Novel non-nucleobase inhibitors of Staphylococcus aureus DNA polymerase IIIC

Bioorganic and Medicinal Chemistry Letters

Volumn 16, Issue 4, 2006, Pages 891-896

  Rose, Yannick ^a   Ciblat, Stéphane ^a   Reddy, Ranga ^a   Belley, Adam C ^a   Dietrich, Evelyne ^a   Lehoux, Dario ^a   McKay, Geoffrey A ^a   Poirier, Hugo ^a   Far, Adel Rafai ^a   Delorme, Daniel ^a,b  

^a INSTITUTE FOR RESEARCH IN IMMUNOLOGY AND CANCER   (Canada)

^b Neurochem Inc   (Canada)

Author keywords

Antibacterial; Antimicrobial; DNA polymerase IIIC; In vivo; Protein binding

Indexed keywords

6 HYDROXY 2 (ANILINO)PYRIMIDINONE; BACTERIAL ENZYME; DNA POLYMERASE; PROTEIN DNA POLYMERASE IIIC; PYRIMIDINONE DERIVATIVE; UNCLASSIFIED DRUG; VANCOMYCIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIAL STRAIN; CONTROLLED STUDY; DNA REPLICATION; DRUG EFFICACY; DRUG INHIBITION; DRUG MECHANISM; DRUG SYNTHESIS; ENZYME INHIBITION; IC 50; IN VITRO STUDY; IN VIVO STUDY; MINIMUM INHIBITORY CONCENTRATION; MOUSE; NONHUMAN; PERITONITIS; SERUM; STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS INFECTION; STRUCTURE ACTIVITY RELATION; SURVIVAL RATE;

DNA POLYMERASE III; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; PYRIMIDINONES; STAPHYLOCOCCUS AUREUS; STRUCTURE-ACTIVITY RELATIONSHIP;

ANIMALIA; BACTERIA (MICROORGANISMS); POSIBACTERIA; STAPHYLOCOCCUS; STAPHYLOCOCCUS AUREUS;

EID: 30344482903     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2005.11.009     Document Type: Article

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