New DNA polymerase IIIC inhibitors: 3-Subtituted anilinouracils with potent antibacterial activity in vitro and in vivo

ChemMedChem

Volumn 3, Issue 10, 2008, Pages 1604-1615

  Svenstrup, Niels ^a   Ehlert, Kerstin ^a   Ladel, Christoph ^a   Kuhl, Alexander ^a   Häbich, Dieter ^a  

^a BAYER PHARMA AG   (Germany)

Author keywords

Anilinouracils; Antibiotics; DNA polymerase IIIC; Drug resistance; Gram positive bacteria

Indexed keywords

ANTIINFECTIVE AGENT; DNA DIRECTED DNA POLYMERASE GAMMA; DRUG DERIVATIVE; URACIL;

ANIMAL; ANIMAL MODEL; ARTICLE; CELL CULTURE; CHEMISTRY; DRUG ANTAGONISM; DRUG DESIGN; HUMAN; IC 50; METABOLISM; MICROBIOLOGICAL EXAMINATION; MOUSE; SYNTHESIS;

ANIMALS; ANTI-BACTERIAL AGENTS; CELLS, CULTURED; DNA POLYMERASE III; DRUG DESIGN; HUMANS; INHIBITORY CONCENTRATION 50; MICE; MICROBIAL SENSITIVITY TESTS; MODELS, ANIMAL; URACIL;

EID: 54849417792     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.200800117     Document Type: Article

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