Synthesis and antibacterial activity of 3-substituted-6-(3-ethyl-4- methylanilino)uracils

Journal of Medicinal Chemistry

Volumn 48, Issue 22, 2005, Pages 7063-7074

  Zhi, Chengxin ^a   Long, Zheng Yu ^a   Manikowski, Andrzej ^a   Brown, Neal C ^a   Tarantino Jr , Paul M ^a   Holm, Karsten ^a   Dix, Edward J ^a   Wright, George E ^a   Foster, Kim A ^b   Butler, Michelle M ^b   LaMarr, William A ^b   Skow, Donna J ^b   Motorina, Irina ^c   Lamothe, Serge ^c   Storer, Richard ^c,d  

^a GLSYNTHESIS INC   (United States)

^b MICROBIOTIX INC   (United States)

^c Shire Canada   (Canada)

^d Laboratoires Idenix   (France)

Author keywords

[No Author keywords available]

Indexed keywords

2 METHOXY 6 AMINO 4 PYRIMIDONE; 3 [4 (N MORPHOLINYL)BUTYL] 6 (3 ETHYL 4 METHYLANILINO)URACIL; 3 ETHYL 4 METHYLANILINE; 6 (3 ETHYL 4 METHYLANILINO)URACIL DERIVATIVE; ANTIINFECTIVE AGENT; DNA DIRECTED DNA POLYMERASE GAMMA; UNCLASSIFIED DRUG; URACIL DERIVATIVE; VANCOMYCIN;

ALKYLATION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBACTERIAL ACTIVITY; AREA UNDER THE CURVE; ARTICLE; BACILLUS SUBTILIS; BACTERIAL GROWTH; BACTERIAL INFECTION; CONTROLLED STUDY; DEMETHYLATION; DRUG EFFICACY; DRUG HALF LIFE; DRUG PROTEIN BINDING; DRUG SOLUBILITY; DRUG SYNTHESIS; ENTEROCOCCUS FAECALIS; ENTEROCOCCUS FAECIUM; ENZYME INHIBITION; GRAM POSITIVE BACTERIUM; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VITRO STUDY; MALE; MINIMUM INHIBITORY CONCENTRATION; MOUSE; NONHUMAN; STAPHYLOCOCCUS AUREUS;

ANILINE COMPOUNDS; ANIMALS; ANTI-BACTERIAL AGENTS; DNA POLYMERASE III; GRAM-POSITIVE BACTERIA; MICE; MICROBIAL SENSITIVITY TESTS; STAPHYLOCOCCAL INFECTIONS; STAPHYLOCOCCUS AUREUS; STRUCTURE-ACTIVITY RELATIONSHIP; URACIL;

EID: 27444434636     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm050517r     Document Type: Article

References (12)

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