Direct N3 Alkylation of Uracil and Derivatives via N1-[2-(trimethylsilyl)ethoxymethyl] Protection

Synlett

Volumn 1997, Issue 11, 1997, Pages 1233-1234

  Arias, L ^a   Guzman A ^a   Jaime Figueroa, S ^a   Lopez, F J ^a   Morgans Jr , D J ^a   Padilla, F ^a   Perez Medrano A ^a   Quintero, C ^a   Romero, M ^a   Sandoval, L ^a  

^a ROCHE BIOSCIENCE   (United States)

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[No Author keywords available]

Indexed keywords

EID: 0000450816     PISSN: 09365214     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-1997-1029     Document Type: Article

References (23)

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8. b) For use of the protecting SEM group in other heterocyclic systems, see: Phadtare, S.; Zemlicka, J. J. Org. Chem. 1989, 54, 3675. Whitten J. P.; Matthews, D. P.; McCarthy, J. R. J. Org. Chem. 1986, 51, 1891. Muchowski, J. M.; Solas, D. R. J. Org. Chem. 1984, 49, 203. Edwards, M. P.; Ley, S. V.; Lister, S. G.; Palmer, B. D.; Williams, D. J. J. Org. Chem. 1984, 49, 3503.
9. b) For use of the protecting SEM group in other heterocyclic systems, see: Phadtare, S.; Zemlicka, J. J. Org. Chem. 1989, 54, 3675. Whitten J. P.; Matthews, D. P.; McCarthy, J. R. J. Org. Chem. 1986, 51, 1891. Muchowski, J. M.; Solas, D. R. J. Org. Chem. 1984, 49, 203. Edwards, M. P.; Ley, S. V.; Lister, S. G.; Palmer, B. D.; Williams, D. J. J. Org. Chem. 1984, 49, 3503.
10. b) For use of the protecting SEM group in other heterocyclic systems, see: Phadtare, S.; Zemlicka, J. J. Org. Chem. 1989, 54, 3675. Whitten J. P.; Matthews, D. P.; McCarthy, J. R. J. Org. Chem. 1986, 51, 1891. Muchowski, J. M.; Solas, D. R. J. Org. Chem. 1984, 49, 203. Edwards, M. P.; Ley, S. V.; Lister, S. G.; Palmer, B. D.; Williams, D. J. J. Org. Chem. 1984, 49, 3503.
11. b) For use of the protecting SEM group in other heterocyclic systems, see: Phadtare, S.; Zemlicka, J. J. Org. Chem. 1989, 54, 3675. Whitten J. P.; Matthews, D. P.; McCarthy, J. R. J. Org. Chem. 1986, 51, 1891. Muchowski, J. M.; Solas, D. R. J. Org. Chem. 1984, 49, 203. Edwards, M. P.; Ley, S. V.; Lister, S. G.; Palmer, B. D.; Williams, D. J. J. Org. Chem. 1984, 49, 3503.
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15. 3Si: C, 51.56; H, 7.81; N, 10.93. Found: C, 51.79; H, 8.14; N, 10.86.
16. All compounds have been characterized spectroscopically and elemental composition established by combustion analysis or high resolution mass spectrometry.
17. Tanaka, H.; Takashima, H.; Ubasawa, M.; Sekiya, K.; Nitta, I.; Baba, M.; Shigeta, S.; Walker, R. T.; De Clercq, E.; Miyasaka, T. J. Meet. Chem. 1992, 35, 4713.
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20. 18 mp 200-202°C).
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