5521
26. Jones SA, Brooks AN, Challis JRG 1989 Steroids modulate corticotropin-releasing hormone production in human fetal membranes and placenta. J Clin Endocrinol Metab 68:825-830
27. Belsham DD, Wetsel WC, Mellon PL 1996 NMDA and nitric oxide act through the cGMP signal transduction pathway to repress hypothalamic gonadotropin-releasing hormone gene expression. EMBO J 15:538-547
28. Chomczynski P, Sacchi N 1987 Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 162:156-159
29. Maniatis T, Fritsch EF, Sambrook J 1982 Molecular Cloning: A Laboratory Manual. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY
30. Adelman JP, Mason AJ, Hayflick JS, Seeburg PH 1986 Isolation of the gene and hypothalamic cDNA for the common precursor of gonadotropin-releasing hormone and prolactin release-inhibiting factor in human and rat. Proc Natl Acad Sci USA 83:179-183
31. Brinkmann AO, Faber PW, van Rooij HC, Kuiper GG, Ris C, Klaassen P, van der Korput JA, Voorhorst MM, van Laar JH, Mulder E, Trapman J 1989 The human androgen receptor: domain structure, genomic organization and regulation of expression. J Steroid Biochem 34:307-310
32. Gunning P, Ponte P, Okayama H, Engel J, Blau H, Kedes L 1983 Isolation and characterization of full-length cDNA clones for human α-, β, and γ-actin mRNAs: skeletal but not cytoplasmic actins have an amino-terminal cysteine that is subsequently removed. Mol Cell Biol 3:787-795
33. Feinberg AP, Vogelstein B 1983 A technique forradiolabeling DNA restriction endonuclease fragments to high specific activity. Anal Biochem 132:6-13
34. Bradford M 1976 A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principles of protein-dye binding. Anal Biochem 72:248-254
35. Heisler LE, Evangelou A, Lew AM, Trachtenberg J, Elsholtz HP, Brown TJ 1997 Androgen-dependent cell cycle arrest and apoptotic death in PC-3 prostatic cell cultures expressing a full-length human androgen receptor. Mol Cell Endocrinol 126:59-73
36. Puy L, MacLusky NJ, Becker L, Karsan N, Trachtenberg J, Brown TJ 1995 Immunocytochemical detection of androgen receptor in human temporal cortex: characterization and application of polyclonal androgen receptor antibodies in frozen and paraffin-embedded tissues. J Steroid Biochem Mol Biol 55:197-209
37. Mellon PL, Clegg CH, Correll LA, McKnight GS 1989 Regulation of transcription by cyclic AMP-dependent protein kinase. Proc Natl Acad Sci USA 86:4887-4891
38. Gorman C 1985 High efficiency gene transfer into mammalian cells. IRL Press, Oxford, pp 143-190
39. Tilley WD, Wilson CM, Marcelli M, McPhaul MJ 1990 Androgen receptor gene expression in human prostate carcinoma cell lines. Cancer Res 50:5382-5386
40. Cato AC, Henderson D, Ponta H 1987 The hormone response element of the mouse mammary tumour virus DNA mediates the progestin and androgen induction of transcription in the proviral long terminal repeat region. EMBO J 6:363-368
41. Kalra SP, Kalra PS 1989 Do testosterone and estradiol-17β enforce inhibition or stimulation of luteinizing hormone-releasing hormone secretion? Biol Reprod 41:559-570
42. Steger RW, Bartke A 1995 Neuroendocrine control of reproduction. Adv Exp Med Biol 377:15-32
43. Komm BS, Terpening CM, Benz DK, Graeme KA, Gallegos A, Korc M, Greene GL, O'Malley BW, Haussler MR 1988 Estrogen binding, mRNA, and biologic response in osteoblast-like osteosarcoma cells. Science 232:81-84
44. Erikson EF, Colcard DS, Berg NJ, Graham ML, Mann KG, Spelsberg TC, Riggs BL 1988 Evidence of estrogen receptors in normal human osteoblast-like cells. Science 304:84-86
45. Wolf DA, Herzinger T, Hermeking H, Blaschke D, Horz W 1993 Transcriptional and posttranscriptional regulation of human androgen receptor expression by androgen. Mol Endocrinol 7:924-936
46. Grossmann ME, Lindzey J, Blok L, Perry JE, Kumar MV, Tindall DJ 1994 The mouse androgen receptor gene contains a second functional promoter which is regulated by dihydrotestosterone. Biochemistry 33:14594-14600
47. Toranzo D, Dupont E, Simard J, Labrie C, Couet J, Labrie F, Pelletier G 1989 Regulation of pro-gonadotropin-releasing hormone gene expression by sex steroids in the brain of male and female rats. Mol Endocrinol 3:1748-1756
48. Selmanoff M, Shu C, Petersen SL, Barraclough CA, Zoeller RT 1991 Single cell levels of hypothalamic messenger ribonucleic acid encoding luteinizing hormone-releasing hormone in intact, castrated, and hyperlactinaemic male rats. Endocrinology 128:459-466
49. Li S, Garcia de Yebenes E, Pelletier G 1995 Effects of dehydroepiandrosterone (DHEA) on GnRH gene expression in the rat brain as studied by in situ hybridization. Peptides 16:425-430
50. Wiemann JN, Clifton DK, Steiner RA 1990 Gonadotropin-releasing hormone messenger ribonucleic acid levels are unaltered with changes in the gonadal hormone milieu of the adult male rat. Endocrinology 127:523-532
51. Malik KF, Silverman A-J, Morrell JI 1991 Gonadotropin-releasing hormone mRNA in the rat: distribution and neuronal content over the estrous cycle and after castration in males. Anat Rec 231:457-466
52. Park Y, Park SD, Cho WK, Kim K 1988 Testosterone stimulates LHRH-like mRNA level in the rat hypothalamus. Brain Res 451:255-261
53. Spratt DP, Herbison AE 1997 Regulation of preoptic area gonadotropin-releasing hormone (GnRH) mRNA expression by gonadal steroids in the long-term gonadectomized male rat. Mol Brain Res 47:125-133
54. Li S, Pelletier G 1994 Involvement of an autoregulatory mechanism for the regulation of gonadotropin-releasing hormone (GnRH) gene expression in neurons in the rat preoptic area. Neurosci Lett 174:61-63
55. Kepa JK, Boen EA, Localization of an androgen responsive cis-acting DNA element in the rat GnRH gene. Program of the 75th Annual Meeting of The Endocrine Society, Las Vegas, NV, 1993, p 546